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|  | | 26 June 2012 | | | Featured image: | |  | | | Chen et al. sequence the full genome of the Ganoderma lucidum mushroom. |
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Advertisement | | Nature Genetics and the Wellcome Trust present:
The Genomics of Common Diseases 2012
September 19-22, 2012 - Potomac, MD, USA
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Abstract submission deadline- June 28, 2012
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| | | | | | Latest Articles | View all Articles | | | | | Deep-tissue focal fluorescence imaging with digitally time-reversed ultrasound-encoded light OPEN | | | Ying Min Wang, Benjamin Judkewitz, Charles A. DiMarzio and Changhuei Yang | | | Fluorescence imaging is important for biomedical research and applications, but the turbidity of biological material prohibits deep tissue study. By combining ultrasound-encoding with digital time-reversal, Wang et al. perform focussed fluorescence imaging at a tissue depth of 2.5mm. | | | 26 Jun | Nat Commun 3:928 doi:10.1038/ncomms1925 (2012) | | | Physical sciences Applied physics | | | Optical physics | | Abstract | Full Text | PDF (592 kB) |
Supplementary Information |
| Protein L-isoaspartyl methyltransferase regulates p53 activity OPEN | | | Jae-Cheol Lee, Sung-Ung Kang, Yeji Jeon, Jong Woo Park, Jueng-Soo You, Shin-Won Ha, Narkhyun Bae, Gert Lubec, So Hee Kwon, Ju-Seog Lee, Eun-Jung Cho and Jeung-Whan Han | | | Protein L-isoaspartyl methyltransferase (PIMT) is a carboxyl methyltransferase, but its role in regulating the tumour suppressor p53 is unclear. Here, PIMT is shown to methylate p53, obstructing the tumour suppressor function of p53 through reduced protein levels and stability. | | | 26 Jun | Nat Commun 3:927 doi:10.1038/ncomms1933 (2012) | | | Biological sciences Cancer | | | Molecular biology | | Abstract | Full Text | PDF (1,223 kB) |
Supplementary Information |
| Chloroplast-mediated activation of plant immune signalling in Arabidopsis | | | Hironari Nomura, Teiko Komori, Shuhei Uemura, Yui Kanda, Koji Shimotani, Kana Nakai, Takuya Furuichi, Kohsuke Takebayashi, Takanori Sugimoto, Satoshi Sano, I Nengah Suwastika, Eiichiro Fukusaki, Hirofumi Yoshioka, Yoichi Nakahira and Takashi Shiina | | | Mediators of plant immunity, such as salicylic acid, are produced in the chloroplasts, but the molecular link between chloroplasts and the immune system is unclear. This work finds that pathogen-associated molecular pattern signals are relayed to chloroplasts and evoke Ca2+ signatures in the stroma. | | | 26 Jun | Nat Commun 3:926 doi:10.1038/ncomms1926 (2012) | | | Biological sciences Cell biology | | | Plant sciences | | Abstract | Full Text | PDF (575 kB) |
Supplementary Information |
| ABCA4 is an N-retinylidene-phosphatidylethanolamine and phosphatidylethanolamine importer | | | Faraz Quazi, Stepan Lenevich and Robert S. Molday | | | In mammalian cells, ABC transporter proteins were thought to exclusively export a range of substrates out of cells. Quazi and colleagues show that, in retinal photoreceptor cells, ABCA4 is acting as an importer of phospholipids and that mutations known to cause Stargardt disease decrease its activity. | | | 26 Jun | Nat Commun 3:925 doi:10.1038/ncomms1927 (2012) | | | Biological sciences Biochemistry | | | | Abstract | Full Text | PDF (731 kB) |
Supplementary Information |
| Unravelling cerebellar pathways with high temporal precision targeting motor and extensive sensory and parietal networks | | | Fahad Sultan, Mark Augath, Salah Hamodeh, Yusuke Murayama, Axel Oeltermann, Alexander Rauch and Peter Thier | | | The cerebellum has important roles in motor control and sensory perception. Sultan and colleagues use electrical stimulation and functional magnetic resonance imaging to reveal that the cerebellum provides inputs to specialized cortical regions of the brain that modulate cerebro-cortical processing. | | | 26 Jun | Nat Commun 3:924 doi:10.1038/ncomms1912 (2012) | | | Biological sciences Neuroscience | | | | Abstract | Full Text | PDF (976 kB) |
