The EMBO Journal - Table of Contents alert Volume 30 Issue 23

TABLE OF CONTENTS 30 November 2011 | Volume 30, Issue 23 Have you seen? Articles Corrigendum Also new AOP Advertisement Eppendorf Award Winner 2011 In 2011 the prize was awarded to Assistant Professor Suzan Rooijakkers, PhD, (University Medical Center Utrecht, Department of Medical Microbiology, Utrecht, The Netherlands). Find out more about her research here. If you want to apply for the Eppendorf Award 2012, click here. Sign up for e-alerts Recommend to your library Web feed Subscribe Advertisement Dermatogenetics February 9-12, 2012 • Miami, FL, USA The conference will cover: genetic variation, gene expression and cellular mechanisms in this shared area of exceptional interest to basic researchers, biopharma and translational medicine. Abstract Submission and Early Registration Deadline: December 1, 2011 For more information and to register visit: www.nature.com/natureconferences/dg2012   /> Have you seen? Top New WAVEs in neuronal PI3K signalling NYAPs or ‘Neuronal tYrosine-phosphorylated Adaptor for the PI3K’ are novel regulators of PI3K signalling in neurons. NYAPs link PI3K to the WAVE1 complex to regulate neuronal morphology. Till G A Mack and Britta J Eickholt The EMBO Journal (2011), 30, 4693 - 4695; 10.1038/emboj.2011.405 Abstract | Full text | PDF Published online: 30 November 2011 Target of γ-secretase modulators, presenilin marks the spot GSMs reduce the production of Aβ42 and are promising compounds for the treatment of Alzheimer disease. However, the target and mechanism of GSMs have been controversial. A study published in this issue of The EMBO Journal adds insight into this and shows that GSMs bind directly to the catalytic subunit of γ-secretase leading to altered cleavage of APP. Christina J Crump, Douglas S Johnson and Yue-Ming Li The EMBO Journal (2011), 30, 4696 - 4698; 10.1038/emboj.2011.410 Abstract | Full text | PDF Published online: 30 November 2011 Di-rectifying Tau The axon initial segment (AIS) functions as a retrograde trafficking barrier, or axonal rectifier, to exclude axonal Tau from re-entry into the somatodendritic compartment. Smita Jha and Matthew N Rasband The EMBO Journal (2011), 30, 4699 - 4700; 10.1038/emboj.2011.409 Abstract | Full text | PDF Published online: 30 November 2011 Articles Top Autophagy-based unconventional secretory pathway for extracellular delivery of IL-1β Autophagy is a central process within the cell that plays roles well beyond autodigestion and quality control. This study reveals that autophagy is involved in unconventional secretion of the proinflammatory cytokine IL-1β, a pathway that involves Atg5, inflammasome, GRASP55 (GORASP2), and Rab8a. Nicolas Dupont, Shanya Jiang, Manohar Pilli, Wojciech Ornatowski, Dhruva Bhattacharya and Vojo Deretic The EMBO Journal (2011), 30, 4701 - 4711; 10.1038/emboj.2011.398 Abstract | Full text | PDF | Supp. info. | Review Process File Published online: 08 November 2011 Regulation of integrin affinity on cell surfaces It has been proposed that integrin activation involves the generation of traction by binding to immobilized extracellular matrix and coupling to the actin cytoskeleton. Direct evidence, however, is lacking. Here, comparison of integrin affinity for soluble versus immobilized ligands supports this traction model. Thomas Schürpf and Timothy A Springer The EMBO Journal (2011), 30, 4712 - 4727; 10.1038/emboj.2011.333 Abstract | Full text | PDF | Supp. info. | Review Process File Published online: 23 September 2011 Lateral assembly of the immunoglobulin protein SynCAM 1 controls its adhesive function and instructs synapse formation SynCAM 1 is a neuronal homo- and heterophilic cell adhesion molecule. This study shows that cis oligomerization of SynCAM 1 promotes cell adhesion and contributes to the formation and organization of synaptic adhesion sites. Adam I Fogel, Massimiliano Stagi, Karen Perez de Arce and Thomas Biederer The EMBO Journal (2011), 30, 4728 - 4738; 10.1038/emboj.2011.336 Abstract | Full text | PDF | Supp. info. | Review Process File Published online: 16 September 2011 NYAP: a phosphoprotein family that links PI3K to WAVE1 signalling in neurons NYAP is a newly identified protein family that governs actin remodelling and neurite outgrowth. NYAPs are phosphorylated by the tyrosine kinase Fyn, which enhances interaction with PI3K and the WAVE1 complex and thereby regulating the cytoskeleton. Kazumasa Yokoyama, Tohru Tezuka, Masaharu Kotani, Takanobu Nakazawa, Naosuke Hoshina, Yasushi Shimoda, Shigeru Kakuta, Katsuko Sudo, Kazutada Watanabe, Yoichiro Iwakura and Tadashi Yamamoto The EMBO Journal (2011), 30, 4739 - 4754; 10.1038/emboj.2011.348 Abstract | Full text | PDF | Supp. info. | Review Process File Published online: 23 September 2011 Structural basis of initial RNA polymerase II transcription Several RNA polymerase II–nucleic acid crystal structures reveal the transition of the initiating polymerase from the open complex (OC) state to the initially transcribing complex (ITC) containing several RNA nucleotides. Alan C M Cheung, Sarah Sainsbury and Patrick Cramer The EMBO Journal (2011), 30, 4755 - 4763; 10.1038/emboj.2011.396 Abstract | Full