Nature Reviews Cancer contents November 2011 Volume 11 Number 11 pp 755-823

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TABLE OF CONTENTS
November 2011 Volume 11 Number 11		Advertisement
Impact Factor 37.178 * Subscribe to Nature Reviews Cancer Recommend to your library	In this issue Research Highlights Reviews Perspectives Correspondence Also this month  Featured article: Targeting protein prenylation for cancer therapy Norbert Berndt, Andrew D. Hamilton & Saïd M. Sebti	Effectively screen formalin fixed tissue Formalin-Fixed Paraffin Embedded tissue can provide invaluable information, but is notoriously difficult to use. The MassARRAY® system enables highly sensitive, reproducible somatic mutation profiling and methylation analysis even with minimal amounts of degraded FFPE tissue. Discover the potential of your archival samples. www.sequenom.com
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NATURE REVIEWS CANCER TURNS 10 Nature Reviews Cancer celebrates its 10 year anniversary with a specially commissioned Article Series that explores today's hottest research areas such as epigenetics, heterogeneity and metastasis, as well as forward looking concepts that could result in new treatments for cancer patients. Read the OCTOBER ANNIVERSARY ISSUE online: www.nature.com/nrc Read the ARTICLE SERIES online: www.nature.com/nrc/series/thenext10
From the editors p755 | doi:10.1038/nrc3165 PDF
RESEARCH HIGHLIGHTS Top Metabolism: Letting glucose take hold p756 | doi:10.1038/nrc3159 Daley and colleagues show that LIN28-mediated suppression of let-7 microRNAs activates the insulin–PI3K–mTOR pathway to regulate glucose metabolism, connecting type 2 diabetes and cancer. PDF Tumorigenesis: USP1 keeps ID proteins stable p757 | doi:10.1038/nrc3158 USP1 stabilizes ID proteins to inhibit differentiation in mesenchymal stem cells and osteosarcoma cells. PDF Metabolism: Catabolic effects p757 | doi:10.1038/nrc3161 A recent Nature paper identifies a catabolite of tryptophan as an endogenous ligand of aryl hydrocarbon receptor and links this pathway to tumorigenesis and suppression of antitumour immunity. PDF Tumour suppressors: HOTS makes antisense p758 | doi:10.1038/nrc3154 Expression of an antisense transcript from the imprinted H19 gene is implicated in tumour suppression. PDF Pancreatic cancer: Fibroblast co-conspirators p758 | doi:10.1038/nrc3157 Chemokine signalling through CXCR2 in stromal fibroblasts can improve survival in a mouse model of pancreatic ductal adenocarcinoma. PDF Gene expression: Variety is the splice of strife p759 | doi:10.1038/nrc3156 Two new studies propose a role for splicing deregulation in tumorigenesis. PDF Tumour suppressors: Silencing heterochromatin p760 | doi:10.1038/nrc3152 A recent Nature paper describes a new function for BRCA1 in regulating the silencing of pericentric heterochromatin. PDF IN BRIEF Aneuploidy: Lack of a full set is damaging | Therapy: Wager of war on bromodomains | Breast cancer: Suppressing a resistant population PDF Cancer JOBS of the week Project Scientist or postdoctoral fellow University of California, San Diego San Diego, US Postdoctoral associate The University of North Carolina at Chapel Hill Chapel Hill, US Assistant Professor: New Haven, CT, USA Yale University, School of Medicine New Haven, US Cancer Biomarker Lab Supervisor Massachusetts General Hospital, Boston, MA Boston, US PostDoctoral Fellow Texas Tech University Health Sciences Center Lubbock, US More Science jobs from Cancer EVENT Active Surveillance for Low Risk Prostate Cancer 12.-13.01.12 Rotterdam, Netherlands More science events from
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REVIEWS		Top
RAS oncogenes: weaving a tumorigenic web Yuliya Pylayeva-Gupta, Elda Grabocka & Dafna Bar-Sagi p761 | doi:10.1038/nrc3106 The RAS oncogenes have far-reaching effects when they are oncogenically mutated. This Review discusses our current knowledge about the cell-autonomous and non-cell-autonomous effects of oncogenic RAS and how different RAS isoforms and substitutions seem to have different effects. Abstract | Full Text | PDF
Targeting protein prenylation for cancer therapy Norbert Berndt, Andrew D. Hamilton & Saïd M. Sebti p775 | doi:10.1038/nrc3151 It was hoped that targeting protein prenylation would inhibit the oncogenic signalling of RAS family members. However, preclinical and clinical trials of prenyltransferase inhibitors have conflicting results. This Review discusses why these differences might occur and the future of targeting prenylation. Abstract | Full Text | PDF | Supplementary information
TRIM proteins and cancer Shigetsugu Hatakeyama p792 | doi:10.1038/nrc3139 Several members of the tripartite motif (TRIM) proteins (one of the subfamilies of the RING type E3 ubiquitin ligases) seem to function as important regulators for carcinogenesis. This Review focuses on TRIM proteins that are involved in tumour development and progression. Abstract | Full Text | PDF | Supplementary information
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PERSPECTIVES		Top
Novel cancer immunotherapy agents with survival benefit: recent successes and next steps Padmanee Sharma, Klaus Wagner, Jedd D. Wolchok & James P. Allison p805 | doi:10.1038/nrc3153 The US Food and Drug Administration (FDA) recently approved the immunotherapy agents sipuleucel-T and ipilimumab for the treatment of metastatic prostate cancer and melanoma, respectively. This Opinion article discusses how immunotherapy might be improved by understanding the mechanisms that are responsible for clinical benefit, identifying biomarkers that predict response or toxicity and developing combination therapies. Abstract | Full Text | PDF
Parkinson's disease and cancer: two wars, one front Michael J. Devine, Hélène Plun-Favreau & Nicholas W. Wood p812 | doi:10.1038/nrc3150 Epidemiological studies indicate that patients with Parkinson's disease seem to have a reduced risk of developing cancer (although exceptions exist). This Opinion article discusses the genes that are associated with Parkinson's disease and their possible roles in cancer biology. Abstract | Full Text | PDF
Erratum: Aminoacyl-tRNA synthetases and tumorigenesis: more than housekeeping Sunghoon Kim, Sungyong You & Daehee Hwang p813 | doi:10.1038/nrc3155 Full Text | PDF
CORRESPONDENCE		Top
Correspondence: ESR1 gene amplification: another mechanism regulating the cellular levels of ERα Ke-Da Yu & Zhi-Ming Shao p823 | doi:10.1038/nrc3093-c1 Full Text | PDF
Correspondence: Not enough evidence to include ESR1 amplification Christoforos Thomas & Jan-Åke Gustafsson p823 | doi:10.1038/nrc3093-c2 Full Text | PDF
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*2010 Journal Citation Report (Thomson Reuters, 2011)

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