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| | | | | | Specials - Outlook: Taste | | | | | | Taste is central to our being, but this vital sense is only now becoming clear at the biological level. Scientists have identified the receptors that respond to the five basic stimuli of sweet, sour, bitter, salty and umami (savoury), and are now exploring how the brain interprets them. Nature Outlook Taste reports the latest findings from the front lines of flavour. ▼ more | | | | | | | | | | | | | | Engineering H5N1 avian influenza viruses to study human adaptation | | This Perspective article discusses concerns that were raised about making the data from two papers describing the production of ferret-transmissible H5N1 influenza viruses — one was submitted to Nature and one to Science. The authors conclude that when considering the threat of bioterrorism or accidental release of genetically engineered viruses, nature is the ultimate bioterrorist. To prepare for the possibility of future devastating influenza pandemics, the critical importance of advancing scientific knowledge needs to be kept as the main priority. | | | | | | | | | | | | | | Multiscale gigapixel photography | | A 'supercamera' that can take gigapixel-sized images is described in Nature this week. It measures 75 by 75 by 50 cm, a size dictated by the need to effectively cool the electronic control boards. The authors are hopeful that as the electronics are developed, the age of hand-held gigapixel photography may follow and with it the emphasis in digital photography will switch from image capture to post-capture analysis and data-mining. | | | | | | | | | | | | | | | | | | | | | | | | First dairying in green Saharan Africa in the fifth millennium BC | | Rock-art scenes depicting domesticated cattle are common in the mountains of Libyan Sahara, suggesting that cattle played a big part in the lives of ancient humans. Rock art is notoriously difficult to date, but now isotope analysis of absorbed food residues in pottery excavated from the Takarkori rock shelter in the Libyan Sahara provides the first unequivocal chemical evidence of dairying in the archaeological record, in prehistoric Africa in the fifth millennium BC. | | | | | | | | | | | | | | | | In this week's podcast: some very early dairy farming, a gigapixel camera, a quiet place for theoretical physicists and a crack at the Turing test. | | | | | | | |
| | | | | | | | | | | | | | | | | | | | | | | | | | | Time to open up ▶ | | | | If scientists want the public to continue to volunteer for research projects, they must learn to be a lot more forthcoming about the ways in which the information they garner will be used. | | | | | | | | | | | | Renewed vigour ▶ | | | | Stem-cell researchers must engage with politicians to keep their work alive in Europe. | | | | | | | | | | | | Serious questions ▶ | | | | Nature Publishing Group's reader survey on lab-safety practices needs your input. | | | | | | | | | | | | | | | | | | | | | | | | Seven days: 15–21 June 2012 ▶ | | | | The week in science: US reclaims world's top supercomputer; Australia unveils plans for largest marine reserves; and China celebrates another space programme success. | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | History: Aspen physics turns 50 ▶ | | | | Michael S. Turner reflects on how mountain serenity has bred big breakthroughs at the Aspen Center for Physics in Colorado. | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| | | | | | | | | | | | Emerging Microbes & Infections (EMI) - New open access journal launching in July 2012! EMI aims to provide a forum to publish articles related to all aspects of emerging pathogens, such as their previously unknown genotypic or phenotypic characteristics, their mechanisms of pathogenesis and evasion of immunity, and the diseases they cause. Submit today! | | | | | | | | | | |
| | | | | | | | | | | | | | | | | | | | | | | | | | | | | | Novel mutations target distinct subgroups of medulloblastoma ▶ | | | | Giles Robinson, Matthew Parker, Tanya A. Kranenburg, Charles Lu, Xiang Chen et al. | | | | Whole-genome sequencing of medulloblastoma samples reveals several recurrent mutations in genes not previously implicated in the disease, many of which affect components of the epigenetic machinery in different disease subgroups. | | | | | | | | | | | | Reconciling the temperature dependence of respiration across timescales and ecosystem types ▶ | | | | Gabriel Yvon-Durocher, Jane M. Caffrey, Alessandro Cescatti, Matteo Dossena, Paul del Giorgio et al. | | | | The sensitivity of ecosystem respiration to seasonal changes in temperature is shown to be remarkably similar for a wide range of ecosystem types spanning the globe; however, terrestrial and aquatic ecosystems differ markedly in their temperature sensitivity over annual timescales. | | | | | | | | | | | | Disentangling nestedness from models of ecological complexity ▶ | | | | Alex James, Jonathan W. Pitchford & Michael J. Plank | | | | Examination of previous results and computational analysis of empirical data sets representing mutualistic plant–pollinator networks shows that a simple metric—the number of mutualistic partners a species has—is a better predictor of individual species survival (and hence, community persistence) than is the