Scientific Reports Biology Table of Contents e-alert: June 2012

01 June 2012      • Visit Scientific Reports • Submit your manuscript to Scientific Reports     Welcome to your Table of Contents e-alert for Scientific Reports             Nature Reviews Cancer POSTER - MITOCHONDRIAL FUNCTION AND CANCER Author: Douglas C. Wallace Access the Poster FREE online! This Poster is freely available thanks to sponsorship from Abcam               Biological Sciences               Comparative genomics of the Hedgehog loci in chordates and the origins of Shh regulatory novelties ▶     Manuel Irimia, Jose L. Royo, Demian Burguera et al.     The origin and evolution of the complex regulatory landscapes of some vertebrate developmental genes, often spanning hundreds of Kbp and including neighboring genes, remain poorly …             EMT and induction of miR-21 mediate metastasis development in Trp53-deficient tumours ▶     Olga Bornachea, Mirentxu Santos, Ana Belén Martínez-Cruz et al.     Missense mutations in TP53 gene promote metastasis in human tumours. However, little is known about the complete loss of function of p53 in tumour metastasis. Here we show that …             Correlative Light and Scanning X-Ray Scattering Microscopy of Healthy and Pathologic Human Bone Sections ▶     C. Giannini, D. Siliqi, O. Bunk et al.     Scanning small and wide angle X-ray scattering (scanning SWAXS) experiments were performed on healthy and pathologic human bone sections. Via crystallographic tools the data were …             TGR5 potentiates GLP-1 secretion in response to anionic exchange resins ▶     Taoufiq Harach, Thijs W. H. Pols, Mitsunori Nomura et al.     Anionic exchange resins are bona fide cholesterol-lowering agents with glycemia lowering actions in diabetic patients. Potentiation of intestinal GLP-1 secretion has been proposed …             High-fat diet transition reduces brain DHA levels associated with altered brain plasticity and behaviour ▶     Sandeep Sharma, Yumei Zhuang, Fernando Gomez-Pinilla     To assess how the shift from a healthy diet rich in omega-3 fatty acids to a diet rich in saturated fatty acid affects the substrates for brain plasticity and function, we used …             siRNA off-target effects in genome-wide screens identify signaling pathway members ▶     Eugen Buehler, Aly A. Khan, Shane Marine et al.     We introduce a method for analyzing small interfering RNA (siRNA) genetic screens based entirely on off-target effects. Using a screen for members of the Wnt pathway, we …             Computer-assisted and fractal-based morphometric assessment of microvascularity in histological specimens of gliomas ▶     Antonio Di Ieva, Emiliano Bruner, Georg Widhalm et al.     Fractal analysis is widely applied to investigate the vascular system in physiological as well as pathological states. We propose and examine a computer-aided and fractal-based …             Muscle or liver-specific Sirt3 deficiency induces hyperacetylation of mitochondrial proteins without affecting global metabolic homeostasis ▶     Pablo J. Fernandez-Marcos, Ellen H. Jeninga, Carles Canto et al.     Sirt3 is a mitochondrial sirtuin, predominantly expressed in highly metabolic tissues. Germline ablation of Sirt3 has major metabolic consequences, including increased …             Hair organ regeneration via the bioengineered hair follicular unit transplantation ▶     Kyosuke Asakawa, Koh-ei Toyoshima, Naoko Ishibashi et al.     Organ regenerative therapy aims to reproduce fully functional organs to replace organs that have been lost or damaged as a result of disease, injury, or aging. For the fully …             Dynamic Mechanism for the Transcription Apparatus Orchestrating Reliable Responses to Activators ▶     Yaolai Wang, Feng Liu, Wei Wang     The transcription apparatus (TA) is a huge molecular machine. It detects the time-varying concentrations of transcriptional activators and initiates mRNA transcripts at …             Characterizing global evolutions of complex systems via intermediate network representations ▶     Koji Iwayama, Yoshito Hirata, Kohske Takahashi et al.     