Wednesday, March 30, 2011

Nature contents: 31 March 2011

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View Table of Contents http://links.ealert.nature.com/ctt?kn=48&m=36438196&r=MjA1NzcwMjE4MQS2&b=2&j=OTc5OTExMzMS1&mt=1&rt=0

=========================== ADVERTISEMENT ===========================
A-IMBN Research - Research highlights from the Asia-Pacific
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=====================================================================

=========================== ADVERTISEMENT ===========================
---THIS WEEK'S HIGHLIGHTS:

--Earth & Environmental Sciences
-Winter cold of eastern continental boundaries induced by warm ocean
waters
Why are New England winters so chilly? Climate models suggest that
paradoxically, it is a response to the presence of the warm waters
of the Gulf Stream off the North American coast.
[ http://links.ealert.nature.com/ctt?kn=93&m=36438196&r=MjA1NzcwMjE4MQS2&b=2&j=OTc5OTExMzMS1&mt=1&rt=0 ]

--Biological Sciences
-A eudicot from the Early Cretaceous of China
A steady stream of fossil discoveries from the Early Cretaceous of
China is beginning to fill the gaps in our knowledge of the early
history of flowering plants -- and the latest find records a burst
of angiosperm evolution some 125 million years ago.
[ http://links.ealert.nature.com/ctt?kn=95&m=36438196&r=MjA1NzcwMjE4MQS2&b=2&j=OTc5OTExMzMS1&mt=1&rt=0 ]

--Physical Sciences
-Gravity modes as a way to distinguish between hydrogen- and
helium-burning red giant stars
The primary role of NASA's Kepler mission is to discover extrasolar
planets, but here Kepler data are used to distinguish between different
types of red giant star.
[ http://links.ealert.nature.com/ctt?kn=90&m=36438196&r=MjA1NzcwMjE4MQS2&b=2&j=OTc5OTExMzMS1&mt=1&rt=0 ]

=========================== ADVERTISEMENT ===========================
Nature Publishing Index 2010: Asia-Pacific http://links.ealert.nature.com/ctt?kn=118&m=36438196&r=MjA1NzcwMjE4MQS2&b=2&j=OTc5OTExMzMS1&mt=1&rt=0
Announcing the publication of the 2010 rankings of top institutions and
countries in the Asia-Pacific by number of papers published during 2010.
NEW this year is a global ranking of the top 50 institutions in the
world, placing the Asia-Pacific in a global context.
You can download the yearly print publication or view the Nature
Publishing Index: Asia-Pacific, which is updated weekly.
NB: the supplement was written before the earthquake disaster in Japan
=====================================================================

--Podcast & Video
-This week, 25 years since the Chernobyl nuclear disaster, star gazing
with Kepler and a chemical dye that extends life span. Plus, the best
of the rest from Nature.
[ http://links.ealert.nature.com/ctt?kn=123&m=36438196&r=MjA1NzcwMjE4MQS2&b=2&j=OTc5OTExMzMS1&mt=1&rt=0 ]
=====================================================================

======================== NEWS AND COMMENT ========================
Read daily news coverage http://links.ealert.nature.com/ctt?kn=125&m=36438196&r=MjA1NzcwMjE4MQS2&b=2&j=OTc5OTExMzMS1&mt=1&rt=0

EDITORIALS
** Lessons from the past
The Chernobyl disaster still has much to tell us about the long-term
risks of low-level radiation exposure. But only if the necessary
follow-up studies are supported.
http://links.ealert.nature.com/ctt?kn=91&m=36438196&r=MjA1NzcwMjE4MQS2&b=2&j=OTc5OTExMzMS1&mt=1&rt=0

** Announcement: Nature mentoring awards
http://links.ealert.nature.com/ctt?kn=99&m=36438196&r=MjA1NzcwMjE4MQS2&b=2&j=OTc5OTExMzMS1&mt=1&rt=0

** Courtroom drama
Forensic science faces rough justice on both sides of the Atlantic.
http://links.ealert.nature.com/ctt?kn=101&m=36438196&r=MjA1NzcwMjE4MQS2&b=2&j=OTc5OTExMzMS1&mt=1&rt=0

** Journal launch: Welcome Nature Climate Change
http://links.ealert.nature.com/ctt?kn=96&m=36438196&r=MjA1NzcwMjE4MQS2&b=2&j=OTc5OTExMzMS1&mt=1&rt=0

WORLD VIEW
** Concerns over nuclear energy are legitimate
Reassurances from 'experts' on the safety of nuclear power will not wash,
says Colin Macilwain. The Fukushima crisis raises genuine questions.
http://links.ealert.nature.com/ctt?kn=68&m=36438196&r=MjA1NzcwMjE4MQS2&b=2&j=OTc5OTExMzMS1&mt=1&rt=0

SEVEN DAYS
** Seven days: 31 March 2011
The week in science
http://links.ealert.nature.com/ctt?kn=20&m=36438196&r=MjA1NzcwMjE4MQS2&b=2&j=OTc5OTExMzMS1&mt=1&rt=0

NEWS
** Radioactivity spreads in Japan
Fallout is localized, but could persist for years in some regions.
http://links.ealert.nature.com/ctt?kn=19&m=36438196&r=MjA1NzcwMjE4MQS2&b=2&j=OTc5OTExMzMS1&mt=1&rt=0

** Japan faces up to failure of its earthquake preparations
Systems for forecasting, early warning and tsunami protection all fell
short on 11 March.
http://links.ealert.nature.com/ctt?kn=18&m=36438196&r=MjA1NzcwMjE4MQS2&b=2&j=OTc5OTExMzMS1&mt=1&rt=0

** NIH firm on grant application rules
Unpopular policy limiting applicants to two submissions has sped up
approvals.
http://links.ealert.nature.com/ctt?kn=26&m=36438196&r=MjA1NzcwMjE4MQS2&b=2&j=OTc5OTExMzMS1&mt=1&rt=0