nestedness of ecological networks. | | | | | | | | | | | | | | | | | | | | Genetic dissection of the circuit for hand dexterity in primates ▶ | | | | Masaharu Kinoshita, Ryosuke Matsui, Shigeki Kato, Taku Hasegawa, Hironori Kasahara et al. | | | | A new double-infection technique with viral vectors is used to interrupt transmission through the propriospinal neurons (PNs) in macaque monkeys, and this is found to impair reach and grasp movements, revealing a critical role for the PN-mediated pathway in the control of hand dexterity. | | | | | | | | | | | | | | | | | | | | Whole-genome analysis informs breast cancer response to aromatase inhibition ▶ | | | | Matthew J. Ellis, Li Ding, Dong Shen, Jingqin Luo, Vera J. Suman et al. | | | | Whole-genome analysis of oestrogen-receptor-positive tumours in patients treated with aromatase inhibitors show that distinct phenotypes are associated with specific patterns of somatic mutations; however, most recurrent mutations are relatively infrequent so prospective clinical trials will require comprehensive sequencing and large study populations. | | | | | | | | | | | | Large-scale prediction and testing of drug activity on side-effect targets ▶ | | | | Eugen Lounkine, Michael J. Keiser, Steven Whitebread, Dmitri Mikhailov, Jacques Hamon et al. | | | | A large-scale computational effort is used to predict the activity of 656 drugs against 73 protein targets that have been associated with adverse drug reactions; the abdominal pain side effect of the synthetic oestrogen chlorotrianisene is shown to be mediated through its inhibition of cyclooxygenase-1. | | | | | | | | | | | | Structure of yeast Argonaute with guide RNA ▶ | | | | Kotaro Nakanishi, David E. Weinberg, David P. Bartel & Dinshaw J. Patel | | | | Argonaute proteins are an essential part of the guide-RNA–protein complex that carries out RNA-induced gene silencing; structure–function studies of the yeast complex reveal conserved features of the eukaryotic complex, which underlie formation of the catalytically active conformation. | | | | | | | | | | | | First dairying in green Saharan Africa in the fifth millennium bc ▶ | | | | Julie Dunne, Richard P. Evershed, Mélanie Salque, Lucy Cramp, Silvia Bruni et al. | | | | Lipid biomarker and stable carbon isotope analysis of absorbed food residues in prehistoric pottery from the Libyan Sahara has identified the first adoption of dairying practices in Neolithic Africa in the fifth millennium bc. | | | | | | | | | | | | | | | | | | | | Sequence analysis of mutations and translocations across breast cancer subtypes ▶ | | | | Shantanu Banerji, Kristian Cibulskis, Claudia Rangel-Escareno, Kristin K. Brown, Scott L. Carter et al. | | | | This paper reports one of the largest breast cancer whole-exome and whole-genome sequencing efforts so far, identifying previously unknown recurrent mutations in CBFB, deletions of RUNX1 and recurrent MAGI1–AKT3 fusion; the fusion suggests that the use of ATP-competitive AKT inhibitors should be evaluated in clinical trials. | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| | | | | | | | | | | | | | Lindau Nobel Community The Interactive home of the Lindau Meetings The 62nd Lindau Meeting of Nobel Laureates is dedicated to physics. We invite you to visit the Lindau Nobel Community site to access multilingual blogs, follow tweets about the event and view pictures from Instagram. You can watch footage by Nature Video from past and present meetings and more. Access the site online. | | | | | | | | | | |
| | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | Large-scale prediction and testing of drug activity on side-effect targets ▶ | | | | Eugen Lounkine, Michael J. Keiser, Steven Whitebread, Dmitri Mikhailov, Jacques Hamon et al. | | | | A large-scale computational effort is used to predict the activity of 656 drugs against 73 protein targets that have been associated with adverse drug reactions; the abdominal pain side effect of the synthetic oestrogen chlorotrianisene is shown to be mediated through its inhibition of cyclooxygenase-1. | | | | | | | | | | | | Structure of yeast Argonaute with guide RNA ▶ | | | | Kotaro Nakanishi, David E. Weinberg, David P. Bartel & Dinshaw J. Patel | | | | Argonaute proteins are an essential part of the guide-RNA–protein complex that carries out RNA-induced gene silencing; structure–function studies of the yeast complex reveal conserved features of the eukaryotic complex, which underlie formation of the catalytically active conformation. | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | The signature of the first stars in atomic hydrogen at redshift 20 ▶ | | | | Eli Visbal, Rennan Barkana, Anastasia Fialkov, Dmitriy Tseliakhovich & Christopher M. Hirata | | | | A simulation of the distribution of the first stars at a cosmic age of about 180 million years reveals that the 21-cm atomic hydrogen signature of these stars is an enhanced (ten millikelvin) fluctuation signal on scales of a few hundred million light-years. | | | | | | | | | | | | | | | | Optical nano-imaging of gate-tunable graphene plasmons ▶ | | | | Jianing Chen, Michela Badioli, Pablo Alonso-González, Sukosin Thongrattanasiri, Florian Huth et al. | | | | Propagating optical plasmons — collective electron excitations coupled to photons — are launched in graphene