Nature Reviews Cancer contents February 2013 Volume 13 Number 2 pp 75-143

TABLE OF CONTENTS
February 2013 Volume 13 Number 2
Impact Factor 37.545 *	In this issue Research Highlights Reviews Perspectives Also this month  Featured article: Regulatory networks defining EMT during cancer initiation and progression Bram De Craene & Geert Berx
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RESEARCH HIGHLIGHTS Top Metastasis: Polarizing metastasis p75 | doi:10.1038/nrc3456 Jeffrey Wrana and colleagues find that exosomes from cancer-associated fibroblasts activate WNT-planar cell polarity signalling in recipient breast tumour cells, which promotes motility and metastasis. PDF Polarity: Merlin and ezrin get organized p76 | doi:10.1038/nrc3453 The tumour suppressor neurofibromatosis type 2 (NF2) restricts ezrin localization to establish cortical asymmetry and correctly position centrosomes and spindles during cell division in polarized epithelial cells. PDF Epigenetics: The long view p76 | doi:10.1038/nrc3454 Susan Clark and colleagues have found evidence in cancer cells that epigenetic changes can occur over long stretches of chromatin, leading to increased gene expression. PDF Microenvironment: Secreted DNA damage? p77 | doi:10.1038/nrc3455 This paper finds that secreted chromatin fragments from leukaemia cells activate DNA damage responses in recipient stromal cells, which leads to their death. PDF Metabolism: Sensitivity to serine starvation p77 | doi:10.1038/nrc3457 Karen Vousden and colleagues have found that cancer cells that have lost the expression of the tumour suppressor p53 are unable to adapt in conditions of serine starvation. PDF Metastasis: Going places with VHL p78 | doi:10.1038/nrc3450 Joan Massague and colleagues have found that epigenetic changes contribute to metastasis in clear-cell renal-cell carcinomas in which the tumour suppressor gene von Hippel-Lindau (VHL) is inactivated. PDF IN THE NEWS Drug trials: in a spin p78 | doi:10.1038/nrc3463 A new study suggests that positive results of breast cancer clinical trials are being exaggerated and side effects downplayed. PDF Apoptosis: Refined and lethal p79 | doi:10.1038/nrc3462 Two studies now describe new approaches to targeting anti-apoptotic BCL-2 family members in various cancer types. PDF Therapeutics: Assault on MALT1 p80 | doi:10.1038/nrc3451 Two new studies identify inhibitors of MALT1 that show anticancer activity in vitro and in vivo for an aggressive subtype of lymphoma. PDF Tumorigenesis: WNT branches out p80 | doi:10.1038/nrc3452 WNT signalling has been linked to the transcriptional coactivators TAZ and YAP1. PDF IN BRIEF Genetics: Mosaic predisposition mutations | Therapeutics: Balancing risks and benefits | Tumorigenesis: A spiny Hedgehog | Imaging: On the edge PDF Cancer JOBS of the week Computational Biology and Cancer Genomics- Postdoctoral Fellow University of Southern California (USC), Keck School of Medicine Bioinformatic Position in Cancer Research San Raffaele Scientific Institute Post-Docs in Cell Death Signaling & Cancer Goethe Universität Frankfurt, Institute for Experimental Cancer Research in Pediatrics Faculty Positions in Cancer Inflammation and Tolerance Georgia Health Sciences University Cancer Center Director Of Synergie Lyon Cancer Bioinformatics Facility Synergie Lyon Cancer Foundation More Science jobs from Cancer EVENT 1st Symposium of the Cancer Research Center of Lyon 13.-15.02.13 Lyon, France More science events from
REVIEWS		Top
MDM2, MDMX and p53 in oncogenesis and cancer therapy Mark Wade, Yao-Cheng Li & Geoffrey M. Wahl p83 | doi:10.1038/nrc3430 The reactivation of wild-type p53 could potentially improve the treatment of many cancer patients. One strategy to achieve this is to target the p53 regulators MDM2 and MDMX. This Review discusses our understanding of how these proteins regulate p53 and the progress that has been made in targeting them. Abstract | Full Text | PDF
Regulatory networks defining EMT during cancer initiation and progression Bram De Craene & Geert Berx p97 | doi:10.1038/nrc3447 Epithelial to mesenchymal transition (EMT) is essential for driving plasticity during development, but can also occur in tumour cells during cancer progression. This Review discusses the layers of regulation (including the transcriptional and translational machinery, non-coding RNAs, alternative splicing and protein stability) that control the process and plasticity of EMT. Abstract | Full Text | PDF
LIM-domain-only proteins in cancer Jacqueline M. Matthews, Krystal Lester, Soumya Joseph & David J. Curtis p111 | doi:10.1038/nrc3418 LIM-domain-only (LMO) proteins are a subset of the LIM-domain protein family and function primarily as transcriptional regulators. They are associated with various cancers, including T cell acute lymphoblastic leukaemia (T-ALL) that resulted from unintended activation of LMO2 by insertional mutagenesis in human gene therapy trials. This Review discusses the roles and potential mechanisms of LMO proteins in cancer and the potential for therapeutic targeting. Abstract | Full Text | PDF
Pathogenic mechanisms in HBV- and HCV-associated hepatocellular carcinoma Alla Arzumanyan, Helena M. G. P. V. Reis & Mark A. Feitelson p123 | doi:10.1038/nrc3449 Hepatocellular carcinoma (HCC) is mainly associated with chronic hepatitis B virus (HBV) and/or hepatitis C virus (HCV) infections. This Review outlines pathogenic mechanisms that seem to be common to both HBV and HCV, in the hope that this might suggest innovative approaches for the prevention and treatment of HCC. Abstract | Full Text | PDF
PERSPECTIVES		Top
OPINION p63 steps into the limelight: crucial roles in the suppression of tumorigenesis and metastasis Xiaohua Su, Deepavali Chakravarti & Elsa R. Flores p136 | doi:10.1038/nrc3446 p63 is expressed as various isoforms that seem to have opposing roles in cancer, with some being tumour suppressive and others being oncogenic. This Opinion article discusses the functions of the p63 isoforms and their interplay with other members of the p53 family. Abstract | Full Text | PDF | Supplementary information
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