** Research sans frontières
Academy report finds that international collaboration is on the rise,
and should not be seen as an 'easy target' for cuts.
http://links.ealert.nature.com/ctt?kn=25&m=36438196&r=MjA1NzcwMjE4MQS2&b=2&j=OTc5OTExMzMS1&mt=1&rt=0

** Canadian forest deal at risk
Pact to preserve vast swathe of wilderness faces reluctance from
industry and resistance from native groups.
http://links.ealert.nature.com/ctt?kn=23&m=36438196&r=MjA1NzcwMjE4MQS2&b=2&j=OTc5OTExMzMS1&mt=1&rt=0

** Melanoma drug wins US approval
Therapy is the first to extend lifespan in advanced cases.
http://links.ealert.nature.com/ctt?kn=69&m=36438196&r=MjA1NzcwMjE4MQS2&b=2&j=OTc5OTExMzMS1&mt=1&rt=0

FEATURES
** Chernobyl's legacy
Twenty-five years after the nuclear disaster, the clean-up grinds
on and health studies are faltering. Are there lessons for Japan?
http://links.ealert.nature.com/ctt?kn=21&m=36438196&r=MjA1NzcwMjE4MQS2&b=2&j=OTc5OTExMzMS1&mt=1&rt=0

** Social science: Web of war
Can computational social science help to prevent or win wars? The
Pentagon is betting millions of dollars on the hope that it will.
http://links.ealert.nature.com/ctt?kn=31&m=36438196&r=MjA1NzcwMjE4MQS2&b=2&j=OTc5OTExMzMS1&mt=1&rt=0

TECHNOLOGY FEATURE
** Tissue models: A Living system on a chip
For years, scientists have struggled to reconstruct tissues and organs
by combining cells and nanotechnology. These devices are now edging
from cool concept to practical application.
http://links.ealert.nature.com/ctt?kn=98&m=36438196&r=MjA1NzcwMjE4MQS2&b=2&j=OTc5OTExMzMS1&mt=1&rt=0

COMMENT
** Time to rethink the NIH
A radical restructure is the only way to solve the systemic problems
of the world's biggest funder of biomedical research,
argues Michael M. Crow.
http://links.ealert.nature.com/ctt?kn=88&m=36438196&r=MjA1NzcwMjE4MQS2&b=2&j=OTc5OTExMzMS1&mt=1&rt=0

BOOKS AND ARTS
** Earth science: Mind your head
From Roman reverence to dinosaur extinctions, Birger Schmitz is
riveted by a history of the meteorite.
http://links.ealert.nature.com/ctt?kn=76&m=36438196&r=MjA1NzcwMjE4MQS2&b=2&j=OTc5OTExMzMS1&mt=1&rt=0

** Gastronomy: A visual feast
Felice Frankel grapples with a 20-kilogram cookbook.
http://links.ealert.nature.com/ctt?kn=75&m=36438196&r=MjA1NzcwMjE4MQS2&b=2&j=OTc5OTExMzMS1&mt=1&rt=0

** Q&A: Steakhouse science
Nathan Myhrvold trained as a quantum cosmologist with Stephen Hawking
and was chief technology officer of Microsoft before founding
Intellectual Ventures, a US company that funds inventors and acquires
patents. As he publishes a six-volume work on the science of cooking,
Myhrvold explains why chemistry techniques could soon be seen in
every restaurant.
http://links.ealert.nature.com/ctt?kn=79&m=36438196&r=MjA1NzcwMjE4MQS2&b=2&j=OTc5OTExMzMS1&mt=1&rt=0

** Museums: Out of the cellar
Thomas Schnalke calls on Germany to turn its historical scientific
collections into centres for object research.
http://links.ealert.nature.com/ctt?kn=78&m=36438196&r=MjA1NzcwMjE4MQS2&b=2&j=OTc5OTExMzMS1&mt=1&rt=0

** Books in brief
http://links.ealert.nature.com/ctt?kn=81&m=36438196&r=MjA1NzcwMjE4MQS2&b=2&j=OTc5OTExMzMS1&mt=1&rt=0

CORRESPONDENCE
** Unite to assess contaminant risk
Paige J. Novak
http://links.ealert.nature.com/ctt?kn=80&m=36438196&r=MjA1NzcwMjE4MQS2&b=2&j=OTc5OTExMzMS1&mt=1&rt=0

** Funding studies of the unpredictable
Brajesh K. Singh
http://links.ealert.nature.com/ctt?kn=83&m=36438196&r=MjA1NzcwMjE4MQS2&b=2&j=OTc5OTExMzMS1&mt=1&rt=0

** Turkey's research council clarifies role
Nuket Yetis
http://links.ealert.nature.com/ctt?kn=82&m=36438196&r=MjA1NzcwMjE4MQS2&b=2&j=OTc5OTExMzMS1&mt=1&rt=0

** Microbial sequences benefit health now
Edward J. P. Cartwright, Claudio U. Koser and Sharon J. Peacock
http://links.ealert.nature.com/ctt?kn=116&m=36438196&r=MjA1NzcwMjE4MQS2&b=2&j=OTc5OTExMzMS1&mt=1&rt=0

** Career postdocs increase scrap heap
Robert Insall
http://links.ealert.nature.com/ctt?kn=117&m=36438196&r=MjA1NzcwMjE4MQS2&b=2&j=OTc5OTExMzMS1&mt=1&rt=0

CORRECTION
** Correction
http://links.ealert.nature.com/ctt?kn=97&m=36438196&r=MjA1NzcwMjE4MQS2&b=2&j=OTc5OTExMzMS1&mt=1&rt=0


