TABLE OF CONTENTS
| | 19 October 2011 | Volume 30, Issue 20 |  | | |  |  Have you seen?
Review
Articles | | | |  | | Advertisement | | | | | | | | | | | Have you seen? | Top | |  | | Duelling functions of the V-ATPase The V-ATPase cellular proton pump has been implicated in membrane fusion, although its role here remains poorly understood. New evidence sheds light on the functional interaction between the V0 domain of the pump and the core membrane fusion machinery. Cameron C Scott, Christin Bissig and Jean Gruenberg The EMBO Journal (2011), 30, 4113 - 4115; 10.1038/emboj.2011.355 Abstract | Full text | PDF Published online: 19 October 2011 | | | | Releasing a tiny molecular brake may improve memory MicroRNAs are regulators of transcriptome plasticity and have been linked to the pathogenesis of neurodegenerative diseases. Here, the role of miR-34c in the cognitive decline associated with Alzheimer's disease and ageing is discussed. Roberto Fiore and Gerhard Schratt The EMBO Journal (2011), 30, 4116 - 4118; 10.1038/emboj.2011.356 Abstract | Full text | PDF Published online: 19 October 2011 | | Review | Top | | | | After half a century mitochondrial calcium in- and efflux machineries reveal themselves Mitochondrial Ca2+ uptake and release play a fundamental role in the cell, but the molecular identities of the channels and transporters involved have remained mysterious. This article reviews recent work that finally unravelled the mitochondrial calcium in- and efflux machineries. Ilaria Drago, Paola Pizzo and Tullio Pozzan The EMBO Journal (2011), 30, 4119 - 4125; 10.1038/emboj.2011.337 Abstract | Full text | PDF Published online: 20 September 2011 | | Articles | Top | | | | The V-ATPase proteolipid cylinder promotes the lipid-mixing stage of SNARE-dependent fusion of yeast vacuoles The V-ATPase pumps protons from the cytosol into the vacuole. In addition, its membrane-embedded sector V0 has been implicated in driving membrane fusion events. This study demonstrates a direct role of V0 in the lipid-mixing step of vacuolar fusion. Bernd Strasser, Justyna Iwaszkiewicz, Olivier Michielin and Andreas Mayer The EMBO Journal (2011), 30, 4126 - 4141; 10.1038/emboj.2011.335 Abstract | Full text | PDF | Supp. info. | Review Process File Published online: 20 September 2011 | | | | Class IIb HDAC6 regulates endothelial cell migration and angiogenesis by deacetylation of cortactin The histone deacetylase HDAC6 is essential for endothelial cell sprouting and migration, and hence the formation of functional vascular networks in zebrafish and mouse. HDAC6 regulates angiogenesis through deacetylation of the actin-remodelling protein cortactin. David Kaluza, Jens Kroll, Sabine Gesierich, Tso-Pang Yao, Reinier A Boon, Eduard Hergenreider, Marc Tjwa, Lothar Rössig, Edward Seto, Hellmut G Augustin, Andreas M Zeiher, Stefanie Dimmeler and Carmen Urbich The EMBO Journal (2011), 30, 4142 - 4156; 10.1038/emboj.2011.298 Abstract | Full text | PDF | Supp. info. | Review Process File Published online: 16 August 2011 | | | | Stabilizing the VE-cadherin–catenin complex blocks leukocyte extravasation and vascular permeability Leukocyte exit from the bloodstream involves crossing the endothelial barrier. Both trans- and paracellular routes have been proposed for transmigration. Preventing opening of intercellular junctions blocks extravasation - providing strong evidence for the importance of the paracellular route. Dörte Schulte, Verena Küppers, Nina Dartsch, Andre Broermann, Hang Li, Alexander Zarbock, Olena Kamenyeva, Friedemann Kiefer, Alexander Khandoga, Steffen Massberg and Dietmar Vestweber The EMBO Journal (2011), 30, 4157 - 4170; 10.1038/emboj.2011.304 Abstract | Full text | PDF | Supp. info. | Review Process File Published online: 19 August 2011 | | | | A thermodynamic switch modulates abscisic acid receptor sensitivity Structural and biochemical data suggest that the PYR/PYL family of abscisic acid (ABA) receptors can be classified according to their monomeric or dimeric status, having differential affinities for ABA. The properties of these two types of receptor might lead to distinct signalling responses in plants. Florine Dupeux, Julia Santiago, Katja Betz, Jamie Twycross, Sang-Youl Park, Lesia Rodriguez, Miguel Gonzalez-Guzman, Malene Ringkjøbing Jensen, Natalio Krasnogor, Martin Blackledge, Michael Holdsworth, Sean R Cutler, Pedro L Rodriguez