Laboratory Investigation - Table of Contents alert Volume 91 Issue 10

TABLE OF CONTENTS Volume 91, Issue 10 (October 2011) In this issue Inside LI Research Articles Also new AOP Sign up for e-alerts Recommend to your library Web feed Subscribe Advertisement 2011 Reader Survey As a reader of Laboratory Investigation, we invite you to take part in a survey on your use of NPG journals and their associated websites. The survey should take around 5 minutes to complete. Your participation is entirely anonymous; responses will be analyzed in the aggregate only and will never be associated with individual participants. In return for your participation, you will be entered to win one of three DELL MINI 10 NETBOOKS! CLICK HERE to take the survey.   Inside LI Top Inside Lab Invest 2011 91: 1412-1413; 10.1038/labinvest.2011.142 Full Text Research Articles Top BREAST, SKIN, SOFT TISSUE AND BONE Role of β4 integrin phosphorylation in human invasive squamous cell carcinoma: regulation of hemidesmosome stability modulates cell migration Hemidesmosomes anchor epithelial cells to the basement membrane and are disassembled during cell migration and carcinoma invasion. The increased phosphorylation of β4 integrin in squamous cell carcinoma potentially plays an important role in hemidesmosome disassembly, allowing the cells to migrate and disseminate. Trinayan Kashyap, Emily Germain, Michael Roche, Stephen Lyle and Isaac Rabinovitz 2011 91: 1414-1426; advance online publication, July 18, 2011; 10.1038/labinvest.2011.104 Abstract | Full Text Nodular fasciitis: a novel model of transient neoplasia induced by MYH9-USP6 gene fusion Nodular fasciitis is a self-limited myofibroblastic proliferation historically viewed as a reactive process of uncertain etiology. Most cases of nodular fasciitis are now shown to harbor the fusion gene MYH9-USP6, making it the first example of a selflimited human disease characterized by a recurrent somatic gene fusion event. Michele R Erickson-Johnson, Margaret M Chou, Barbara R Evers, Christopher W Roth, Amber R Seys, Long Jin, Ying Ye, Alan W Lau, Xiaoke Wang and Andre M Oliveira 2011 91: 1427-1433; advance online publication, August 8, 2011; 10.1038/labinvest.2011.118 Abstract | Full Text Cell-specific effects of TNF-α and IL-1β on alkaline phosphatase: implication for syndesmophyte formation and vascular calcification TNF-α and IL-1β stimulate tissue non-specific alkaline phosphatase activity in vascular smooth muscle cells through PPARc inhibition. In contrast, inhibition of PPARc by both cytokines decreases the enzyme's activity in entheseal chondrocytes from organotypic cultures of mouse bones, suggesting that in ankylosing spondylitis, TNF-α and IL-1β inhibit syndesmophyte formation. Philippe Lencel, Séverine Delplace, Paul Pilet, Damien Leterme, Flore Miellot, Sophie Sourice, Axelle Caudrillier, Pierre Hardouin, Jérome Guicheux and David Magne 2011 91: 1434-1442; advance online publication, May 9, 2011; 10.1038/labinvest.2011.83 Abstract | Full Text GENITOURINARY AND REPRODUCTIVE SYSTEMS Expression of Snail and Slug in renal cell carcinoma: E-cadherin repressor Snail is associated with cancer invasion and prognosis In renal cell carcinoma, Snail protein expression is associated with tumor stage and poor prognosis. Targeting Snail expression in the 786-O RCC cell line with siRNA inhibits invasion in vitro, which suggests that Snail plays an important role in invasion and metastasis, and that gene silencing is a potential therapeutic strategy. Shuji Mikami, Ken-Ichi Katsube, Mototsugu Oya, Masaru Ishida, Takeo Kosaka, Ryuichi Mizuno, Makio Mukai and Yasunori Okada 2011 91: 1443-1458; advance online publication, August 1, 2011; 10.1038/labinvest.2011.111 Abstract | Full Text Inhibition of inflammation by pentosan polysulfate impedes the development and progression of severe diabetic nephropathy in aging C57B6 mice Pentosan polysulfate (PPS) treatment prevents the progression of nephropathy in streptozotocin-induced diabetes in aging C57B6 mice by decreasing albuminuria, renal macrophage infiltration and TNF-α expression. These effects are associated with improvement of histopathologic changes and renal function. PPS suppresses inflammation mediated by TNFa, high glucose, and advanced glycation end products. Jin Wu, Tian-jun Guan, Shirong Zheng, Fabrizio Grosjean, Weicheng Liu, Huabao Xiong, Ronald Gordon, Helen Vlassara, Gary E Striker and Feng Zheng 2011 91: 1459-1471; advance online publication, August 1, 2011; 10.1038/labinvest.2011.93 Abstract | Full Text HEPATIC AND PANCREATIC SYSTEMS MicroRNA-148a is down-regulated in human pancreatic ductal adenocarcinomas and regulates cell survival by targeting CDC25B miRNA-148a is significantly down-regulated in human pancreatic ductal adenocarcinomas, and decreased expression leads to a higher proliferation rate and increased colony formation. The dual specificity protein phosphatase CDC25B is verified as a miR-148a target, indicating that this miRNA exhibits tumor-suppressor function in pancreatic ductal adenocarcinomas. Sven-T Liffers, Johanna B Munding, Markus Vogt, Jan D Kuhlmann, Berlinda Verdoodt, Sandeep Nambiar, Abdelouahid Maghnouj, Alireza Mirmohammadsadegh, Stephan A Hahn and Andrea