Nature Immunology Contents: November 2011 Volume 12 pp 1017 - 1126

Advertisement A-IMBN Research - Research highlights from the Asia-Pacific International Molecular Biology Network Recent highlights: Mapping human diversity | Pulling the brake on inflammation | Profiling the mechanisms of fate controllers Register today for biweekly email alerts and never miss the latest in molecular biology research in Asia. TABLE OF CONTENTS November 2011 Volume 12, Issue 11 Correspondence Commentary News and Views Research Highlights Review Articles Advertisement Ozgene can generate mouse models for your next publication Knockout Mice . Knockin Mice . Transgenic Mice . Vector Design . Vector Construction . Custom Breeding . http://www.ozgene.com Recommend to your library Web feed Available online only Subscribe Advertisement Nature Immunology presents a webcast on Current Controversies: Human Immunology Please join our discussion on how to better understand the human immune system, followed by a live question and answer session. October 26th 2011 • 12 noon Eastern / 9 a.m. Pacific/ 5 p.m. GMT / 6 p.m. CET Register for FREE: www.nature.com/webcasts/human_immunology Sponsored by:   Correspondence Top Failure to detect production of IL-10 by activated human neutrophils pp1017 - 1018 Martin S Davey, Nicola Tamassia, Marzia Rossato, Flavia Bazzoni, Federica Calzetti, Kirsten Bruderek, Marina Sironi, Lisa Zimmer, Barbara Bottazzi, Alberto Mantovani, Sven Brandau, Bernhard Moser, Matthias Eberl and Marco A Cassatella doi:10.1038/ni.2111 Full Text | PDF Reply to "Failure to detect production of IL-10 by activated human neutrophils" pp1018 - 1020 Carmela De Santo, Mariolina Salio, Tao Dong, Yoram Reiter and Vincenzo Cerundolo doi:10.1038/ni.2132 Full Text | PDF Commentary Top Effective presentations: tips for success pp1021 - 1023 Janet P Hafler doi:10.1038/ni.2119 Presentations are given in a variety of environments, and effective strategies can be used to improve a speaker's presenting skills. Full Text | PDF News and Views Top Innate lymphoid cells wield a double-edged sword pp1025 - 1027 Marsha Wills-Karp and Fred D Finkelman doi:10.1038/ni.2142 Type 2 cytokine-producing innate lymphoid cells are present in human and mouse lungs, where they contribute to both type 2 immune responses and tissue repair. Full Text | PDF TL we meet again pp1027 - 1028 Cathryn Nagler and Joanna Wroblewska doi:10.1038/ni.2138 The MHC class I-like molecule TL selects high-affinity effector memory T cells to man the barriers in the intestinal mucosa. Full Text | PDF Don't move: LRRK2 arrests NFAT in the cytoplasm pp1029 - 1030 Bana Jabri and Luis B Barreiro doi:10.1038/ni.2139 The kinase LRRK2 is a risk factor for inflammatory bowel disease. New data show that LRRK2 blocks the transport of NFAT to the nucleus and that LRRK2 deficiency results in enhanced susceptibility to experimental colitis in mice. Full Text | PDF PKC-θ: hitting the bull's eye pp1031 - 1032 Michael L Dustin doi:10.1038/ni.2141 How the kinase PKC-θ is targeted to the immunological synapse and is activated once there remains unclear. A targeting motif in PKC-θ and the previously unsuspected kinase GLK identified in two separate papers now explains this. Full Text | PDF Immunology JOBS of the week Senior Scientist, Antibody production GenScript USA Inc. Nanjing, CN Three Postdoctoral Positions at the Interface between Physics and Biology IGBMC Strasbourg, FR R&D Product Safety & Regulatory Affairs - Global Project Stewardship (M / F) Procter & Gamble Brussels, BE Pharmaceutical Primary Care Sales Rep Musculoskeletal (50431610) Lilly USA, LLC Lakeland, US Postdoctoral Fellow - Differentiation of Embryonic Stem Cells Mount Sinai School of Medicine (Baron Lab) New York, US More Science jobs from Immunology EVENT Vaccines for Chronic Diseases Symposium 7 Feb - 9 Feb 2012 TX, US More science events from Research Highlights Top Primitive gut interactions | Neural-iNKT communication | Autoimmunity and PTPN22 | Distributed memory | Lineage priming | Inflammasome receptors Review Top Phenotypic and functional plasticity of cells of innate immunity: macrophages, mast cells and neutrophils pp1035 - 1044 Stephen J Galli, Niels Borregaard and Thomas A Wynn doi:10.1038/ni.2109 Abstract | Full Text | PDF Advertisement Introducing a new dye: BD Horizon™ PE-CF594 The new BD Horizon PE-CF594 reagent maximizes choice and flexibility by providing an additional bright dye that can be used in multicolor panels. Get more choice, more color, and improved brightness over existing dyes offered for this detector. See sample data and take advantage of free online tools here. bdbiosciences.com/go/bright   Articles Top Innate lymphoid cells promote lung-tissue homeostasis after infection with influenza virus pp1045 - 1054 Laurel A Monticelli, Gregory F Sonnenberg, Michael C Abt, Theresa Alenghat, Carly G K Ziegler, Travis A Doering, Jill M Angelosanto, Brian J Laidlaw, Cliff Y Yang, Taheri Sathaliyawala, Masaru Kubota, Damian Turner, Joshua M Diamond, Ananda W Goldrath, Donna L Farber, Ronald G Collman, E John Wherry and David Artis doi:10.1038/ni.2131 Cytokine-producing innate lymphoid cells are found at mucosal surfaces. Artis and Wherry and their colleagues show that innate 'nuocyte-like' cells accumulate in virus-infected