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TABLE OF CONTENTS
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October 2011 Volume 29, Issue 10 |
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 |  In This Issue
Editorial
News
News Feature
Bioentrepreneur
Opinion and Comment
Features
News and Views
Research Highlights
Computational Biology
 Research
Careers and Recruitment
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Earn your MASTER'S degree FULLY ONLINE with JHU's Advanced Biotechnology Studies programs. Attend an ONLINE Info Session for - Biotechnology Enterprise & Entrepreneurship (10/12), Biotechnology (10/13), Bioscience Regulatory Affairs & Enterprise (10/18), Bioinformatics (10/20). Learn more and RSVP online at biotechnology.jhu.edu. | |
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In This Issue |  Top |
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In this issue ppvii - viii
doi:10.1038/nbt.2010
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Editorial | Top |
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Enlightened engineering p849
doi:10.1038/nbt.2016
Optogenetics—until now primarily a tool for asking questions in basic research—is starting to spur efforts oriented toward biomedical applications.
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News | Top |
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Seattle Genetics rare cancer drug sails through accelerated approval pp851 - 852
Laura DeFrancesco
doi:10.1038/nbt1011-851
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HIV drugs made in tobacco p852
Jeffrey L Fox
doi:10.1038/nbt1011-852
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Engineered T-cell therapy shows efficacy in blood cancer pp853 - 855
Simon Frantz
doi:10.1038/nbt1011-853
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9,000 tumors for stratified medicine p854
Susan Aldridge
doi:10.1038/nbt1011-854a
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Chinese inventors catch up p854
Nuala Moran
doi:10.1038/nbt1011-854b
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ATM cash for biotechs p856
Brian Orelli
doi:10.1038/nbt1011-856a
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Pertuzumab to bolster Roche/Genentech's breast cancer franchise? pp856 - 858
Cormac Sheridan
doi:10.1038/nbt1011-856b
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Gilead donates patents for generics p857
Simon Frantz
doi:10.1038/nbt1011-857a
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South Korea's stem cell approval p857
Heiko Yang
doi:10.1038/nbt1011-857b
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| Data Page |
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Drug pipeline: Q311 p859
Wayne Peng
doi:10.1038/nbt.1999
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News Feature | Top |
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Attacks on asthma pp860 - 863
Sarah Webb
doi:10.1038/nbt.1994
The current standard of care for asthma leaves large numbers of sufferers at risk for severe exacerbations and even death. But emerging targeted therapies that may provide better treatment options also face obstacles. Sarah Webb reports.
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Off-axis StepWave™ ion transfer technology, now integrated in the SYNAPT® G2-S Mass Spectrometry System from Waters, provides a significant increase in sensitivity in all available data acquisition modes.
Learn More
SYNAPT G2-S from Waters provides scientists with a UPLC/HDMSE solution with an easy-to-use and highly specific lipid analysis method that delivers robust and reproducible results.
Click Here To Learn More |  | |
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Bioentrepreneur | Top |
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| Building a business |
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Headwinds into opportunity pp864 - 866
Prabhavathi Fernandes
doi:10.1038/bioe.2011.8
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Opinion and Comment | Top |
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| Correspondence |
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A methodological framework to enhance the clinical success of cancer immunotherapy pp867 - 870
Axel Hoos, Cedrik M Britten, Christoph Huber and Jill O'Donnell-Tormey
doi:10.1038/nbt.2000
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Pharmacogenetics and the immunogenicity of protein therapeutics pp870 - 873
Chen Yanover, Nisha Jain, Glenn Pierce, Tom E Howard and Zuben E Sauna
doi:10.1038/nbt.2002
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Wanted: bioprospecting consultants pp873 - 875
Kazuo N Watanabe and Guat Hong Teh
doi:10.1038/nbt.2001
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Features | Top |
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| Patents |
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Evergreening: a common practice to protect new drugs pp876 - 878
Kate S Gaudry
doi:10.1038/nbt.1993
The common strategy of evergreening using patents and other exclusivity periods likely contributes to the total incentives that justify a pharmaceutical company's investment in a new drug.
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Recent patent applications in drug screening p879
doi:10.1038/nbt.2007
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Exclusive discounts are now available online
Nature Lab Offers provides researchers like you with exclusive discounts on products used in your lab. Browse through US Offers or Global Offers on antibodies, cell culture, PCR, software, pipettors, reagents, and more!
US Offers Global Offers |  | |
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News and Views | Top |
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Research Highlights | Top |
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Cancer stem cells predict patient survival | FcγRIIb engagement kills tumors | Arming yeast for synthetic biology | Broad-spectrum antiviral strategy | Motor neurons to order
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Computational Biology | Top |
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| Analysis |
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Extracting a cellular hierarchy from high-dimensional cytometry data with SPADE pp886 - 891
Peng Qiu, Erin F Simonds, Sean C Bendall, Kenneth D Gibbs Jr, Robert V Bruggner, Michael D Linderman, Karen Sachs, Garry P Nolan and Sylvia K Plevritis
doi:10.1038/nbt.1991
New instruments can measure the presence of >30 molecular markers for massive numbers of single cells, but data analysis algorithms have lagged behind. Qiu et al. describe an approach called SPADE for recovering cellular hierarchies from mass or flow cytometry data.
