| Editorials |  Top |  |  | | Focus on Cell cycle and DNA damage p1153
doi:10.1038/ncb2357a
How cells accurately duplicate and segregate their genetic information remains a topic of intense research. A series of specially commissioned articles in this issue presents recent insights into different aspects of the cell division cycle and genomic surveillance.
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| | | | UK Parliament comments on peer review p1153
doi:10.1038/ncb2357b
Recognizing the importance of sound scientific advice to the government, the UK Parliament has examined the peer review system.
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| | Reviews | Top | | | | The centrosome cycle: Centriole biogenesis, duplication and inherent asymmetries pp1154 - 1160
Erich A. Nigg and Tim Stearns
doi:10.1038/ncb2345
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| | | | More than just a focus: The chromatin response to DNA damage and its role in genome integrity maintenance pp1161 - 1169
Jiri Lukas, Claudia Lukas and Jiri Bartek
doi:10.1038/ncb2344
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| | | | Cohesin: a catenase with separate entry and exit gates? pp1170 - 1177
Kim Nasmyth
doi:10.1038/ncb2349
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| | Historical Perspective | Top | | | | A brief history of error pp1178 - 1182
Andrew W. Murray
doi:10.1038/ncb2348
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| | | | Articles | Top | | | | Apicobasal domain identities of expanding tubular membranes depend on glycosphingolipid biosynthesis pp1189 - 1201
Hongjie Zhang, Nessy Abraham, Liakot A. Khan, David H. Hall, John T. Fleming and Verena Gobel
doi:10.1038/ncb2328
Cell polarity is critically important for organogenesis. Using a series of RNA-interference-based screens, Gobel and colleagues reveal the role of the glycosphingolipid glucosylceramide (GlcCer) in determining apicobasal polarity and maintaining the organization of the intestinal lumen in the developing worm.
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See also: News and Views by Hyenne & Labouesse
| | | | VEGFR-3 controls tip to stalk conversion at vessel fusion sites by reinforcing Notch signalling pp1202 - 1213
Tuomas Tammela, Georgia Zarkada, Harri Nurmi, Lars Jakobsson, Krista Heinolainen, Denis Tvorogov, Wei Zheng, Claudio A. Franco, Aino Murtomäki, Evelyn Aranda, Naoyuki Miura, Seppo Ylä-Herttuala, Marcus Fruttiger, Taija Mäkinen, Anne Eichmann, Jeffrey W. Pollard, Holger Gerhardt and Kari Alitalo
doi:10.1038/ncb2331
Notch and VEGF signalling controls the specification of endothelial cells to tip and stalk cells during angiogenesis sprouting. Alitalo and colleagues show that macrophage-derived VEGF-C activates VEGFR2 to contribute to the conversion of endothelial cells from a tip- to a stalk-cell fate when two sprouts fuse to ensure vessel growth and branching.
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| | | | Midbody accumulation through evasion of autophagy contributes to cellular reprogramming and tumorigenicity pp1214 - 1223
Tse-Chun Kuo, Chun-Ting Chen, Desiree Baron, Tamer T. Onder, Sabine Loewer, Sandra Almeida, Cara M. Weismann, Ping Xu, Jean-Marie Houghton, Fen-Biao Gao, George Q. Daley and Stephen Doxsey
doi:10.1038/ncb2332
Doxsey and colleagues report that midbodies accumulate in stem cells, including induced pluripotent stem cells and potential cancer-initiating cells. Loss of midbodies accompanies stem-cell differentiation and is mediated through binding of the autophagy receptor NBR1 to the midbody protein CEP55. Downregulation of NBR1 is associated with enrichment of midbodies, enhanced reprogramming and increased tumorigenicity in cancer cells.
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| | | | Bcl-xL regulates metabolic efficiency of neurons through interaction with the mitochondrial F1FO ATP synthase pp1224 - 1233
Kambiz N. Alavian, Hongmei Li, Leon Collis, Laura Bonanni, Lu Zeng, Silvio Sacchetti, Emma Lazrove, Panah Nabili, Benjamin Flaherty, Morven Graham, Yingbei Chen, Shanta M. Messerli, Maria A. Mariggio, Christoph Rahner, Ewan McNay, Gordon C. Shore, Peter J. S. Smith, J. Marie Hardwick and Elizabeth A. Jonas
doi:10.1038/ncb2330
ATP production by mitochondria requires the efficient flow of protons through the F1FO ATP-synthase complex. Jonas and colleagues show that Bcl-xL interacts with the F1FO complex in the mitochondrial matrix and increases the efficiency of this enzyme by decreasing proton leak.
