| | Advertisement | | Nature Sustainability publishes significant original research from a broad range of natural, social and engineering fields about sustainability, its policy dimensions and possible solutions. It brings together novel research on the drivers of human practices and their environmental and social impacts, as well as applied research that identifies viable solutions — technological, infrastructural or institutional — to sustain ecosystems and the well-being of populations across the globe. Submit your research. | | | | | | | | | | Advertisement | | | | | Advertisement | | Climate change is not the only research topic in the Earth and environmental sciences, but few researchers in the discipline work without reference to it. Just as we have depended on them to identify the problem, we look to them for solutions that will help create a better future. 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Visit our open access funding page or contact openaccess@nature.com to learn more about APC funding. | | | | Latest Comment | | | | | | | | Latest Articles | View all Articles | | | Rapid transport of deformation-tuned nanoparticles across biological hydrogels and cellular barriers OPEN | | Miaorong Yu, Lu Xu, Falin Tian, Qian Su, Nan Zheng, Yiwei Yang, Jiuling Wang, Aohua Wang, Chunliu Zhu, Shiyan Guo, XinXin Zhang, Yong Gan, Xinghua Shi & Huajian Gao | | | Penetration of the mucus and tumor interstitial matrix is an important consideration for drug delivery devices. Here, the authors report on a study into the optimization of rigidity for the transport of nanoparticles through biological hydrogels using core-shell polymer-lipid nanoparticles. | | 04 July 2018 | doi: 10.1038/s41467-018-05061-3 | | Applications of AFM Cancer therapy Microfluidics Nanoparticles Nanostructures | Deep coverage whole genome sequences and plasma lipoprotein(a) in individuals of European and African ancestries OPEN | | Seyedeh M. Zekavat, Sanni Ruotsalainen, Robert E. Handsaker, Maris Alver, Jonathan Bloom, Timothy Poterba, Cotton Seed, Jason Ernst, Mark Chaffin, Jesse Engreitz, Gina M. Peloso, Ani Manichaikul, Chaojie Yang, Kathleen A. Ryan, Mao Fu, W. Craig Johnson, Michael Tsai, Matthew Budoff, Vasan S. Ramachandran, L. Adrienne Cupples et al. | | | Circulating lipoprotein(a) is an important risk factor for cardiovascular disease and shows variability between different ethnic groups. Here, Zekavat et al. perform whole-genome sequencing in individuals of European and African ancestries and find ancestry-specific genetic determinants for lipoprotein(a) levels. | | 04 July 2018 | doi: 10.1038/s41467-018-04668-w | | Atherosclerosis Fat metabolism Genetic association study Population genetics | The REN4 rheostat dynamically coordinates the apical and lateral domains of Arabidopsis pollen tubes OPEN | | Hui Li, Nan Luo, Weidong Wang, Zengyu Liu, Jisheng Chen, Liangtao Zhao, Li Tan, Chunyan Wang, Yuan Qin, Chao Li, Tongda Xu & Zhenbiao Yang | | | Polar growth of pollen tubes is established by polar localization of ROP1 GTPase activity at the apical tip. Here, Li et al. identify REN4 as a ROP1 interaction partner that restrains the ROP1 distribution to the apex by promoting ROP1 endocytosis from lateral domains of the pollen tube membrane. | | 03 July 2018 | doi: 10.1038/s41467-018-04838-w | | Apicobasal polarity Plant polarity Pollen Pollen tube | Postprandial FGF19-induced phosphorylation by Src is critical for FXR function in bile acid homeostasis OPEN | | Sangwon Byun, Dong-Hyun Kim, Daniel Ryerson, Young-Chae Kim, Hao Sun, Bo Kong, Peter Yau, Grace Guo, H. Eric Xu, Byron Kemper & Jongsook Kim Kemper | | | FXR plays an important role in bile acid homeostasis by transcriptionally modulating several enterohepatic genes, including intestinal FGF19, that repress hepatic bile acid synthesis. Here the authors show that postprandial FGF19 regulates FXR transcriptional activity via its action on the tyrosine kinase Src, which phosphorylates FXR. | | 03 July 2018 | doi: 10.1038/s41467-018-04697-5 | | Cholestasis Homeostasis Phosphorylation Primary biliary cirrhosis | Monoacylglycerol lipase regulates cannabinoid receptor 2-dependent macrophage activation and cancer progression OPEN | | Wei Xiang, Rongchen Shi, Xia Kang, Xuan Zhang, Peng Chen, Lili Zhang, Along Hou, Rui Wang, Yuanyin Zhao, Kun Zhao, Yingzhe Liu, Yue Ma, Huan Luo, Shenglan Shang, Jinyu Zhang, Fengtian He, Songtao Yu, Lixia Gan, Chunmeng Shi, Yongsheng Li et al. | | | Tumour associated macrophages (TAMs) have an altered lipid metabolism. Here the authors show that downregulation of monoacylglycerols lipase MGLL in TAMs induces lipid accumulation and tumor progression by polarizing TAMs toward tumor-promoting through activation of cannabinoid receptor CB2. | | 03 July 2018 | doi: 10.1038/s41467-018-04999-8 | | Cancer microenvironment Tumour immunology | Discovery of coexisting Dirac and triply degenerate magnons in a three-dimensional antiferromagnet OPEN | | Song Bao, Jinghui Wang, Wei Wang, Zhengwei Cai, Shichao Li, Zhen Ma, Di Wang, Kejing Ran, Zhao-Yang Dong, D. L. Abernathy, Shun-Li Yu, Xiangang Wan, Jian-Xin Li & Jinsheng Wen | | | Topological magnonic materials display exotic properties which may enable high-efficiency and low-cost spintronic devices. Here the authors demonstrate a three-dimensional antiferromagnet Cu3TeO6 that hosts symmetry-protected Dirac and triply degenerate magnons. | | 03 July 2018 | doi: 10.1038/s41467-018-05054-2 | | Magnetic properties and materials Topological matter | The role of momentum-dark excitons in the elementary optical response of bilayer WSe2 OPEN | | Jessica Lindlau, Malte Selig, Andre Neumann, Léo Colombier, Jonathan Förste, Victor Funk, Michael Förg, Jonghwan Kim, Gunnar Berghäuser, Takashi Taniguchi, Kenji Watanabe, Feng Wang, Ermin Malic & Alexander Högele | | | The electronic band structure of atomically thin transition metal dichalcogenides is strongly sensitive to the number of layers, resulting in modified light emission. Here, the authors investigate the cryogenic emission from bilayer WSe2 to identify the role of momentum-indirect excitons for its optical response. | | 03 July 2018 | doi: 10.1038/s41467-018-04877-3 | | Two-dimensional materials | Spin–phonon couplings in transition metal complexes with slow magnetic relaxation OPEN | | Duncan H. Moseley, Shelby E. Stavretis, Komalavalli Thirunavukkuarasu, Mykhaylo Ozerov, Yongqiang Cheng, Luke L. Daemen, Jonathan Ludwig, Zhengguang Lu, Dmitry Smirnov, Craig M. Brown, Anup Pandey, A. J. Ramirez-Cuesta, Adam C. Lamb, Mihail Atanasov, Eckhard Bill, Frank Neese & Zi-Ling Xue | | | Transition metal complexes that display slow magnetic relaxation show promise for information storage, but our mechanistic understanding of the magnetic relaxation of such compounds remains limited. Here, the authors spectroscopically and computationally characterize the strength of spin–phonon couplings, which play an important role in the relaxation process. | | 