and José Antonio Márquez The EMBO Journal (2011), 30, 4171 - 4184; 10.1038/emboj.2011.294 Abstract | Full text | PDF | Supp. info. | Review Process File Published online: 16 August 2011 | | | | Structural analysis of the Ras-like G protein MglA and its cognate GAP MglB and implications for bacterial polarity The small G protein MglA and its cognate GAP MglB exemplify a new type of GTPase activation mechanism. In contrast to other Ras-like proteins, the key 'arginine finger' is provided not by the GAP, but by MglA itself. Mandy Miertzschke, Carolin Koerner, Ingrid R Vetter, Daniela Keilberg, Edina Hot, Simone Leonardy, Lotte Søgaard-Andersen and Alfred Wittinghofer The EMBO Journal (2011), 30, 4185 - 4197; 10.1038/emboj.2011.291 Abstract | Full text | PDF | Supp. info. | Review Process File Published online: 16 August 2011 | | | | H3K4 tri-methylation provides an epigenetic signature of active enhancers Global analysis of histon H3 methylation during T-lymphocyte development identifies an increase in H3K4me2 or H3K4me3 at enhancer elements that are associated with genomic loci activated upon differentiation. Aleksandra Pekowska, Touati Benoukraf, Joaquin Zacarias-Cabeza, Mohamed Belhocine, Frederic Koch, Hélène Holota, Jean Imbert, Jean-Christophe Andrau, Pierre Ferrier and Salvatore Spicuglia The EMBO Journal (2011), 30, 4198 - 4210; 10.1038/emboj.2011.295 Abstract | Full text | PDF | Supp. info. | Review Process File Published online: 16 August 2011 | | | | Pin1 and WWP2 regulate GluR2 Q/R site RNA editing by ADAR2 with opposing effects While the essential role of the adenosine deaminase ADAR2 in RNA editing is well established, how it is regulated remains largely unknown. Here, the prolyl isomerase Pin1 and the E3 ubiquitin ligase WWP2 are shown to play a role in regulating ADAR2 localisation and stability. Roberto Marcucci, James Brindle, Simona Paro, Angela Casadio, Sophie Hempel, Nicholas Morrice, Andrea Bisso, Liam P Keegan, Giannino Del Sal and Mary A O'Connell The EMBO Journal (2011), 30, 4211 - 4222; 10.1038/emboj.2011.303 Abstract | Full text | PDF | Supp. info. | Review Process File Published online: 16 August 2011 | | | | An extended dsRBD with a novel zinc-binding motif mediates nuclear retention of fission yeast Dicer The Dicer ribonuclease Dcr1 plays an important role in the biogenesis of small regulatory RNAs. Surprisingly, RNA binding by the double-stranded RNA binding domain (dsRBD) is dispensable for Dcr1 function, while zinc coordination of the extended dsRBD is required for its nuclear localization and RNA silencing. Pierre Barraud, Stephan Emmerth, Yukiko Shimada, Hans-Rudolf Hotz, Frédéric H-T Allain and Marc Bühler The EMBO Journal (2011), 30, 4223 - 4235; 10.1038/emboj.2011.300 Abstract | Full text | PDF | Supp. info. | Review Process File Published online: 16 August 2011 | | | | Structure of the SSB–DNA polymerase III interface and its role in DNA replication Structure-based analyses show the significance of replicative DNA polymerase binding to single-strand binding proteins. In E. coli, this interaction appears dispensable for Okazaki fragment synthesis but important for stabilizing the replisome. Aimee H Marceau, Soon Bahng, Shawn C Massoni, Nicholas P George, Steven J Sandler, Kenneth J Marians and James L Keck The EMBO Journal (2011), 30, 4236 - 4247; 10.1038/emboj.2011.305 Abstract | Full text | PDF | Supp. info. | Review Process File Published online: 19 August 2011 | | | | LPA-producing enzyme PA-PLA1α regulates hair follicle development by modulating EGFR signalling Lysophosphatidic acid, LPA, via its receptor P2Y5, regulates the differentiation and maturation of hair follicles by promoting TACE-dependent shedding of membrane-bound TGFα and EGFR transactivation. Asuka Inoue, Naoaki Arima, Jun Ishiguro, Glenn D Prestwich, Hiroyuki Arai and Junken Aoki The EMBO Journal (2011), 30, 4248 - 4260; 10.1038/emboj.2011.296 Abstract | Full text | PDF | Supp. info. | Review Process File Published online: 19 August 2011 | | | | iASPP/p63 autoregulatory feedback loop is required for the homeostasis of stratified epithelia This manuscript identifies an essential role for the p53 inhibitor iASPP in keratinocyte biology. By regulating two new microRNAs, iASPP controls p63, a key transcriptional regulator for the formation of stratified epithelia. Anissa Chikh, Rubeta N H Matin, Valentina Senatore, Martin