=========================== ADVERTISEMENT ===========================
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Proposals due by 4/29/11 for projects focused on modulation of:

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http://links.ealert.nature.com/ctt?kn=127&m=36438196&r=MjA1NzcwMjE4MQS2&b=2&j=OTc5OTExMzMS1&mt=1&rt=0
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======================== BIOLOGICAL SCIENCES ========================
RESEARCH
** Linear ubiquitination prevents inflammation and regulates immune
signalling
Bjorn Gerlach, Stefanie M. Cordier, Anna C. Schmukle,
Christoph H. Emmerich, Eva Rieser et al.
Members of the tumour necrosis factor (TNF) receptor superfamily
have important...
http://links.ealert.nature.com/ctt?kn=109&m=36438196&r=MjA1NzcwMjE4MQS2&b=2&j=OTc5OTExMzMS1&mt=1&rt=0

** Habenular [alpha]5 nicotinic receptor subunit signalling controls
nicotine intake
Christie D. Fowler, Qun Lu, Paul M. Johnson, Michael J. Marks and
Paul J. Kenny
Genetic variation in CHRNA5, the gene encoding the [alpha]5 nicotinic
acetylcho...
http://links.ealert.nature.com/ctt?kn=106&m=36438196&r=MjA1NzcwMjE4MQS2&b=2&j=OTc5OTExMzMS1&mt=1&rt=0

** CRISPR RNA maturation by trans-encoded small RNA and host factor
RNase III
Elitza Deltcheva, Krzysztof Chylinski, Cynthia M. Sharma,
Karine Gonzales, Yanjie Chao et al.
CRISPR/Cas systems constitute a widespread class of immunity systems
that prote...
http://links.ealert.nature.com/ctt?kn=104&m=36438196&r=MjA1NzcwMjE4MQS2&b=2&j=OTc5OTExMzMS1&mt=1&rt=0

** A eudicot from the Early Cretaceous of China
Ge Sun, David L. Dilcher, Hongshan Wang and Zhiduan Chen
The current molecular systematics of angiosperms recognizes the basal
angiosper...
http://links.ealert.nature.com/ctt?kn=95&m=36438196&r=MjA1NzcwMjE4MQS2&b=2&j=OTc5OTExMzMS1&mt=1&rt=0

** Cross-dressed dendritic cells drive memory CD8+ T-cell activation
after viral infection
Linda M. Wakim and Michael J. Bevan
After an infection, cytotoxic T lymphocyte precursors proliferate and
become ef...
http://links.ealert.nature.com/ctt?kn=102&m=36438196&r=MjA1NzcwMjE4MQS2&b=2&j=OTc5OTExMzMS1&mt=1&rt=0

** SHARPIN is a component of the NF-[kgr]B-activating linear ubiquitin
chain assembly complex
Fuminori Tokunaga, Tomoko Nakagawa, Masaki Nakahara, Yasushi Saeki,
Masami Taniguchi et al.
Cpdm (chronic proliferative dermatitis) mice develop chronic dermatitis
and an ...
http://links.ealert.nature.com/ctt?kn=114&m=36438196&r=MjA1NzcwMjE4MQS2&b=2&j=OTc5OTExMzMS1&mt=1&rt=0

** SHARPIN forms a linear ubiquitin ligase complex regulating NF-[kgr]B
activity and apoptosis
Fumiyo Ikeda, Yonathan Lissanu Deribe, Sigrid S. Skanland,
Benjamin Stieglitz, Caroline Grabbe et al.
SHARPIN is a ubiquitin-binding and ubiquitin-like-domain-containing
protein whi...
http://links.ealert.nature.com/ctt?kn=112&m=36438196&r=MjA1NzcwMjE4MQS2&b=2&j=OTc5OTExMzMS1&mt=1&rt=0

** Aberrant chromosome morphology in human cells defective for Holliday
junction resolution
Thomas Wechsler, Scott Newman and Stephen C. West
In somatic cells, Holliday junctions can be formed between sister
chromatids du...
http://links.ealert.nature.com/ctt?kn=111&m=36438196&r=MjA1NzcwMjE4MQS2&b=2&j=OTc5OTExMzMS1&mt=1&rt=0

** The complete biosynthesis of the genetically encoded amino acid
pyrrolysine from lysine
Marsha A. Gaston, Liwen Zhang, Kari B. Green-Church and Joseph A. Krzycki
Pyrrolysine, the twenty-second amino acid found to be encoded in the
natural ge...
http://links.ealert.nature.com/ctt?kn=110&m=36438196&r=MjA1NzcwMjE4MQS2&b=2&j=OTc5OTExMzMS1&mt=1&rt=0

** Crystal structure of metarhodopsin II
Hui-Woog Choe, Yong Ju Kim, Jung Hee Park, Takefumi Morizumi,
Emil F. Pai et al.
G-protein-coupled receptors (GPCRs) are seven transmembrane helix
(TM) proteins...
http://links.ealert.nature.com/ctt?kn=52&m=36438196&r=MjA1NzcwMjE4MQS2&b=2&j=OTc5OTExMzMS1&mt=1&rt=0

** The structural basis of agonist-induced activation in constitutively
active rhodopsin
Jorg Standfuss, Patricia C. Edwards, Aaron D'Antona, Maikel Fransen,
Guifu Xie et al.
G-protein-coupled receptors (GPCRs) comprise the largest family of
membrane pro...
http://links.ealert.nature.com/ctt?kn=44&m=36438196&r=MjA1NzcwMjE4MQS2&b=2&j=OTc5OTExMzMS1&mt=1&rt=0

** Distinct representations of olfactory information in different
cortical centres
Dara L. Sosulski, Maria Lissitsyna Bloom, Tyler Cutforth, Richard Axel
and Sandeep Robert Datta
Sensory information is transmitted to the brain where it must be
processed to t...
http://links.ealert.nature.com/ctt?kn=45&m=36438196&r=MjA1NzcwMjE4MQS2&b=2&j=OTc5OTExMzMS1&mt=1&rt=0

