EMBO Reports - Table of Contents alert Volume 13 Issue 6, pp 471-576

TABLE OF CONTENTS June 2012 | Volume 13, Issue 6 Upfront Science & Society Reviews Scientific Reports Also new AOP Sign up for e-alerts Recommend to your library Web feed Subscribe Advertisement The EMBO Meeting 2012 22 - 25 September in Nice, France Keynotes: Paul Nurse & Linda Partridge 20 concurrent sessions covering the life sciences Speakers include: Kari Alitalo, Karl Deisseroth, Steven Henikoff, Ruth Lehmann, Dirk Schübeler & Rob Singer Abstract submission & early registration: 12 June 2012 www.the-embo-meeting.org   Upfront Top Editorial Mama Grizzly and the polar bears Mis-reporting of the science behind climate change has called into question the judgement and integrity of scientists. Howy argues that better communication between scientists and journalists is needed, to restore public confidence in both. Howy Jacobs EMBO reports (2012), 13, 471; 10.1038/embor.2012.56 Abstract | Full text | PDF Published online: 01 June 2012 Subject Categories: Evolution, Environment & Agriculture | Societal Issues & Politics A balancing act: focus on aneuploidy Aneuploidy has emerged as a major health concern in cancer and fertility. This issue of EMBO reports features four reviews that discuss aneuploidy and its consequences from different viewpoints, and are contextualized in this editorial. Nonia Pariente EMBO reports (2012), 13, 472; 10.1038/embor.2012.66 Abstract | Full text | PDF Published online: 01 June 2012 Opinion The neglected genome The mitochondrial genome, though tiny, is vital to life. Modern high-throughput investigations should pay closer attention to this minute genetic treasure trove. Graziano Pesole, John F Allen, Nick Lane, William Martin, David M Rand, Gottfried Schatz and Cecilia Saccone EMBO reports (2012), 13, 473 - 474; 10.1038/embor.2012.57 Abstract | Full text | PDF Published online: 04 May 2012 Subject Categories: Genomic & Computational Biology A tribute to the ERC—long live basic research In the five years since its creation, the European Research Council has had a major influence on the support for and quality of basic research in Europe. It does not, however, solve the underlying problem that basic research remains under-appreciated. Ilkka Hanski EMBO reports (2012), 13, 474; 10.1038/embor.2012.64 Abstract | Full text | PDF Published online: 11 May 2012 Subject Categories: Science Policy & Funding Meeting Point Molecular ecology in Vienna: hot topics in a chilly place The international VIPCA conference on Molecular Ecology showcased the diversity of tools and approaches in this flourishing field, which lies at the interface of ecology, evolution and molecular biology. Thomas Städler EMBO reports (2012), 13, 475 - 477; 10.1038/embor.2012.63 Abstract | Full text | PDF Published online: 15 May 2012 Subject Categories: Molecular Evolution Keystone microbiome meeting 2012: a mountain top experience The joint Keystone Symposia on Innate Immunity and the Microbiome took place in March 2012 in Keystone, Colorado. Joint and concurrent talks and poster sessions between the groups made for a sensational meeting with active exchange between participants. Aleksandar D Kostic and Wendy S Garrett EMBO reports (2012), 13, 478 - 480; 10.1038/embor.2012.69 Abstract | Full text | PDF Published online: 18 May 2012 Subject Categories: Microbiology & Pathogens | Molecular Biology of Disease | Immunology Correspondence Response to “The anglerfish deception” The correspondents argue that “The anglerfish deception” contains omissions, errors, misunderstandings and misinterpretations. Joe N Perry, Salvatore Arpaia, Detlef Bartsch, Jozsef Kiss, Antoine Messéan, Marco Nuti, Jeremy B Sweet and Christoph C Tebbe EMBO reports (2012), 13, 481 - 482; 10.1038/embor.2012.70 Abstract | Full text | PDF Published online: 15 May 2012 Subject Categories: Genetically Modified Organisms | Science Policy & Funding | Technology, Development & Applications Reply to J.N. Perry et al The authors of “The anglerfish deception” respond to the criticism of their article. Brian Wynne and Fern Wickson EMBO reports (2012), 13, 482 - 483; 10.1038/embor.2012.71 Abstract | Full text | PDF Published online: 15 May 2012 Subject Categories: Genetically Modified Organisms | Science Policy & Funding | Technology, Development & Applications Science & Society Top To serve and protect research integrity David Wright, the Director of the US Office of Research Integrity, discusses the causes and consequences of research misconduct and ways to address the problem. EMBO reports (2012), 13, 484 - 486; 10.1038/embor.2012.67 Abstract | Full text | PDF Published online: 11 May 2012 Subject Categories: Science Policy & Funding The effects of artificial gender imbalance The use of reproductive technology to service a preference for male offspring has created an artificial gender imbalance, notably in Asian countries. The social effects of this large surplus of young men are not yet clear, but concerted action might be necessary to address the problem Therese Hesketh and Jiang Min Min EMBO reports (2012), 13, 487 - 492; 10.1038/embor.2012.62 Abstract | Full text | PDF Published online: 15 May 2012 Subject Categories: Societal Issues & Politics Stop worrying; start growing Opponents of genetically modified crops continue to raise concerns about risk, despite 20 years of research disproving their claims. Science should close the book on risk research and turn to studying the economic and environmental benefits of agricultural biotechnology Torbjörn Fagerström, Christina Dixelius, Ulf Magnusson and Jens F Sundström EMBO reports (2012), 13, 493 - 497; 10.1038/embor.2012.59 Abstract | Full text | PDF Published online: 11 May 2012 Subject Categories: Genetically Modified Organisms | Societal Issues & Politics The