Supplementary Information |
| Trim71 cooperates with microRNAs to repress Cdkn1a expression and promote embryonic stem cell proliferation | | | Hao-Ming Chang, Natalia J. Martinez, James E. Thornton, John P. Hagan, Khang D. Nguyen and Richard I. Gregory | | | Embryonic stem cells have a shortened cell cycle that allows for rapid proliferation, but the exact mechanisms are unclear. Here, a microRNA target, Trim71, is shown to inhibit the expression of a cyclin-dependent kinase inhibitor, thus enabling the G1–S phase cell cycle transition in embryonic stem cells. | | | 26 Jun | Nat Commun 3:923 doi:10.1038/ncomms1909 (2012) | | | Biological sciences Cell biology | | | Molecular biology | | | | | Abstract | Full Text | PDF (529 kB) |
| Critical thickness for ferromagnetism in LaAlO3 /SrTiO3 heterostructures | | | Beena Kalisky, Julie A. Bert, Brannon B. Klopfer, Christopher Bell, Hiroki K. Sato, Masayuki Hosoda, Yasuyuki Hikita, Harold Y. Hwang and Kathryn A. Moler | | | The interface within heterostructures consisting of LaAlO3 and SrTiO3 has been reported to give rise to magnetism, in addition to a two-dimensional electron gas. Kalisky et al. observe that magnetism can occur only above a critical thickness, and that it occurs in heterogeneous patches. | | | 26 Jun | Nat Commun 3:922 doi:10.1038/ncomms1931 (2012) | | | Physical sciences Condensed matter | | | Materials science | | | Abstract | Full Text | PDF (326 kB) |
| Microscopic magnetic stimulation of neural tissue OPEN | | | Giorgio Bonmassar, Seung Woo Lee, Daniel K. Freeman, Miloslav Polasek, Shelley I. Fried and John T. Gale | | | Electrical stimulation is used to treat a range of neurological diseases, but there are limitations that reduce its benefits. Bonmassar and colleagues show that magnetic stimulation delivered by small coils, close to the targeted neural tissue, can also be used to activate neurons and with fewer limitations. | | | 26 Jun | Nat Commun 3:921 doi:10.1038/ncomms1914 (2012) | | | Biological sciences Neuroscience | | | | Abstract | Full Text | PDF (775 kB) |
Supplementary Information |
| Cleavage and nuclear localization of the rice XA21 immune receptor OPEN | | | Chang-Jin Park and Pamela C. Ronald | | | The rice pattern recognition receptor—XA21—confers immunity against the Gram-negative bacterial pathogen, Xanthomonas oryzae pv. oryzae. This study shows that the intracellular kinase domain of XA21 translocates to the nucleus and that this translocation is essential for the XA21-mediated immune response. | | | 26 Jun | Nat Commun 3:920 doi:10.1038/ncomms1932 (2012) | | | Biological sciences Plant sciences | | Abstract | Full Text | PDF (386 kB) |
Supplementary Information |
| Emergence of stable polymorphisms driven by evolutionary games between mutants OPEN | | | Weini Huang, Bernhard Haubold, Christoph Hauert and Arne Traulsen | | | Mutation, selection and random drift determine evolutionary dynamics and can give rise to polymorphisms. Here, an evolutionary game model, in which each new mutation generates a new evolutionary game, is applied to study the emergence of polymorphism, resulting in higher diversity than seen in previous models. | | | 26 Jun | Nat Commun 3:919 doi:10.1038/ncomms1930 (2012) | | | Biological sciences Bioinformatics | | | Ecology Evolution | | Abstract | Full Text | PDF (553 kB) |
Supplementary Information |
| Optically rewritable patterns of nuclear magnetization in gallium arsenide | | | Jonathan P. King, Yunpu Li, Carlos A. Meriles and Jeffrey A. Reimer | | | Controlling nuclear spin patterns is important to manage decoherence and control electron spin currents in spintronic devices. This study demonstrates the optical creation of rewritable patterns of nuclear polarization in gallium arsenide without ferromagnets, lithographic patterning or field gradients. | | | 26 Jun | Nat Commun 3:918 doi:10.1038/ncomms1918 (2012) | | | Physical sciences Condensed matter | | | Optical physics | | | Abstract | Full Text | PDF (648 kB) |