** Amyloid-binding compounds maintain protein homeostasis during ageing
and extend lifespan
Silvestre Alavez, Maithili C. Vantipalli, David J. S. Zucker,
Ida M. Klang and Gordon J. Lithgow
Genetic studies indicate that protein homeostasis is a major
contributor to met...
http://links.ealert.nature.com/ctt?kn=38&m=36438196&r=MjA1NzcwMjE4MQS2&b=2&j=OTc5OTExMzMS1&mt=1&rt=0

** Dual functions of Tet1 in transcriptional regulation in mouse
embryonic stem cells
Hao Wu, Ana C. D'Alessio, Shinsuke Ito, Kai Xia, Zhibin Wang et al.
Epigenetic modification of the mammalian genome by DNA methylation
(5-methylcyt...
http://links.ealert.nature.com/ctt?kn=40&m=36438196&r=MjA1NzcwMjE4MQS2&b=2&j=OTc5OTExMzMS1&mt=1&rt=0

** Sensory maps in the olfactory cortex defined by long-range viral
tracing of single neurons
Sulagna Ghosh, Stephen D. Larson, Hooman Hefzi, Zachary Marnoy,
Tyler Cutforth et al.
Sensory information may be represented in the brain by stereotyped
mapping of a...
http://links.ealert.nature.com/ctt?kn=41&m=36438196&r=MjA1NzcwMjE4MQS2&b=2&j=OTc5OTExMzMS1&mt=1&rt=0

** A Raf-induced allosteric transition of KSR stimulates phosphorylation
of MEK
Damian F. Brennan, Arvin C. Dar, Nicholas T. Hertz, William C. H. Chao,
Alma L. Burlingame et al.
In metazoans, the Ras-Raf-MEK (mitogen-activated protein-kinase...
http://links.ealert.nature.com/ctt?kn=43&m=36438196&r=MjA1NzcwMjE4MQS2&b=2&j=OTc5OTExMzMS1&mt=1&rt=0

** A conserved mechanism of DEAD-box ATPase activation by nucleoporins
and InsP6 in mRNA export
Ben Montpetit, Nathan D. Thomsen, Kara J. Helmke, Markus A. Seeliger,
James M. Berger et al.
Superfamily 1 and superfamily 2 RNA helicases are ubiquitous messenger-RNA
http://links.ealert.nature.com/ctt?kn=34&m=36438196&r=MjA1NzcwMjE4MQS2&b=2&j=OTc5OTExMzMS1&mt=1&rt=0

** Metabolic trade-offs and the maintenance of the fittest and the
flattest
Robert E. Beardmore, Ivana Gudelj, David A. Lipson and
Laurence D. Hurst
How is diversity maintained? Environmental heterogeneity is
considered to be im...
http://links.ealert.nature.com/ctt?kn=35&m=36438196&r=MjA1NzcwMjE4MQS2&b=2&j=OTc5OTExMzMS1&mt=1&rt=0

** Digoxin and its derivatives suppress TH17 cell differentiation by
antagonizing ROR[ggr]t activity
Jun R. Huh, Monica W. L. Leung, Pengxiang Huang, Daniel A. Ryan,
Michael R. Krout et al.
CD4+ T helper lymphocytes that express interleukin-17 (TH17 cells)
have critica...
http://links.ealert.nature.com/ctt?kn=36&m=36438196&r=MjA1NzcwMjE4MQS2&b=2&j=OTc5OTExMzMS1&mt=1&rt=0

** Robins have a magnetic compass in both eyes
Christine Maira Hein, Svenja Engels, Dmitry Kishkinev and
Henrik Mouritsen
Arising from W. Wiltschko et al. Nature 419, 467-470 (2002); Wiltschko
The magnetic compass of migratory birds is embedded in the visual
system and it...
http://links.ealert.nature.com/ctt?kn=37&m=36438196&r=MjA1NzcwMjE4MQS2&b=2&j=OTc5OTExMzMS1&mt=1&rt=0

** Wiltschko et al. reply
Wolfgang Wiltschko, Joachim Traudt, Onur Gunturkun, Helmut Prior and
Roswitha Wiltschko
Replying to C. M. Hein, S. Engels, D. Kishkinev & H. Mouritsen...
http://links.ealert.nature.com/ctt?kn=64&m=36438196&r=MjA1NzcwMjE4MQS2&b=2&j=OTc5OTExMzMS1&mt=1&rt=0

** Immunology: Cross-dressers turn on T cells
Jonathan W. Yewdell and Brian P. Dolan
Memory T cells remember viruses from previous infections, providing
immunity by facilitating the killing of infected cells. For this,
they exploit cross-dressing, the transfer of antigens between a
ntigen-presenting cells.
http://links.ealert.nature.com/ctt?kn=62&m=36438196&r=MjA1NzcwMjE4MQS2&b=2&j=OTc5OTExMzMS1&mt=1&rt=0

** Molecular genetics: The sound of silence
Laurence D. Hurst
There are various ways in which apparently 'silent' DNA mutations --
those that don't result in a change in the encoded protein -- have
untoward consequences. A striking example has emerged in a study of
Crohn's disease.
http://links.ealert.nature.com/ctt?kn=63&m=36438196&r=MjA1NzcwMjE4MQS2&b=2&j=OTc5OTExMzMS1&mt=1&rt=0

** Biochemistry: How two amino acids become one
Stephen W. Ragsdale
Twenty amino acids form the basis of all proteins, but another two
genetically encoded amino acids have also been discovered. The
biosynthesis of one of these, pyrrolysine, has now been elucidated.
http://links.ealert.nature.com/ctt?kn=60&m=36438196&r=MjA1NzcwMjE4MQS2&b=2&j=OTc5OTExMzMS1&mt=1&rt=0