03 July 2018 | doi: 10.1038/s41467-018-04896-0 | | Electronic structure of atoms and molecules Inorganic chemistry Magnetic materials Optical spectroscopy | Novofumigatonin biosynthesis involves a non-heme iron-dependent endoperoxide isomerase for orthoester formation OPEN | | Yudai Matsuda, Tongxuan Bai, Christopher B. W. Phippen, Christina S. Nødvig, Inge Kjærbølling, Tammi C. Vesth, Mikael R. Andersen, Uffe H. Mortensen, Charlotte H. Gotfredsen, Ikuro Abe & Thomas O. Larsen | | | Novofumigatonin is a meroterpenoid found in the fungus Aspergillus novofumigatus. Here, the authors elucidate the biosynthetic pathway of novofumigatonin and show that the endoperoxidase NvfI and the endoperoxide isomerase NvfE are involved in it. | | 03 July 2018 | doi: 10.1038/s41467-018-04983-2 | | Biocatalysis Isomerases | Evidence for line width and carrier screening effects on excitonic valley relaxation in 2D semiconductors OPEN | | Yuhei Miyauchi, Satoru Konabe, Feijiu Wang, Wenjin Zhang, Alexander Hwang, Yusuke Hasegawa, Lizhong Zhou, Shinichiro Mouri, Minglin Toh, Goki Eda & Kazunari Matsuda | | | Atomically thin transition metal dichalcogenides offer a platform to explore the valley degree of freedom originating from their electronic band structure. Here, the authors use polarization- and time-resolved spectroscopy to investigate the temperature-dependent valley pseudospin relaxation processes in WSe2 monolayers. | | 03 July 2018 | doi: 10.1038/s41467-018-04988-x | | Two-dimensional materials | Control over the emerging chirality in supramolecular gels and solutions by chiral microvortices in milliseconds OPEN | | Jiashu Sun, Yike Li, Fusheng Yan, Chao Liu, Yutao Sang, Fei Tian, Qiang Feng, Pengfei Duan, Li Zhang, Xinghua Shi, Baoquan Ding & Minghua Liu | | | Symmetry breaking and chiral amplification are fundamental principles in chemistry and biology but the control of initial chiral bias remains a great challenge. Here the authors show that chiral microvortices can lead to a selection of initial chiral bias of supramolecular systems composed of achiral molecules. | | 03 July 2018 | doi: 10.1038/s41467-018-05017-7 | | Mechanical engineering Self-assembly | Topochemical conversion of an imine- into a thiazole-linked covalent organic framework enabling real structure analysis OPEN | | Frederik Haase, Erik Troschke, Gökcen Savasci, Tanmay Banerjee, Viola Duppel, Susanne Dörfler, Martin M. J. Grundei, Asbjörn M. Burow, Christian Ochsenfeld, Stefan Kaskel & Bettina V. Lotsch | | | Stabilization of covalent organic frameworks (COFs) by post-synthetic locking is a powerful tool to push the limits of COF utilization. Here the authors demonstrate a sulfur-assisted conversion of an imine-linked COF into a thiazole-linked COF, with retention of crystallinity and porosity, allowing for direct imaging of defects in COFs. | | 03 July 2018 | doi: 10.1038/s41467-018-04979-y | | Organic molecules in materials science Structural properties | Genomic analysis of a pre-elimination Malaysian Plasmodium vivax population reveals selective pressures and changing transmission dynamics OPEN | | Sarah Auburn, Ernest D. Benavente, Olivo Miotto, Richard D. Pearson, Roberto Amato, Matthew J. Grigg, Bridget E. Barber, Timothy William, Irene Handayuni, Jutta Marfurt, Hidayat Trimarsanto, Rintis Noviyanti, Kanlaya Sriprawat, Francois Nosten, Susana Campino, Taane G. Clark, Nicholas M. Anstey, Dominic P. Kwiatkowski & Ric N. Price | | | Plasmodium vivax incidence in Malaysia has declined