Nature Chemistry Contents October 2011 Volume 3 Number 10 pp 745-830

TABLE OF CONTENTS October 2011 Volume 3, Issue 10 Commentary Thesis Research Highlights News and Views Review Articles Errata In Your Element Recommend to your library Web feed Subscribe Advertisement Frontiers in Electronic Materials: Correlation Effects and Memristive Phenomena June 17-20, 2012 • Aachen, Germany This conference will bring together leaders in the field to discuss breakthroughs and challenges in fundamental research as well as prospects for future applications. To register and for more information, visit: www.nature.com/natureconferences/fem2012   Commentary Top Open science is a research accelerator pp745 - 748 Michael Woelfle, Piero Olliaro and Matthew H. Todd doi:10.1038/nchem.1149 An open-source approach to the problem of producing an off-patent drug in enantiopure form serves as an example of how academic and industrial researchers can join forces to make new scientific discoveries that could have a huge impact on human health. Full Text | PDF Thesis Top A tale of two compounds pp749 - 750 Bruce C. Gibb doi:10.1038/nchem.1152 Two constitutional isomers with exceptionally similar structures have had very different impacts in chemistry and beyond. With this example, Bruce Gibb highlights just how difficult it is to predict how much a particular compound or piece of chemical research will contribute to society, especially in the short term. Full Text | PDF Research Highlights Top Metal-organic frameworks: Fullerene fashion | Main-group clusters: A question of bonding | CO oxidation: Stand and deliver | Endohedral fullerenes: Water behind walls | Gas-phase kinetics: Analysing the α-effect Blogroll: Angry chemists p753 doi:10.1038/nchem.1139 Full Text | PDF News and Views Top Single-molecule biophysics: Untying a nanoscale knot pp754 - 755 Micah J. McCauley and Mark C. Williams doi:10.1038/nchem.1159 Mechanical unfolding of a single DNA G-quadruplex structure with and without a stabilizing ligand can be used to calculate the binding strength of the ligand and could help to identify drugs to target these important biological assemblies. Full Text | PDF See also: Article by Koirala et al. Synthetic biology: Minimal cell mimicry pp755 - 756 Pier Luigi Luisi and Pasquale Stano doi:10.1038/nchem.1156 The self-reproduction of a giant lipid vesicle has been linked to the replication of encapsulated DNA — a promising combination for the construction of a minimalistic synthetic cell. Full Text | PDF See also: Article by Kurihara et al. Catalysis: Oxidizing water two ways pp757 - 758 Thomas J. Meyer doi:10.1038/nchem.1161 Iridium complexes can show impressive homogeneous water-oxidation activity, but they can also act as precursors to heterogeneous catalysts. Understanding exactly what the catalytically active species is can be difficult, but now a technique has been applied that reveals the true nature of a catalyst, helping to remove this ambiguity. Full Text | PDF Ionothermal synthesis: A new spin on frustration pp758 - 759 Kenneth R. Poeppelmeier and Masaki Azuma doi:10.1038/nchem.1160 Solid-state science and technology in the twentieth century was defined by the transistor and the integrated circuit. Will the quest for a quantum spin liquid, which is inspired by theoretical and experimental advances, spawn the information technology of tomorrow? Full Text | PDF See also: Article by Aidoudi et al. Protein NMR spectroscopy: Spinning into focus pp759 - 760 Tatyana Polenova doi:10.1038/nchem.1143 Transient sedimentation of proteins inside a solid-state NMR rotor under fast magic-angle spinning offers a promising solution to the challenge of determining the structures of high-molecular-weight proteins with atomic resolution. This opens new opportunities for structural analysis of large macromolecules and macromolecular assemblies. Full Text | PDF Iron-oxo complexes: Elusive iron(V) species identified pp761 - 762 Aidan R. McDonald and Lawrence Que Jr doi:10.1038/nchem.1153 A (hydroxo)oxoiron(V) oxidant has been implicated in cis-dihydroxylation reactions catalysed by Rieske dioxygenases and biomimetic non-haem iron complexes, but with only indirect proof of its existence. Variable-temperature mass spectrometry now provides persuasive evidence for just such a reactive intermediate in a synthetic system. Full Text | PDF See also: Article by Prat et al. Chemistry JOBS of the week Expert – Mechanical and Application Testing of Polyolefins Borealis Linz, AT Professor of Biochemistry University of Tuebingen Tübingen, DE International PhD program: From Biology to Medicine Max Planck Institute of Biochemistry and Max Planck Institute of Neurobiology Munich, DE Mathematical Epidemiology Postdoc Texas A & M University College Station, US More Science jobs from Chemistry EVENT The 3rd Maghreb Conference on Desalination and Water Treatment 18.-22.12.11 Hammamet, Tunisia More science events from Review Top Lessons from nature about solar light harvesting pp763 - 774 Gregory D. Scholes, Graham R. Fleming, Alexandra Olaya-Castro and Rienk van Grondelle doi:10.1038/nchem.1145 Photosynthesis starts when light is absorbed and the associated excitation energy is directed to reaction centres by antenna complexes. The principles learned from studying these complexes are described in this Review, and provide the framework from which the authors suggest how to elucidate strategies for designing light-harvesting systems that route the flow of energy in sophisticated ways. Abstract | Full Text | PDF Articles Top Self-reproduction of supramolecular giant vesicles combined with the amplification of encapsulated DNA pp775 - 781 Kensuke Kurihara, Mieko Tamura, Koh-ichiroh Shohda, Taro Toyota, Kentaro Suzuki and Tadashi Sugawara doi:10.1038/nchem.1127 The self-replication process of a giant vesicle encapsulating double-stranded DNA has been observed, which represents a supramolecular approach to the construction of a protocell. Growth and division of the vesicle occurred rapidly on addition of a membrane precursor, and amplified DNA was distributed amongst the resulting daughter giant vesicles. Abstract | Full Text | PDF | Chemical compounds See also: News and Views by Luisi & Stano A single-molecule platform for investigation of interactions between G-quadruplexes and small-molecule ligands pp782 - 787 Deepak Koirala, Soma Dhakal, Beth Ashbridge, Yuta Sannohe, Raphaël Rodriguez, Hiroshi Sugiyama, Shankar Balasubramanian and Hanbin Mao doi:10.1038/nchem.1126 G-quadruplex structures in telomeric DNA inhibit the action of telomerase — an enzyme over-expressed in many cancer cells. Small molecules that stabilize the formation of G-quadruplex structures are therefore of interest as potential cancer treatments. Here, a platform is described that allows the interactions between small-molecule ligands and human telomeric G-quadruplexes to be measured at the single-molecule level. Abstract | Full Text | PDF | Chemical compounds See also: News and Views by McCauley & Williams Observation of Fe(V)=O using variable-temperature mass spectrometry and its enzyme-like C–H and C=C oxidation reactions pp788 - 793 Irene Prat, Jennifer S. Mathieson, Mireia Güell, Xavi Ribas, Josep M. Luis, Leroy Cronin and Miquel Costas doi:10.1038/nchem.1132 Variable-temperature mass spectrometry, isotopic labelling and computational analysis have been used to characterize a metastable non-haem oxo-iron(V) intermediate generated at cryogenic temperatures, as well as to study its cis-dihydroxylation reaction with olefins. The study provides experimental evidence for the existence of this powerful and biologically important oxidant, under conditions relevant to catalysis. Abstract | Full Text | PDF | Chemical compounds See also: News and Views by McDonald & Que Reversible bond formation enables the replication and amplification of a crosslinking salen complex as an orthogonal base pair pp794 - 800 Corinna Kaul, Markus Müller, Mirko Wagner, Sabine Schneider and Thomas Carell doi:10.1038/nchem.1117 Adding one