** Developmental biology: A hair-raising tale
Bruce A. Morgan
Signals from the external microenvironment or 'niche' determine the
fate of stem cells. In the hair follicle, stem cells themselves seem
to act as a niche for the adjoining muscle cells that cause goosebumps.
http://links.ealert.nature.com/ctt?kn=61&m=36438196&r=MjA1NzcwMjE4MQS2&b=2&j=OTc5OTExMzMS1&mt=1&rt=0

** Microbiology: Dicing defence in bacteria
Susan Gottesman
A newly discovered variation in the process by which bacteria resist
invasion by foreign nucleic acids provides an intriguing parallel
between the defence mechanisms of the different domains of life.
http://links.ealert.nature.com/ctt?kn=58&m=36438196&r=MjA1NzcwMjE4MQS2&b=2&j=OTc5OTExMzMS1&mt=1&rt=0

NEWS & COMMENT
** Archaeology: North America's first tool users?
http://links.ealert.nature.com/ctt?kn=59&m=36438196&r=MjA1NzcwMjE4MQS2&b=2&j=OTc5OTExMzMS1&mt=1&rt=0

** Cancer immunology: Hide no more, tumour
http://links.ealert.nature.com/ctt?kn=56&m=36438196&r=MjA1NzcwMjE4MQS2&b=2&j=OTc5OTExMzMS1&mt=1&rt=0

** Neuroscience: No sleep, better mood
http://links.ealert.nature.com/ctt?kn=57&m=36438196&r=MjA1NzcwMjE4MQS2&b=2&j=OTc5OTExMzMS1&mt=1&rt=0

** Biophysics: Tiny swimmers trapped by lasers
http://links.ealert.nature.com/ctt?kn=53&m=36438196&r=MjA1NzcwMjE4MQS2&b=2&j=OTc5OTExMzMS1&mt=1&rt=0

** Ecology: Feasting fish scatter seeds
http://links.ealert.nature.com/ctt?kn=10&m=36438196&r=MjA1NzcwMjE4MQS2&b=2&j=OTc5OTExMzMS1&mt=1&rt=0

** Archaeology: Early farmers caused floods
http://links.ealert.nature.com/ctt?kn=11&m=36438196&r=MjA1NzcwMjE4MQS2&b=2&j=OTc5OTExMzMS1&mt=1&rt=0

** Stem cells: The roots of insulin production
http://links.ealert.nature.com/ctt?kn=12&m=36438196&r=MjA1NzcwMjE4MQS2&b=2&j=OTc5OTExMzMS1&mt=1&rt=0

** Time to rethink the NIH
A radical restructure is the only way to solve the systemic problems
of the world's biggest funder of biomedical research,
argues Michael M. Crow.
http://links.ealert.nature.com/ctt?kn=88&m=36438196&r=MjA1NzcwMjE4MQS2&b=2&j=OTc5OTExMzMS1&mt=1&rt=0

** Museums: Out of the cellar
Thomas Schnalke calls on Germany to turn its historical scientific
collections into centres for object research.
http://links.ealert.nature.com/ctt?kn=78&m=36438196&r=MjA1NzcwMjE4MQS2&b=2&j=OTc5OTExMzMS1&mt=1&rt=0

** Books in brief
http://links.ealert.nature.com/ctt?kn=81&m=36438196&r=MjA1NzcwMjE4MQS2&b=2&j=OTc5OTExMzMS1&mt=1&rt=0

** Turkey's research council clarifies role
Nuket Yetis
http://links.ealert.nature.com/ctt?kn=82&m=36438196&r=MjA1NzcwMjE4MQS2&b=2&j=OTc5OTExMzMS1&mt=1&rt=0

** Microbial sequences benefit health now
Edward J. P. Cartwright, Claudio U. Koser and Sharon J. Peacock
http://links.ealert.nature.com/ctt?kn=116&m=36438196&r=MjA1NzcwMjE4MQS2&b=2&j=OTc5OTExMzMS1&mt=1&rt=0


** More News & Comment on BIOLOGICAL SCIENCES
http://links.ealert.nature.com/ctt?kn=70&m=36438196&r=MjA1NzcwMjE4MQS2&b=2&j=OTc5OTExMzMS1&mt=1&rt=0


=========================== ADVERTISEMENT ===========================
Nature Immunology webcast
Current Controversies: Lineage Differentiation!
http://links.ealert.nature.com/ctt?kn=71&m=36438196&r=MjA1NzcwMjE4MQS2&b=2&j=OTc5OTExMzMS1&mt=1&rt=0

Join us for a lively discussion on current models of myeloid versus
lymphoid lineage commitment, lineage exclusion and cell plasticity,
followed by a live question and answer session.

Registration is FREE!
http://links.ealert.nature.com/ctt?kn=71&m=36438196&r=MjA1NzcwMjE4MQS2&b=2&j=OTc5OTExMzMS1&mt=1&rt=0

Sponsored by: Stemcell
http://links.ealert.nature.com/ctt?kn=13&m=36438196&r=MjA1NzcwMjE4MQS2&b=2&j=OTc5OTExMzMS1&mt=1&rt=0

=====================================================================

======================== CHEMICAL SCIENCES ========================
RESEARCH
** Linear ubiquitination prevents inflammation and regulates immune
signalling
Bjorn Gerlach, Stefanie M. Cordier, Anna C. Schmukle,
Christoph H. Emmerich, Eva Rieser et al.
Members of the tumour necrosis factor (TNF) receptor superfamily
have important...
http://links.ealert.nature.com/ctt?kn=109&m=36438196&r=MjA1NzcwMjE4MQS2&b=2&j=OTc5OTExMzMS1&mt=1&rt=0

