Nature Reviews Genetics Contents July 2012 Volume 13 Number 7 pp 449-516

Advertisement
In an iDEAL world, ChIP-Seq would work. Diagenode now offers the powerful, complete iDEAL ChIP-Seq kit, the only kit on the market validated for GAIIx (Illumina®) and PGM™ (Ion Torrent™) sequencers. Our long history in developing optimal epigenetics tools and our expertise with ChIP-seq enables reproducible, efficient, and high quality results every time. Learn more about the iDEAL ChIP-Seq kit.
TABLE OF CONTENTS
July 2012 Volume 13 Number 7		Advertisement
Impact Factor 32.745 *	In this issue Research Highlights Reviews Also this month Article series: Regulatory elements  Featured article: Functions of DNA methylation: islands, start sites, gene bodies and beyond Peter A. Jones	Don’t just predict miRNA targets! Validate them! SwitchGear offers 12,000 pre-cloned 3'UTR luciferase reporter vectors for cell-based assays. Validate the targets of any miRNA quickly and easily with our full LightSwitch miRNA Target Validation System including 3’UTR reporters, controls, miRNA mimics and inhibitors, and luciferase assay reagents. Visit SwitchGear Genomics and explore our sets of genome-wide, assay-ready promoter and 3’UTR reporters.
Subscribe   Facebook   RSS   Recommend to library   Twitter
Advertisement
Scientific Reports publishes 457 open access papers in its first year Publishing technically sound research articles, Scientific Reports is Nature Publishing Group’s fastest growing journal. Given the speed and visibility offered, no wonder 93% of our authors said that they are “likely” or “very likely” to submit again. Keep your research moving. Submit to Scientific Reports
RESEARCH HIGHLIGHTS Top Chromosome biology: Pairing up for the genetic exchange p449 | doi:10.1038/nrg3265 PDF Complex traits: Predicting phenotypes p450 | doi:10.1038/nrg3267 PDF Post transcriptional regulation: Chimeric protein production p450 | doi:10.1038/nrg3268 PDF Gene expression: More roles and details for polymerase pausing p450 | doi:10.1038/nrg3269 PDF Genome evolution: Functional antagonism and human brain evolution p452 | doi:10.1038/nrg3266 PDF AN INTERVIEW WITH... Howard Green p453 | doi:10.1038/nrg3264 PDF IN BRIEF Evolution: Orthologues undergo functional repurposing | Microbial transcriptomics: Features of virulence and non-coding RNAs | Genotyping: Economical yet informative sequencing strategy | Genome evolution: Introgression and fixation of mimicry genes | RNA: Transcriptome-wide N 6-methyladenosine analysis | Gene regulation: Cis versus trans enhancers | Cancer: Clonal mosaicism linked to age and cancer risk PDF Genetics JOBS of the week Transcriptomics and population genetics of two Antarctic notothenioid fish Università degli Studi di Padova - Dipartimento di Biologia Microbiology and Molecular Genetics Faculty positions The University of Texas Health Science Center at Houston Chair - Department of Human Genetics McGill University Post-doctoral position in Plant Genetics French National Institute for Agricultural Research (INRA) Research worker in the Laboratory of Molecular, Cellular and Quantitative Genetics The University of South Bohemia in Ceske Budejovice, The Faculty of Fisheries and Protection of Waters More Science jobs from Genetics EVENT International conference on Genetic Syndromes & Gene Therapy 22.-24.10.12 Chicago, US More science events from
Erratum: Technology: Less could be more for genome editing Darren J. Burgess p452 | doi:10.1038/nrg3274 Full Text | PDF
REVIEWS		Top
Biomolecular computing systems: principles, progress and potential Yaakov Benenson p455 | doi:10.1038/nrg3197 This Review introduces the core concepts of using biological building blocks to carry out computation. The author explains models of computation, experimental examples — sometimes inspired by the complex computation that is part of natural biological systems — and potential applications. Abstract | Full Text | PDF | Supplementary information
Article series: Regulatory elements Genomic approaches towards finding cis-regulatory modules in animals Ross C. Hardison & James Taylor p469 | doi:10.1038/nrg3242 Several approaches exist for identifying cis-regulatory modules, which are the regions in the genome that regulate gene expression. The authors describe these strategies and assess how they perform (either alone or in combination) and how they can be improved. Abstract | Full Text | PDF | Supplementary information
Functions of DNA methylation: islands, start sites, gene bodies and beyond Peter A. Jones p484 | doi:10.1038/nrg3230 Our understanding of the function of DNA methylation is developing now that we are able to look beyond CpG-rich regions at transcriptional start sites. The emerging picture is of a complex relationship between DNA methylation and transcription and of possible additional roles of methylation. Abstract | Full Text | PDF
Human aneuploidy: mechanisms and new insights into an age-old problem So I. Nagaoka, Terry J. Hassold & Patricia A. Hunt p493 | doi:10.1038/nrg3245 Aneuploidy is the leading cause of congenital defects in humans and nearly always results from errors occurring in oocytes. Here, the authors review the evidence pointing towards the mechanistic basis of meiotic defects leading to aneuploidy and discuss the potential role of environmental factors. Abstract | Full Text | PDF
Comparative studies of gene expression and the evolution of gene regulation Irene Gallego Romero, Ilya Ruvinsky & Yoav Gilad p505 | doi:10.1038/nrg3229 Gene expression levels can now be compared among species at greater resolution. Focusing on work in primates, the authors discuss the evolution of gene expression, ways of exploring mechanisms that underlie expression changes and complementary work in model organisms on the functional effects of expression changes. Abstract | Full Text | PDF
Advertisement
SPECIAL FOCUS The great strides in advancing resolution in genetic diagnosis, largely due to molecular techniques with nextgen sequencing as trailblazer, is fuelling the debate on the discordance between resolution and precision. Somewhere between those two lies the holy grail of patient benefit. Do we need to find everything, and can we, already? Follow the debate on the EJHG web focus on Psychosocial aspects of advancing genetics.
Natureevents is a fully searchable, multi-disciplinary database designed to maximise exposure for events organisers. The contents of the Natureevents Directory are now live. The digital version is available here. Find the latest scientific conferences, courses, meetings and symposia on natureevents.com. For event advertising opportunities across the Nature Publishing Group portfolio please contact natureevents@nature.com More Nature Events

*2010 Journal Citation Report (Thomson Reuters, 2011)

You have been sent this Table of Contents Alert because you have opted in to receive it. You can change or discontinue your e-mail alerts at any time, by modifying your preferences on your nature.com account at: www.nature.com/myaccount (You will need to log in to be recognised as a nature.com registrant). For further technical assistance, please contact our registration department For print subscription enquiries, please contact our subscription department For other enquiries, please contact our feedback department Nature Publishing Group | 75 Varick Street, 9th Floor | New York | NY 10013-1917 | USA Nature Publishing Group's worldwide offices: London - Paris - Munich - New Delhi - Tokyo - Melbourne San Diego - San Francisco - Washington - New York - Boston Macmillan Publishers Limited is a company incorporated in England and Wales under company number 785998 and whose registered office is located at Brunel Road, Houndmills, Basingstoke, Hampshire RG21 6XS. © 2012 Nature Publishing Group, a division of Macmillan Publishers Limited. All Rights Reserved.