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| | | | APC15 drives the turnover of MCC-CDC20 to make the spindle assembly checkpoint responsive to kinetochore attachment pp1234 - 1243
Jörg Mansfeld, Philippe Collin, Mark O. Collins, Jyoti S. Choudhary and Jonathon Pines
doi:10.1038/ncb2347
The spindle assembly checkpoint halts cell-cycle progression in the presence of unattached kinetochores by preventing activation of APC/C. Pines and colleagues find that APC15 has a critical role in regulating APC/C activation by promoting release of the inhibitory MCC complex from APC/C once the spindle assembly checkpoint is satisfied.
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| | | Advertisement | | | | | | Letters | Top | | | | Notch post-translationally regulates β-catenin protein in stem and progenitor cells pp1244 - 1251
Chulan Kwon, Paul Cheng, Isabelle N. King, Peter Andersen, Lincoln Shenje, Vishal Nigam and Deepak Srivastava
doi:10.1038/ncb2313
Srivastava and colleagues find that membrane-bound Notch associates with and negatively regulates active β-catenin in embryonic stem cells, cardiac progenitors and colon cancer cells. This ligand-independent effect of Notch requires the endocytic adaptor protein Numb and targeting of β-catenin to lysosomes.
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| | | | Dynamic maintenance of asymmetric meiotic spindle position through Arp2/3-complex-driven cytoplasmic streaming in mouse oocytes pp1252 - 1258
Kexi Yi, Jay R. Unruh, Manqi Deng, Brian D. Slaughter, Boris Rubinstein and Rong Li
doi:10.1038/ncb2320
Mammalian oocyte maturation involves two asymmetric meiotic divisions that require the positioning of the meiotic spindle near the cortical area from which the extrusion of the polar bodies occurs. Li and colleagues show that the nucleating activity of the Arp2/3 complex, localized at the cortical actin cap, induces actin-filament flow away from the complex, creating a cytoplasmic streaming that pushes the spindle towards the cortex.
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See also: News and Views by Verlhac
| | | | Adaptive braking by Ase1 prevents overlapping microtubules from sliding completely apart pp1259 - 1264
Marcus Braun, Zdenek Lansky, Gero Fink, Felix Ruhnow, Stefan Diez and Marcel E. Janson
doi:10.1038/ncb2323
Overlapping antiparallel microtubules are important in cellular structures such as the mitotic spindle. Diez and colleagues use an in vitro system and mathematical modelling to show that the formation of stable overlaps involves a motor such as kinesin-14, which slides microtubules apart, and a passive microtubule crosslinker, Ase1, which accumulates at microtubule overlapping regions and slows microtubule sliding to prevent their separation.
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| | | | Formation of stable attachments between kinetochores and microtubules depends on the B56-PP2A phosphatase pp1265 - 1271
Emily A. Foley, Maria Maldonado and Tarun M. Kapoor
doi:10.1038/ncb2327
The microtubules that attach kinetochores to chromosomes (K-fibres) are stabilized in prometaphase to allow for accurate chromosome segregation. Kapoor and colleagues find that the B56-PP2A phosphatase stabilizes K-fibres potentially by counteracting the phosphorylation of kinetochore substrates that is mediated by Aurora B and Plk1.
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| | | | NF-κB controls energy homeostasis and metabolic adaptation by upregulating mitochondrial respiration pp1272 - 1279
Claudio Mauro, Shi Chi Leow, Elena Anso, Sonia Rocha, Anil K. Thotakura, Laura Tornatore, Marta Moretti, Enrico De Smaele, Amer A. Beg, Vinay Tergaonkar, Navdeep S. Chandel and Guido Franzoso
doi:10.1038/ncb2324
Franzoso and colleagues show that NF-κB protects cells from nutrient-starvation-induced necrosis by upregulating mitochondrial respiration through increased p53-dependent expression of the SCO2 enzyme. Conversely, inhibition of NF-κB results in increased aerobic glycolysis, known as the Warburg effect, thus promoting oncogenic transformation, and affects metabolic adaptation during tumorigenesis in vivo.
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| | Corrigendum | Top | | | | Control of vertebrate multiciliogenesis by miR-449 through direct repression of the Delta/Notch pathway p1280
Brice Marcet, Benoît Chevalier, Guillaume Luxardi, Christelle Coraux, Laure-Emmanuelle Zaragosi, Marie Cibois, Karine Robbe-Sermesant, Thomas Jolly, Bruno Cardinaud, Chimène Moreilhon, Lisa Giovannini-Chami, Béatrice Nawrocki-Raby, Philippe Birembaut, Rainer Waldmann, Laurent Kodjabachian and Pascal Barbry
doi:10.1038/ncb2358
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