Molecular Systems Biology - New articles published 26 June 2012

Latest Articles 26th June 2012   Featured Article Research Articles News and Views   Web feeds About Open access Advertisement Novel insights into microbial functional genomics: Comparative transcriptomics of pathogenic and non-pathogenic Listeria species open Omri Wurtzel, Pascale Cossart, Rotem Sorek and colleagues. Mol Syst Biol 8:583 Transcription start site associated RNAs in bacteria open Eva Yus, Luis Serrano and colleagues. Mol Syst Biol 8:585   Featured Article Glucose deprivation activates a metabolic and signaling amplification loop leading to cell death In cancer cells dependent upon glucose for survival, glucose withdrawal activates a positive feedback loop involving reactive oxygen species (ROS), ROS-mediated inhibition of tyrosine phosphatases, and tyrosine kinase signaling. This loop amplifies ROS to toxic levels, resulting in cell death. Nicholas A Graham, Martik Tahmasian, Bitika Kohli, Evangelia Komisopoulou, Maggie Zhu, Igor Vivanco, Michael A Teitell, Hong Wu, Antoni Ribas, Roger S Lo, Ingo K Mellinghoff, Paul S Mischel & Thomas G Graeber Molecular Systems Biology 8:589; doi:10.1038/msb.2012.20; published 26 June 2012 Full Text | PDF | Supp. Inf. | Review Process Research Articles Model-driven multi-omic data analysis elucidates metabolic immunomodulators of macrophage activation Genome-scale metabolic network reconstruction and analysis of the murine leukemic macrophage cell line RAW 264.7 reveal a complementary relationship between how known metabolic immunomodulators are biochemically processed and their role in macrophage activation. Aarash Bordbar, Monica L Mo, Ernesto S Nakayasu, Alexandra C Schrimpe-Rutledge, Young-Mo Kim, Thomas O Metz, Marcus B Jones, Bryan C Frank, Richard D Smith, Scott N Peterson, Daniel R Hyduke, Joshua N Adkins & Bernhard O Palsson Molecular Systems Biology 8:558; doi:10.1038/msb.2012.21; published 26 June 2012 Full Text | PDF | Supp. Inf. | Review Process Competing G protein-coupled receptor kinases balance G protein and β-arrestin signaling The molecular mechanisms and hidden dynamics governing ERK activation by the angiotensin II type 1A receptor are studied and deciphered, revealing a signal balancing mechanism that is found to be relevant to a range of other seven transmembrane receptors. Domitille Heitzler, Guillaume Durand, Nathalie Gallay, Aurélien Rizk, Seungkirl Ahn, Jihee Kim, Jonathan D Violin, Laurence Dupuy, Christophe Gauthier, Vincent Piketty, Pascale Crépieux, Anne Poupon, Frédérique Clément, François Fages, Robert J Lefkowitz & Eric Reiter Molecular Systems Biology 8:590; doi:10.1038/msb.2012.22; published 26 June 2012 Full Text | PDF | Supp. Inf. | Review Process News and Views Signaling for death: tyrosine phosphorylation in the response to glucose deprivation Bryan D Bryson & Forest M White Molecular Systems Biology 8:591; doi:10.1038/msb.2012.27; published 26 June 2012 Full Text | PDF

Advertisement

Follow EMBO on Facebook for access to news, comments and articles and make it a place to share information with others interested in the field. https://www.facebook.com/EMBO.excellence.in.life.sciences

You have been sent this Table of Contents Alert because you have opted in to receive it. You can change or discontinue your e-mail alerts at any time, by modifying your preferences on your nature.com account at: www.nature.com/nams/svc/myaccount (You will need to log in to be recognised as a nature.com registrant). For further technical assistance, please contact our registration department. For print subscription enquiries, please contact our subscription department. For other enquiries, please contact our customer feedback department. Nature Publishing Group | 75 Varick Street, 9th Floor | New York | NY 10013-1917 | USA Nature Publishing Group's worldwide offices: London - Paris - Munich - New Delhi - Tokyo - Melbourne San Diego - San Francisco - Washington - New York - Boston Macmillan Publishers Limited is a company incorporated in England and Wales under company number 785998 and whose registered office is located at Brunel Road, Houndmills, Basingstoke, Hampshire RG21 6XS. © 2012 Nature Publishing Group, a division of Macmillan Publishers Limited. All Rights Reserved.