Recent developments in measurement techniques have enabled us to observe the time series of many components simultaneously. Thus, it is important to understand not only the …             Template-Cut: A Pattern-Based Segmentation Paradigm ▶     Jan Egger, Bernd Freisleben, Christopher Nimsky et al.     We present a scale-invariant, template-based segmentation paradigm that sets up a graph and performs a graph cut to separate an object from the background. Typically graph-based …             Noradrenergic ‘Tone’ Determines Dichotomous Control of Cortical Spike-Timing-Dependent Plasticity ▶     Humberto Salgado, Georg Köhr, Mario Treviño     Norepinephrine (NE) is widely distributed throughout the brain. It modulates intrinsic currents, as well as amplitude and frequency of synaptic transmission affecting the …             Quantitative assessment on the cloning efficiencies of lentiviral transfer vectors with a unique clone site ▶     Gang Zhang, Anurag Tandon     Lentiviral vectors (LVs) are powerful tools for transgene expression in vivo and in vitro. However, the construction of LVs is of low efficiency, due to the large sizes and lack …             A short-term in situ CO2 enrichment experiment on Heron Island (GBR) ▶     David I. Kline, Lida Teneva, Kenneth Schneider et al.     Ocean acidification poses multiple challenges for coral reefs on molecular to ecological scales, yet previous experimental studies of the impact of projected CO2 concentrations …             The Network Architecture of Cortical Processing in Visuo-spatial Reasoning ▶     Ehsan Shokri-Kojori, Michael A. Motes, Bart Rypma et al.     Reasoning processes have been closely associated with prefrontal cortex (PFC), but specifically emerge from interactions among networks of brain regions. Yet it remains a …             From wing to wing: the persistence of long ecological interaction chains in less-disturbed ecosystems ▶     Douglas J. McCauley, Paul A. DeSalles, Hillary S. Young et al.     Human impact on biodiversity usually is measured by reduction in species abundance or richness. Just as important, but much more difficult to discern, is the anthropogenic …             Microcrystals coating the wing membranes of a living insect (Psocoptera: Psyllipsocidae) from a Brazilian cave ▶     Charles Lienhard, Rodrigo L. Ferreira, Edwin Gnos et al.     Two specimens of Psyllipsocus yucatan with black wings were found with normal individuals of this species on guano piles produced by the common vampire bat Desmodus rotundus. …             Formation of Nano-Bio-Complex as Nanomaterials Dispersed in a Biological Solution for Understanding Nanobiological Interactions ▶     Mingsheng Xu, Jie Li, Hideo Iwai et al.     Information on how cells interface with nanomaterials in biological environments has important implications for the practice of nanomedicine and safety consideration of …             Statistical organelle dissection of Arabidopsis guard cells using image database LIPS ▶     Takumi Higaki, Natsumaro Kutsuna, Yoichiroh Hosokawa et al.     To comprehensively grasp cell biological events in plant stomatal movement, we have captured microscopic images of guard cells with various organelles markers. The 28,530 serial …             Effect of rapamycin on immunity induced by vector-mediated dystrophin expression in mdx skeletal muscle ▶     Saman Eghtesad, Siddharth Jhunjhunwala, Steven R. Little et al.     Duchenne muscular dystrophy (DMD) is caused by mutations in the dystrophin gene. Therapeutic gene replacement of a dystrophin cDNA into dystrophic muscle can provide functional …             Universal features of correlated bursty behaviour ▶     Márton Karsai, Kimmo Kaski, Albert-László Barabási et al.     Inhomogeneous temporal processes, like those appearing in human communications, neuron spike trains, and seismic signals, consist of high-activity bursty intervals alternating …                     Nature Reviews Immunology Focus on Transplant immunology The articles in this Focus cover the recent developments that have been made in understanding the immune response in transplantation. 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