markedly over the last decade, despite evidence of chloroquine resistance. Here, Auburn et al. compare population structure of P. vivax in Malaysia to regions with intermediate and high transmission and identify genetic regions under putative selection. | | 03 July 2018 | doi: 10.1038/s41467-018-04965-4 | | Epidemiology Parasite genetics Parasite genomics Population genetics | TGF-β signaling alters H4K20me3 status via miR-29 and contributes to cellular senescence and cardiac aging OPEN | | Guoliang Lyu, Yiting Guan, Chao Zhang, Le Zong, Lei Sun, Xiaoke Huang, Li Huang, Lijun Zhang, Xiao-Li Tian, Zhongjun Zhou & Wei Tao | | | Cellular senescence is associated with epigenetic remodeling. Here, the authors report that TGF-β signaling promotes miR-29 mediated loss of H4K20me3 thus accelerating senescence. | | 02 July 2018 | doi: 10.1038/s41467-018-04994-z | | Cell biology Senescence | Human in vivo-generated monocyte-derived dendritic cells and macrophages cross-present antigens through a vacuolar pathway OPEN | | Tsing-Lee Tang-Huau, Paul Gueguen, Christel Goudot, Mélanie Durand, Mylène Bohec, Sylvain Baulande, Benoit Pasquier, Sebastian Amigorena & Elodie Segura | | | Cross-presentation, or the presentation of exogenous antigens on MHC-I, is thought to be restricted to dendritic cells (DCs). Here the authors show that human DCs and macrophages developed in vivo from monocytes can both perform cross-presentation using a non-conventional pathway, but only DCs are capable of inducing cytotoxic CD8+ T cells. | | 02 July 2018 | doi: 10.1038/s41467-018-04985-0 | | Antigen processing and presentation Cellular immunity Dendritic cells Peritoneal macrophages | CEACAM1 promotes CD8+ T cell responses and improves control of a chronic viral infection OPEN | | Vishal Khairnar, Vikas Duhan, Ashwini M. Patil, Fan Zhou, Hilal Bhat, Christine Thoens, Piyush Sharma, Tom Adomati, Sarah-Kim Friendrich, Judith Bezgovsek, Janine D. Dreesen, Gunther Wennemuth, Astrid M. Westendorf, Gennadiy Zelinskyy, Ulf Dittmer, Cornelia Hardt, Jörg Timm, Joachim R. Göthert, Philipp A. Lang, Bernhard B. Singer et al. | | | Chronic viral infections are frequently associated with the dysfunction of CD8+ T cells which includes loss of function and results in CD8+ T cell exhaustion. Here the authors show a role of CEACAM1 in promoting responsive CD8+ T cells in the context of a chronic lymphocytic choriomeningitis virus (LCMV) infection model. | | 02 July 2018 | doi: 10.1038/s41467-018-04832-2 | | CD8-positive T cells Cellular immunity Viral infection | Prognostic significance of frequent CLDN18-ARHGAP26/6 fusion in gastric signet-ring cell cancer OPEN | | Yang Shu, Weihan Zhang, Qianqian Hou, Linyong Zhao, Shouyue Zhang, Jiankang Zhou, Xiaohai Song, Yan Zhang, Dan Jiang, Xinzu Chen, Peiqi Wang, Xuyang Xia, Fei Liao, Dandan Yin, Xiaolong Chen, Xueyan Zhou, Duyu Zhang, Senlin Yin, Kun Yang, Jianping Liu et al. | | | Signet-ring cell carcinoma (SRCC) is a unique type of gastric cancer with no prognostic features. Here, the authors report a CLDN18-ARHGAP26/6 gene fusion in patients with a high signet-ring cell content, poor survival outcomes, and who experience no benefit from platinum/fluoropyrimidines-based chemotherapy. | | 30 June 2018 | doi: 10.1038/s41467-018-04907-0 | | Cancer genomics Gastric cancer | High-performance bifunctional porous non-noble metal phosphide catalyst for overall water splitting OPEN | | Fang Yu, Haiqing Zhou, Yufeng Huang, Jingying Sun, Fan Qin, Jiming Bao, William