Hufbauer, Danielle Lavery, Claudio Raimondi, Paola Ostano, Maurizia Mello-Grand, Chiara Ghimenti, Adiam Bahta, Sahira Khalaf, Baki Akgül, Kristin M Braun, Giovanna Chiorino, Michael P Philpott, Catherine A Harwood and Daniele Bergamaschi The EMBO Journal (2011), 30, 4261 - 4273; 10.1038/emboj.2011.302 Abstract | Full text | PDF | Supp. info. | Review Process File Published online: 06 September 2011 | | | | PIKE-mediated PI3-kinase activity is required for AMPA receptor surface expression Trafficking of AMPA receptor to the synaptic membrane is a dynamic process and important for synaptic plasticity. PIKE-L, a GTPase that interacts with and enhances the activity of PI3K, is shown here to regulate AMPA receptor trafficking during LTP. Chi Bun Chan, Yongjun Chen, Xia Liu, Xiaoling Tang, Chi Wai Lee, Lin Mei and Keqiang Ye The EMBO Journal (2011), 30, 4274 - 4286; 10.1038/emboj.2011.281 Abstract | Full text | PDF | Supp. info. | Review Process File Published online: 16 August 2011 | | | | CBP is required for environmental enrichment-induced neurogenesis and cognitive enhancement An enriched environment (EE) promotes neurogenesis and improves learning and memory in rodents. Here, the findings show that the histone acetyltransferase CBP is needed for EE-dependent enhancement of cognitive function and adult neurogenesis. Jose P Lopez-Atalaya, Alessandro Ciccarelli, Jose Viosca, Luis M Valor, Maria Jimenez-Minchan, Santiago Canals, Maurizio Giustetto and Angel Barco The EMBO Journal (2011), 30, 4287 - 4298; 10.1038/emboj.2011.299 Abstract | Full text | PDF | Supp. info. | Review Process File Published online: 16 August 2011 | | | | microRNA-34c is a novel target to treat dementias The miRNAome of the mouse hippocampus reveals miR-34c as a specific negative regulator of memory formation. miR-34c levels are elevated in a mouse model of Alzheimer's Disease as well as in Alzheimer's patients, and miR-34c inhibition restores memory performance in the animal model. Athanasios Zovoilis, Hope Y Agbemenyah, Roberto C Agis-Balboa, Roman M Stilling, Dieter Edbauer, Pooja Rao, Laurent Farinelli, Ivana Delalle, Andrea Schmitt, Peter Falkai, Sanaz Bahari-Javan, Susanne Burkhardt, Farahnaz Sananbenesi and Andre Fischer The EMBO Journal (2011), 30, 4299 - 4308; 10.1038/emboj.2011.327 Abstract | Full text | PDF | Supp. info. | Review Process File Published online: 23 September 2011 | | | | CAMTA1 is a novel tumour suppressor regulated by miR-9/9* in glioblastoma stem cells This work identifies the calmodulin-binding transcription activator CAMTA1 as a crucial miRNA-9/9* target in glioblastoma, and provides evidence that CAMTA1 is a therapeutically relevant tumour suppressor. Daniel Schraivogel, Lasse Weinmann, Dagmar Beier, Ghazaleh Tabatabai, Alexander Eichner, Jia Yun Zhu, Martina Anton, Michael Sixt, Michael Weller, Christoph P Beier and Gunter Meister The EMBO Journal (2011), 30, 4309 - 4322; 10.1038/emboj.2011.301 Abstract | Full text | PDF | Supp. info. | Review Process File Published online: 19 August 2011 | | | | C/EBPβ mediates tumour-induced ubiquitin ligase atrogin1/MAFbx upregulation and muscle wasting Cancer is often accompanied by muscle atrophy—a syndrome known as cachexia. Here, the underlying molecular pathway is investigated: tumour cells activate p38 MAPK and C/EBPbeta, leading to upregulation of the ubiquitin ligase atrogin that promotes muscle wasting. Guohua Zhang, Bingwen Jin and Yi-Ping Li The EMBO Journal (2011), 30, 4323 - 4335; 10.1038/emboj.2011.292 Abstract | Full text | PDF | Supp. info. | Review Process File Published online: 16 August 2011 | | | | Advertisement | | | | | | | | Please note that you need to be a subscriber or site-licence holder to enjoy full-text access to The EMBO Journal. In order to do so, please purchase a subscription. You have been sent this Table of Contents Alert because you have opted in to receive it. You can change or discontinue your e-mail alerts at any time, by modifying your preferences on your nature.com account at: www.nature.com/nams/svc/myaccount (You will need to log in to be recognised as a nature.com registrant). For further technical assistance, please contact our registration department. For print subscription enquiries, please contact our subscription department. For other enquiries, please contact our customer feedback department. 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