Abstract | Full Text | PDF
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Research | Top |
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| Review |
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Direct lineage conversions: unnatural but useful? pp892 - 907
Thomas Vierbuchen and Marius Wernig
doi:10.1038/nbt.1946
Abstract | Full Text | PDF
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| Analysis |
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Performance comparison of exome DNA sequencing technologies pp908 - 914
Michael J Clark, Rui Chen, Hugo Y K Lam, Konrad J Karczewski, Rong Chen, Ghia Euskirchen, Atul J Butte and Michael Snyder
doi:10.1038/nbt.1975
Capturing and sequencing only the coding regions of the human genome leverages resources in the pursuit of rare disease-causing mutations. Clark et al. compare the performance of three leading exome-capture methods and their advantages over whole-genome sequencing.
Abstract | Full Text | PDF
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| Articles |
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Efficient de novo assembly of single-cell bacterial genomes from short-read data sets pp915 - 921
Hamidreza Chitsaz, Joyclyn L Yee-Greenbaum, Glenn Tesler, Mary-Jane Lombardo, Christopher L Dupont, Jonathan H Badger, Mark Novotny, Douglas B Rusch, Louise J Fraser, Niall A Gormley, Ole Schulz-Trieglaff, Geoffrey P Smith, Dirk J Evers, Pavel A Pevzner and Roger S Lasken
doi:10.1038/nbt.1966
DNA can be amplified and sequenced from a single cell, but unevenness of the sequence coverage complicates efforts to assemble a high-quality genome. Chitsaz et al. devise an algorithm to address this problem and apply it to assemble a genome draft of an uncultured single-cell marine organism from one lane of Illumina sequence data.
Abstract | Full Text | PDF
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Comparative genomic analysis of the thermophilic biomass-degrading fungi Myceliophthora thermophila and Thielavia terrestris pp922 - 927
Randy M Berka, Igor V Grigoriev, Robert Otillar, Asaf Salamov, Jane Grimwood, Ian Reid, Nadeeza Ishmael, Tricia John, Corinne Darmond, Marie-Claude Moisan, Bernard Henrissat, Pedro M Coutinho, Vincent Lombard, Donald O Natvig, Erika Lindquist, Jeremy Schmutz, Susan Lucas, Paul Harris, Justin Powlowski, Annie Bellemare, David Taylor, Gregory Butler, Ronald P de Vries, Iris E Allijn, Joost van den Brink, Sophia Ushinsky, Reginald Storms, Amy J Powell, Ian T Paulsen, Liam D H Elbourne, Scott E Baker, Jon Magnuson, Sylvie LaBoissiere, A John Clutterbuck, Diego Martinez, Mark Wogulis, Alfredo Lopez de Leon, Michael W Rey and Adrian Tsang
doi:10.1038/nbt.1976
Thermostable enzymes are used for a range of industrial processes, including biofuel production. Berka et al. report the genome sequences of two thermophilic eukaryotic fungi with enzymes that operate at the elevated temperatures needed to digest biomass and prepare many biochemicals.
Abstract | Full Text | PDF
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Tracking single hematopoietic stem cells in vivo using high-throughput sequencing in conjunction with viral genetic barcoding pp928 - 933
Rong Lu, Norma F Neff, Stephen R Quake and Irving L Weissman
doi:10.1038/nbt.1977
Heterogeneity within populations of stem cells, cancer cells or other cell types of interest presents a formidable barrier to analysis. Lu et al. use viral barcoding and high-throughput sequencing to track the differentiation of single hematopoietic stem cells in vivo.
Abstract | Full Text | PDF
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CD140a identifies a population of highly myelinogenic, migration-competent and efficiently engrafting human oligodendrocyte progenitor cells pp934 - 941
Fraser J Sim, Crystal R McClain, Steven J Schanz, Tricia L Protack, Martha S Windrem and Steven A Goldman
doi:10.1038/nbt.1972
Oligodendrocyte progenitors capable of myelination in myelin-deficient mice have been isolated from human fetal brain cells, but at low purity. Sim et al. show that sorting based on PDGFR[alpha] expression yields a purer population of myelinogenic cells free of neuronal and committed astrocyte cells.
Abstract | Full Text | PDF
See also: News and Views by Miller & Tesar
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A reversibly photoswitchable GFP-like protein with fluorescence excitation decoupled from switching pp942 - 947
Tanja Brakemann, Andre C Stiel, Gert Weber, Martin Andresen, Ilaria Testa, Tim Grotjohann, Marcel Leutenegger, Uwe Plessmann, Henning Urlaub, Christian Eggeling, Markus C Wahl, Stefan W Hell and Stefan Jakobs
doi:10.1038/nbt.1952
Brakemann et al. present a reversibly photoswitchable fluorescent protein, called Dreiklang, that can be turned on and off at wavelengths distinct from those used for imaging. They show that the protein is advantageous for studying protein dynamics in living cells and for super-resolution imaging.
Abstract | Full Text | PDF
See also: News and Views by Vaughan & Zhuang
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Careers and Recruitment | Top |
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A global need for women's biotech leadership pp948 - 949
Laurel Smith-Doerr, Gintare Kemekliene, Rita Teutonico, Lene Lange, Lydia Villa-Komaroff, Line Matthiessen-Guyader and Fiona Murray
doi:10.1038/nbt.1998
Increasing women's participation in leadership of biotech policy making, funding, research and implementation will strengthen the race to solve global problems.
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| People |
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People p950
doi:10.1038/nbt.2006
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Nature Reprint Collection
The future of drug innovation
This special reprint collection provides a comprehensive overview of the factors underlying the challenges in drug innovation and the evolution of possible scientific and strategic solutions.
Access the Collection by visiting:
www.nature.com/reprintcollections/lilly/drug-innovation
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