The EMBO Journal - Table of Contents alert Volume 13 Issue 13

TABLE OF CONTENTS 29 June 2012 | Volume 31, Issue 13 Have you seen? Articles Corrigenda Also new AOP Sign up for e-alerts Recommend to your library Web feed Subscribe Advertisement The EMBO Journal 2012 focus issue: 'Three decades of Wnt signalling' To mark the 30th anniversary of the discovery of the first mammalian Wnt gene, The EMBO Journal features a historic perspective on the field authored by Roel Nusse and Harold Varmus, followed by five authoritative reviews from leading experts in the field. Access the free focus online today.   Have you seen? Top Telomere dysfunction puts the brakes on oncogene-induced cancers The analysis of clinical samples combined with experimental exploration highlights telomere dysfunction-induced senescence (TDIS) as tumour suppressive activity in a variety of human malignancies. Cagatay Günes and Karl Lenhard Rudolph The EMBO Journal (2012), 31, 2833 - 2834; 10.1038/emboj.2012.162 Abstract | Full text | PDF | Related article Published online: 29 May 2012 Up for grabs; trashing peroxisomes In this issue, Motley et al identify Atg36 in Saccharomyces cerevisiae and show it has a function related to Atg30 in methylotrophic yeasts in bringing peroxisomes to the site of autophagosomes biogenesis to coordinate their autophagy (pexophagy). Adabella van der Zand and Fulvio Reggiori The EMBO Journal (2012), 31, 2835 - 2836; 10.1038/emboj.2012.152 Abstract | Full text | PDF | Related article Published online: 29 May 2012 Untangling the mysteries of maternal inheritance with polyCOMB Deletion of PRC1 components in growing mouse oocytes establishes their crucial function in maternal inheritance by determining chromatin states for the following generation. Roopsha Sengupta and M Azim Surani The EMBO Journal (2012), 31, 2837 - 2838; 10.1038/emboj.2012.140 Abstract | Full text | PDF | Related article Published online: 11 May 2012 Articles Top Oncogene-induced telomere dysfunction enforces cellular senescence in human cancer precursor lesions This study offers a novel view on the role of telomere attrition in human tumours, providing evidence for tumour suppressor activity resulting from telomere dysfunction-induced DNA damage responses. Anitha Suram, Jessica Kaplunov, Priyanka L Patel, Haihe Ruan, Aurora Cerutti, Virginia Boccardi, Marzia Fumagalli, Raffaella Di Micco, Neena Mirani, Resham Lal Gurung, Manoor Prakash Hande, Fabrizio d’Adda di Fagagna and Utz Herbig The EMBO Journal (2012), 31, 2839 - 2851; 10.1038/emboj.2012.132 Abstract | Full text | PDF | Supp. info. | Review Process File Published online: 08 May 2012 Pex3-anchored Atg36 tags peroxisomes for degradation in Saccharomyces cerevisiae Pexophagy, peroxysome autophagy, is regulated in Saccharomyces cerevisiae by Atg36 by direct binding to peroxysome regulator Pex3, Atg8 and Atg11 of the core autophagy machinery. Alison M Motley, James M Nuttall and Ewald H Hettema The EMBO Journal (2012), 31, 2852 - 2868; 10.1038/emboj.2012.151 Abstract | Full text | PDF | Supp. info. | Review Process File Published online: 29 May 2012 The KDEL receptor couples to Gαq/11 to activate Src kinases and regulate transport through the Golgi The KDEL receptor regulates intra-Golgi trafficking homoeostasis via a cargo fluxdriven signalling pathway. This study reveals that KDEL-R, which is predicted to resemble a G-protein-coupled receptor, activates the heterotrimeric signalling G-protein G[α]q/1 at the Golgi membrane. Monica Giannotta, Carmen Ruggiero, Mauro Grossi, Jorge Cancino, Mirco Capitani, Teodoro Pulvirenti, Grazia Maria Letizia Consoli, Corrada Geraci, Francesca