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|  | | 29 May 2012 | | | Featured image: | |  | | | Tian et al. find novel roles for O-glycosylation in organ development using confocal microscopy of mouse submandibular glands. | | | | | | |
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FOCUS ON CILIOGENESIS
Cilia are dynamic organelles that modulate various developmental and physiological processes. Perturbation of cilia function has been linked to a range of diseases. Nature Cell Biology presents a collection of Research articles published in the journal in the past few years that highlights current knowledge of cilia biogenesis and function.
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nature.com/ncb/webfocus/ciliogenesis | | | | | | | Latest Articles | View all Articles | | | | | Stable magnetostructural coupling with tunable magnetoresponsive effects in hexagonal ferromagnets OPEN | | | Enke Liu, Wenhong Wang, Lin Feng, Wei Zhu, Guijiang Li, Jinglan Chen, Hongwei Zhang, Guangheng Wu, Chengbao Jiang, Huibin Xu and Frank de Boer | | | The coupling that occurs between the structural and the magnetic properties of magnetic materials leads to a host of magnetoresponsive effects that are useful for potential technological applications. Here, a strong magnetostructural coupling that persists over a wide temperature range is reported in MnNiGe:Fe alloys. | | | 29 May | Nat Commun 3:873 doi:10.1038/ncomms1868 (2012) | | | Physical sciences Applied physics | | | Condensed matter Materials science | | Abstract | Full Text | PDF (1,426 kB) |
Supplementary Information |
| Unsupported boron—carbon σ-coordination to platinum as an isolable snapshot of σ-bond activation | | | Holger Braunschweig, Peter Brenner, Rian D. Dewhurst, Ivo Krummenacher, Bernd Pfaffinger and Alfredo Vargas | | | σ-Complexes of transition metals are key intermediates in metal-mediated bond activation, but have traditionally been isolable only when chelating or when one of the participating atoms is hydrogen. Here, a complex is isolated with an unsupported borirene ligand bound not through the unsaturated C=C bond, but exclusively via a B—C single bond. | | | 29 May | Nat Commun 3:872 doi:10.1038/ncomms1884 (2012) | | | Chemical sciences Catalysis | | | | Abstract | Full Text | PDF (454 kB) |
Supplementary Information |
| Logic gates based on ion transistors | | | Klas Tybrandt, Robert Forchheimer and Magnus Berggren | | | Transistors based on ions, as opposed to electrons, offer the promise of bridging the gap between technological and biological systems. Tybrandt et al. present logic gates based on ion bipolar junction transistors that operate at concentrations compatible with biological systems. | | | 29 May | Nat Commun 3:871 doi:10.1038/ncomms1869 (2012) | | | Physical sciences Applied physics | | | Materials science | | Abstract | Full Text | PDF (708 kB) |
Supplementary Information |
| Twisted optical metamaterials for planarized ultrathin broadband circular polarizers | | | Y. Zhao, M.A. Belkin and A. Alù | | | Three-dimensional optical metamaterials provide a range of exciting features, such as broadband circular dichroism, yet their fabrication is challenging. Here, a broadband optical circular polarizer is presented based on twisted stacks of metasurfaces, avoiding the issues of three-dimensional fabrication. | | | 29 May | Nat Commun 3:870 doi:10.1038/ncomms1877 (2012) | | | Physical sciences Applied physics | | | Nanotechnology | | | Optical physics | | | | Abstract | Full Text | PDF (1,159 kB) |
| O-glycosylation modulates integrin and FGF signalling by influencing the secretion of basement membrane components | | | E. Tian, Matthew P. Hoffman and Kelly G. Ten Hagen | | | Altered O-glycosylation of proteins is implicated in various human diseases. In this study, Tian and co-workers study mice that are deficient in the O-glycosylation enzyme Galnt1, and find reduced cell proliferation and organogenesis as well as increased endoplasmic reticulum stress. | | | 29 May | Nat Commun 3:869 doi:10.1038/ncomms1874 (2012) | | | Biological sciences Cell biology | | | Developmental biology | | Abstract | Full Text | PDF (1,886 kB) |
Supplementary Information |
| Prediction of variable translation rate effects on cotranslational protein folding | | | Edward P. O'Brien, Michele Vendruscolo and Christopher M. Dobson | | | Proteins can undergo folding while being translated by the ribosome, and the extent of this folding is influenced by the rate at which amino acids are added to the nascent chain. This study provides a framework for predicting domain folding probabilities as a function of the kinetics of amino-acid addition. | | | 29 May | Nat Commun 3:868 doi:10.1038/ncomms1850 (2012) | | | Biological sciences Biophysics | | | Molecular biology | | Abstract | Full Text | PDF (1,025 kB) |
Supplementary Information |
| Ultra-low-loss optical delay line on a silicon chip OPEN | | | Hansuek Lee, Tong Chen, Jiang Li, Oskar Painter and Kerry J. Vahala | | | Fibre-optic waveguides are used to provide timing delays for different sensing and signal processing applications, but their transfer to on-chip platforms is a challenge. Here low-loss delay lines based on whispering-gallery spiral waveguides up to 27 m long are produced, presenting a scalable alternative. | | | 29 May | Nat Commun 3:867 doi:10.1038/ncomms1876 (2012) | | | Physical sciences Applied physics | | | Optical physics | | | Abstract | Full Text | PDF (1,419 kB) |