text | PDF | Supp. info. | Review Process File Published online: 04 November 2011 Oestrogen receptor–co-factor–chromatin specificity in the transcriptional regulation of breast cancer Genome-wide maps of oestrogen receptor α co-regulators (SRC1, SRC2 and SRC3 and histone acetyltransferases p300, CBP) in breast cancer cells reveal unique signalling networks and non-redundant functions. Integration with primary tumour expression data identifies SRC3 and CBP-target genes as novel therapeutic classifiers for ER-positive breast tumours. Wilbert Zwart, Vasiliki Theodorou, Marleen Kok, Sander Canisius, Sabine Linn and Jason S Carroll The EMBO Journal (2011), 30, 4764 - 4776; 10.1038/emboj.2011.368 Abstract | Full text | PDF | Supp. info. | Review Process File Published online: 14 October 2011 Ablation of Smurf2 reveals an inhibition in TGF-β signalling through multiple mono-ubiquitination of Smad3 Smurf2 knockout unexpectedly reveals that this ubiquitin ligase suppresses the TGF-β pathway via Smad3 mono-ubiquitination that dissociates Smad signalling complexes, and not via poly-ubiquitin/proteasome-mediated Smad degradation. Liu-Ya Tang, Motozo Yamashita, Nathan P Coussens, Yi Tang, Xiangchun Wang, Cuiling Li, Chu-Xia Deng, Steven Y Cheng and Ying E Zhang The EMBO Journal (2011), 30, 4777 - 4789; 10.1038/emboj.2011.393 Abstract | Full text | PDF | Supp. info. | Review Process File Published online: 01 November 2011 The human microcephaly protein STIL interacts with CPAP and is required for procentriole formation Several genes mutated in human primary microcephaly encode key centrosome proteins. STIL/MCPH7 now joins this cast, with centriole biogenesis roles similar to those played by its distant relatives CeSAS-5/DmAna2 in invertebrates. Chieh-Ju C Tang, Shin-Yi Lin, Wen-Bin Hsu, Yi-Nan Lin, Chien-Ting Wu, Yu-Chih Lin, Ching-Wen Chang, Kuo-Sheng Wu and Tang K Tang The EMBO Journal (2011), 30, 4790 - 4804; 10.1038/emboj.2011.378 Abstract | Full text | PDF | Supp. info. | Review Process File Published online: 21 October 2011 Limiting replication initiation factors execute the temporal programme of origin firing in budding yeast Early-firing replication origins appear to out-compete late-firing origins for certain key initiation factors. The resulting stepwise progression of genome duplication helps to maintain sufficient nucleotide pools throughout the S-phase. Davide Mantiero, Amanda Mackenzie, Anne Donaldson and Philip Zegerman The EMBO Journal (2011), 30, 4805 - 4814; 10.1038/emboj.2011.404 Abstract | Full text | PDF | Supp. info. | Review Process File Published online: 11 November 2011 Phenylpiperidine-type γ-secretase modulators target the transmembrane domain 1 of presenilin 1 γ-Secretase modulators (GSMs) reduce the amyloid-β peptide Aβ42 and are promising therapeutic agents for Alzheimer's disease; however, their mechanism of action remained unclear. Here, GSM-1 is shown to directly bind the γ-secretase component PS1, leading to allosteric regulation of the protease and altered production of Aβ42. Yu Ohki, Takuya Higo, Kengo Uemura, Naoaki Shimada, Satoko Osawa, Oksana Berezovska, Satoshi Yokoshima, Tohru Fukuyama, Taisuke Tomita and Takeshi Iwatsubo The EMBO Journal (2011), 30, 4815 - 4824; 10.1038/emboj.2011.372 Abstract | Full text | PDF | Supp. info. | Review Process File Published online: 14 October 2011 Novel diffusion barrier for axonal retention of Tau in neurons and its failure in neurodegeneration The missorting of Tau protein from axons is associated with Alzheimer's disease. A novel microtubule-based diffusion barrier located at the axon initial segment restricts the movement of Tau and prevents its retrograde flow back into the soma and dendrites. Xiaoyu Li, Yatender Kumar, Hans Zempel, Eva-Maria Mandelkow, Jacek Biernat and Eckhard Mandelkow The EMBO Journal (2011), 30, 4825 - 4837; 10.1038/emboj.2011.376 Abstract | Full text | PDF | Supp. info. | Review Process File Published online: 18 October 2011 PKC alpha regulates Sendai virus-mediated interferon induction through HDAC6 and β-catenin A number of intracellular signalling cascades are activated in response to viral infection and induce an interferon response. This study identifies another branch of the pathway, promoting nuclear translocation of β-catenin, where it acts as a cofactor for IRF3-dependent gene expression. Jianzhong Zhu, Carolyn B Coyne and Saumendra N Sarkar The EMBO Journal (2011), 30, 4838 - 4849; 10.1038/emboj.2011.351 Abstract | Full text | PDF | Supp. info. | Review Process File Published online: 27 September 2011 Corrigendum Top Oestrogen receptor–co-factor–chromatin specificity in the transcriptional regulation of breast cancer Wilbert Zwart, Vasiliki Theodorou, Marleen Kok, Sander Canisius, Sabine Linn and Jason S Carroll The EMBO Journal (2011), 30, 4850; 10.1038/emboj.2011.414 Abstract | Full text | PDF Published online: 30 November 2011 Please note that you need to be a subscriber or site-licence holder to enjoy full-text access to The EMBO Journal. In order to do so, please purchase a subscription. You have been sent this Table of Contents Alert because you have opted in to receive it. 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