Nature Reviews Immunology Contents October 2018 Volume 18 Number 10 pp 597-659

If you are unable to see the message below, click here to view.

Advertisement Announcing The Global Grants for Gut Health The Global Grants for Gut Health is a competitive programme for investigator-initiated research into the human gut microbiota, supported by Yakult and Nature Research.  Learn more about funding opportunities. TABLE OF CONTENTS October 2018 Volume 18, Issue 10 Comment Research Highlights Reviews   Comment   From the Human Cell Atlas to dynamic immune maps in human disease    Lorenz Adlung & Ido Amit pp597 - 598 | doi:10.1038/s41577-018-0050-2 Scientists involved in the Human Cell Atlas Project describe its potential as a resource for future research and the challenges that lie ahead. Full Text | PDF   Research Highlights   T cells home in on brain cancer Yvonne Bordon p599 | doi:10.1038/s41577-018-0069-4 T cells are engineered to home specifically to brain tumours. PDF   Baby steps for the immune system Yvonne Bordon pp600 - 601 | doi:10.1038/s41577-018-0062-y Infant immune systems are highly diverse at birth but then show convergence in the first three months of life. PDF   T cells under starter’s orders Kirsty Minton pp600 - 601 | doi:10.1038/s41577-018-0067-6 Naive CD4+ T cells are prepared for rapid activation and metabolic remodelling through the derepression of a poised translational machinery, which occurs independently of nutrient-sensing pathways. PDF   An avian foundation for dominant tolerance Adrian Liston p601 | doi:10.1038/s41577-018-0053-z Adrian Liston describes two papers by Nicole Le Douarin and colleagues from the 1980s that used a chick–quail graft system to show the existence of dominant T cell tolerance. PDF   Studying tumour-specific T cell responses in 3D Kirsty Minton pp602 - 603 | doi:10.1038/s41577-018-0058-7 Autologous T cell–tumour organoid co-cultures provide a minimally invasive method to study patient-specific antitumour immune responses. PDF   Asthma exacerbated by neutrophil ghosts Lucy Bird pp602 - 603 | doi:10.1038/s41577-018-0059-6 Neutrophil cytoplasts promote T helper 17 cell responses that propagate neutrophilic inflammation in severe asthma. PDF   Bacteria-primed T cells identified as culprit in glaucoma Alexandra Flemming p603 | doi:10.1038/s41577-018-0063-x Bacterially primed T cells reactive against heat shock proteins enter the eye and cause neurodegeneration in glaucoma. PDF   Nature Reviews Immunology EVENT Immunogenicity and Bioassay Summit 2018 22.10.18 Alexandria, USA More science events from Advertisement Accellerate Your Research Accellerate your understanding of the adaptive immune response by rapidly profiling individual human or mouse cell phenotypes at scale! 10x Genomics' Chromium Single Cell Immune Profiling Solution enables you to examine the cellular context of the adaptive immune response and immune repertoires simultaneously.  Learn more   Reviews   CAR T cells for infection, autoimmunity and allotransplantation    Colby R. Maldini, Gavin I. Ellis & James L. Riley pp605 - 616 | doi:10.1038/s41577-018-0042-2 This Review explores the challenges and opportunities of taking CARs down new therapeutic roads, in terms of developing chimeric antigen receptors (CARs) for treating infectious disease, autoimmunity and transplant rejection. Full Text | PDF   Histone deacetylase function in CD4+ T cells    Wilfried Ellmeier & Christian Seiser pp617 - 634 | doi:10.1038/s41577-018-0037-z Histone deacetylases (HDACs) and histone acetyltransferases mediate reversible acetylation of histones and many other non-histone proteins to regulate gene expression and protein function. Here, the authors describe the myriad activities of HDACs in CD4+ T cells and the potential use of HDAC inhibitors as therapeutics for immune-mediated diseases. Full Text | PDF   CD4+ T cell help in cancer immunology and immunotherapy    Jannie Borst, Tomasz Ahrends, Nikolina Bąbała, Cornelis J. M. Melief & Wolfgang Kastenmüller pp635 - 647 | doi:10.1038/s41577-018-0044-0 CD4+ T cells provide help to CD8+ T cells via lymph node-resident dendritic cells. In this Review, the authors discuss the molecular nature of help signals and how they can be harnessed to improve cancer immunotherapy. Full Text | PDF   Biology and regulation of IL-2: from molecular mechanisms to human therapy    Rosanne Spolski, Peng Li & Warren J. Leonard pp648 - 659 | doi:10.1038/s41577-018-0046-y IL-2 is well known for its crucial role in driving T cell responses. Now, with improved knowledge of its expression, signalling and regulation, the therapeutic potential of administering or inhibiting IL-2 is being explored to treat autoimmune diseases, infectious diseases and cancer. Full Text | PDF   Advertisement Nature Briefing is an essential round-up of science news, opinion and analysis, free in your inbox every weekday. With Nature Briefing, we'll keep you updated on the latest research, so you can focus on yours. Click here to sign up.   Natureevents is a fully searchable, multi-disciplinary database designed to maximise exposure for events organisers. The contents of the Natureevents Directory are now live. The digital version is available here. Find the latest scientific conferences, courses, meetings and symposia on natureevents.com. For event advertising opportunities across the Nature Publishing Group portfolio please contact natureevents@nature.com More Nature Events

You have been sent this Table of Contents Alert because you have opted in to receive it. You can change or discontinue your e-mail alerts at any time, by modifying your preferences on your nature.com account at: www.nature.com/myaccount (You will need to log in to be recognised as a nature.com registrant) For further technical assistance, please contact our registration department For print subscription enquiries, please contact our subscription department For other enquiries, please contact our customer feedback department Springer Nature | One New York Plaza, Suite 4500 | New York | NY 10004-1562 | USA Springer Nature's worldwide offices: London - Paris - Munich - New Delhi - Tokyo - Melbourne San Diego - San Francisco - Washington - New York - Boston Macmillan Publishers Limited is a company incorporated in England and Wales under company number 785998 and whose registered office is located at The Campus, 4 Crinan Street, London, N1 9XW. Nature is part of Springer Nature. © 2018 Springer Nature Limited. All rights reserved.