| Systems biology technologies series |  | New technologies are pushing the limits of biological measurements in terms of scale, resolution and accuracy, which is enabling the engineering of living organisms in unprecedented ways. Increasingly sophisticated computational methods are used to analyze and integrate quantitative and large-scale biological data. This series features Reviews on the technological platforms and methodologies that are driving the fields of systems and synthetic biology forward to reach new frontiers in biology.
See full series page | | |  | Reading and writing omes | | George M Church Molecular Systems Biology 9:642; doi:10.1038/msb.2012.75; published 22 January 2013 Full Text | PDF | |  | High-throughput sequencing for biology and medicine | | Genome sequencing technologies have advanced rapidly, dramatically decreasing cost and increasing throughput. But beyond faster and cheaper, these advances have also stimulated the development of innovative new experimental approaches, and are opening new doors in human medicine and health. Wendy Weijia Soon, Manoj Hariharan & Michael P Snyder Molecular Systems Biology 9:640; doi:10.1038/msb.2012.61; published 22 January 2013 Full Text | PDF |  | |  | Genome-scale engineering for systems and synthetic biology | | This review provides an overview of methodologies and technologies enabling genome-scale engineering, focusing on the design, construction, and testing of modified genomes in a variety of organisms. Future applications for systems and synthetic biology are discussed. Kevin M Esvelt & Harris H Wang Molecular Systems Biology 9:641; doi:10.1038/msb.2012.66; published 22 January 2013 Full Text | PDF | | | Featured Article | |  | Autonomous bacterial localization and gene expression based on nearby cell receptor density | | Escherichia coli were engineered to enable programmed motility, sensing and phenotypic response to the density of epidermal growth factor receptor expressed on the surface of cancer cells. Hsuan-Chen Wu, Chen-Yu Tsao, David N Quan, Yi Cheng, Matthew D Servinsky, Karen K Carter, Kathleen J Jee, Jessica L Terrell, Amin Zargar, Gary W Rubloff, Gregory F Payne, James J Valdes & William E Bentley Molecular Systems Biology 9:636; doi:10.1038/msb.2012.71; published 22 January 2013 Full Text | PDF | Supp. Inf. | Review Process | | | Research Articles | |  | Widespread splicing changes in human brain development and aging | | Human brain transcriptome analysis revealed widespread age-related splicing changes in the prefrontal cortex and cerebellum. While most of the splicing changes take place in development, approximately one-third of them extends into aging. Pavel Mazin, Jieyi Xiong, Xiling Liu, Zheng Yan, Xiaoyu Zhang, Mingshuang Li, Liu He, Mehmet Somel, Yuan Yuan, Yi-Ping Phoebe Chen, Na Li, Yuhui Hu, Ning Fu, Zhibin Ning, Rong Zeng, Hongyi Yang, Wei Chen, Mikhail Gelfand & Philipp Khaitovich Molecular Systems Biology 9:633; doi:10.1038/msb.2012.67; published 22 January 2013 Full Text | PDF | Supp. Inf. | Review Process | | |  | Systematic analysis of somatic mutations in phosphorylation signaling predicts novel cancer drivers | | Phosphorylation sites of human proteins are frequently mutated in cancer. Statistical analysis of phosphorylation-associated single nucleotide variants (pSNVs) predicts novel cancer drivers and phospho-mutation mechanisms in known cancer genes. J�ri Reimand & Gary D Bader Molecular Systems Biology 9:637; doi:10.1038/msb.2012.68; published 22 January 2013 Full Text | PDF | Supp. Inf. | Review Process | | |  | Shared control of gene expression in bacteria by transcription factors and global physiology of the cell | | A simple, parameterless mathematical model, in combination with real-time monitoring of promoter activities, shows how control of gene expression in bacteria is shared between transcription factors and global physiological effects. Sara Berthoumieux, Hidde de Jong, Guillaume Baptist, Corinne Pinel, Caroline Ranquet, Delphine Ropers & Johannes Geiselmann Molecular Systems Biology 9:634; doi:10.1038/msb.2012.70; published 22 January 2013 Full Text | PDF | Supp. Inf. | Review Process | | |  | Accurate measurements of dynamics and reproducibility in small genetic networks | | Precise analysis of systematic errors shows suitability of immunofluorescence protocols to quantify gene expression means, variances, and cross-correlations. Application to Drosophila gap genes enables reconstructing expression level dynamics and the progression of positional accuracy. Julien O Dubuis, Reba Samanta & Thomas Gregor Molecular Systems Biology 9:639; doi:10.1038/msb.2012.72; published 22 January 2013 Full Text | PDF | Supp. Inf. | Review Process | | |  | An in vivo control map for the eukaryotic mRNA translation machinery | | A new quantitative strategy has generated a comprehensive rate control map for protein synthesis in exponentially growing yeast cells. This analysis reveals the modularity of the system as well as highly non-stoichiometric relationships between components. Helena Firczuk, Shichina Kannambath, J�rgen Pahle, Amy Claydon, Robert Beynon, John Duncan, Hans Westerhoff, Pedro Mendes & John EG McCarthy Molecular Systems Biology 9:635; doi:10.1038/msb.2012.73; published 22 January 2013 Full Text | PDF | Supp. Inf. | Review Process | | |  | Genome-wide analysis of FOXO3 mediated transcription regulation through RNA polymerase II profiling | | By comparative analysis of RNA polymerase II and FOXO3 ChIP-sequencing, combined with 4C-sequencing and ChIPs on histone modifications, general mechanisms of FOXO3-mediated target gene regulation are identified. Astrid Eijkelenboom, Michal Mokry, Elzo de Wit, Lydia M Smits, Paulien E Polderman, Miranda H van Triest, Ruben van Boxtel, Almut Schulze, Wouter de Laat, Edwin Cuppen & Boudewijn M T Burgering Molecular Systems Biology 9:638; doi:10.1038/msb.2012.74; published 22 January 2013 Full Text | PDF | Supp. Inf. | Review Process | | | | | | | You have been sent this Table of Contents Alert because you have opted in to receive it. You can change or discontinue your e-mail alerts at any time, by modifying your preferences on your nature.com account at: www.nature.com/nams/svc/myaccount (You will need to log in to be recognised as a nature.com registrant). For further technical assistance, please contact our registration department. For print subscription enquiries, please contact our subscription department. For other enquiries, please contact our customer feedback department. 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