Nature Reviews Molecular Cell Biology contents July 2012 Volume 13 Number 7

TABLE OF CONTENTS
July 2012 Volume 13 Number 7
Impact Factor 38.65 *	In this issue Research Highlights Reviews Perspectives Addendum Also this month Article series: Post-translational modifications  Featured article: Towards a molecular architecture of centriole assembly Pierre Gönczy
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Novel insights into microbial functional genomics: Comparative transcriptomics of pathogenic and non-pathogenic Listeria species open Omri Wurtzel, Pascale Cossart, Rotem Sorek and colleagues. Mol Syst Biol 8:583 Transcription start site associated RNAs in bacteria open Eva Yus, Luis Serrano and colleagues. Mol Syst Biol 8:585
RESEARCH HIGHLIGHTS Top Protein aggregation: The secret recipe for RNA granules p405 | doi:10.1038/nrm3372 Reversible, domain-driven RNA-binding protein (RBP) polymerization underlies RNA granule formation. PDF Metabolism: WeightWatching for stem cells p406 | doi:10.1038/nrm3374 mTORC1 inhibition in Paneth cells promotes ISC self-renewal following calorie restriction. PDF Autophagy: Who presses the self-destruct button? p406 | doi:10.1038/nrm3384 This study identifies Atg36 as the selective receptor for pexophagy. PDF Nuclear transport: A new way out p407 | doi:10.1038/nrm3378 Nuclear ribonucleoproteins can be exported by budding of the nuclear envelope. PDF Cell signalling: The NEMO guide to IκB p408 | doi:10.1038/nrm3380 NEMO acts as a scaffold directing IKKβ activity to IκB. PDF Gene expression: A longer 'tail' of repression p408 | doi:10.1038/nrm3381 PABP enhances translation repression by facilitating miRISC association with target mRNAs. PDF JOURNAL CLUB Goodbye homunculus p410 | doi:10.1038/nrm3370 Studies in the late nineteenth century showed that both the sperm and the egg contribute to the generation of new life. PDF Post-translational modification: ES cells have a sweet tooth p410 | doi:10.1038/nrm3375 O-GlcNAcylation of OCT4 regulates pluripotency. PDF IN BRIEF Telomeres: A new level of protection | Technology: Computer programming with mammalian cells | Nuclear envelope: The structure behind the force | Chromosomes: Finding your pair | Cell adhesion: Cell–cell contacts with talin | Cell signalling: Breaking down cilia PDF Molecular Cell Biology JOBS of the week PhD student Nano sciences - molecular imprinted polymers Hasselt University Postdoctoral Fellowship in Bioinformatics for Molecular Neurosciences UNICAMP Postdoctoral Position In Molecular and Cellular Biology (Signal Transduction) Boston University School of Medicine Biologist - Molecular biologist SCI biotechnology Molecular Medicine Postdoc San Raffaele Scientific Institute More Science jobs from Molecular Cell Biology EVENT Introduction to Molecular Biology Techniques - Applications in Biotechnology and Pharmaceutical Industries 05.-07.09.12 PA, US More science events from
REVIEWS		Top
Article series: Post-translational modifications New insights into the molecular and cellular functions of poly(ADP-ribose) and PARPs Bryan A. Gibson & W. Lee Kraus p411 | doi:10.1038/nrm3376 Poly(ADP-ribosyl)ation (PARylation) is a dynamic protein modification, the control of which is important for diverse cell biological processes and normal physiology. Common mechanistic themes are being characterized by which PARylation alters the functions of target proteins, and the PAR-binding modules that mediate this. Abstract | Full Text | PDF
Towards a molecular architecture of centriole assembly Pierre Gönczy p425 | doi:10.1038/nrm3373 The centriole is crucial for the formation of flagella, cilia and centrosomes. The ultrastructure of the centriole reveals a striking ninefold radial arrangement of microtubules. Emerging insights into the molecular mechanisms of centriole assembly include the function of spindle assembly abnormal 6 (SAS-6) proteins in imparting the ninefold symmetry. Abstract | Full Text | PDF
New insights into nucleosome and chromatin structure: an ordered state or a disordered affair? Karolin Luger, Mekonnen L. Dechassa & David J. Tremethick p436 | doi:10.1038/nrm3382 Chromatin compaction has profound implications for the regulation of transcription, replication and DNA repair. Changes in nucleosome structure and stability — due to the incorporation of variant histones and post-translational modifications of histones — affect chromatin compaction. Chromatin structures are not nearly as uniform as previously assumed, which should be taken into account in the context of specific biological functions. Abstract | Full Text | PDF
Article series: Post-translational modifications Vertebrate protein glycosylation: diversity, synthesis and function Kelley W. Moremen, Michael Tiemeyer & Alison V. Nairn p448 | doi:10.1038/nrm3383 Approximately half of human proteins are glycosylated, and the resulting diverse glycan patterns encode an additional level of information. The process of protein glycosylation is mediated by numerous enzymes with dynamic localization, regulation and specificity. High-throughput techniques facilitate the study of complex protein glycans and may give further insights into their roles in protein homeostasis, cell signalling and cell adhesion. Abstract | Full Text | PDF
PERSPECTIVES		Top
OPINION Coordination between RAB GTPase and phosphoinositide regulation and functions Steve Jean & Amy A. Kiger p463 | doi:10.1038/nrm3379 Membrane trafficking relies on changes in membrane identity, which are determined by RAB GTPases and phosphoinositides. Coordinated regulation of RABs and phosphoinositides, which is achieved by direct physical and functional interactions between their regulatory enzymes, is emerging as a central mechanism to ensure membrane trafficking fidelity. Abstract | Full Text | PDF
VIEWPOINT Stem cells assessed Cédric Blanpain, George Q. Daley, Konrad Hochedlinger, Emmanuelle Passegué, Janet Rossant & Shinya Yamanaka p471 | doi:10.1038/nrm3371 Six scientists in the field of stem cell research comment on our basic understanding of stem cells and other pluripotent cells, on their potential therapeutic use and on key challenges that remain. Abstract | Full Text | PDF
ADDENDUM		Top
Illuminating the functional and structural repertoire of human TBC/RABGAPs Marieke A. M. Frasa, Katja T. Koessmeier, M. Reza Ahmadian & Vania M. M. Braga p476 | doi:10.1038/nrm3364 Full Text | PDF | Supplementary information
Erratum: TFIIH: when transcription met DNA repair Emmanuel Compe & Jean-Marc Egly p476 | doi:10.1038/nrm3377 Full Text | PDF
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*Journal Citation Reports, Thomson, 2011

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