Nature Reviews Neuroscience contents November 2011 Volume 12 Number 11 pp 613-700

Advertisement
Cell Cycle Analysis: A streamlined approach. New BD FACSuite™ software on the BD FACSVerse™ flow cytometry system provides predefined research assays matched with reagent kits, making it easy to achieve reproducible, consistent results. Download a free application note on cell cycle analysis and see the exciting innovations behind the new BD FACSVerse. bdbiosciences.com/go/verse
TABLE OF CONTENTS
November 2011 Volume 12 Number 11		Advertisement
Impact Factor 29.51 * Subscribe to Nature Reviews Neuroscience Recommend to your library	In this issue Research Highlights Foreword Focus on: Addiction Correspondence Also this month  Featured article: Transcriptional and epigenetic mechanisms of addiction Alfred J. Robison & Eric J. Nestler	Exclusive discounts are now available online Nature Lab Offers provides researchers like you with exclusive discounts on products used in your lab. Browse through US Offers or Global Offers on antibodies, cell culture, PCR, software, pipettors, reagents, and more! US Offers Global Offers
Advertisement
Nature Outlook: Medical Research Masterclass Following the recent 61st Meeting of Nobel Laureates at Lindau, Nature Outlook examines the areas of biomedical science that challenge and inspire the world's finest scientific minds. Access the Outlook free online for six months. Produced with support from: Mars, Incorporated Porsche
From the editors p613 | doi:10.1038/nrn3130 PDF
RESEARCH HIGHLIGHTS Top Neurodevelopmental disorders: Mice that mirror autism p615 | doi:10.1038/nrn3129 Mice lacking Cntnap2 show abnormal neuronal migration, asynchronous firing patterns and have an autism-like phenotype that can be partially normalized by treatment with risperidone. PDF Neural development: Neurogenesis ends near the beginning p616 | doi:10.1038/nrn3128 Neurogenesis in the subventricular zone is robust in infancy, with cells migrating to olfactory regions and also to the prefrontal cortex, but this declines sharply before the age of two. PDF Learning and memory: Small molecule, big hindrance to memory p617 | doi:10.1038/nrn3126 microRNA-34c interferes with memory consolidation in the mouse hippocampus and could be a novel target for the treatment of cognitive impairment. PDF Synaptic plasticity: Transporting memories p617 | doi:10.1038/nrn3127 KIBRA may modulate learning and memory through the regulation of AMPA receptor trafficking and synaptic plasticity. PDF Sensory systems: Charting vomeronasal receptor function p618 | doi:10.1038/nrn3123 Identification of the chemical cues that activate specific vomeronasal receptors sheds light on the organization of the vomeronasal system. PDF Pain: A prickly solution? p618 | doi:10.1038/nrn3124 A new study reveals an unexpected role for Hedgehog signalling in thermal allodynia and hyperalgesia. PDF IN BRIEF Neuropharmacology: Pain, pain, go away | Olfactory coding: Smell gets organized! | Neurogenetics: Expanding ALS and FTD genetics PDF Neuroscience JOBS of the week Alzheimer’s Research UK Senior Research Fellowship Alzheimer’s Research UK GB Postdoc: Membrane Protein Structural Biology Duke University Durham, US Alzheimer’s Research UK Clinical Research Fellowship Alzheimer’s Research UK GB Assistant Professor or Post Doc in Epigenetics Linkoping University Hospital Linkoping, SE Research Associate in Bioinformatics The University of Hong Kong Hong Kong, HK More Science jobs from Neuroscience EVENT International Symposium on Learning, Memory and Cognitive Function. Mechanisms, Pathology and Therapeutics. 01.-03.12.11 Valencia, Spain More science events from
FOREWORD		Top
Addiction: from mechanisms to treatment Leonie Welberg p621 | doi:10.1038/nrn3131 Abstract | Full Text | PDF