lungs and contribute to the repair of tissues. Abstract | Full Text | PDF Human IL-25- and IL-33-responsive type 2 innate lymphoid cells are defined by expression of CRTH2 and CD161 pp1055 - 1062 Jenny M Mjösberg, Sara Trifari, Natasha K Crellin, Charlotte P Peters, Cornelis M van Drunen, Berber Piet, Wytske J Fokkens, Tom Cupedo and Hergen Spits doi:10.1038/ni.2104 Mice have lineage-negative IL-7Rα+ (innate lymphoid) cells that contribute to type 2 immunity. Spits and colleagues identify a similar CRTH2+CD161+ population in human lungs and gut that produces IL-13 after stimulation. Abstract | Full Text | PDF The kinase LRRK2 is a regulator of the transcription factor NFAT that modulates the severity of inflammatory bowel disease pp1063 - 1070 Zhihua Liu, Jinwoo Lee, Scott Krummey, Wei Lu, Huaibin Cai and Michael J Lenardo doi:10.1038/ni.2113 The adaptor LRRK2 has been identified as a major susceptibility factor for Crohn's disease. Lenardo and colleagues show that LRRK2 negatively regulates activation of the transcription factor NFAT independently of NFAT phosphorylation. Abstract | Full Text | PDF An IL-9 fate reporter demonstrates the induction of an innate IL-9 response in lung inflammation pp1071 - 1077 Christoph Wilhelm, Keiji Hirota, Benjamin Stieglitz, Jacques Van Snick, Mauro Tolaini, Katharina Lahl, Tim Sparwasser, Helena Helmby and Brigitta Stockinger doi:10.1038/ni.2133 The cellular sources of IL-9 in lung inflammation remain unknown. Stockinger and colleagues use an IL-9 reporter to show IL-9 production is restricted to innate lymphoid cells during papain-induced lung inflammation. Abstract | Full Text | PDF The carboxypeptidase ACE shapes the MHC class I peptide repertoire pp1078 - 1085 Xiao Z Shen, Sandrine Billet, Chentao Lin, Derick Okwan-Duodu, Xu Chen, Aron E Lukacher and Kenneth E Bernstein doi:10.1038/ni.2107 Production of MHC class I epitopes involves the proteasome and multiple peptidases. Bernstein and colleagues show that angiotensin-converting enzyme (ACE) contributes to the generation of this peptide repertoire by trimming carboxyl termini. Abstract | Full Text | PDF Mucosal memory CD8+ T cells are selected in the periphery by an MHC class I molecule pp1086 - 1095 Yujun Huang, Yunji Park, Yiran Wang-Zhu, Alexandre Larange, Ramon Arens, Ivan Bernardo, Danyvid Olivares-Villagomez, Dietmar Herndler-Brandstetter, Ninan Abraham, Beatrix Grubeck-Loebenstein, Stephen P Schoenberger, Luc Van Kaer, Mitchell Kronenberg, Michael A Teitell and Hilde Cheroutre doi:10.1038/ni.2106 Establishing effector memory cells at mucosal barriers is critical for immune protection against pathogens. Cheroutre and colleagues show that interactions between thymus leukemia antigen and CD8αα contribute to the generation of CD8αβ+ effector memory T cells. Abstract | Full Text | PDF Regulated release of nitric oxide by nonhematopoietic stroma controls expansion of the activated T cell pool in lymph nodes pp1096 - 1104 Veronika Lukacs-Kornek, Deepali Malhotra, Anne L Fletcher, Sophie E Acton, Kutlu G Elpek, Prakriti Tayalia, Ai-ris Collier and Shannon J Turley doi:10.1038/ni.2112 Efficient T cell priming occurs in organized lymphoid tissues. Turley and colleagues show that activated T cells induce nitric oxide production by lymph node stromal cells, thus limiting T cell proliferation. Abstract | Full Text | PDF A motif in the V3 domain of the kinase PKC-θ determines its localization in the immunological synapse and functions in T cells via association with CD28 pp1105 - 1112 Kok-Fai Kong, Tadashi Yokosuka, Ann J Canonigo-Balancio, Noah Isakov, Takashi Saito and Amnon Altman doi:10.1038/ni.2120 The kinase PKC-θ translocates to the center of the immune synapse, but the molecular basis of this interaction is unclear. Altman and colleagues identify a conserved proline-rich motif in the V3 domain of PKC-θ required for its association with CD28 and localization to the immunological synapse. Abstract | Full Text | PDF The kinase GLK controls autoimmunity and NF-κB signaling by activating the kinase PKC-θ in T cells pp1113 - 1118 Huai-Chia Chuang, Joung-Liang Lan, Der-Yuan Chen, Chia-Yu Yang, Yi-Ming Chen, Ju-Pi Li, Ching-Yu Huang, Pao-En Liu, Xiaohong Wang and Tse-Hua Tan doi:10.1038/ni.2121 The enzyme that directly activates the kinase PKC-θ during T cell antigen receptor signaling is still unknown. Tan and colleagues show that the serine-threonine kinase GLK is a direct activator of PKC-θ. Abstract | Full Text | PDF Endocytosed BCRs sequentially regulate MAPK and Akt signaling pathways from intracellular compartments pp1119 - 1126 Akanksha Chaturvedi, Rebecca Martz, David Dorward, Michael Waisberg and Susan K Pierce doi:10.1038/ni.2116 Antigen recognition by surface immunoglobulin triggers downstream signaling and endocytosis of B cell antigen receptors. Pierce and colleagues show that distinct kinase-activation patterns distinguish surface receptor signaling from that of internalized receptors. Abstract | Full Text | PDF Advertisement Apoptosis Detection: A streamlined approach. New BD FACSuite™ software on the BD FACSVerse™ flow cytometry system provides predefined research assays matched with reagent kits, making it easy to achieve reproducible, consistent results. 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