Nature Reviews Immunology Contents June 2012 Volume 12 Number 6 pp 397-471

TABLE OF CONTENTS
June 2012 Volume 12 Number 6
Impact Factor 35.196 *	In this issue Research Highlights Focus on: Transplant immunology Also this month  Featured article: Regulatory immune cells in transplantation Kathryn J. Wood, Andrew Bushell & Joanna Hester
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RESEARCH HIGHLIGHTS Top Regulatory T cells: Stabilizing immune regulation in the gut p397 | doi:10.1038/nri3230 MicroRNA-10a helps to maintain the phenotype of regulatory T cells and prevent conversion to other T cell fates. PDF B cells: Selecting the best, without BCR signalling p398 | doi:10.1038/nri3231 Germinal centre B cells are responsive to BCR stimulation only in the cell cycle G2 phase. PDF Infectious disease: Pro-resolving lipids offer a helping hand to antibiotics p398 | doi:10.1038/nri3234 Pro-resolving lipid mediators lower the required antibiotic dose needed to clear E. coli infection. PDF Transplant immunology: Gut bugs and grafts p399 | doi:10.1038/nri3236 Composition of the intestinal flora influences the severity of graft-versus-host disease. PDF Innate immunity: AP3 links endosomal TLRs and antigen presentation p400 | doi:10.1038/nri3232 Adaptor protein 3 delivers TLR4 to phagosomes for pro-inflammatory signalling and effective MHC class II-mediated presentation of phagocytosed antigens. PDF Mucosal immunology: Inflammasomes induce sepsis following community breakdown p400 | doi:10.1038/nri3235 Gut pathobionts can trigger sepsis-like disease via the NAIP5–NLRC4 inflammasome. PDF Innate immunity: Pathogen and xenobiotic sensing — back to basics p400 | doi:10.1038/nri3237 Surveillance of basic cellular activities alerts Caenorhabditis elegans to pathogens or toxins. PDF IN BRIEF Reproductive immunology: Autoantibodies bring out the son | Asthma and allergy: IL-25-responsive myeloid cells promote type 2 lung pathology | B cells: A metabolic checkpoint for B cell development | Transplantation: Handling complement for transplant success | T cells: 'Leaky' cytokine secretion by immunological synapses | Innate immunity: MHC class I as a negative regulator of TLR signalling PDF Immunology JOBS of the week Postdoctoral Scientist – Immunology / leishmaniasis Infectious Disease Research Institute (IDRI) Safety Scientist (MD), Immunology Genentech Postdoctoral Position (Focus: Transplant Immunology) University of Patras Junior Faculty (G5) Recruitment in Immunology Institut Pasteur More Science jobs from Immunology EVENT Cell Symposia: Human Immunity 19.-21.08.12 Lisbon, Portugal More science events from
Focus on: Transplant immunology REVIEWS Top Emerging concepts in haematopoietic cell transplantation Hao Wei Li & Megan Sykes p403 | doi:10.1038/nri3226 Haematopoietic cell transplantation (HCT) is most frequently performed as a cancer therapy. However, more recently HCT has been used to treat patients with autoimmune diseases and to promote tolerance to other allografts. Here, the authors discuss the latest advances in HCT and the challenges still faced by researchers in the field. Abstract | Full Text | PDF Regulatory immune cells in transplantation Kathryn J. Wood, Andrew Bushell & Joanna Hester p417 | doi:10.1038/nri3227 Establishing immune tolerance in transplant recipients is essential for promoting the long-term survival of an allograft and for preventing the development of harmful graft-versus-host responses. This Review considers the clinical potential of manipulating different immunosuppressive cell populations, including regulatory T cells, B cells and macrophages, in the setting of transplantation. Abstract | Full Text | PDF The role of complement in the early immune response to transplantation Steven H. Sacks & Wuding Zhou p431 | doi:10.1038/nri3225 In this article, the importance of the peripheral production of complement in driving the immediate response of a transplanted organ to tissue stress and in the activation of alloreactive T cells is discussed, as well as the role of complement in antibody-mediated rejection. The authors also focus on new complement-targeted treatments for the prevention of transplant rejection. Abstract | Full Text | PDF | Supplementary information Advances in graft-versus-host disease biology and therapy Bruce R. Blazar, William J. Murphy & Mehrdad Abedi p443 | doi:10.1038/nri3212 Here, the authors review the most promising strategies for preventing or treating graft-versus-host disease after allogeneic haematopoietic stem cell transplantation. Approaches that target alloreactive T cells are often favoured, but those that exploit regulatory cell populations are now showing increasing success. Abstract | Full Text | PDF The impact of infection and tissue damage in solid-organ transplantation Anita S. Chong & Maria-Luisa Alegre p459 | doi:10.1038/nri3215 It has long been known that infections and tissue damage can be detrimental for the survival of transplanted allografts but the underlying mechanisms that trigger both innate and adaptive immunity are only beginning to be understood and are reviewed here. Abstract | Full Text | PDF
Corrigendum: Standardizing immunophenotyping for the Human Immunology Project Holden T. Maecker, J. Philip McCoy & Robert Nussenblatt p471 | doi:10.1038/nri3229 Full Text | PDF
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