Focus on: Addiction REVIEWS Top Transcriptional and epigenetic mechanisms of addiction Alfred J. Robison & Eric J. Nestler p623 | doi:10.1038/nrn3111 Chronic drug exposure induces long-term changes in the brain, which are partly due to alterations in gene expression. Robison and Nestler review the mechanisms by which drugs of abuse alter the transcriptional potential of genes through the regulation of transcription factors and epigenetic mechanisms, including the regulation of gene expression by non-coding RNAs. Abstract | Full Text | PDF Common cellular and molecular mechanisms in obesity and drug addiction Paul J. Kenny p638 | doi:10.1038/nrn3105 The regulation of the hedonic properties of food and addictive drugs involves common neural circuits and molecular substrates. Kenny reviews the shared mechanisms that may contribute to both obesity and drug addiction. Abstract | Full Text | PDF Dysfunction of the prefrontal cortex in addiction: neuroimaging findings and clinical implications Rita Z. Goldstein & Nora D. Volkow p652 | doi:10.1038/nrn3119 Functional imaging studies have pointed to a key role for the prefrontal cortex (PFC) in addiction, both through its regulation of limbic regions and its involvement in higher-order executive function. Goldstein and Volkow review these studies, showing that disruption of the PFC in addiction not only underlies compulsive drug taking but also accounts for the disadvantageous behaviours that are associated with addiction and the erosion of non-drug related motivation and self-control. Abstract | Full Text | PDF | Supplementary information Pharmacogenetic approaches to the treatment of alcohol addiction Markus Heilig, David Goldman, Wade Berrettini & Charles P. O'Brien p670 | doi:10.1038/nrn3110 Current addiction pharmacotherapies have limited success. Focusing on alcohol addiction, Heilig and colleagues review the evidence that genetic heterogeneity in the opioid, corticotropin-releasing factor, GABA and serotonin systems may underlie differential treatment responses, and that personalized therapies tailored to patient genotype may lead to more successful treatment for alcohol addiction. Abstract | Full Text | PDF PERSPECTIVES Top OPINION Opiate versus psychostimulant addiction: the differences do matter Aldo Badiani, David Belin, David Epstein, Donna Calu & Yavin Shaham Published online: 05 October 2011 p685 | doi:10.1038/nrn3104 Current theories of addiction all argue for a unitary account of drug addiction. Badiani and colleagues challenge this view by highlighting behavioural, cognitive and neurobiological differences between opiate addiction and psychostimulant addiction. They argue that these differences have important implications for addiction treatment, addiction theories and future research. Abstract | Full Text | PDF | Supplementary information
CORRESPONDENCE		Top
Correspondence: The regional specificity of rapid actions of cocaine Brandon J. Aragona p700 | doi:10.1038/nrn3043-c1 Full Text | PDF
Correspondence: On the speed of cocaine Roy A. Wise & Eugene A. Kiyatkin p700 | doi:10.1038/nrn3043-c2 Full Text | PDF
Advertisement
Our high impact. Your low price. Exclusive Offer: One full year print and online subscription to Nature and all the Nature research journals at a price equivalent to their individual Impact Factor. Don't miss out. Take advantage of this opportunity to get personal access to world class scientific content at an exceptional value. Subscribe today!
Natureevents is a fully searchable, multi-disciplinary database designed to maximise exposure for events organisers. The contents of the Natureevents Directory are now live. The digital version is available here. Find the latest scientific conferences, courses, meetings and symposia on natureevents.com. For event advertising opportunities across the Nature Publishing Group portfolio please contact natureevents@nature.com More Nature Events

*2010 Journal Citation Report (Thomson Reuters, 2011)

You have been sent this Table of Contents Alert because you have opted in to receive it. You can change or discontinue your e-mail alerts at any time, by modifying your preferences on your nature.com account at: www.nature.com/myaccount (You will need to log in to be recognised as a nature.com registrant). For further technical assistance, please contact our registration department For print subscription enquiries, please contact our subscription department For other enquiries, please contact our feedback department Nature Publishing Group | 75 Varick Street, 9th Floor | New York | NY 10013-1917 | USA Nature Publishing Group's worldwide offices: London - Paris - Munich - New Delhi - Tokyo - Melbourne San Diego - San Francisco - Washington - New York - Boston Macmillan Publishers Limited is a company incorporated in England and Wales under company number 785998 and whose registered office is located at Brunel Road, Houndmills, Basingstoke, Hampshire RG21 6XS. © 2011 Nature Publishing Group, a division of Macmillan Publishers Limited. All Rights Reserved.