Nature Reviews Microbiology contents February 2013 Volume 11 Number 2 pp 67-141

TABLE OF CONTENTS
February 2013 Volume 11 Number 2
Impact Factor 21.182 *	In this issue Editorial Research Highlights News and Analysis Progress Reviews Perspectives Also this month Article Series: Antibiotic alternatives Vector-borne diseases  Featured article: Microbial life under extreme energy limitation Tori M. Hoehler & Bo Barker Jørgensen
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EDITORIAL		Top
Protecting our public health workers p67 | doi:10.1038/nrmicro2967 The escalation of violence against public health workers associated with the polio vaccination campaign in Pakistan bodes ill for the global eradication effort and must cease. Full Text | PDF
RESEARCH HIGHLIGHTS Top Bacterial physiology: Diffusion barrier segments the stalk p69 | doi:10.1038/nrmicro2951 Cross-bands in the stalks of Caulobacter crescentus are composed of at least four proteins and act as diffusion barriers for both soluble and membrane proteins. PDF Viral evolution: It takes two genomes p70 | doi:10.1038/nrmicro2952 Experimental evolution of measles virus reveals that a new phenotype emerges through cooperation between two different viral genomes in a single virion. PDF Host response: Getting the trigger the right way round p70 | doi:10.1038/nrmicro2959 IgG concentrations determine the binding orientation of IgG on S. pyogenes and, thus, affect opsonization and killing. PDF IN THE NEWS Norovirus strikes back p70 | doi:10.1038/nrmicro2962 PDF Parasite biology: Cell division goes back to its roots p71 | doi:10.1038/nrmicro2954 Homologues of algal flagellum components act as spatial and temporal organizers of Toxoplasma gondii cell division. PDF Host response: PF4 — platelets' poison p72 | doi:10.1038/nrmicro2955 Platelet factor 4 is the effector molecule used by platelets to kill P. falciparum in infected erythrocytes. PDF Phage biology: Giving CRISPR the slip p72 | doi:10.1038/nrmicro2958 The first report of phage-encoded genes that inactivate bacterial CRISPR-Cas immunity. PDF Bacterial physiology: Antisense suppression p72 | doi:10.1038/nrmicro2961 Global RNA profiling reveals that the transcription terminator Rho is involved in the widespread suppression of antisense transcription. PDF IN BRIEF Bacillus : Biofilms grow with the flow | Antimicrobials: Statins wise up to cerebral infection | Environmental microbiology: Soil bacteria that don't make the cut PDF Microbiology JOBS of the week Assistant Professor / Postdoc Bacterial Ecology and Microevolution University of Innsbruck, Faculty of Biology, AUSTRIA Postdoctoral position in Metabolic Engineering RWTH Aachen University - Institute of Applied Microbiology Faculty Positions of Professor of Systems Biology of Microbiology ,Professor of Synthetic Biology of Microbiology Nankai University MRC PhD Studentships in Vaccine Research London School of Hygiene & Tropical Medicine Graduate Studentship Microbial Evolution Massey University New Zealand More Science jobs from Microbiology EVENT Society for General Microbiology Spring Conference 2013 03.5.13 Manchester, UK More science events from
NEWS AND ANALYSIS		Top
GENOME WATCH Playing the 'Next-Generation Game' Helena Seth-Smith p74 | doi:10.1038/nrmicro2956 Advances in single-molecule DNA sequencing are enabling research into the fine resolution of DNA structure, and rapid, direct sequencing of pathogen genomes. PDF
PROGRESS		Top
The excludon: a new concept in bacterial antisense RNA-mediated gene regulation Nina Sesto, Omri Wurtzel, Cristel Archambaud, Rotem Sorek & Pascale Cossart p75 | doi:10.1038/nrmicro2934 In this Progress article, Cossart and colleagues discuss the unique features of unusually long antisense RNAs and discuss the excludon paradigm, which describes a genomic locus that encodes a long antisense RNA which inhibits the expression of one operon while simultaneously driving the expression of the adjacent operon. Abstract | Full Text | PDF
REVIEWS		Top
Microbial life under extreme energy limitation Tori M. Hoehler & Bo Barker Jørgensen p83 | doi:10.1038/nrmicro2939 The discovery of abundant microbial life in the deep subsurface, where energy fluxes can be orders of magnitude lower than in laboratory cultures, challenges many of our assumptions about the requirements to sustain life. Here, Tori Hoehler and Bo Barker Jørgensen review our understanding of life in these extremely low-energy environments. Abstract | Full Text | PDF
Article series: Antibiotic alternatives Bacteriocins — a viable alternative to antibiotics? Paul D. Cotter, R. Paul Ross & Colin Hill p95 | doi:10.1038/nrmicro2937 The rise of antibiotic resistance, together with collateral damage to the human microbiota as a result of antibiotic use, means that new antimicrobials need to be developed. Here, Cotter, Ross and Hill discuss the potential of bacteriocins, which are active against a range of bacteria, have low toxicity towards the host, are easily modifiable and can even be produced in situ. Abstract | Full Text | PDF
Structure, function and biosynthesis of O2-tolerant hydrogenases Johannes Fritsch, Oliver Lenz & Bärbel Friedrich p106 | doi:10.1038/nrmicro2940 The reversible oxidation of H2 into protons and electrons is mediated by metalloenzymes known as hydrogenases. Here, Fritsch, Lenz and Friedrich discuss recent progress in our understanding of the structure, function and biosynthesis of a subtype of [NiFe]-hydrogenases mainly found in H2-oxidizing bacteria that can sustain H2 conversion in the presence of ambient O2 levels, a process that has been defined as O2-tolerant H2 cycling. Abstract | Full Text | PDF
Article series: Vector-borne diseases West Nile virus infection and immunity Mehul S. Suthar, Michael S. Diamond & Michael Gale Jr p115 | doi:10.1038/nrmicro2950 Here, Suthar, Diamond and Gale review recent insights into West Nile virus pathogenesis and the host immune responses that this virus activates. Given the continuing spread of the virus in the Western hemisphere, a better understanding of these host-virus interactions is crucial and should facilitate the development of effective vaccines and therapeutics. Abstract | Full Text | PDF | Supplementary information
PERSPECTIVES		Top
ESSAY Fungal systematics: is a new age of enlightenment at hand? David S. Hibbett & John W. Taylor p129 | doi:10.1038/nrmicro2963 Fungal taxonomy has recently undergone its biggest shake-up and embraced the modernization of its nomenclatural rules. Here, Hibbett and Taylor describe these changes and what their implications might be for fungal researchers. Abstract | Full Text | PDF
ESSAY The changing face of pathogen discovery and surveillance W. Ian Lipkin p133 | doi:10.1038/nrmicro2949 The emergence of new microbial infections is ever more likely with the globalization of trade and travel, changes to agricultural practices and climate change. However, as Lipkin describes in this Essay, this threat is being met by dramatic technological advances in pathogen discovery, surveillance and modelling. Abstract | Full Text | PDF
Corrigendum: Molecular mechanisms of Escherichia coli pathogenicity Matthew A. Croxen & B. Brett Finlay p141 | doi:10.1038/nrmicro2953 Full Text | PDF
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