The EMBO Journal - Table of Contents alert Volume 31 Issue 1

TABLE OF CONTENTS 04 January 2012 | Volume 31, Issue 1 Have you seen? EMBO Members Review Articles Corrigendum Also new AOP Sign up for e-alerts Recommend to your library Web feed Subscribe Advertisement Dermatogenetics February 9-12, 2012 - Miami, FL, USA The conference will cover: genetic variation, gene expression and cellular mechanisms in this shared area of exceptional interest to basic researchers, biopharma and translational medicine. For more information and to register visit: www.nature.com/natureconferences/dg2012   Have you seen? Top Ubiquitin-mediated regulation of RhoGTPase signalling: IAPs and HACE1 enter the fray Two recent studies, including one EMBO Journal article, add ubiquitination by the distinct IAP and HACE1 ubiquitin ligases to the complex network regulating the multiple cellular activities of Rac1. Mariam Orme, Katiuscia Bianchi and Pascal Meier The EMBO Journal (2012), 31, 1 - 2; 10.1038/emboj.2011.452 Abstract | Full text | PDF Published online: 04 January 2012 EMBO Members Review Top The dark sides of capillary morphogenesis gene 2 CMG2 is the major cellular receptor for the anthrax toxin, and its mutation causes Hyaline Fibromatosis Syndrome. This review discusses the role of CMG2 in these two diverse diseases, as well as its poorly understood physiological functions. Julie Deuquet, Ekkehart Lausch, Andrea Superti-Furga and F Gisou van der Goot The EMBO Journal (2012), 31, 3 - 13; 10.1038/emboj.2011.442 Abstract | Full text | PDF Published online: 06 December 2011 Subject Categories: Molecular Biology of Disease Articles Top IAPs regulate the plasticity of cell migration by directly targeting Rac1 for degradation This study reveals targeting of the small GTPase Rac1 by the IAP family of E3 ligases. Functionally, this contributes to Rac1-dependent cellular migration in cancer cells and neuronal polarization in the developing zebrafish hindbrain. Tripat Kaur Oberoi, Taner Dogan, Jennifer C Hocking, Rolf-Peter Scholz, Juliane Mooz, Carrie L Anderson, Christiaan Karreman, Dagmar Meyer zu Heringdorf, Gudula Schmidt, Mika Ruonala, Kazuhiko Namikawa, Gregory S Harms, Alejandro Carpy, Boris Macek, Reinhard W Köster and Krishnaraj Rajalingam The EMBO Journal (2012), 31, 14 - 28; 10.1038/emboj.2011.423 Abstract | Full text | PDF | Supp. info. | Review Process File Published online: 25 November 2011 Subject Categories: Signal Transduction | Differentiation and Death | Neuroscience Lats2 kinase potentiates Snail1 activity by promoting nuclear retention upon phosphorylation The Lats2 kinase, a Hippo pathway component, is here shown to promote the epithelial–mesenchymal transition by phosphorylating the transcription factor Snail1. Kun Zhang, Eva Rodriguez-Aznar, Norikazu Yabuta, Robert J Owen, Jose M Mingot, Hiroshi Nojima, M Angela Nieto and Gregory D Longmore The EMBO Journal (2012), 31, 29 - 43; 10.1038/emboj.2011.357 Abstract | Full text | PDF | Supp. info. | Review Process File Published online: 27 September 2011 Subject Categories: Signal Transduction | Molecular Biology of Disease Distinct role of Mediator tail module in regulation of SAGA-dependent, TATA-containing genes in yeast The Mediator complex is thought to play a near universal role in eukaryotic RNA Pol II transcription. However, in this study the Mediator tail module is shown to selectively regulate TATA- and SAGA-dependent genes, but not those dependent on TFIID. Suraiya A Ansari, Mythily Ganapathi, Joris J Benschop, Frank C P Holstege, Joseph T Wade and Randall H Morse The EMBO Journal (2012), 31, 44 - 57; 10.1038/emboj.2011.362 Abstract | Full text | PDF | Supp. info. | Review Process File Published online: 04 October 2011 Subject Categories: Chromatin and Transcription MYST protein acetyltransferase activity requires