Tannapfel 2011 91: 1472-1479; advance online publication, June 27, 2011; 10.1038/labinvest.2011.99 Abstract | Full Text MODELS AND TECHNIQUES Development and characterization of xenograft model systems for adenoid cystic carcinoma The study of adenoid cystic carcinoma (ACC) has been hampered by the lack of model systems. The development and characterization of 12 distinct xenograft lines of ACC are outlined. The models recapitulate the morphologic, gene expression and genetic characteristics of primary ACC tumors, providing the basis for further discovery and hypothesis-driven research in this disease. Christopher A Moskaluk, Alexander S Baras, Stefani A Mancuso, Hao Fan, Robert J Davidson, Dawn C Dirks, Wendy L Golden and Henry F Frierson, Jr 2011 91: 1480-1490; advance online publication, June 27, 2011; 10.1038/labinvest.2011.105 Abstract | Full Text High-throughput detection of fusion genes in cancer using the Sequenom MassARRAY platform Identification of recurrent expressed fusion genes through FISH and RT-PCR are time-consuming and prone to artefacts. A novel high-throughput strategy for the detection of recurrent fusion genes based on the Sequenom MassARRAY platform is described, and shows promise as a high-throughput screening tool for these genes in human cancer. Maryou BK Lambros, Paul M Wilkerson, Rachael Natrajan, Neill Patani, Vidya Pawar, Radost Vatcheva, Marthe Mansour, Mirja Laschet, Beatrice Oelze, Nicholas Orr, Susanne Muller and Jorge S Reis-Filho 2011 91: 1491-1501; advance online publication, August 1, 2011; 10.1038/labinvest.2011.110 Abstract | Full Text BLOOD, LYMPHATICS, IMMUNE SYSTEM, STEM CELLS Induction of metastatic cancer stem cells from the NK/LAK-resistant floating, but not adherent, subset of the UP-LN1 carcinoma cell line by IFN-γ Floating and adherent subsets of a lymph node metastatic carcinoma cell line displayed CD44high/CD24low and CD44low/CD24high phenotypes, which respectively corresponded to monodispersed and compact tumor cells in the patient's metastatic lesion. The floating subset is the major niche for cancer stem cells, and upon IFN-γ treatment could be induced to CXCR4+ metastatic cells. Hung-Chang Chen, Andy Shau-Bin Chou, Yu-Chen Liu, Chin-Hsuan Hsieh, Chen-Chen Kang, See-Tong Pang, Chi-Tai Yeh, Hui-Ping Liu and Shuen-Kuei Liao 2011 91: 1502-1513; advance online publication, June 20, 2011; 10.1038/labinvest.2011.91 Abstract | Full Text ANGIOGENESIS, CARDIOVASCULAR AND PULMONARY SYSTEMS Elf3 plays a role in regulating bronchiolar epithelial repair kinetics following Clara cell-specific injury Elf3 is an epithelial-specific transcription factor that is highly expressed during fetal lung development. The kinetics of cell proliferation and Clara cell renewal are delayed within the regenerating bronchiolar airway epithelium of Elf3-deficient mice after injury, which reveals an important role for Elf3 in the regulation of epithelial repair. Jordan R Oliver, Rahul Kushwah, Jing Wu, Jie Pan, Ernest Cutz, Herman Yeger, Thomas K Waddell and Jim Hu 2011 91: 1514-1529; advance online publication, June 27, 2011; 10.1038/labinvest.2011.100 Abstract | Full Text Neonatal chlamydial pneumonia induces altered respiratory structure and function lasting into adult life Neonatal pulmonary Chlamydia muridarum infection in mice leads to reduced numbers of alveoli and impaired pulmonary function as adults. Antimicrobial therapy of infected neonates partially alleviates the Chlamydia-induced pulmonary dysfunction, supporting the role of Chlamydia in pathological sequelae following respiratory infection. Madhulika Jupelli, Ashlesh K Murthy, Bharat KR Chaganty, M Neal Guentzel, Dale M Selby, Margarita M Vasquez, Shamimunisa B Mustafa, Barbara M Henson, Steven R Seidner, Guangming Zhong and Bernard P Arulanandam 2011 91: 1530-1539; advance online publication, July 18, 2011; 10.1038/labinvest.2011.103 Abstract | Full Text Pathogenic role of B cells in the development of diffuse alveolar hemorrhage induced by pristane A single intraperitoneal injection of pristane induces alveolar hemorrhage in C57BL/6 mice within two weeks. The effect is independent of MyD88, TLR7, FcγR, TCR, and Fas; however, absence of B-cells reduces the prevalence. This model can be useful for determining the pathogenesis of this life-threatening complication and for testing new therapies. Tolga T Barker, Pui Y Lee, Kindra M Kelly-Scumpia, Jason S Weinstein, Dina C Nacionales, Yutaro Kumagai, Shizuo Akira, Byron P Croker, Eric S Sobel, Westley H Reeves and Minoru Satoh 2011 91: 1540-1550; advance online publication, August 1, 2011; 10.1038/labinvest.2011.108 Abstract | Full Text Advertisement Ensure your access If you are unable to access the articles in this alert, your library may not subscribe to this journal. Our online recommendation form is a simple way to make your librarian aware that this journal is valuable to your research. Recommend now!   Please note that you need to be a subscriber or site-licence holder to enjoy full-text access to Laboratory Investigation. In order to do so, please purchase a subscription. You have been sent this Table of Contents Alert because you have opted in to receive it. 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