and studied with near-field optical microscopy, revealing ultra-strong optical field confinement and gate-tunable control of optical fields at nanoscale dimensions. | | | | | | | | | | | | | | | | Superallowed Gamow–Teller decay of the doubly magic nucleus 100Sn ▶ | | | | C. B. Hinke, M. Böhmer, P. Boutachkov, T. Faestermann, H. Geissel et al. | | | | Measurements of the half-life and decay energy of the β-decay of 100Sn show that Gamow–Teller transitions of this nucleus have the greatest strength found so far and are ‘superallowed’. | | | | | | | | | | | | An abundance of small exoplanets around stars with a wide range of metallicities ▶ | | | | Lars A. Buchhave, David W. Latham, Anders Johansen, Martin Bizzarro, Guillermo Torres et al. | | | | Whereas large planets, such as gas giants, are more likely to form around high-metallicity stars, terrestrial-sized planets are found to form around stars with a wide range of metallicities, indicating that they may be widespread in the disk of the Galaxy. | | | | | | | | | | | | Constraints on the volatile distribution within Shackleton crater at the lunar south pole ▶ | | | | Maria T. Zuber, James W. Head, David E. Smith, Gregory A. Neumann, Erwan Mazarico et al. | | | | Observations from the Lunar Orbiter Laser Altimeter reveal the Moon’s Shackleton crater to be an ancient, unusually well-preserved simple crater whose interior walls are younger than its floor and rim; the relative brightness of the floor at 1,064 nanometres is most readily explained by minimal volatile accumulation since crater formation and decreased space weathering due to permanent shadow. | | | | | | | | | | | | Electronic nematicity above the structural and superconducting transition in BaFe2(As1−xPx)2 ▶ | | | | S. Kasahara, H. J. Shi, K. Hashimoto, S. Tonegawa, Y. Mizukami et al. | | | | Electronic nematicity, a unidirectional self-organized state that breaks the rotational symmetry of the underlying lattice, has been observed in an iron-based superconductor, BaFe2(As1−xPx)2, over a wide range of phosphorus concentration, resulting in a phase diagram similar to the pseudogap phase diagram of the copper oxides. | | | | | | | | | | | | Multiscale gigapixel photography ▶ | | | | D. J. Brady, M. E. Gehm, R. A. Stack, D. L. Marks, D. S. Kittle et al. | | | | The AWARE-2 camera uses a parallel array of microcameras to capture one-gigapixel images at three frames per minute. | | | | | | | | | | | | | | | | | | | | | | | | Brief Communications Arising | | | | | | | | | | | | | | | | | | | | Rest et al. reply ▶ | | | | A. Rest, J. L. Prieto, N. R. Walborn, N. Smith, F. B. Bianco et al. | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | Reconciling the temperature dependence of respiration across timescales and ecosystem types ▶ | | | | Gabriel Yvon-Durocher, Jane M. Caffrey, Alessandro Cescatti, Matteo Dossena, Paul del Giorgio et al. | | | | The sensitivity of ecosystem respiration to seasonal changes in temperature is shown to be remarkably similar for a wide range of ecosystem types spanning the globe; however, terrestrial and aquatic ecosystems differ markedly in their temperature sensitivity over annual timescales. | | | | | | | | | | | | | | | | An abundance of small exoplanets around stars with a wide range of metallicities ▶ | | | | Lars A. Buchhave, David W. Latham, Anders Johansen, Martin Bizzarro, Guillermo Torres et al. | | | | Whereas large planets, such as gas giants, are more likely to form around high-metallicity stars, terrestrial-sized planets are found to form around stars with a wide range of metallicities, indicating that they may be widespread in the disk of the Galaxy. | | | | | | | | | | | | Constraints on the volatile distribution within Shackleton crater at the lunar south pole ▶ | | | | Maria T. Zuber, James W. Head, David E. Smith, Gregory A. Neumann, Erwan Mazarico et al. | | | | Observations from the Lunar Orbiter Laser Altimeter reveal the Moon’s Shackleton crater to be an ancient, unusually well-preserved simple crater whose interior walls are younger than its floor and rim; the relative brightness of the floor at 1,064 nanometres is most readily explained by minimal volatile accumulation since crater formation and decreased space weathering due to permanent shadow. | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | Perspective: Complexities of flavour ▶ | | | | Is flavour an intrinsic objective property, or a subjective experience that varies from person to person? Barry Smith sorts out the implications. | | | | | | | | | | | | | | | | Cooking: Delicious science ▶ | | | | Chefs are teaming up with researchers to create avant-garde dishes. Is 'molecular gastronomy' more than a fad? | | | | | | | | | | | | Obesity: Insensitive issue ▶ | | | | It is becoming clear that links between taste preferences and obesity go beyond simply having a sweet tooth. | | | | | | | | | | | | | | | | | | | | | | | | | | | |
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| | | | | | | | | | | | | | | | | | | | | | | | Piled too high ▶ | | | | A passion for science is admirable, but can have unwanted outcomes, argues Mariano A. Loza-Coll. | | | | | | | | | | | | | | | | | | | | | | | | Careers related news & comment | | | | | | | | | | | | | | | |
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