active site lysine autoacetylation This structural and biochemical characterization of MYST histone acetyltransferase autoacetylation and activation draws parallels from the autoregulation of kinases where the modification of the activation loop induces a conformation that facilitates substrate binding and catalysis. Hua Yuan, Dorine Rossetto, Hestia Mellert, Weiwei Dang, Madhusudan Srinivasan, Jamel Johnson, Santosh Hodawadekar, Emily C Ding, Kaye Speicher, Nebiyu Abshiru, Rocco Perry, Jiang Wu, Chao Yang, Y George Zheng, David W Speicher, Pierre Thibault, Alain Verreault, F Bradley Johnson, Shelley L Berger, Rolf Sternglanz, Steven B McMahon, Jacques Côté and Ronen Marmorstein The EMBO Journal (2012), 31, 58 - 70; 10.1038/emboj.2011.382 Abstract | Full text | PDF | Supp. info. | Review Process File Published online: 21 October 2011 Subject Categories: Chromatin and Transcription | Structural Biology Cohesin acetyltransferase Esco2 is a cell viability factor and is required for cohesion in pericentric heterochromatin Genetic deletion of murine Esco2 (an acetylase known to establish cohesin during S-phase and genetically linked to Roberts syndrome) results in embryonic lethality that can be molecularly linked to novel and specific functions of Esco2 at pericentric heterochromatin. Gabriela Whelan, Emanuel Kreidl, Gordana Wutz, Alexander Egner, Jan-Michael Peters and Gregor Eichele The EMBO Journal (2012), 31, 71 - 82; 10.1038/emboj.2011.381 Abstract | Full text | PDF | Supp. info. | Review Process File Published online: 18 November 2011 Subject Categories: Chromatin and Transcription | Molecular Biology of Disease Nuclear retention of importin α coordinates cell fate through changes in gene expression Importin α, responsible for nuclear translocation of cargo proteins, also has a direct role in transcriptional control, binding DNA and regulating the expression of a number of target genes. Yoshinari Yasuda, Yoichi Miyamoto, Tomoko Yamashiro, Munehiro Asally, Ayumi Masui, Chin Wong, Kate L Loveland and Yoshihiro Yoneda The EMBO Journal (2012), 31, 83 - 94; 10.1038/emboj.2011.360 Abstract | Full text | PDF | Supp. info. | Review Process File Published online: 30 September 2011 Subject Categories: Membranes and Transport | Chromatin and Transcription Physical and functional interaction between PML and TBX2 in the establishment of cellular senescence This paper molecularly links two important regulators of cellular senescence. While PML is recruited to the promoter of the transcription factor Tbx2 via p130 and E2F4, Tbx2 in turn abrogates PML function via direct protein interaction. Nadine Martin, Moussa Benhamed, Karim Nacerddine, Maud D Demarque, Maarten van Lohuizen, Anne Dejean and Oliver Bischof The EMBO Journal (2012), 31, 95 - 109; 10.1038/emboj.2011.370 Abstract | Full text | PDF | Supp. info. | Review Process File Published online: 14 October 2011 Subject Categories: Signal Transduction | Molecular Biology of Disease SET8 promotes epithelial–mesenchymal transition and confers TWIST dual transcriptional activities The histone H4 methyltransferase SET8 is a novel transcriptional co-regulator for the transcription factor Twist, promoting epithelial–mesenchymal transition. Mouse in vivo studies and co-expression data in human metastatic breast cancers reveal that Set8 is involved in Twist-associated tumour metastization. Fen Yang, Luyang Sun, Qian Li, Xiao Han, Liandi Lei, Hua Zhang and Yongfeng Shang The EMBO Journal (2012), 31, 110 - 123; 10.1038/emboj.2011.364 Abstract | Full text | PDF | Supp. info. | Review Process File Published online: 07 October 2011 Subject Categories: Chromatin and Transcription | Molecular Biology of Disease Nucleosomal organization of replication origins and meiotic recombination hotspots in fission yeast Eukaryotic replication origins