| Dynamic force-induced direct dissociation of protein complexes in a nuclear body in living cells | | | Yeh-Chuin Poh, Sergey P. Shevtsov, Farhan Chowdhury, Douglas C. Wu, Sungsoo Na, Miroslav Dundr and Ning Wang | | | Cells can sense their local environment by a process termed mechanotransduction, but whether these signals are relayed to the nucleus is unclear. This study demonstrates that a force applied at the cell surface can alter the localization of proteins within Cajal bodies that are found in the nuclear compartment. | | | 29 May | Nat Commun 3:866 doi:10.1038/ncomms1873 (2012) | | | Biological sciences Bioengineering | | | Biophysics Cell biology | | | | Abstract | Full Text | PDF (914 kB) |
Supplementary Information |
| Metformin elicits anticancer effects through the sequential modulation of DICER and c-MYC | | | Giovanni Blandino, Mariacristina Valerio, Mario Cioce, Federica Mori, Luca Casadei, Claudio Pulito, Andrea Sacconi, Francesca Biagioni, Giancarlo Cortese, Sergio Galanti, Cesare Manetti, Gennaro Citro, Paola Muti and Sabrina Strano | | | Metformin is used to treat diabetes and its use has been associated with reduced cancer incidence, but the mechanism is unclear. In this study, metformin is shown to alter microRNA expression including an increase in mir-33a, which decreases the expression of the oncogene c-Myc. | | | 29 May | Nat Commun 3:865 doi:10.1038/ncomms1859 (2012) | | | Biological sciences Cancer | | | Cell biology Medical research | | | Molecular biology | | Abstract | Full Text | PDF (935 kB) |
Supplementary Information |
| Robust classification of salient links in complex networks | | | Daniel Grady, Christian Thiemann and Dirk Brockmann | | | Methods to study the structure of complex networks often rely on case-sensitive parameters that have limited applications. In this study, a new method—link salience—is used to classify network elements based on a consensus estimate of all nodes, finding generic topological features in many empirical networks. | | | 29 May | Nat Commun 3:864 doi:10.1038/ncomms1847 (2012) | | | Physical sciences Applied physics | | | | Abstract | Full Text | PDF (19,799 kB) |
Supplementary Information |
| Inbreeding causes early death in a passerine bird | | | N.L. Hemmings, J. Slate and T.R. Birkhead | | | Inbreeding reduces the fitness of birds and mammals, but at which stage in development this occurs is not always clear. Hemmings et al. show that when closely related zebra finches breed together, fertilisation proceeds normally, but the offspring are more likely to die during development of the embryo. | | | 29 May | Nat Commun 3:863 doi:10.1038/ncomms1870 (2012) | | | Biological sciences Ecology | | | Genetics Zoology | | | Abstract | Full Text | PDF (220 kB) |
| The oceanic biological pump modulates the atmospheric transport of persistent organic pollutants to the Arctic | | | Cristóbal Galbán-Malagón, Naiara Berrojalbiz, María-José Ojeda and Jordi Dachs | | | Persistent organic pollutants can reach and pollute pristine environments, such as the Arctic Ocean, through atmospheric transport. This study shows that the oceanic biological pump can sequester atmospheric polychlorinated biphenyls, reducing the transport of pollutants to the Arctic Ocean. | | | 29 May | Nat Commun 3:862 doi:10.1038/ncomms1858 (2012) | | | Earth sciences Atmospheric science | | | Biogeochemistry Oceanography | | Abstract | Full Text | PDF (713 kB) |
Supplementary Information |
| Assembly kinetics determine the architecture of α-actinin crosslinked F-actin networks | | | Tobias T. Falzone, Martin Lenz, David R. Kovar and Margaret L. Gardel | | | Processes that regulate the mechanical and dynamic properties of actin cytoskeleton are important for multiple eukaryotic cell functions. In this study, using reconstituted crosslinked actin networks, organization is found to be determined by the competing kinetics of actin gelation and bundle formation. | | | 29 May | Nat Commun 3:861 doi:10.1038/ncomms1862 (2012) | | | Biological sciences Biophysics | | | Cell biology | | Abstract | Full Text | PDF (3,812 kB) |
Supplementary Information |
| Orbital switching in a frustrated magnet | | | Hiroyuki Yoshida, Jun-ichi Yamaura, Masaaki Isobe, Yoshihiko Okamoto, Gøran J. Nilsen and Zenji Hiroi | | | The d orbitals of transition metal compounds influence their crystallographic and physical properties. This study reports a unique structural transition in single crystals of the S=1/2 kagomé antiferromagnet, volborthite, whereby an unpaired electron 'switches' from one d orbital to another upon cooling. | | | 29 May | Nat Commun 3:860 doi:10.1038/ncomms1875 (2012) | | | Chemical sciences Inorganic chemistry | | | Physical chemistry | | Abstract | Full Text | PDF (1,312 kB) |
Supplementary Information |
| The Dishevelled-associating protein Daple controls the non-canonical Wnt/Rac pathway and cell motility OPEN | | | Maki Ishida-Takagishi, Atsushi Enomoto, Naoya Asai, Kaori Ushida, Takashi Watanabe, Takahiko Hashimoto, Takuya Kato, Liang Weng, Shinji Matsumoto, Masato Asai, Yoshiki Murakumo, Kozo Kaibuchi, Akira Kikuchi and Masahide Takahashi | | | The non-canonical Wnt signalling pathway mediates cell migration via the GTPase Rac but the detailed mechanism is unclear. In this study, the Daple protein is shown to regulate Wnt5a mediated activation of Rac, resulting in the formation of lamellipodia and cell migration. | | | 29 May | Nat Commun 3:859 doi:10.1038/ncomms1861 (2012) | | | Biological sciences Cell biology | | | Developmental biology | | | | Abstract | Full Text | PDF (1,783 kB) |
Supplementary Information | | | | | | |
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ARTICLE SERIES ON NEURAL CIRCUITS
This article series explores different approaches for the analysis of the structure and function of neural circuits and describes the methodological advances that are driving research in this area.
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