** SHARPIN is a component of the NF-[kgr]B-activating linear ubiquitin
chain assembly complex
Fuminori Tokunaga, Tomoko Nakagawa, Masaki Nakahara, Yasushi Saeki,
Masami Taniguchi et al.
Cpdm (chronic proliferative dermatitis) mice develop chronic
dermatitis and an ...
http://links.ealert.nature.com/ctt?kn=114&m=36438196&r=MjA1NzcwMjE4MQS2&b=2&j=OTc5OTExMzMS1&mt=1&rt=0

** SHARPIN forms a linear ubiquitin ligase complex regulating NF-[kgr]B
activity and apoptosis
Fumiyo Ikeda, Yonathan Lissanu Deribe, Sigrid S. Skanland,
Benjamin Stieglitz, Caroline Grabbe et al.
SHARPIN is a ubiquitin-binding and ubiquitin-like-domain-containing
protein whi...
http://links.ealert.nature.com/ctt?kn=112&m=36438196&r=MjA1NzcwMjE4MQS2&b=2&j=OTc5OTExMzMS1&mt=1&rt=0

** Aberrant chromosome morphology in human cells defective for
Holliday junction resolution
Thomas Wechsler, Scott Newman and Stephen C. West
In somatic cells, Holliday junctions can be formed between sister
chromatids du...
http://links.ealert.nature.com/ctt?kn=111&m=36438196&r=MjA1NzcwMjE4MQS2&b=2&j=OTc5OTExMzMS1&mt=1&rt=0

** The complete biosynthesis of the genetically encoded amino acid
pyrrolysine from lysine
Marsha A. Gaston, Liwen Zhang, Kari B. Green-Church and Joseph A. Krzycki
Pyrrolysine, the twenty-second amino acid found to be encoded in the
natural ge...
http://links.ealert.nature.com/ctt?kn=110&m=36438196&r=MjA1NzcwMjE4MQS2&b=2&j=OTc5OTExMzMS1&mt=1&rt=0

** Crystal structure of metarhodopsin II
Hui-Woog Choe, Yong Ju Kim, Jung Hee Park, Takefumi Morizumi,
Emil F. Pai et al.
G-protein-coupled receptors (GPCRs) are seven transmembrane helix
(TM) proteins...
http://links.ealert.nature.com/ctt?kn=52&m=36438196&r=MjA1NzcwMjE4MQS2&b=2&j=OTc5OTExMzMS1&mt=1&rt=0

** The structural basis of agonist-induced activation in constitutively
active rhodopsin
Jorg Standfuss, Patricia C. Edwards, Aaron D'Antona, Maikel Fransen,
Guifu Xie et al.
G-protein-coupled receptors (GPCRs) comprise the largest family of
membrane pro...
http://links.ealert.nature.com/ctt?kn=44&m=36438196&r=MjA1NzcwMjE4MQS2&b=2&j=OTc5OTExMzMS1&mt=1&rt=0

** Amyloid-binding compounds maintain protein homeostasis during
ageing and extend lifespan
Silvestre Alavez, Maithili C. Vantipalli, David J. S. Zucker,
Ida M. Klang and Gordon J. Lithgow
Genetic studies indicate that protein homeostasis is a major contributor
to met...
http://links.ealert.nature.com/ctt?kn=38&m=36438196&r=MjA1NzcwMjE4MQS2&b=2&j=OTc5OTExMzMS1&mt=1&rt=0

** A Raf-induced allosteric transition of KSR stimulates phosphorylation
of MEK
Damian F. Brennan, Arvin C. Dar, Nicholas T. Hertz, William C. H. Chao,
Alma L. Burlingame et al.
In metazoans, the Ras-Raf-MEK (mitogen-activated protein-kinase...
http://links.ealert.nature.com/ctt?kn=43&m=36438196&r=MjA1NzcwMjE4MQS2&b=2&j=OTc5OTExMzMS1&mt=1&rt=0

** A conserved mechanism of DEAD-box ATPase activation by nucleoporins
and InsP6 in mRNA export
Ben Montpetit, Nathan D. Thomsen, Kara J. Helmke, Markus A. Seeliger,
James M. Berger et al.
Superfamily 1 and superfamily 2 RNA helicases are ubiquitous messenger-RNA
http://links.ealert.nature.com/ctt?kn=34&m=36438196&r=MjA1NzcwMjE4MQS2&b=2&j=OTc5OTExMzMS1&mt=1&rt=0

** Correction
http://links.ealert.nature.com/ctt?kn=97&m=36438196&r=MjA1NzcwMjE4MQS2&b=2&j=OTc5OTExMzMS1&mt=1&rt=0

** Biochemistry: How two amino acids become one
Stephen W. Ragsdale
Twenty amino acids form the basis of all proteins, but another two
genetically encoded amino acids have also been discovered. The
biosynthesis of one of these, pyrrolysine, has now been elucidated.
http://links.ealert.nature.com/ctt?kn=60&m=36438196&r=MjA1NzcwMjE4MQS2&b=2&j=OTc5OTExMzMS1&mt=1&rt=0

NEWS & COMMENT
** Chemistry: Vesicles form with pH shift
http://links.ealert.nature.com/ctt?kn=14&m=36438196&r=MjA1NzcwMjE4MQS2&b=2&j=OTc5OTExMzMS1&mt=1&rt=0

** Gastronomy: A visual feast
Felice Frankel grapples with a 20-kilogram cookbook.
http://links.ealert.nature.com/ctt?kn=75&m=36438196&r=MjA1NzcwMjE4MQS2&b=2&j=OTc5OTExMzMS1&mt=1&rt=0