and meiotic recombination sites typically lack consensus sequences but correlate with certain chromatin states. In fission yeast, nucleosome-depleted regions are required for meiotic double-strand break formation, but not for replication initiation. Elisa de Castro, Ignacio Soriano, Laura Marín, Rebeca Serrano, Luis Quintales and Francisco Antequera The EMBO Journal (2012), 31, 124 - 137; 10.1038/emboj.2011.350 Abstract | Full text | PDF | Supp. info. | Review Process File Published online: 11 October 2011 Subject Categories: Chromatin and Transcription | Genome Stability and Dynamics DNA-end capping by the budding yeast transcription factor and subtelomeric binding protein Tbf1 Budding yeast Rap1 has taken over the double-stranded telomeric repeat capping roles played in vertebrates by shelterin proteins TRF1/2. Their closest yeast homologue Tbf1 nevertheless remains able to maintain telomeres, by mechanisms revealed in this study. Virginie Ribaud, Cyril Ribeyre, Pascal Damay and David Shore The EMBO Journal (2012), 31, 138 - 149; 10.1038/emboj.2011.349 Abstract | Full text | PDF | Supp. info. | Review Process File Published online: 27 September 2011 Subject Categories: Genome Stability and Dynamics RNA/DNA hybrid binding affinity determines telomerase template-translocation efficiency An engineered human telomerase enzyme-lacking template RNA provides insights into the mechanisms underlying telomere repeat-addition and telomerase processivity. Xiaodong Qi, Mingyi Xie, Andrew F Brown, Christopher J Bley, Joshua D Podlevsky and Julian J-L Chen The EMBO Journal (2012), 31, 150 - 161; 10.1038/emboj.2011.363 Abstract | Full text | PDF | Supp. info. | Review Process File Published online: 11 October 2011 Subject Categories: Genome Stability and Dynamics A syn–anti conformational difference allows SRSF2 to recognize guanines and cytosines equally well RNA splicing factor SRSF2 binds equally well to defined pyrimidine- and purine-rich sequences. The structural basis for this broad RNA binding specificity is poorly understood; this study demonstrates that a conformational switch in the RNA rather than the protein is responsible for the recognition of both sequences. Gerrit M Daubner, Antoine Cléry, Sandrine Jayne, James Stevenin and Frédéric H-T Allain The EMBO Journal (2012), 31, 162 - 174; 10.1038/emboj.2011.367 Abstract | Full text | PDF | Supp. info. | Review Process File Published online: 14 October 2011 Subject Categories: RNA | Structural Biology Iron and ROS control of the DownSTream mRNA decay pathway is essential for plant fitness mRNA decay is an important post-transcriptional regulatory mechanism. This study characterizes Arabidopsis genes that contain DownSTream (DST) cis-acting elements in their 3′-UTRs, which mediate mRNA decay in response to iron treatment and ROS production. Karl Ravet, Guilhem Reyt, Nicolas Arnaud, Gabriel Krouk, El-Batoul Djouani, Jossia Boucherez, Jean-François Briat and Frédéric Gaymard The EMBO Journal (2012), 31, 175 - 186; 10.1038/emboj.2011.341 Abstract | Full text | PDF | Supp. info. | Review Process File Published online: 23 September 2011 Subject Categories: RNA | Plant Biology Quantitative modelling of amyloidogenic processing and its influence by SORLA in Alzheimer's disease This study puts forward a kinetic model for the processing of amyloid precursor protein (APP) relevant for Alzheimer's disease. APP oligomerization exerts a cooperative effect, causing large changes in processing efficiency in response to subtle differences in the level of SORLA, an inhibitor of APP processing and Alzheimer's risk factor. Vanessa Schmidt, Katharina Baum, Angelyn Lao, Katja Rateitschak, Yvonne Schmitz, Anke Teichmann, Burkhard Wiesner, Claus Munck Petersen, Anders Nykjaer, Jana Wolf, Olaf Wolkenhauer and Thomas E Willnow The EMBO Journal (2012), 31, 187 - 200; 10.1038/emboj.2011.352 Abstract | Full text | PDF | Supp. info. | Review Process File Published online: 11 October 2011 Subject Categories: Membranes and Transport | Neuroscience | Molecular Biology of Disease Expression of type I interferon by splenic macrophages suppresses adaptive immunity during sepsis While the initial phase of sepsis is characterized by a strong inflammatory response, the second phase is associated with suppression of adaptive immunity, which places the organism at risk of secondary infections. This immune suppression is unexpectedly regulated by type I interferon. Timo Schwandt, Beatrix Schumak, Gerrit H Gielen, Frank Jüngerkes, Patricia Schmidbauer, Katrin Klocke, Andrea Staratschek-Jox, Niko van Rooijen, Georg Kraal, Isis Ludwig-Portugall, Lars Franken, Sven Wehner, Jörg C Kalff, Olaf Weber, Carsten Kirschning, Christoph Coch, Ulrich Kalinke, Jörg Wenzel, Christian Kurts, Rainer Zawatzky, Bernhard Holzmann, Laura Layland, Joachim L Schultze, Sven Burgdorf, Joke MM den Haan, Percy A Knolle and Andreas Limmer The EMBO Journal (2012), 31, 201 - 213; 10.1038/emboj.2011.380 Abstract | Full text | PDF | Supp. info. | Review Process File Published online: 28 October 2011 Subject Categories: Immunology | Molecular Biology of Disease Myosin-5, kinesin-1 and myosin-17 cooperate in secretion of fungal chitin synthase The interactions between cytoskeletal motors are here explored in the context of polarized secretion in fungi, revealing unexpected complexity in the regulation of vesicle transport to and docking at the hyphal tip. Martin Schuster, Steffi Treitschke, Sreedhar Kilaru, Justin Molloy, Nicholas J Harmer and Gero Steinberg The EMBO Journal (2012), 31, 214 - 227; 10.1038/emboj.2011.361 Abstract | Full text | PDF | Supp. info. | Review Process File Published online: 25 October 2011 Subject Categories: Membranes and Transport | Cell and Tissue Architecture Insights into transport mechanism from LeuT engineered to transport tryptophan LeuT is a model protein for studying the structure and mechanism of the neurotransmitter/sodium symporter family. This study reveals how the ability of a ligand to promote the structural transition to the occluded state modulates transport specificity. Chayne L Piscitelli and Eric Gouaux The EMBO Journal (2012), 31, 228 - 235; 10.1038/emboj.2011.353 Abstract | Full text | PDF | Supp. info. | Review Process File Published online: 27 September 2011 Subject Categories: Membranes and Transport | Structural Biology Three-dimensional reconstructions of Arp2/3 complex with bound nucleation promoting factors Arp2/3-mediated branched actin nucleation is activated by a variety of nucleation promoting factors. Here, the structures of NPF–Arp2/3 complexes revealed by electron microscopy provide insights into the molecular basis of this regulation. Xiao-Ping Xu, Isabelle Rouiller, Brian D Slaughter, Coumaran Egile, Eldar Kim, Jay R Unruh, Xiaoxue Fan, Thomas D Pollard, Rong Li, Dorit Hanein and Niels Volkmann The EMBO Journal (2012), 31, 236 - 247; 10.1038/emboj.2011.343 Abstract | Full text | PDF | Supp. info. | Review Process File Published online: 20 September 2011 Subject Categories: Cell and Tissue Architecture | Structural Biology Corrigendum Top Hen1 is required for oocyte development and piRNA stability in zebrafish Leonie M Kamminga, Maartje J Luteijn, Marjo J den Broeder, Stefan Redl, Lucas JT Kaaij, Elke F Roovers, Peter Ladurner, Eugene Berezikov and René F Ketting The EMBO Journal (2012), 31, 248; 10.1038/emboj.2011.462 Abstract | Full text | PDF Published online: 04 January 2012 Please note that you need to be a subscriber or site-licence holder to enjoy full-text access to The EMBO Journal. In order to do so, please purchase a subscription. 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