changing hypothesis of the gut A rise in immune-related diseases has coincided with increasing levels of hygiene and antibiotic use. In our war against bacteria, are our gut microbiota collateral damage, and can we afford to lose their proven health effects? Philip Hunter EMBO reports (2012), 13, 498 - 500; 10.1038/embor.2012.68 Abstract | Full text | PDF Published online: 15 May 2012 Subject Categories: Health & Disease Reviews Top Losing balance: the origin and impact of aneuploidy in cancer Most solid human tumours are aneuploid, but aneuploidy suppresses cellular proliferation in vitro. This review analyzes how aneuploidy can provide a growth advantage and facilitate cellular transformation, as well as explores the possibilities of targeting aneuploidy therapeutically. Andrew J Holland and Don W Cleveland EMBO reports (2012), 13, 501 - 514; 10.1038/embor.2012.55 Abstract | Full text | PDF Published online: 08 May 2012 Subject Categories: Cell Cycle | Molecular Biology of Disease | Genome Stability & Dynamics Chromosomal instability and aneuploidy in cancer: from yeast to man Aneuploidy is linked to developmental abnormalities and is predominant in cancer. This review explores the model systems that have informed our understanding of the role of aneuploidy in cancer, highlighting the complexity of the results and proposing a unifying model Sarah J Pfau and Angelika Amon EMBO reports (2012), 13, 515 - 527; 10.1038/embor.2012.65 Abstract | Full text | PDF Published online: 22 May 2012 Subject Categories: Genome Stability & Dynamics | Molecular Biology of Disease Cancer chromosomal instability: therapeutic and diagnostic challenges This review provides a much-needed translational perspective into the issue of aneuploidy and chromosomal instability, discussing the prognostic value of CIN assessment in human tumours, methods to analyze it and how it could be therapeutically targeted. Nicholas McGranahan, Rebecca A Burrell, David Endesfelder, Marco R Novelli and Charles Swanton EMBO reports (2012), 13, 528 - 538; 10.1038/embor.2012.61 Abstract | Full text | PDF Published online: 18 May 2012 Subject Categories: Cell Cycle | Molecular Biology of Disease Age-related aneuploidy through cohesion exhaustion Pregnancy in older women is problematic, as oocytes are particularly prone to chromosome missegregation, and aneuploidy increases with age. Sister chromatid cohesion is weakened or lost with age, having a major impact in age-dependent aneuploidy, as discussed here. Rolf Jessberger EMBO reports (2012), 13, 539 - 546; 10.1038/embor.2012.54 Abstract | Full text | PDF Published online: 08 May 2012 Subject Categories: Cell Cycle Scientific Reports Top Neurl4, a novel daughter centriole protein, prevents formation of ectopic microtubule organizing centres This study identifies Neurl4 as a novel CP110-interacting protein that localizes to daughter centrioles where it promotes ubiquitylation and destabilization of CP110. Ablation of Neurl4 leads to the formation of ectopic microtubule organizing centres. Ji Li, Sehyun Kim, Tetsuo Kobayashi, Feng-Xia Liang, Nina Korzeniewski, Stefan Duensing and Brian D Dynlacht EMBO reports (2012), 13, 547 - 553; 10.1038/embor.2012.40 Abstract | Full text | PDF | Supp. info. | Review Process File Published online: 23 March 2012 Subject Categories: Cell & Tissue Architecture | Cell Cycle AKT-dependent phosphorylation of Niban regulates nucleophosmin- and MDM2-mediated p53 stability and cell apoptosis UV irradiation induces Niban phosphorylation by AKT, which increases the association of Niban with nucleophosmin and frees nucleophosmin from the MDM2 complex, resulting in p53 degradation and inhibition of apoptosis. Haitao Ji, Zhiyong Ding, David Hawke, Dongming Xing, Bing-Hua Jiang, Gordon B Mills and Zhimin Lu EMBO reports (2012), 13, 554 - 560; 10.1038/embor.2012.53 Abstract | Full text | PDF | Supp. info. | Review Process File Published online: 17 April 2012 Subject Categories: Signal Transduction CDK targeting of NBS1 promotes DNA-end resection, replication restart and homologous recombination NBS1—a component of the MRN complex, which senses DNA double-strand breaks and promotes repair—is phosphorylated by CDKs in a cell-cycle dependent manner. This controls the choice of DNA repair mode and promotes replication restart after fork stalling. Jacob Falck, Josep V Forment, Julia Coates, Martin Mistrik, Jiri Lukas, Jiri Bartek and Stephen P Jackson EMBO reports (2012), 13, 561 - 568; 10.1038/embor.2012.58 Abstract | Full text | PDF | Supp. info. | Review Process File Published online: 08 May 2012 Subject Categories: Cell Cycle | Genome Stability & Dynamics Immune response to bacteria induces dissemination of Ras-activated Drosophila hindgut cells Drosophila hindgut cells exposed to bacterial infection activate the innate immune response. Concomitant expression of the Ras1V12 oncogene leads to extracellular matrix degradation, basal cell invasion and dissemination in the body cavity. Erdem Bangi, Chrysoula Pitsouli, Laurence G Rahme, Ross Cagan and Yiorgos Apidianakis EMBO reports (2012), 13, 569 - 576; 10.1038/embor.2012.44 Abstract | Full text | PDF | Supp. info. | Review Process File Published online: 13 April 2012 Subject Categories: Molecular Biology of Disease | Microbiology & Pathogens Advertisement Follow EMBO on Facebook for access to news, comments and articles make it a place to share information with others interested in the life sciences. https://www.facebook.com/EMBO.excellence.in.life.sciences   Please note that you need to be a subscriber or site-licence holder to enjoy full-text access to EMBO reports. In order to do so, please purchase a subscription. You have been sent this Table of Contents Alert because you have opted in to receive it. 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