** Q&A: Steakhouse science
Nathan Myhrvold trained as a quantum cosmologist with Stephen Hawking
and was chief technology officer of Microsoft before founding
Intellectual Ventures, a US company that funds inventors and acquires
patents. As he publishes a six-volume work on the science of cooking,
Myhrvold explains why chemistry techniques could soon be seen in
every restaurant.
http://links.ealert.nature.com/ctt?kn=79&m=36438196&r=MjA1NzcwMjE4MQS2&b=2&j=OTc5OTExMzMS1&mt=1&rt=0

** Books in brief
http://links.ealert.nature.com/ctt?kn=81&m=36438196&r=MjA1NzcwMjE4MQS2&b=2&j=OTc5OTExMzMS1&mt=1&rt=0


** More News & Comment on CHEMICAL SCIENCES
http://links.ealert.nature.com/ctt?kn=42&m=36438196&r=MjA1NzcwMjE4MQS2&b=2&j=OTc5OTExMzMS1&mt=1&rt=0


======================== PHYSICAL SCIENCES ========================
RESEARCH
** Gravity modes as a way to distinguish between hydrogen- and
helium-burning red giant stars
Timothy R. Bedding, Benoit Mosser, Daniel Huber, Josefina Montalban,
Paul Beck et al.
Red giants are evolved stars that have exhausted the supply of
hydrogen in thei...
http://links.ealert.nature.com/ctt?kn=90&m=36438196&r=MjA1NzcwMjE4MQS2&b=2&j=OTc5OTExMzMS1&mt=1&rt=0

** Magnetic and non-magnetic phases of a quantum spin liquid
F. L. Pratt, P. J. Baker, S. J. Blundell, T. Lancaster,
S. Ohira-Kawamura et al.
A quantum spin-liquid phase is an intriguing possibility for a system
of strong...
http://links.ealert.nature.com/ctt?kn=1&m=36438196&r=MjA1NzcwMjE4MQS2&b=2&j=OTc5OTExMzMS1&mt=1&rt=0

** Controlling inelastic light scattering quantum pathways in graphene
Chi-Fan Chen, Cheol-Hwan Park, Bryan W. Boudouris, Jason Horng,
Baisong Geng et al.
Inelastic light scattering spectroscopy has, since its first
discovery, been an...
http://links.ealert.nature.com/ctt?kn=2&m=36438196&r=MjA1NzcwMjE4MQS2&b=2&j=OTc5OTExMzMS1&mt=1&rt=0

** Winter cold of eastern continental boundaries induced by warm
ocean waters
Yohai Kaspi and Tapio Schneider
In winter, northeastern North America and northeastern Asia are both
colder tha...
http://links.ealert.nature.com/ctt?kn=93&m=36438196&r=MjA1NzcwMjE4MQS2&b=2&j=OTc5OTExMzMS1&mt=1&rt=0

** Transient ferromagnetic-like state mediating ultrafast reversal
of antiferromagnetically coupled spins
I. Radu, K. Vahaplar, C. Stamm, T. Kachel, N. Pontius et al.
Ferromagnetic or antiferromagnetic spin ordering is governed by the
exchange in...
http://links.ealert.nature.com/ctt?kn=4&m=36438196&r=MjA1NzcwMjE4MQS2&b=2&j=OTc5OTExMzMS1&mt=1&rt=0

** Astrophysics: The inner lives of red giants
Travis S. Metcalfe
The natural pulse of a red-giant star provides crucial insight into
what makes it shine. Observations of red giants by the Kepler space
telescope shed light on a previously untested prediction of stellar
evolution theory.
http://links.ealert.nature.com/ctt?kn=5&m=36438196&r=MjA1NzcwMjE4MQS2&b=2&j=OTc5OTExMzMS1&mt=1&rt=0

** Climate: Cold winters from warm oceans
William R. Boos
Winters are colder in northeastern North America and Asia than in other
regions at the same latitude. Previous explanations may be incomplete,
having overlooked the radiation of atmospheric wave energy.
http://links.ealert.nature.com/ctt?kn=6&m=36438196&r=MjA1NzcwMjE4MQS2&b=2&j=OTc5OTExMzMS1&mt=1&rt=0

** Condensed-matter physics: Transitions on triangles
Thomas F. Rosenbaum
An exquisitely sensitive technique shows that a magnetic field only
a few hundred times greater than Earth's can bring an exotic phase
of matter known as a quantum spin liquid to an ordered magnetic state.
http://links.ealert.nature.com/ctt?kn=7&m=36438196&r=MjA1NzcwMjE4MQS2&b=2&j=OTc5OTExMzMS1&mt=1&rt=0

NEWS & COMMENT
** Astronomy: An embarrassment of planets
http://links.ealert.nature.com/ctt?kn=22&m=36438196&r=MjA1NzcwMjE4MQS2&b=2&j=OTc5OTExMzMS1&mt=1&rt=0

** Lessons from the past
The Chernobyl disaster still has much to tell us about the long-term
risks of low-level radiation exposure. But only if the necessary
follow-up studies are supported.
http://links.ealert.nature.com/ctt?kn=91&m=36438196&r=MjA1NzcwMjE4MQS2&b=2&j=OTc5OTExMzMS1&mt=1&rt=0

** Funding studies of the unpredictable
Brajesh K. Singh
http://links.ealert.nature.com/ctt?kn=83&m=36438196&r=MjA1NzcwMjE4MQS2&b=2&j=OTc5OTExMzMS1&mt=1&rt=0

** City seeks facility bids
Hundreds of faculty posts to be created in New York.
http://links.ealert.nature.com/ctt?kn=29&m=36438196&r=MjA1NzcwMjE4MQS2&b=2&j=OTc5OTExMzMS1&mt=1&rt=0


** More News & Comment on PHYSICAL SCIENCES
http://links.ealert.nature.com/ctt?kn=51&m=36438196&r=MjA1NzcwMjE4MQS2&b=2&j=OTc5OTExMzMS1&mt=1&rt=0


