SciBX: Science-Business eXchange Contents: January 24 2013, Volume 6 / Issue 3

TABLE OF CONTENTS January 24 2013, Volume 6 / Issue 3 Analysis Cover Story Translational Notes Targets and Mechanisms Tools The Distillery: Therapeutics Cancer Cardiovascular disease Endocrine/metabolic disease Infectious disease Inflammation Neurology The Distillery: Techniques Assays and screens Chemistry Disease models Drug delivery Drug platforms Imaging Advertisement BioPharma Dealmakers  A supplement to Nature Biotechnology and Nature Reviews Drug Discovery The October 2012 issue of BioPharma Dealmakers showcases companies with partnering opportunities and contains a focus feature on those active in Neuro-partnering. This week, find out about how you can collaborate with Open Monoclonal Technology, Inc. New Partnering Opportunities in Alzheimer's Disease! A comprehensive interactive dashboard from Relay Technology Management.  Click here for more information on Alzheimer's partnering opportunities.   SciBX: Science-Business eXchange Recommend SciBX to your library today SciBx is a weekly publication that identifies and analyzes the most important translational research articles from over 40 journals. Find out which papers have real scientific and commercial potential, and why. Subscribe to SciBX and you won't miss the next big thing. For more information visit: www.nature.com/scibx.   Trade Secrets A Nature Network blog by BIOENTREPRENEUR Brought to you by Nature Biotechnology Access the insights, advice and commentary from scientists and entrepreneurs building biotech sectors around the world. Join the global dialogue on life science entrepreneurship: http://blogs.nature.com/trade_secrets   Analysis Cover Story Top In silico drug design Joanne Kotz doi:10.1038/scibx.2013.50 A Dundee-UNC team has created a computational algorithm that mines medicinal chemistry literature to predict new ligands that bind specific combinations of GPCRs. Ex Scientia was spun out of Dundee to commercialize the technology. Full Text | PDF Translational Notes Top IMI's collaborative chemistry Chris Cain doi:10.1038/scibx.2013.51 Europe's Innovative Medicines Initiative has launched seven new public-private partnerships with a total budget of €237 million. In contrast to many of the organization's prior disease-focused projects, three of the new consortia are taking drug-centric approaches. Full Text | PDF Targets and Mechanisms Top Giving the NOD2 microbiota Kai-Jye Lou doi:10.1038/scibx.2013.52 European researchers have shown that NOD2 deficiency can disrupt enteric microbiota and predispose the host to colitis and colitis-associated cancer. The group is seeking to understand how NOD2 deficiency leads to microbiota disruption and is looking for bacterial strains that could correct the microbial imbalance. Full Text | PDF Tools Top Sarepta's hemorrhagic mouse Tracey Baas doi:10.1038/scibx.2013.53 A Sarepta team has developed a mouse model of arenavirus infection that recapitulates key symptoms of the disease including hemorrhagic fever and multiorgan failure. The researchers are now interested in using the mice to study the Lassa arenavirus. Full Text | PDF Distillery: Therapeutics Cancer Top Pyruvate kinase M2 isozyme (PKM2); PKM1 doi:10.1038/scibx.2013.54 Cell culture and mouse studies suggest targeting PKM2 may not be sufficient to inhibit tumor growth. Full Text | PDF Cardiovascular disease Top Apelin (APLN); microRNA-424 (miR-424); miR-503 doi:10.1038/scibx.2013.55 In vitro and rodent studies suggest miR-424 and miR-503 could help treat pulmonary arterial hypertension (PAH). Full Text | PDF Endocrine/metabolic disease Top Not applicable doi:10.1038/scibx.2013.56 Nuclear transfer between oocytes could prevent transmission of disorders related to mutations in mitochondrial DNA. Full Text | PDF Infectious disease Top Calcitonin receptor-like (CALCRL; CRLR) doi:10.1038/scibx.2013.57 Rat studies suggest decreasing CRLR expression in the intestines could help treat Clostridium difficile infection. Full Text | PDF HMG-CoA reductase doi:10.1038/scibx.2013.58 Mouse studies suggest statins could help prevent malaria- and sepsis-associated cognitive dysfunction. Full Text | PDF Inflammation Top Lactadherin (MFGE8; HMFG) doi:10.1038/scibx.2013.59 Mouse studies suggest increasing MFGE8 levels could help treat asthma. Full