| | Solution-processable 2D semiconductors for high-performance large-area electronics
By intercalating large ammonium molecules to exfoliate MoS2 with preservation of the 2H-phase, highly uniform solution-processable 2D semiconductor nanosheets are obtained for the scalable fabrication of large-area thin-film electronics.
Zhaoyang Lin, Yuan Liu, Udayabagya Halim et al. | The eukaryotic ancestor shapes up
Asgard archaea are the closest known relatives of nucleus-bearing organisms called eukaryotes. A study indicates that these archaea have a dynamic network of actin protein — a trait thought of as eukaryote-specific.
Laura Eme, Thijs J. G. Ettema | OTX2 restricts entry to the mouse germline
The transcription factor OTX2 ensures that germline induction is initially kept in check and proceeds only after OTX2 downregulation.
Jingchao Zhang, Man Zhang, Dario Acampora et al. | Crystal structure of a membrane-bound O-acyltransferase
Crystal structures of DltB, a bacterial membrane-bound O-acyltransferase, are reported both alone and in complex with the D-alanyl donor protein DltC.
Dan Ma, Zhizhi Wang, Christopher N. Merrikh et al. | CRISPR tool puts RNA on the record
The bacterial-defence system CRISPR–Cas can store DNA snippets that correspond to encountered viral RNA sequences. One such system has now been harnessed to record gene expression over time in bacteria.
Chase L. Beisel | Effects of climate warming on photosynthesis in boreal tree species depend on soil moisture
Low soil moisture may reduce, or even reverse, the potential benefits of climate warming on photosynthesis in mesic, seasonally cold environments, both during drought and in regularly occurring, modestly dry periods during the growing season.
Peter B. Reich, Kerrie M. Sendall, Artur Stefanski et al. | Handover mechanism of the growing pilus by the bacterial outer-membrane usher FimD
The structure of a pilus assembly intermediate reveals the timing of subunit polymerization and how chaperone–subunit complexes are transferred from N-terminal to C-terminal domains of the usher in the formation of bacterial pili.
Minge Du, Zuanning Yuan, Hongjun Yu et al. | Multi-axial self-organization properties of mouse embryonic stem cells into gastruloids
Cultures grown from small aggregates of mouse embryonic stem cells can be induced to organize spatial and temporal patterns of gene expression that parallel those of the early embryo, offering a potentially useful system for studying early development.
Leonardo Beccari, Naomi Moris, Mehmet Girgin et al. | Transcriptional recording by CRISPR spacer acquisition from RNA
An RNA-adapting CRISPR–Cas system is coupled with amplification and sequencing steps to record, retrieve and analyse changes in the transcriptome of a bacterial cell over time.
Florian Schmidt, Mariia Y. Cherepkova, Randall J. Platt | Antibody and TLR7 agonist delay viral rebound in SHIV-infected monkeys
In monkeys infected with an AIDS-like virus, a combination of a broadly neutralizing antibody and an immune stimulator during antiretroviral therapy suppressed viral rebound after antiretroviral drug discontinuation.
Erica N. Borducchi, Jinyan Liu, Joseph P. Nkolola et al. | Combination treatment prevents HIV re-emergence in monkeys
Antiviral drugs prevent HIV from replicating, but the virus can hide in the cells of infected individuals in a non-replicating, latent form. A two-pronged approach to target this latent virus shows promise in monkeys.
Sharon R. Lewin | Single-cell transcriptomics of 20 mouse organs creates a Tabula Muris
A 'mouse atlas', comprising single-cell transcriptomic data from more than 100,000 cells from 20 organs and tissues, has been created as a resource for cell biology.
The Tabula Muris Consortium | Genomes of Asgard archaea encode profilins that regulate actin
Asgard archaea encode functional profilins that can interact with mammalian actin, which suggests that—similar to eukaryotic cells—they possess a regulated actin cytoskeleton.
Caner Akıl, Robert C. Robinson | How to lose your inheritance
In developing embryos, molecular and physical differences divide the cells that will form eggs or sperm and those that will form the body. The mouse protein OTX2 directs this decision by blocking reproductive-cell fate.
Diana J. Laird | Foraging skills develop over generations in the wild
The movements of relocated wild animals reveal that a lost migratory skill was regained over successive generations. This suggests that skill improvements can occur over time as animals learn expertise from each other.
Andrew Whiten | Nearly all the sky is covered by Lyman-α emission around high-redshift galaxies
Lyman-α emission from atomic hydrogen shows the location of warm gas and is ubiquitous around galaxies between redshifts of 3 and 6, thereby covering nearly all of the sky.
L. Wisotzki, R. Bacon, J. Brinchmann et al. | | | A new era in the search for dark matter
The current state of the search for dark-matter particles is reviewed, and a broader experimental and theoretical approach is proposed to solve the dark-matter problem.
Gianfranco Bertone, Tim M. P. Tait | | | Plant functional trait change across a warming tundra biome
Analyses of the relationships between temperature, moisture and seven key plant functional traits across the tundra and over time show that community height increased with warming across all sites, whereas other traits lagged behind predicted rates of change.
Anne D. Bjorkman, Isla H. Myers-Smith, Sarah C. Elmendorf et al. | | Necroptosis microenvironment directs lineage commitment in liver cancer
The tumour microenvironment determines which type of liver cancer develops, with transformed hepatocytes giving rise to intrahepatic cholangiocarcinoma or hepatocellular carcinoma depending or whether they are surrounded by cells undergoing necroptosis or apoptosis.
Marco Seehawer, Florian Heinzmann, Luana D'Artista et al. | | | Asymmetric α-arylation of amino acids
This approach introduces an aryl substituent to the α-carbon of amino acids without a transition-metal catalyst, and uses the inherent chirality of the amino acid itself as the source of asymmetry.
Daniel J. Leonard, John W. Ward, Jonathan Clayden | | | | | |
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