Nature Reviews Immunology Contents February 2013 Volume 13 Number 2 pp 67-149

TABLE OF CONTENTS
February 2013 Volume 13 Number 2
Impact Factor 33.287 *	In this issue Research Highlights Focus on: The inbetweeners: innate-like lymphocytes Also this month  Featured article: Innate lymphoid cells — how did we miss them? Jennifer A. Walker, Jillian L. Barlow & Andrew N. J. McKenzie
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RESEARCH HIGHLIGHTS Top Innate-like lymphocytes: Will the real ILC1 please stand up? p67 | doi:10.1038/nri3397 T-bet instructs the development of IFNγ-producing innate lymphoid cells in mice and humans. PDF Innate immunity: Caspase 8 prevents inflammasome activation p68 | doi:10.1038/nri3387 Caspase 8 inhibits ripoptosome-mediated activation of the NLRP3 inflammasome. PDF Mast cells: Fishing for circulating IgE p68 | doi:10.1038/nri3390 Perivascular mast cells in the skin extend projections into the blood vessel lumen to acquire circulating IgE. PDF Neuroinflammation: Inflammatory brain drain p69 | doi:10.1038/nri3392 Loss of the dopamine D2 receptor or activation of the NLRP3 inflammasome can enhance CNS inflammation and contribute to neurodegenerative disease. PDF Autoimmunity: An innate triple hit initiates diabetes p70 | doi:10.1038/nri3382 B-1a cells, neutrophils and pDCs cooperate to initiate type 1 diabetes. PDF Cytokines: T cells take a break from IL-7 p70 | doi:10.1038/nri3388 Prolonged IL-7-mediated signalling in CD8+ T cells induces apoptosis. PDF Neuroimmunology: ChATty B cells p70 | doi:10.1038/nri3396 B cells secrete the neurotransmitter acetylcholine to control neutrophil recruitment. PDF IN BRIEF Haematopoiesis: Role for NLRP1a inflammasome unravelled | Innate-like lymphocytes: An antifungal role for innate lymphoid cells | Innate-like lymphocytes: Diet shapes the natural killer cell response PDF Immunology JOBS of the week Regulatory Affairs Scientist - Switzerland Paramount Recruitment Postdoc in Vector-borne infectious disease Gong Cheng Clinical Senior Lecturer or Reader in Medical Mycology / Fungal Immunology University of Aberdeen Trial Physician Crucell Holland B,V. Postdoctoral Fellow in Immunology Purdue Univeristy More Science jobs from Immunology EVENT Tumor Immunology and Immunotherapy 10.08.13 Suzhou, China More science events from
Focus on: The inbetweeners: innate-like lymphocytes   FOREWORD Top Shades of grey — the blurring view of innate and adaptive immunity Lewis L. Lanier p73 | doi:10.1038/nri3389 Abstract | Full Text | PDF
Focus on: The inbetweeners: innate-like lymphocytes REVIEWS Top Innate lymphoid cells — how did we miss them? Jennifer A. Walker, Jillian L. Barlow & Andrew N. J. McKenzie p75 | doi:10.1038/nri3349 This Review discusses the key features of innate lymphoid cells (ILCs), which despite their fairly recent identification have emerged as an important cellular component of the immune system. ILCs can rapidly release effector cytokines and promote protective immunity following infection. However, aberrant activation of ILCs may contribute to immunopathology in allergic and autoimmune diseases. Abstract | Full Text | PDF Six-of-the-best: unique contributions of γδ T cells to immunology Pierre Vantourout & Adrian Hayday p88 | doi:10.1038/nri3384 This Review critically assesses six signatory roles of the often overlooked γδ T cells that may collectively distinguish these cells from αβ T cells, and thereby define their unique contributions to lymphocyte biology. Abstract | Full Text | PDF Invariant natural killer T cells: an innate activation scheme linked to diverse effector functions Patrick J. Brennan, Manfred Brigl & Michael B. Brenner p101 | doi:10.1038/nri3369 Invariant natural killer T (iNKT) cells are innate-like lymphocytes that express T cell receptors that can be activated by lipid antigens presented on CD1d molecules. Here, the authors describe different models of iNKT cell activation and discuss how activated iNKT cells can contribute to both protective and pathological immune responses. Abstract | Full Text | PDF Marginal zone B cells: virtues of innate-like antibody-producing lymphocytes Andrea Cerutti, Montserrat Cols & Irene Puga p118 | doi:10.1038/nri3383 Marginal zone B cells are strategically positioned at the interface between the circulation and the white pulp of the spleen, where they can mediate a rapid, innate-like humoral response against both pathogens and commensals that breach the mucosal barrier. Understanding the interplay of these cells with other immune components and the species-specific differences between mice and humans is of clinical importance. Abstract | Full Text | PDF
Focus on: The inbetweeners: innate-like lymphocytes PERSPECTIVES Top OPINION Variable NK cell receptors and their MHC class I ligands in immunity, reproduction and human evolution Peter Parham & Ashley Moffett p133 | doi:10.1038/nri3370 The role of natural killer (NK) cells in both immunity to infection and reproductive success is postulated to have placed competing demands on the evolution of NK cell receptors and their MHC class I ligands during the migration of humans out of Africa. Abstract | Full Text | PDF GUIDELINES Innate lymphoid cells — a proposal for uniform nomenclature Hergen Spits, David Artis, Marco Colonna, Andreas Diefenbach, James P. Di Santo, Gerard Eberl, Shigeo Koyasu, Richard M. Locksley, Andrew N. J. McKenzie, Reina E. Mebius, Fiona Powrie & Eric Vivier p145 | doi:10.1038/nri3365 Innate lymphoid cells (ILCs) have key roles in immune responses, lymphoid tissue development and tissue regeneration. Recently, several new ILC subsets were identified. Here, the authors propose the use of a uniform nomenclature to describe all ILC subsets to avoid confusion and further promote the development of this field. Abstract | Full Text | PDF
Erratum: Transcriptional programming of the dendritic cell network Gabrielle T. Belz & Stephen L. Nutt p149 | doi:10.1038/nri3385 Full Text | PDF
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