A. Goddard III, Shuo Chen & Zhifeng Ren | | | Water electrolysis provides a carbon-neutral means to generate hydrogen fuel from water, but the process typically requires expensive, rare metal catalysts. Here, the authors prepare hydrogen- and oxygen-evolving electrocatalysts from earth-abundant elements that outperform noble-metal counterparts. | | 29 June 2018 | doi: 10.1038/s41467-018-04746-z | | Electrocatalysis Materials chemistry Nanoscale materials | Targeting EZH2 reactivates a breast cancer subtype-specific anti-metastatic transcriptional program OPEN | | Alison Hirukawa, Harvey W. Smith, Dongmei Zuo, Catherine R. Dufour, Paul Savage, Nicholas Bertos, Radia M. Johnson, Tung Bui, Guillaume Bourque, Mark Basik, Vincent Giguère, Morag Park & William J. Muller | | | Histone modifications in cancer can contribute to pathogenesis. Here, the authors demonstrate that targeting epigenetic modifier Ezh2 hinders metastatic behaviour in Luminal B breast cancer models, and highlight a mechanism where Ezh2 contributes to metastatic behaviour by repression of FOXC1. | | 29 June 2018 | doi: 10.1038/s41467-018-04864-8 | | Breast cancer Metastasis | Oridonin is a covalent NLRP3 inhibitor with strong anti-inflammasome activity OPEN | | Hongbin He, Hua Jiang, Yun Chen, Jin Ye, Aoli Wang, Chao Wang, Qingsong Liu, Gaolin Liang, Xianming Deng, Wei Jiang & Rongbin Zhou | | | The small molecule oridonin (Ori) from the traditional Chinese herb Rabdosia rubescens has anti-inflammatory activity. Here the authors show that Ori can be covalently linked to NLRP3 to prevent assembly of the NLRP3 inflammasome, and to ameliorate inflammation in several mouse disease models. | | 29 June 2018 | doi: 10.1038/s41467-018-04947-6 | | Chronic inflammation Inflammasome Target identification Target validation | 2D transition metal dichalcogenides with glucan multivalency for antibody-free pathogen recognition OPEN | | Tae Woog Kang, Juhee Han, Sin Lee, In-Jun Hwang, Su-Ji Jeon, Jong-Min Ju, Man-Jin Kim, Jin-Kyoung Yang, Byoengsun Jun, Chi Ho Lee, Sang Uck Lee & Jong-Ho Kim | | | The detection of pathogenic microorganisms is key consideration for safety across a wide range of fields. Here, the authors report on the simultaneous exfoliation and functionalisation of transition metal dichalcogenides with dextran for antibody-free detection of pathogenic Escherichia coli. | | 29 June 2018 | doi: 10.1038/s41467-018-04997-w | | Bacteria Biosensors Two-dimensional materials | Understanding crystallization pathways leading to manganese oxide polymorph formation OPEN | | Bor-Rong Chen, Wenhao Sun, Daniil A. Kitchaev, John S. Mangum, Vivek Thampy, Lauren M. Garten, David S. Ginley, Brian P. Gorman, Kevin H. Stone, Gerbrand Ceder, Michael F. Toney & Laura T. Schelhas | | | Minor variations in synthesis conditions can redirect crystallization pathways through different nonequilibrium intermediates. Here, the authors present a theoretical framework to predict which polymorphs appear during MnO2 precipitation, which is validated by in situ X-ray scattering of reaction progression. | | 29 June 2018 | doi: 10.1038/s41467-018-04917-y | | Computational chemistry Materials chemistry Materials for energy and catalysis | Surface ocean pH variations since 1689 CE and recent ocean acidification in the tropical South Pacific OPEN | | Henry C. Wu, Delphine Dissard, Eric Douville, Dominique Blamart, Louise Bordier, Aline Tribollet, Florence Le Cornec, Edwige Pons-Branchu, Arnaud Dapoigny & Claire