Nature Reviews Molecular Cell Biology contents November 2011 Volume 12 Number 11 pp687-763

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TABLE OF CONTENTS
November 2011 Volume 12 Number 11		Advertisement
Impact Factor 38.65 * Subscribe to Nature Reviews Molecular Cell Biology Recommend to your library	In this issue Research Highlights Reviews Perspectives Also this month  Featured article: Microtubule nucleation by γ-tubulin complexes Justin M. Kollman, Andreas Merdes, Lionel Mourey & David A. Agard	NEW patent pending CO2/O2 Gas Control Module (GCM™) Infinite 200PRO with GCM is a breakthrough for cell-experiments • Consistent physiological conditions • Predictable culture growth • No transport of cell cultures from • incubator to reader • Complete data sets overnight Learn more
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From the editors p687 | doi:10.1038/nrm3223 PDF
RESEARCH HIGHLIGHTS Top Ageing: A midlife crisis for sirtuins p688 | doi:10.1038/nrm3218 New findings challenge the idea that sirtuins promote longevity. PDF JOURNAL CLUB Deconstructing the cell cycle p689 | doi:10.1038/nrm3205 Describes how a minimal oscillatory cyclin–CDK module can drive the cell cycle. PDF Cell signalling: PRMT5 restricts ERK activity p689 | doi:10.1038/nrm3213 PRMT5 methylates RAF proteins to decrease their stability and reduce ERK activation. PDF DNA repair: Nuclear receptors in repair p690 | doi:10.1038/nrm3215 NR4A proteins regulate DNA double-strand break repair independently of transcription. PDF Organelle dynamics: Inheritance for pluripotency p690 | doi:10.1038/nrm3216 Midbodies promote stem cell pluripotency and cancer tumorigenicity. PDF Mechanisms of disease: USP1 keeps ID proteins stable p691 | doi:10.1038/nrm3210 USP1 stabilizes ID proteins to inhibit differentiation in MSCs and osteosarcoma. PDF Chromatin: Chromatin state reaches out p692 | doi:10.1038/nrm3208 Shows crosstalk between histone H2B ubiquitylation and Dam1 methylation at kinetochores. PDF Stem cells: The 'backup' intestinal stem cell p692 | doi:10.1038/nrm3211 Slower-cycling stem cells compensate for LGR5-expressing crypt base columnar cells. PDF IN THE NEWS Reprogramming revitalized p692 | doi:10.1038/nrm3219 PDF IN BRIEF Cell polarity: PAR access control | Gene expression: An importin-α stress response | Circadian rhythms: Modifying the clock PDF Molecular Cell Biology JOBS of the week International PhD Program ICA University Salzburg Salzburg, AT Project Scientist or postdoctoral fellow University of California, San Diego San Diego, US Postdoctoral Position- Developmental Neurobiology in C. elegans Cincinnati Children's Hospital Research Foundation Cincinnati, US Postdoctoral Position- Developmental Neurobiology in C. elegans Cincinnati Children's Hospital Research Foundation Cincinnati, US Postdoc in Optical Techniques for Neurobiology The University of Texas at Austin College of Engineering Austin, US More Science jobs from Molecular Cell Biology EVENT 3rd Molecular Diagnostics for Cancer Drug Development 05.-07.12.11 Frankfurt, Germany More science events from
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REVIEWS		Top
The nucleoskeleton as a genome-associated dynamic 'network of networks' Dan N. Simon & Katherine L. Wilson p695 | doi:10.1038/nrm3207 The diverse components of the nucleoskeleton provide physical links, and allow communication, between the cytoskeleton and the nucleus. Together, they form dynamic networks that regulate the shape and mechanical properties of the nucleus and control nuclear function, including gene expression. Abstract | Full Text | PDF
Microtubule nucleation by γ-tubulin complexes Justin M. Kollman, Andreas Merdes, Lionel Mourey & David A. Agard p709 | doi:10.1038/nrm3209 Microtubule nucleation is regulated by the γ-tubulin small complex (γTuSC) and the γ-tubulin ring complex (γTuRC). Recent structural work, including the crystallographic analysis of γ-tubulin complex protein 4 (GCP4), provides new insights into the mechanism of γTuRC-based microtubule nucleation, confirming the hypothesis that the γTuRC functions as a microtubule template. Abstract | Full Text | PDF
Forming functional fat: a growing understanding of adipocyte differentiation Ana G. Cristancho & Mitchell A. Lazar p722 | doi:10.1038/nrm3198 The differentiation of adipocytes from mesenchymal stem cells, known as adipogenesis, occurs in two stages, commitment and terminal differentiation, both of which are tightly regulated by mechanical and molecular cues. A better understanding of the underlying mechanisms may identify therapeutic targets for metabolic diseases. Abstract | Full Text | PDF
The N-end rule pathway: emerging functions and molecular principles of substrate recognition Shashikanth M. Sriram, Bo Yeon Kim & Yong Tae Kwon p735 | doi:10.1038/nrm3217 The N-end rule defines the protein-destabilizing activity of a given amino-terminal residue following its post-translational modification. The N-end rule pathway is emerging as a major cellular proteolytic system, and recent studies provide insights into its components, substrates and functions, as well as the structural basis of substrate recognition. Abstract | Full Text | PDF | Supplementary information
PERSPECTIVES		Top
INNOVATION Imaging the coordination of multiple signalling activities in living cells Christopher M. Welch, Hunter Elliott, Gaudenz Danuser & Klaus M. Hahn p749 | doi:10.1038/nrm3212 Advances in biosensor technology have made it possible to simultaneously study the activation of multiple signalling network components in the same cell. This approach has been enhanced by novel computational approaches (referred to as computational multiplexing) that can reveal relationships between network nodes imaged in separate cells. Abstract | Full Text | PDF | Supplementary information
OPINION It cuts both ways: reconciling the dual roles of caspase 8 in cell death and survival Andrew Oberst & Douglas R. Green p757 | doi:10.1038/nrm3214 Caspase 8 initiates apoptosis but also has non-apoptotic roles during embryonic development and for immune cell proliferation. Recent findings indicate that the non-apoptotic functions of caspase 8 are defined by the suppression of receptor-interacting protein kinase 3 (RIPK3), a kinase that triggers programmed necrosis. Abstract | Full Text | PDF
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