Fanelli, Alberto Luini and Michele Sallese The EMBO Journal (2012), 31, 2869 - 2881; 10.1038/emboj.2012.134 Abstract | Full text | PDF | Supp. info. | Review Process File Published online: 11 May 2012 The dual PH domain protein Opy1 functions as a sensor and modulator of PtdIns(4,5)P2 synthesis The lipid PtdIns(4,5)P2 regulates many cellular processes including exo- and endocytosis. Localized PtdIns(4,5)P2 synthesis is regulated by assembly of the PtdIns(4)P 5-kinase Mss4 in plasma membrane patches and by feedback inhibition by Opy1. Yading Ling, Christopher J Stefan, Jason A MacGurn, Anjon Audhya and Scott D Emr The EMBO Journal (2012), 31, 2882 - 2894; 10.1038/emboj.2012.127 Abstract | Full text | PDF | Supp. info. | Review Process File Published online: 04 May 2012 Notch and Mef2 synergize to promote proliferation and metastasis through JNK signal activation in Drosophila Based on a modifier screen in Drosophila, Mef2 and Notch are shown to functionally cooperate in the control of cellular proliferation and metastasis with further reaching implications for breast cancer. S K Pallavi, Diana M Ho, Chindo Hicks, Lucio Miele and Spyros Artavanis-Tsakonas The EMBO Journal (2012), 31, 2895 - 2907; 10.1038/emboj.2012.129 Abstract | Full text | PDF | Supp. info. | Review Process File Published online: 11 May 2012 miR-124-regulated RhoG reduces neuronal process complexity via ELMO/Dock180/Rac1 and Cdc42 signalling The microRNA miR-124 regulates the expression of the small GTPase RhoG that inhibits dendritic and axonal branching via distinct mechanisms. Kristin Franke, Wolfgang Otto, Sascha Johannes, Jan Baumgart, Robert Nitsch and Stefan Schumacher The EMBO Journal (2012), 31, 2908 - 2921; 10.1038/emboj.2012.130 Abstract | Full text | PDF | Supp. info. | Review Process File Published online: 15 May 2012 A dual function of Bcl11b/Ctip2 in hippocampal neurogenesis The transcription factor Bcl11b/Ctip2 promotes hippocampal progenitor proliferation and neural differentiation in a non-cell autonomous manner by regulating the expression of the cell adhesion molecule Desmoplakin. Forebrain-specific ablation causes defective spatial learning and memory. Ruth Simon, Heike Brylka, Herbert Schwegler, Sathish Venkataramanappa, Jacqueline Andratschke, Christoph Wiegreffe, Pentao Liu, Elaine Fuchs, Nancy A Jenkins, Neal G Copeland, Carmen Birchmeier and Stefan Britsch The EMBO Journal (2012), 31, 2922 - 2936; 10.1038/emboj.2012.142 Abstract | Full text | PDF | Supp. info. | Review Process File Published online: 15 May 2012 Activity-dependent phosphorylation of GABAA receptors regulates receptor insertion and tonic current Neuronal activity-induced activation of Ca2+ channels results in CaMKII-mediated phosphorylation of GABAA receptors, leading to the rapid insertion of GABAA receptors at the cell surface and their persistent activation. Richard S Saliba, Karla Kretschmannova and Stephen J Moss The EMBO Journal (2012), 31, 2937 - 2951; 10.1038/emboj.2012.109 Abstract | Full text | PDF | Supp. info. | Review Process File Published online: 24 April 2012 The p57 CDKi integrates stress signals into cell-cycle progression to promote cell survival upon stress The stress-activated protein kinase p38 phosphorylates p57/Kip2, resulting in enhanced CDK2 inhibition and a cell-cycle delay that helps cells to survive under stress. Manel Joaquin, Albert Gubern, Daniel González-Nuñez, E Josué Ruiz, Isabel Ferreiro, Eulalia de Nadal, Angel R Nebreda and Francesc Posas The EMBO Journal (2012), 31, 2952 - 2964; 10.1038/emboj.2012.122 Abstract | Full text | PDF | Supp. info. | Review Process File Published online: 08 May 2012 Regulation of