| An ultrafast nickel–iron battery from strongly coupled inorganic nanoparticle/nanocarbon hybrid materials | | | Hailiang Wang, Yongye Liang, Ming Gong, Yanguang Li, Wesley Chang, Tyler Mefford, Jigang Zhou, Jian Wang, Tom Regier, Fei Wei and Hongjie Dai | | | Fast rechargeable batteries made from low-cost and abundant electrode materials are attractive for energy storage. Wang et al. develop an ultrafast Ni–Fe battery with carbon/inorganic hybrid electrodes in which the charge and discharge rates are nearly 1,000-fold higher than traditional Ni–Fe batteries. | | | 26 Jun | Nat Commun 3:917 doi:10.1038/ncomms1921 (2012) | | | Chemical sciences Inorganic chemistry | | | Materials science Physical chemistry | | Abstract | Full Text | PDF (736 kB) |
Supplementary Information |
| Three-dimensional nanonetworks for giant stretchability in dielectrics and conductors | | | Junyong Park, Shuodao Wang, Ming Li, Changui Ahn, Jerome K. Hyun, Dong Seok Kim, Do Kyung Kim, John A. Rogers, Yonggang Huang and Seokwoo Jeon | | | Stretchable electronics based on conducting polymers offer new opportunities for designing flexible technologies. Park et al. build three-dimensional nanostructures from elastomers soaked with liquid metal to produce stretchable conductors with greatly improved strain properties over solid films. | | | 26 Jun | Nat Commun 3:916 doi:10.1038/ncomms1929 (2012) | | | Physical sciences Materials science | | | Nanotechnology | | Abstract | Full Text | PDF (657 kB) |
Supplementary Information |
| Spatial complexity due to bulk electronic nematicity in a superconducting underdoped cuprate | | | B. Phillabaum, E.W. Carlson and K.A. Dahmen | | | Recent investigations of high-temperature superconductors suggest rotational symmetry is broken in the pseudogap and superconducting states. This theoretical study examines experimental data obtained for a cuprate system known as Dy-Bi2212, and concludes the nematic state extends into the bulk. | | | 26 Jun | Nat Commun 3:915 doi:10.1038/ncomms1920 (2012) | | | Physical sciences Condensed matter | | | Materials science | | Abstract | Full Text | PDF (510 kB) |
Supplementary Information |
| Fano interference governs wave transport in disordered systems OPEN | | | Alexander N. Poddubny, Mikhail V. Rybin, Mikhail F. Limonov and Yuri S. Kivshar | | | Understanding localization and delocalization phenomena is important for studying wave propagation in many types of disordered photonic systems. Here, a theoretical study of one-dimensional photonic crystal structures reveals the importance of Fano interference in wave transport in the presence of disorder. | | | 26 Jun | Nat Commun 3:914 doi:10.1038/ncomms1924 (2012) | | | Physical sciences Optical physics | | | Abstract | Full Text | PDF (1,022 kB) |
| Genome sequence of the model medicinal mushroom Ganoderma lucidum OPEN | | | Shilin Chen, Jiang Xu, Chang Liu, Yingjie Zhu, David R. Nelson, Shiguo Zhou, Chunfang Li, Lizhi Wang, Xu Guo, Yongzhen Sun, Hongmei Luo, Ying Li, Jingyuan Song, Bernard Henrissat, Anthony Levasseur, Jun Qian, Jianqin Li, Xiang Luo, Linchun Shi, Liu He, Li Xiang, Xiaolan Xu, Yunyun Niu, Qiushi Li, Mira V. Han, Haixia Yan, Jin Zhang, Haimei Chen, Aiping Lv, Zhen Wang, Mingzhu Liu, David C. Schwartz and Chao Sun | | | Ganoderma lucidum is a macrofungus in traditional Chinese medicine known to produce different bioactive compounds. In this study, the genome of G. lucidum is sequenced, making this organism a potential model system for future studies of secondary metabolic pathways and their regulation in medicinal fungi. | | | 26 Jun | Nat Commun 3:913 doi:10.1038/ncomms1923 (2012) | | | Biological sciences Biotechnology | | | Molecular biology | | Abstract | Full Text | PDF (562 kB) |
Supplementary Information |
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