The EMBO Journal - Table of Contents alert Volume 31 Issue 12

TABLE OF CONTENTS 13 June 2012 | Volume 31, Issue 12 Editorial Focus Reviews Have you seen? Articles Also new AOP Sign up for e-alerts Recommend to your library Web feed Subscribe Advertisement The EMBO Meeting 2012 22 - 25 September in Nice, France Keynotes: Paul Nurse & Linda Partridge 20 concurrent sessions covering the life sciences Speakers include: Kari Alitalo, Karl Deisseroth, Steven Henikoff, Ruth Lehmann, Dirk Schübeler & Rob Singer Abstract submission & early registration: 12 June 2012 www.the-embo-meeting.org   Editorial Top Three decades of Wnt signalling Thomas Schwarz-Romond The EMBO Journal (2012), 31, 2664; 10.1038/emboj.2012.159 Abstract | Full text | PDF Published online: 13 June 2012 Focus Reviews Top Three decades of Wnts: a personal perspective on how a scientific field developed Celebrating more than 30 years of Wnt research, Roel Nusse and Harold Varmus share some personal thoughts on the past and the future of this intensely studied field. Roel Nusse and Harold Varmus The EMBO Journal (2012), 31, 2670 - 2684; 10.1038/emboj.2012.146 Abstract | Full text | PDF Published online: 22 May 2012 Adult mammalian stem cells: the role of Wnt, Lgr5 and R-spondins Jurian Schuijers and Hans Clevers highlight the recent discovery of Lgr5 as R-spondin receptors in the regulation of adult stem cells. Jurian Schuijers and Hans Clevers The EMBO Journal (2012), 31, 2685 - 2696; 10.1038/emboj.2012.149 Abstract | Full text | PDF Published online: 22 May 2012 WNTs in synapse formation and neuronal circuitry Mikyoung Park and Kang Shen highlight recent discoveries on the instructive role of Wnt signals in synapse and neuronal circuitry formation. Mikyoung Park and Kang Shen The EMBO Journal (2012), 31, 2697 - 2704; 10.1038/emboj.2012.145 Abstract | Full text | PDF Published online: 22 May 2012 Mitotic and mitogenic Wnt signalling This contribution from Christof Niehrs and Sergio Acebron summarizes the role of Wnt signals during G1 phase and highlights functional activities of distinct pathway components during mitosis. Christof Niehrs and Sergio P Acebron The EMBO Journal (2012), 31, 2705 - 2713; 10.1038/emboj.2012.124 Abstract | Full text | PDF Published online: 22 May 2012 The many faces and functions of β-catenin Konrad Basler and colleagues survey and interpret the vast literature on armadillo/β-catenin. The result is a very broad and informative picture of this evolutionary-conserved, versatile protein. Tomas Valenta, George Hausmann and Konrad Basler The EMBO Journal (2012), 31, 2714 - 2736; 10.1038/emboj.2012.150 Abstract | Full text | PDF Published online: 22 May 2012 Drugging Wnt signalling in cancer Focused on the translational relevance of Wnt signalling, Paul Polakis offers an update on rational drug design, strategies and associated challenges in the development of inhibitors for canonical Wnt components. Paul Polakis The EMBO Journal (2012), 31, 2737 - 2746; 10.1038/emboj.2012.126 Abstract | Full text | PDF Published online: 22 May 2012 Have you seen? Top A lack of commitment for over 500 million years: conserved animal stem cell pluripotency Three recent studies on planarian adult stem cells suggest intriguing evolutionary conservation of germ and somatic stem cells. A Aziz Aboobaker and Damian Kao The EMBO Journal (2012), 31, 2747 - 2749; 10.1038/emboj.2012.131 Abstract | Full text | PDF Published online: 04 May 2012 Innate immunity: regulation of caspases by IAP-dependent ubiquitylation DIAP2-mediated ubiquitylation of the pro-apoptotic initiator caspase Dredd converts it to an activator of the NfκB pathway required for innate immune signalling in Drosophila. Christina Falschlehner and Michael Boutros The EMBO Journal (2012), 31, 2750 - 2752; 10.1038/emboj.2012.148 Abstract | Full text | PDF Published online: 15 May 2012 Transcription: another mark in the tail Recent studies suggest key roles for threonine-4 phosphorylation in the C-terminal domain of vertebrate RNA polymerase II. Jesper Q Svejstrup The EMBO Journal (2012), 31, 2753 - 2754; 10.1038/emboj.2012.154 Abstract | Full text | PDF Published online: 22 May 2012 Articles Top Gene expression of pluripotency determinants is conserved between mammalian and planarian stem cells Planarian are remarkable in their capacity to regenerate. The transcriptome and proteome profiles of