ABCB1/PGP1-catalysed auxin transport by linker phosphorylation Regulation of ABCB1/PGP1-catalysed auxin transport by linker phosphorylation. The kinase PINOID phosphorylates and regulates the activity of the auxin transporter ABCB1 to promote auxin transport in Arabidopsis. Sina Henrichs, Bangjun Wang, Yoichiro Fukao, Jinsheng Zhu, Laurence Charrier, Aurélien Bailly, Sophie C Oehring, Miriam Linnert, Matthias Weiwad, Anne Endler, Paolo Nanni, Stephan Pollmann, Stefano Mancuso, Alexander Schulz and Markus Geisler The EMBO Journal (2012), 31, 2965 - 2980; 10.1038/emboj.2012.120 Abstract | Full text | PDF | Supp. info. | Review Process File Published online: 01 May 2012 DNA methylation in an intron of the IBM1 histone demethylase gene stabilizes chromatin modification patterns Mutations in the Arabidopsis thaliana CG directed DNA methyltransferase MET1 deregulates other chromatin marks. This is caused by the aberrant methylation of an intron of the histone demethylase IBM1, leading to impaired alternative splicing and expression of this chromatin modifier. Mélanie Rigal, Zoltán Kevei, Thierry Pélissier and Olivier Mathieu The EMBO Journal (2012), 31, 2981 - 2993; 10.1038/emboj.2012.141 Abstract | Full text | PDF | Supp. info. | Review Process File Published online: 11 May 2012 Chd2 interacts with H3.3 to determine myogenic cell fate The transcription factor MyoD associates with the chromatin remodelling enzyme chromodomain helicase DNA-binding domain 2 (Chd2), leading to the deposition of the histone variant H3.3 at myogenic regulatory regions prior to their activation during muscle differentiation. Akihito Harada, Seiji Okada, Daijiro Konno, Jun Odawara, Tomohiko Yoshimi, Saori Yoshimura, Hiromi Kumamaru, Hirokazu Saiwai, Toshiaki Tsubota, Hitoshi Kurumizaka, Koichi Akashi, Taro Tachibana, Anthony N Imbalzano and Yasuyuki Ohkawa The EMBO Journal (2012), 31, 2994 - 3007; 10.1038/emboj.2012.136 Abstract | Full text | PDF | Supp. info. | Review Process File Published online: 08 May 2012 Sumoylation of MDC1 is important for proper DNA damage response The SUMO-targeted ubiquitin ligase (STUbL) RNF4 removes the DNA damage signalling mediator MDC1 from DNA break sites to permit orderly homologous recombination repair. Kuntian Luo, Haoxing Zhang, Liewei Wang, Jian Yuan and Zhenkun Lou The EMBO Journal (2012), 31, 3008 - 3019; 10.1038/emboj.2012.158 Abstract | Full text | PDF | Supp. info. | Review Process File Published online: 25 May 2012 3′-Processing and strand transfer catalysed by retroviral integrase in crystallo Structures of a prototype integrase bound to viral cDNA offer insights into the early steps of retroviral host genome integration, and into the mechanisms of action of viral DNA strand transfer inhibitor (INSTI) drugs. Stephen Hare, Goedele N Maertens and Peter Cherepanov The EMBO Journal (2012), 31, 3020 - 3028; 10.1038/emboj.2012.118 Abstract | Full text | PDF | Supp. info. | Review Process File Published online: 11 May 2012 Corrigenda Top The location of splenic NKT cells favours their rapid activation by blood-borne antigen Patricia Barral, María Dolores Sánchez-Niño, Nico van Rooijen, Vincenzo Cerundolo and Facundo D Batista The EMBO Journal (2012), 31, 3029 - 3030; 10.1038/emboj.2012.163 Full text | PDF Published online: 04 July 2012 Adult mammalian stem cells: the role of Wnt, Lgr5 and R-spondins Jurian Schuijers and Hans Clevers The EMBO Journal (2012), 31, 3031 - 3032; 10.1038/emboj.2012.177 Full text | PDF Published online: 04 July 2012 Advertisement Follow EMBO on Twitter for as-it-happens access to news, comments and articles. 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