further base pair to the classic Watson–Crick scheme not only expands the genetic code but also offers opportunities to modify the structure and function of DNA. It has now been shown that an artificial metal–salen base pair can be enzymatically incorporated into DNA duplexes and even amplified by PCR. Abstract | Full Text | PDF An ionothermally prepared S=1/2 vanadium oxyfluoride kagome lattice pp801 - 806 Farida H. Aidoudi, David W. Aldous, Richard J. Goff, Alexandra M. Z. Slawin, J. Paul Attfield, Russell E. Morris and Philip Lightfoot doi:10.1038/nchem.1129 Candidates for 'quantum spin liquid' materials are rare and often composed of two-dimensional kagome arrays of d9 centres. Analogous systems based on d1 metal ions may confer different properties, but there are no previously known examples. An inorganic–organic hybrid vanadium d1 material has now been prepared that seems to be an excellent candidate for a spin-liquid ground state. See also: News and Views by Poeppelmeier & Azuma Abstract | Full Text | PDF Efficient water oxidation catalysts based on readily available iron coordination complexes pp807 - 813 Julio Lloret Fillol, Zoel Codolà, Isaac Garcia-Bosch, Laura Gómez, Juan José Pla and Miquel Costas doi:10.1038/nchem.1140 One of the bottlenecks for the development of sustainable artificial photosynthesis is the water oxidation reaction, which too often relies on expensive and toxic metals. Now, coordination complexes of readily available, environmentally benign iron are found to catalyse homogeneous water oxidation to O2 with high efficiency. Abstract | Full Text | PDF | Chemical compounds Molecular heterometallic hydride clusters composed of rare-earth and d-transition metals pp814 - 820 Takanori Shima, Yi Luo, Timothy Stewart, Robert Bau, Garry J. McIntyre, Sax A. Mason and Zhaomin Hou doi:10.1038/nchem.1147 Well-defined molecular polyhydrides composed of two substantially different types of metals — such as rare-earth and d transition metals — are interesting both in terms of structure and potential properties, but have been largely unexplored so far. Now, a series of such hydride clusters are reported and are found to exhibit unprecedented structural features as well as unique hydrogen addition and release properties. Abstract | Full Text | PDF | Chemical compounds Multi-hierarchical self-assembly of a collagen mimetic peptide from triple helix to nanofibre and hydrogel pp821 - 828 Lesley E. R. O'Leary, Jorge A. Fallas, Erica L. Bakota, Marci K. Kang and Jeffrey D. Hartgerink doi:10.1038/nchem.1123 A short, synthetic peptide has been prepared that mimics much of the assembly process of natural collagen. Electrostatic interactions are used to create a sticky-ended structure, which in turn self-assembles through several levels of structural hierarchy from peptide to triple helix to nanofibre and finally to hydrogel. Abstract | Full Text | PDF Errata Top Programmable molecular recognition based on the geometry of DNA nanostructures p829 Sungwook Woo and Paul W. K. Rothemund doi:10.1038/nchem.1144 Full Text | PDF The transcription factor FOXM1 is a cellular target of the natural product thiostrepton p829 Nagaratna S. Hegde, Deborah A. Sanders, Raphael Rodriguez and Shankar Balasubramanian doi:10.1038/nchem.1162 Full Text | PDF In Your Element Top Anisotropic dysprosium p830 Dante Gatteschi doi:10.1038/nchem.1157 Beginning with its origins as the archetypal and eponymously elusive rare-earth element, Dante Gatteschi explains why dysprosium and other lanthanides have cornered the market in molecular magnetism. Full Text | PDF Top Advertisement Scientific American monthly table of contents e-alerts Sign up today! Scientific American has been reporting on unique insights about inspiring developments in science and technology for more than 165 years. With an expertise for pinpointing emerging trends, in every issue Scientific American provides a greater understanding of current events and issues worldwide. 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