totipotent adult planarian 'stem cells' suggest conservation of genes important for pluripotency in mammals and hint at a common ancestral state of embronic stem cells and germ cells. Pinar Önal, Dominic Grün, Catherine Adamidi, Agnieszka Rybak, Jordi Solana, Guido Mastrobuoni, Yongbo Wang, Hans-Peter Rahn, Wei Chen, Stefan Kempa, Ulrike Ziebold and Nikolaus Rajewsky The EMBO Journal (2012), 31, 2755 - 2769; 10.1038/emboj.2012.110 Abstract | Full text | PDF | Supp. info. | Review Process File Published online: 27 April 2012 Ubiquitylation of the initiator caspase DREDD is required for innate immune signalling Activation of Drosophila innate immune receptors leads to DIAP2-dependent ubiquitylation and activation of the initiator caspase DREDD. Ubiquitination of DREDD is needed for expression of antimicrobial genes in response to a bacterial infection. Annika Meinander, Christopher Runchel, Tencho Tenev, Li Chen, Chan-Hee Kim, Paulo S Ribeiro, Meike Broemer, Francois Leulier, Marketa Zvelebil, Neal Silverman and Pascal Meier The EMBO Journal (2012), 31, 2770 - 2783; 10.1038/emboj.2012.121 Abstract | Full text | PDF | Supp. info. | Review Process File Published online: 01 May 2012 Threonine-4 of mammalian RNA polymerase II CTD is targeted by Polo-like kinase 3 and required for transcriptional elongation Plk3 globally affects elongation by human RNA Polymerase II via phosphorylation of Thr4 in its C-terminal domain (CTD) heptad repeats, adding to the complex transcriptional regulation by CTD post-translational modifications. Corinna Hintermair, Martin Heidemann, Frederic Koch, Nicolas Descostes, Marta Gut, Ivo Gut, Romain Fenouil, Pierre Ferrier, Andrew Flatley, Elisabeth Kremmer, Rob D Chapman, Jean-Christophe Andrau and Dirk Eick The EMBO Journal (2012), 31, 2784 - 2797; 10.1038/emboj.2012.123 Abstract | Full text | PDF | Supp. info. | Review Process File Published online: 01 May 2012 Reshaping of global gene expression networks and sex-biased gene expression by integration of a young gene The Caf40-derived transcription factor Zeus is found to have rapidly evolved a sex-specific gene regulatory network in Drosophila, illustrating how a newly emerged gene acquires functions and integrates with pre-existing genes. Sidi Chen, Xiaochun Ni, Benjamin H Krinsky, Yong E Zhang, Maria D Vibranovski, Kevin P White and Manyuan Long The EMBO Journal (2012), 31, 2798 - 2809; 10.1038/emboj.2012.108 Abstract | Full text | PDF | Supp. info. | Review Process File Published online: 27 April 2012 A transcriptional repressor co-regulatory network governing androgen response in prostate cancers This paper uncovers novel co-regulatory networks that govern androgen responses in prostate cancer based on global binding maps for the androgen receptor with ERG (frequently over-expressed in tumours) and EZH2/HDAC-co-repressors. Kern Rei Chng, Cheng Wei Chang, Si Kee Tan, Chong Yang, Shu Zhen Hong, Noel Yan Wei Sng and Edwin Cheung The EMBO Journal (2012), 31, 2810 - 2823; 10.1038/emboj.2012.112 Abstract | Full text | PDF | Supp. info. | Review Process File Published online: 24 April 2012 Csy4 relies on an unusual catalytic dyad to position and cleave CRISPR RNA Assembly of crRNP complexes, which underlie target recognition in the prokaryotic CRISPR-Cas adaptive immune defenses against foreign genetic elements, relies on previous crRNA cleavage by the Csy4 processing ribonuclease. Rachel E Haurwitz, Samuel H Sternberg and Jennifer A Doudna The EMBO Journal (2012), 31, 2824 - 2832; 10.1038/emboj.2012.107 Abstract | Full text | PDF | Supp. info. | Review Process File Published online: 20 April 2012 Advertisement Follow EMBO on Twitter for as-it-happens access to news, comments and articles.Make Twitter a place to share information and network with others interested in the life sciences. http://twitter.com/#!/EMBOcomm   Please note that you need to be a subscriber or site-licence holder to enjoy full-text access to The EMBO Journal. In order to do so, please purchase a subscription. You have been sent this Table of Contents Alert because you have opted in to receive it. You can change or discontinue your e-mail alerts at any time, by modifying your preferences on your nature.com account at: www.nature.com/nams/svc/myaccount (You will need to log in to be recognised as a nature.com registrant). 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