Text | PDF Neural precursor cell expressed developmentally downregulated 8 (NEDD8); NEDD8 activating enzyme (NAE); ubiquitin-conjugating enzyme E2M (UBE2M; UBC12) doi:10.1038/scibx.2013.60 Mouse and cell culture studies suggest inhibiting the NEDD8 signaling pathway could help prevent inflammation. Full Text | PDF Neurology Top Not applicable doi:10.1038/scibx.2013.61 Rodent studies identified hapten-protein conjugates that could be used as oxycodone immunogens to help treat opioid addiction. Full Text | PDF NLR family pyrin domain containing 3 (NLRP3; NALP3); caspase-1 (CASP1) doi:10.1038/scibx.2013.62 Human tissue, cell culture and mouse studies suggest antagonizing NALP3 or CASP1 could help prevent AD. Full Text | PDF Eukaryotic translation initiation factor 4E (eIF4E) doi:10.1038/scibx.2013.63 Mouse studies suggest inhibiting eIF4E could help treat autism spectrum disorder (ASD). Full Text | PDF Annexin A1 (ANXA1) doi:10.1038/scibx.2013.64 Patient sample and mouse studies suggest ANXA1 could help restore blood brain barrier (BBB) integrity in patients with MS. Full Text | PDF Distillery: Techniques Assays and screens Top Adapted Plasmodium knowlesi parasites that infect cultured human red blood cells doi:10.1038/scibx.2013.65 Culture of modified P. knowlesi strains could help identify new malaria therapies. Full Text | PDF Multiple annealing and looping-based amplification cycles (MALBAC) to identify single-nucleotide and copy-number variations in single human cells doi:10.1038/scibx.2013.66 MALBAC could be used to identify genomic variations at the single cell level. Full Text | PDF Serum protein panel for identifying type 1 diabetes doi:10.1038/scibx.2013.67 An assay of serum peptides could help identify patients with type 1 diabetes. Full Text | PDF Chemistry Top Photosensitive small molecule–mediated cleavage of RNA doi:10.1038/scibx.2013.68 Photosensitive small molecules that bind and cleave RNA could help treat diseases driven by aberrant RNA transcripts, such as myotonic dystrophy type 1 (DM1). Full Text | PDF Disease models Top Sortilin 1 (Sort1) knockout mouse model for Alzheimer's disease (AD) doi:10.1038/scibx.2013.69 Sort1 knockout mice could be useful models for AD pathophysiology. Full Text | PDF Drug delivery Top Polyisoprene nanoparticles for cancer drug delivery doi:10.1038/scibx.2013.70 Polyisoprene nanoparticles could be used to deliver drugs to cancer cells. Full Text | PDF Drug platforms Top Cell-based therapy for photoreceptor layer reconstruction to treat age-related macular degeneration (AMD) and retinitis doi:10.1038/scibx.2013.71 Transplantation of rod precursors could help reconstruct the outer nuclear layer of photoreceptors to treat AMD and retinitis. Full Text | PDF Crystal structure of αβ-tubulin in complex with anticancer microtubule-stabilizing agents doi:10.1038/scibx.2013.72 Protein crystal structure studies identified the molecular mechanism of microtubule-stabilizing cancer therapeutics, which could help guide the development of new treatments. Full Text | PDF Crystal structure of the antifibrotic halofuginone bound to the prolyl-tRNA synthetase domain of human glutamyl-prolyl-tRNA synthetase (EPRS) doi:10.1038/scibx.2013.73 The crystal structure of the antifibrotic halofuginone bound to the prolyl-tRNA synthetase domain of human EPRS could aid the development of new compounds to target the synthetase. Full Text | PDF Genetic correction of spinal muscular atrophy (SMA) neurons with a nonviral, nonintegrating vector doi:10.1038/scibx.2013.74 In vitro and mouse studies suggest genetic modification of patient-derived neurons with a nonviral, nonintegrating vector could help treat SMA. Full Text | PDF Micelle drug delivery with a modified tumor-targeting Tat peptide doi:10.1038/scibx.2013.75 In vitro and mouse studies identified modified Tat peptides that could improve drug delivery to tumors. Full Text | PDF Imaging Top Diffuse reflectance spectroscopy to detect microcalcified breast cancer lesions doi:10.1038/scibx.2013.76 Studies of breast cancer samples suggest diffuse reflectance spectroscopy could help detect microcalcified breast cancer lesions during standard biopsies. Full Text | PDF You have been sent this Table of Contents Alert because you have opted in to receive it. 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