SciBX: Science-Business eXchange Contents: June 07 2012, Volume 5 / Issue 23

TABLE OF CONTENTS June 7 2012, Volume 5 / Issue 23 Analysis Cover Story Targets and Mechanisms Tools The Distillery: Therapeutics Cancer Cardiovascular disease Dermatology Endocrine/metabolic disease Infectious disease Inflammation Musculoskeletal disease Neurology The Distillery: Techniques Chemistry Computational models Disease models Drug platforms Markers Relay Technology Management Real time business intelligence and data visualization for the Life Science Industry Trend monitoring and comparative asset analysis Click here for more information or to arrange a trial.   SciBX: Science-Business eXchange Recommend SciBX to your library today SciBx is a weekly publication that identifies and analyzes the most important translational research articles from over 40 journals. Find out which papers have real scientific and commercial potential, and why. Subscribe to SciBX and you won't miss the next big thing. For more information visit: www.nature.com/scibx.   Trade Secrets A Nature Network blog by BIOENTREPRENEUR Brought to you by Nature Biotechnology Access the insights, advice and commentary from scientists and entrepreneurs building biotech sectors around the world. Join the global dialogue on life science entrepreneurship: http://blogs.nature.com/trade_secrets   Analysis Cover Story Top Two-pronged approach to T1D Kai-Jye Lou doi:10.1038/scibx.2012.588 City of Hope researchers have reversed advanced type 1 diabetes in mice by combining a protocol that promotes immune tolerance with a growth factor cocktail that augments β cell regeneration. The team plans to validate the technique in other autoimmune diseases before applying it to patients with type 1 diabetes. Full Text | PDF Targets and Mechanisms Top Casting out myeloma kidney Lev Osherovich doi:10.1038/scibx.2012.589 A University of Alabama team has developed a cyclic peptide that can treat cast nephropathy, a common renal complication of multiple myeloma. The next step is optimization of the peptide for oral availability. Full Text | PDF Tools Top Blasted brain Tim Fulmer doi:10.1038/scibx.2012.590 U.S. researchers have designed a mouse model of blast-induced brain injury and shown that the animal develops chronic traumatic encephalopathy, a condition associated with concussive injuries in athletes. They plan to use the model to identify biomarkers and therapies for CTE. Full Text | PDF HLA in sequence Lauren Martz doi:10.1038/scibx.2012.591 A group of Australian researchers and an FDA-led team have independently identified a mechanism behind HLA allele–mediated autoimmune reactions to certain drugs. The findings could expand the use of HLA genotyping in drug design, clinical trials and patient care to improve therapeutic outcomes and safety. Full Text | PDF Distillery: Therapeutics Cancer Top BMX non-receptor tyrosine kinase (BMX; ETK) doi:10.1038/scibx.2012.592 Mouse studies suggest inhibiting BMX could help treat cancer. Full Text | PDF Indoleamine 2,3-dioxygenase 1 (IDO1) doi:10.1038/scibx.2012.593 In vitro studies identified an IDO1 inhibitor that could help treat cancer. Full Text | PDF Silver homolog (SILV; PMEL17; GP100) doi:10.1038/scibx.2012.594 In vitro and mouse studies suggest PMEL17 could be a target for melanoma antibody-drug conjugate (ADC) therapy. Full Text | PDF CC chemokine receptor 1 (CCR1; CD191) doi:10.1038/scibx.2012.595 Mouse studies identified a CCR1 antagonist that could help treat MM and associated osteolytic bone disease. Full Text | PDF Epidermal growth factor receptor (EGFR); c-Met proto-oncogene (MET; HGFR) doi:10.1038/scibx.2012.596 Mouse studies suggest combining EGFR and MET inhibitors could help treat drug-resistant NSCLC. Full Text | PDF Myeloid/lymphoid or mixed-lineage leukemia 2 (MLL2) doi:10.1038/scibx.2012.597 Patient sample and cell culture studies suggest inhibiting MLL2 could help treat prostate cancer. Full Text | PDF Speckle-type POZ protein (SPOP) doi:10.1038/scibx.2012.598 Patient sample and cell culture studies suggest SPOP could be useful as a marker for patient stratification and a therapeutic target in prostate cancer. Full Text | PDF DnaJ (Hsp40) homolog subfamily B member 8 (DNAJB8) doi:10.1038/scibx.2012.599 In vitro and mouse studies suggest blocking DNAJB8 on cancer stem cells could help treat renal cell carcinoma. Full Text | PDF Not applicable doi:10.1038/scibx.2012.600 Mouse studies suggest fat removal surgery could help treat and prevent skin cancer in obese subjects. Full Text | PDF Cardiovascular disease Top Cardiolipin synthase 1(CRLS1; CLS) doi:10.1038/scibx.2012.601 Mouse studies suggest increasing CLS activity could help prevent diabetes-associated heart failure. Full Text | PDF Dermatology Top Toll-like receptor 3 (TLR3) doi:10.1038/scibx.2012.602 Studies in mice suggest antagonizing TLR3 could help treat itching. Full Text | PDF Endocrine/metabolic disease Top MAP kinase kinase kinase 14 (MAP3K14; NIK) doi:10.1038/scibx.2012.603 Mouse studies suggest inhibiting NIK in the liver could help treat type 2 diabetes. Full Text | PDF Infectious disease Top Not applicable doi:10.1038/scibx.2012.604 In vitro, mouse and hamster studies suggest auranofin could be repurposed to treat amebiasis, a disease caused by infection with the protozoa Entamoeba histolytica. Full Text | PDF Plasmodium falciparum calcium-dependent protein kinase 4 (PfCDPK4; PF07_0072) doi:10.1038/scibx.2012.605 Studies in cell culture, mosquitoes and mice suggest antagonizing PfCDPK4 could be useful for preventing transmission of malaria to mosquitoes. Full Text | PDF Inflammation Top MicroRNA-181b (miR-181b) doi:10.1038/scibx.2012.606 Patient sample and mouse studies suggest agonizing miR-181b could help treat inflammation. Full Text | PDF p38 Mitogen-activated protein kinase (p38 MAPK; MAPK14) doi:10.1038/scibx.2012.607 Mouse studies suggest inhibiting p38 MAPK in dendritic cells (DCs) could help treat inflammation. Full Text | PDF Musculoskeletal disease Top Adenosine A2A receptor (ADORA2A) doi:10.1038/scibx.2012.608 Mouse and cell culture studies suggest activating ADORA2A could help prevent joint implant failure. Full Text | PDF Neurology Top BCL2-associated agonist of cell death (BAD) doi:10.1038/scibx.2012.609 Mouse studies suggest inhibiting BAD-mediated glucose metabolism could help prevent seizures. Full Text | PDF Distillery: Techniques Chemistry Top A two-step process for generating bispecific antibodies using unnatural amino acids doi:10.1038/scibx.2012.610 A two-step process for generating bispecific antibodies with unnatural amino acids could help optimize production. Full Text | PDF Computational models Top Method for quantifying somatic DNA alterations in tumors to guide treatment decisions doi:10.1038/scibx.2012.611 A computational method for quantifying DNA alterations in tumors may help determine whether a mutation occurs in all or only a subset of cancer cells, which could guide treatment decisions. Full Text | PDF Disease models Top Mouse model of blast-induced neurotrauma doi:10.1038/scibx.2012.612 A mouse model that mimics bomb blasts experienced by soldiers could be useful for identifying and testing compounds to treat chronic traumatic encephalopathy (CTE), a neurodegenerative disease associated with repeated concussions. Full Text | PDF Drug platforms Top Hydrogen peroxide–inactivated viral vaccines doi:10.1038/scibx.2012.613 In vitro and mouse studies suggest hydrogen peroxide–inactivated viral vaccines could be used to prevent viral infections. Full Text | PDF Protocol for generating functional cardiomyocytes from human pluripotent stem cells doi:10.1038/scibx.2012.614 A protocol to generate cardiomyocytes from human pluripotent stem cells could be useful for producing cell replacement therapies. Full Text | PDF Specific and noncovalent binding of small molecule therapeutics to human leukocyte antigen(HLA) polymorphisms alters peptide antigen presentation doi:10.1038/scibx.2012.615 In vitro studies identified a mechanism for drug-related autoimmune reactions that could aid the design of safer therapeutics. Full Text | PDF Markers Top Catalog of rare genetic variants doi:10.1038/scibx.2012.616 A human genetic study has identified a catalog of rare genetic variants that could influence disease. Full Text | PDF You have been sent this Table of Contents Alert because you have opted in to receive it. 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