Molecular Systems Biology - New articles published 25 October 2011

Latest Articles 25 October 2011   Featured Article Research Articles Perspective   Web feeds About Open access Advertisement Cell Research - Submit today! Cell Research publishes articles, research and reviews covering all disciplines within cell biology and molecular biology. With an international authorship and circulation CR is a great outlet for your research. Submit your paper today at: http://mts-cr.nature.com/cgi-bin/main.plex.     Featured Article Recycling, clustering, and endocytosis jointly maintain PIN auxin carrier polarity at the plasma membrane A combination of super-resolution microscopy in live cells and computational modeling provides new insights into the dynamic and interwoven mechanism that maintains the polar distribution of an important plant cargo. Jürgen Kleine-Vehn, Krzysztof Wabnik, Alexandre Martinière, Łukasz Łangowski, Katrin Willig, Satoshi Naramoto, Johannes Leitner, Hirokazu Tanaka, Stefan Jakobs, Stéphanie Robert, Christian Luschnig, Willy Govaerts, Stefan W Hell, John Runions & Jiří Friml Molecular Systems Biology 7:540; doi:10.1038/msb.2011.72; published 25 October 2011 Synopsis | Full Text | PDF | Supp. Inf. | Review Process Research Articles A novel strategy for the comprehensive analysis of the biomolecular composition of isolated plasma membranes A methodology for rapid, high-purity isolation of plasma membranes using superparamagnetic nanoparticles is described. The method is illustrated with high-resolution proteomic, glycomic and lipidomic analyses of presenilin-deficient cells. Deepak B Thimiri Govinda Raj, Bart Ghesquière, Arun Kumar Tharkeshwar, Katrijn Coen, Rita Derua, Dieter Vanderschaeghe, Evelien Rysman, Murali Bagadi, Pieter Baatsen, Bart De Strooper, Etienne Waelkens, Gustaaf Borghs, Nico Callewaert, Johan Swinnen, Kris Gevaert & Wim Annaert Molecular Systems Biology 7:541; doi:10.1038/msb.2011.74; published 25 October 2011 Synopsis | Full Text | PDF | Supp. Inf. | Review Process Carbohydrate-active enzymes exemplify entropic principles in metabolism Statistical thermodynamics and in vitro experimentation demonstrate that metabolic enzymes can be driven by an increase in the entropy of a reaction system, and point to a role for entropy gradients in the emergence of robust metabolic functions in vivo. Önder Kartal, Sebastian Mahlow, Alexander Skupin & Oliver Ebenhöh Molecular Systems Biology 7:542; doi:10.1038/msb.2011.76; published 25 October 2011 Synopsis | Full Text | PDF | Supp. Inf. | Review Process Perspective Controlled vocabularies and semantics in systems biology The use of computational modeling to describe and analyze biological systems is at the heart of systems biology. This Perspective discusses the development and use of ontologies that are designed to add semantic information to computational models and simulations. Mélanie Courtot, Nick Juty, Christian Knüpfer, Dagmar Waltemath, Anna Zhukova, Andreas Dräger, Michel Dumontier, Andrew Finney, Martin Golebiewski, Janna Hastings, Stefan Hoops, Sarah Keating, Douglas B Kell, Samuel Kerrien, James Lawson, Allyson Lister, James Lu, Rainer Machne, Pedro Mendes, Matthew Pocock, Nicolas Rodriguez, Alice Villeger, Darren J Wilkinson, Sarala Wimalaratne, Camille Laibe, Michael Hucka & Nicolas Le Novère Molecular Systems Biology 7:543; doi:10.1038/msb.2011.77; published 25 October 2011 Full Text | PDF

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