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| You'll need these materials. |
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| Pour 100 mL water into 4 cups, and 100 mL vinegar into the other 2 cups. |
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| Add 2 tsp bi-carb soda to two of the water cups. Stir to dissolve. |
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| Set up your cups with the different types of aspirin ready to go. |
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| Drop an aspirin, enteric coated or regular, into each cup. |
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Try this: Acidic aspirin
Warning: This activity uses chemicals. Read any packet safety instructions, do not consume the chemicals used and wash your hands after completing the activity. See the CSIRO Education safety page for more information.
You will need
- 6 plastic cups
- Water
- Vinegar
- Bi-carb soda
- A spoon
- 3 ‘regular’ aspirin tablets
- 3 enteric coated aspirin tablets*
- Marker
*These can be low dose aspirin used to reduce the risk of heart attack and stroke. Ask your pharmacist if you are having trouble finding them.
What to do
- Pour 100 mL water into 4 glasses. Label 2 of these ‘H2O’ and the other 2 ‘bi-carb soda’. Pour 100 mL vinegar into the each of the remaining glasses and label these ‘vinegar’.
- Add 2 tsp bi-carb soda to each of the appropriately labelled glasses. Stir to dissolve.
- Add 1 regular aspirin tablet to each of the 3 types of glasses. Observe what happens.
- Add 1 enteric coated aspirin tablet to each of the remaining glasses. What happens now?
- Leave the glasses for 1 hour. What has changed?
What's happening?
Aspirin is the common name for acetylsalicylic acid, which is soluble in water. When you put the regular aspirin into the water and the vinegar, the tablet will dissolve slowly. This is an example of a physical reaction.
Bi-carb soda is a base and will react quite readily with an acid. When you put the acidic aspirin into the basic solution, they react, forming bubbles of carbon dioxide. This is an example of a chemical reaction.
In many cases, a patient wants aspirin to work fast, so they want it to be absorbed in their stomach. Sometimes, it might be better for the aspirin to be absorbed slowly, not in the stomach, but in the small intestine.
The enteric aspirin has a coating that won’t dissolve easily in water or an acid, but will dissolve faster in a base. The stomach is a highly acidic environment, while the small intestine is basic. Using this coating means the aspirin is absorbed in the right part of the body.
Applications
Acid-base chemistry is used in many different industries, including pharmaceuticals, food production, mining and manufacturing.
Acids and bases can be very reactive, and may cause damage to pipes and equipment used in industrial processes. Using acid and base resistant coatings protects the equipment and extends its working life. Acids and bases can also cause harm to people, so many labs require workers to wear protective clothing such as goggles and gloves.
Different parts of the human body have different levels of acidity, depending on their function. The stomach is highly acidic, as this assists the break down and digestion of food, while the blood is less acidic than the stomach, but at the right level to transport oxygen efficiently.
More information
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