SciBX: Science-Business eXchange Contents: October 6 2011, Volume 4 / Issue 39

TABLE OF CONTENTS October 6 2011, Volume 4 / Issue 39 Analysis Cover Story Targets and Mechanisms Tools The Distillery: Therapeutics Autoimmune disease Cancer Infectious disease Inflammation Neurology Renal disease The Distillery: Techniques Chemistry Disease models Drug delivery Drug platforms Markers Recommend to your library Web feed Available online only Subscribe Advertisement SciBX: Science-Business eXchange Recommend SciBX to your library today SciBx is a weekly publication that identifies and analyzes the most important translational research articles from over 40 journals. Find out which papers have real scientific and commercial potential, and why. Subscribe to SciBX and you won't miss the next big thing. For more information visit: www.nature.com/scibx.   Trade Secrets A Nature Network blog by BIOENTREPRENEUR Brought to you by Nature Biotechnology Access the insights, advice and commentary from scientists and entrepreneurs building biotech sectors around the world. Join the global dialogue on life science entrepreneurship: http://blogs.nature.com/trade_secrets   Analysis Cover Story Top Opening the brain Lev Osherovich doi:10.1038/scibx.2011.1080 Cornell researchers have found that agonizing adenosine receptors in the brain's vasculature can aid the delivery of large-molecule therapeutics into the CNS. Adenios Inc. has licensed the approach and is developing the team's compounds as adjunct therapies for AD, MS and brain tumors. Full Text | PDF Targets and Mechanisms Top ROCKing in hematology Lauren Martz doi:10.1038/scibx.2011.1081 An Indiana University team has published the first evidence that rho kinase inhibitors could help treat AML and other hematological malignancies. The researchers now hope to repurpose the only approved rho kinase inhibitor, Eril fasudil, which is marketed by Asahi Kasei Pharma to treat aneurysm. Full Text | PDF Shark versus virus Tracey Baas doi:10.1038/scibx.2011.1082 The aminosterol squalamine has changed corporate hands a couple of times over 18 years and has been tried in indications ranging from cancer to AMD. Now, the academic who originally isolated the compound from dogfish shark liver thinks it could be used as a broad-spectrum antiviral. Full Text | PDF Tools Top Lung cancer signatures in blood Kai-Jye Lou doi:10.1038/scibx.2011.1083 U.S. researchers have compared mouse proteomes to identify plasma protein signatures that could be mined for biomarkers to aid the detection of lung cancer. The signatures may lead to a noninvasive follow-up test to complement CT scans, which have a high false positive rate. Full Text | PDF Distillery: Therapeutics Autoimmune disease Top Parathyroid hormone receptor (PTHR) doi:10.1038/scibx.2011.1084 Patient samples and mouse studies suggest recombinant human parathyroid hormone (PTH) could help treat osteoarthritis (OA). Full Text | PDF Cancer Top MicroRNA-155 (miR-155) doi:10.1038/scibx.2011.1085 In vitro and mouse studies suggest inhibiting miR-155 could help treat breast cancer 1 early onset (BRCA1)-deficient breast cancers. Full Text | PDF Heat shock 105 kDa protein 1 (HSPH1; HSP105; HSP110) doi:10.1038/scibx.2011.1086 Studies in patient samples and in mice identified a mutant form of HSP110 that improved the sensitivity of CRC cells to chemotherapy. Full Text | PDF Estrogen-related receptor-α (ESRRA; ERRα; NR3B1); ESRRA-C11orf20 doi:10.1038/scibx.2011.1087 A study in patient samples identified a fusion transcript of the ESRRA gene that could be a serum marker for ovarian cancer. Full Text | PDF Nuclear receptor subfamily 5 group A member 2 (NR5A2; LRH-1) doi:10.1038/scibx.2011.1088 In vitro studies suggest inhibiting LRH-1 could help treat pancreatic cancer. Full Text | PDF Infectious disease Top Complement 5a (C5a) doi:10.1038/scibx.2011.1089 Studies in patient samples and in mice suggest inhibiting C5a could help treat pneumococcal meningitis. Full Text | PDF Not applicable doi:10.1038/scibx.2011.1090 Cell culture and rodent studies suggest squalamine could be a broad-spectrum antiviral. Full Text | PDF Inflammation Top Glucocorticoid induced transcript 1 (GLCCI1) doi:10.1038/scibx.2011.1091 A genomewide study identified GLCCI1 variants that could help predict responsiveness to inhaled glucocorticoid therapy for asthma. Full Text | PDF Neurology Top MicroRNA-34c (miR-34c) doi:10.1038/scibx.2011.1092 Mouse studies suggest inhibiting miR-34c could help treat AD and dementia. Full Text | PDF Neuronal nitric oxide synthase 1 (NOS1; nNOS) doi:10.1038/scibx.2011.1093 Rat and tissue culture studies identified 3,6-disubstituted indole derivative–based nNOS inhibitors that could help treat neuropathic pain. Full Text | PDF Norepinephrine transporter doi:10.1038/scibx.2011.1094 Rat and in vitro studies identified selective norepinephrine transporter inhibitors that could help treat pain. Full Text | PDF Lipocalin (LCN2; NGAL) doi:10.1038/scibx.2011.1095 Mouse studies suggest inhibiting LCN2 could help treat SCI. Full Text | PDF Renal disease Top Epidermal growth factor receptor (EGFR) doi:10.1038/scibx.2011.1096 Mouse studies suggest inhibiting heparin-binding EGF could help treat glomerulonephritis. Full Text | PDF Distillery: Techniques Chemistry Top Site-specific N-methylation of macrocycles and cyclic peptides to increase bioavailability doi:10.1038/scibx.2011.1097 N-Methylation may help increase the bioavailability of macrocycles and cyclic peptides. Full Text | PDF Disease models Top Candida albicans–infected mouse model of vulvar pain (vulvodynia) doi:10.1038/scibx.2011.1098 Mouse models that demonstrate a causal role between C. albicans infection and vulvodynia could be useful for testing therapies. Full Text | PDF Mouse model of von Hippel-Lindau renal cancer driven by hypoxia-inducible factor 1α (HIF1A; HIF1α) doi:10.1038/scibx.2011.1099 A mouse model of von Hippel-Lindau renal cancer could help screen for new treatments of the disease. Full Text | PDF Drug delivery Top Cyclic peptides for drug delivery to the nucleus doi:10.1038/scibx.2011.1100 Cyclic peptides containing arginine and tryptophan residues could be used to deliver drugs to cells' nuclei. Full Text | PDF Drug platforms Top Fusion protein for targeted delivery of cancer therapeutics doi:10.1038/scibx.2011.1101 An engineered fusion protein could help improve the specificity of chemotherapy. Full Text | PDF Human induced pluripotent stem (iPS) cell–derived neurospheres for treatment of spinal cord injury (SCI) doi:10.1038/scibx.2011.1102 Human iPS cell–derived neurospheres could be useful for treating SCI. Full Text | PDF Markers Top Plasma protein signatures for lung cancer doi:10.1038/scibx.2011.1103 Plasma protein profiles could help detect, diagnose and monitor treatment response of lung cancers. Full Text | PDF You have been sent this Table of Contents Alert because you have opted in to receive it. 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