======================== EARTH AND ENVIRONMENTAL SCIENCES ========================
RESEARCH
** Winter cold of eastern continental boundaries induced by warm
ocean waters
Yohai Kaspi and Tapio Schneider
In winter, northeastern North America and northeastern Asia are both
colder tha...
http://links.ealert.nature.com/ctt?kn=93&m=36438196&r=MjA1NzcwMjE4MQS2&b=2&j=OTc5OTExMzMS1&mt=1&rt=0

** A eudicot from the Early Cretaceous of China
Ge Sun, David L. Dilcher, Hongshan Wang and Zhiduan Chen
The current molecular systematics of angiosperms recognizes the basal
angiosper...
http://links.ealert.nature.com/ctt?kn=95&m=36438196&r=MjA1NzcwMjE4MQS2&b=2&j=OTc5OTExMzMS1&mt=1&rt=0

** Climate: Cold winters from warm oceans
William R. Boos
Winters are colder in northeastern North America and Asia than in other
regions at the same latitude. Previous explanations may be incomplete,
having overlooked the radiation of atmospheric wave energy.
http://links.ealert.nature.com/ctt?kn=6&m=36438196&r=MjA1NzcwMjE4MQS2&b=2&j=OTc5OTExMzMS1&mt=1&rt=0

NEWS & COMMENT
** Earth science: Mind your head
From Roman reverence to dinosaur extinctions, Birger Schmitz is riveted
by a history of the meteorite.
http://links.ealert.nature.com/ctt?kn=76&m=36438196&r=MjA1NzcwMjE4MQS2&b=2&j=OTc5OTExMzMS1&mt=1&rt=0

** Unite to assess contaminant risk
Paige J. Novak
http://links.ealert.nature.com/ctt?kn=80&m=36438196&r=MjA1NzcwMjE4MQS2&b=2&j=OTc5OTExMzMS1&mt=1&rt=0

** Funding studies of the unpredictable
Brajesh K. Singh
http://links.ealert.nature.com/ctt?kn=83&m=36438196&r=MjA1NzcwMjE4MQS2&b=2&j=OTc5OTExMzMS1&mt=1&rt=0

** City seeks facility bids
Hundreds of faculty posts to be created in New York.
http://links.ealert.nature.com/ctt?kn=29&m=36438196&r=MjA1NzcwMjE4MQS2&b=2&j=OTc5OTExMzMS1&mt=1&rt=0


** More News & Comment on EARTH AND ENVIRONMENTAL SCIENCES
http://links.ealert.nature.com/ctt?kn=50&m=36438196&r=MjA1NzcwMjE4MQS2&b=2&j=OTc5OTExMzMS1&mt=1&rt=0


======================== Specials - Technology Feature: ========================
** Tissue models: A Living system on a chip
Monya Baker
For years, scientists have struggled to reconstruct tissues and
organs by combi...
http://links.ealert.nature.com/ctt?kn=98&m=36438196&r=MjA1NzcwMjE4MQS2&b=2&j=OTc5OTExMzMS1&mt=1&rt=0

=========================== ADVERTISEMENT ===========================
Nature Special: Cancer Genomics
The complete genome sequences of a large number of cancer types are
being obtained, providing us with a comprehensive view of cancer
development. In this Nature special we showcase recent genome-based
efforts to construct such genomic profiles of cancer.

Access selected content free online for one month.
http://links.ealert.nature.com/ctt?kn=132&m=36438196&r=MjA1NzcwMjE4MQS2&b=2&j=OTc5OTExMzMS1&mt=1&rt=0
=====================================================================


======================== CAREERS & JOBS ========================
** Social media: Self-reflection, online
Some scientists might not like the persona they see when they look
online. But they can do something about it.
http://links.ealert.nature.com/ctt?kn=133&m=36438196&r=MjA1NzcwMjE4MQS2&b=2&j=OTc5OTExMzMS1&mt=1&rt=0

** Funding revamp urged
European universities call for a simpler grant-reporting system.
http://links.ealert.nature.com/ctt?kn=107&m=36438196&r=MjA1NzcwMjE4MQS2&b=2&j=OTc5OTExMzMS1&mt=1&rt=0

** Equity rising at MIT
Policies have spurred increase in female scientists.
http://links.ealert.nature.com/ctt?kn=105&m=36438196&r=MjA1NzcwMjE4MQS2&b=2&j=OTc5OTExMzMS1&mt=1&rt=0

** City seeks facility bids
Hundreds of faculty posts to be created in New York.
http://links.ealert.nature.com/ctt?kn=103&m=36438196&r=MjA1NzcwMjE4MQS2&b=2&j=OTc5OTExMzMS1&mt=1&rt=0

** Courtroom drama
Forensic science faces rough justice on both sides of the Atlantic.
http://links.ealert.nature.com/ctt?kn=101&m=36438196&r=MjA1NzcwMjE4MQS2&b=2&j=OTc5OTExMzMS1&mt=1&rt=0

** Unite to assess contaminant risk
Paige J. Novak
http://links.ealert.nature.com/ctt?kn=80&m=36438196&r=MjA1NzcwMjE4MQS2&b=2&j=OTc5OTExMzMS1&mt=1&rt=0

** Funding studies of the unpredictable
Brajesh K. Singh
http://links.ealert.nature.com/ctt?kn=83&m=36438196&r=MjA1NzcwMjE4MQS2&b=2&j=OTc5OTExMzMS1&mt=1&rt=0

** Career postdocs increase scrap heap
Robert Insall
http://links.ealert.nature.com/ctt?kn=117&m=36438196&r=MjA1NzcwMjE4MQS2&b=2&j=OTc5OTExMzMS1&mt=1&rt=0


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