E. Lazareth | | | Ocean acidification due to the industrial era is a major marine environmental concern, yet little is known on the historical ocean pH changes prior to human influence. Here, Wu et al. show that tropical South Pacific seawater pH is linked to ENSO pacing and has recently been decreasing rapidly. | | 29 June 2018 | doi: 10.1038/s41467-018-04922-1 | | Biogeochemistry Climate change Climate sciences Ocean sciences Palaeoceanography | Pervasive genetic interactions modulate neurodevelopmental defects of the autism-associated 16p11.2 deletion in Drosophila melanogaster OPEN | | Janani Iyer, Mayanglambam Dhruba Singh, Matthew Jensen, Payal Patel, Lucilla Pizzo, Emily Huber, Haley Koerselman, Alexis T. Weiner, Paola Lepanto, Komal Vadodaria, Alexis Kubina, Qingyu Wang, Abigail Talbert, Sneha Yennawar, Jose Badano, J. Robert Manak, Melissa M. Rolls, Arjun Krishnan & Santhosh Girirajan | | | The 16p11.2 deletion leads to a range of neurodevelopmental phenotypes, but to date, sequencing studies have not been able to pinpoint individual genes that are causative for the disease on their own. Here, using Drosophila homologs of 14 16p11.2 genes, the authors take a combinatorial approach to show that gene interactions contribute to a neurological phenotype. | | 29 June 2018 | doi: 10.1038/s41467-018-04882-6 | | Autism spectrum disorders Medical genomics | Harnessing synthetic lethality to predict the response to cancer treatment OPEN | | Joo Sang Lee, Avinash Das, Livnat Jerby-Arnon, Rand Arafeh, Noam Auslander, Matthew Davidson, Lynn McGarry, Daniel James, Arnaud Amzallag, Seung Gu Park, Kuoyuan Cheng, Welles Robinson, Dikla Atias, Chani Stossel, Ella Buzhor, Gidi Stein, Joshua J. Waterfall, Paul S. Meltzer, Talia Golan, Sridhar Hannenhalli et al. | | | Synthetic lethality (SL) offers a new precision oncology approach, which is based on targeting cancer-specific vulnerabilities across the whole genome, going beyond cancer drivers. The authors develop an approach termed ISLE to identify clinically relevant SL interactions and use them for patient stratification and novel target identification. | | 29 June 2018 | doi: 10.1038/s41467-018-04647-1 | | Cancer genomics Predictive markers Statistical methods | Doping-induced structural phase transition in cobalt diselenide enables enhanced hydrogen evolution catalysis OPEN | | Ya-Rong Zheng, Ping Wu, Min-Rui Gao, Xiao-Long Zhang, Fei-Yue Gao, Huan-Xin Ju, Rui Wu, Qiang Gao, Rui You, Wei-Xin Huang, Shou-Jie Liu, Shan-Wei Hu, Junfa Zhu, Zhenyu Li & Shu-Hong Yu | | | Transition metal dichalcogenides represent an exciting class of earth-abundant hydrogen-from-water electrocatalysts, although low efficiencies limit commercialization. Here, authors present a doping strategy to induce a phase transition in cobalt selenide and boost H2-evolution performance. | | 28 June 2018 | doi: 10.1038/s41467-018-04954-7 | | Electrocatalysis Solid-state chemistry Structural properties | Quantitative spatial analysis of haematopoiesis-regulating stromal cells in the bone marrow microenvironment by 3D microscopy OPEN | | Alvaro Gomariz, Patrick M. Helbling, Stephan Isringhausen, Ute Suessbier, Anton Becker, Andreas Boss, Takashi Nagasawa, Grégory Paul, Orcun Goksel, Gábor Székely, Szymon Stoma, Simon F. Nørrelykke, Markus G. Manz & César Nombela-Arrieta | | | The bone marrow microenvironment modulates haematopoiesis, stem cell maintenance and differentiation. Here, the authors use 3D microscopy to map the topography of haematopoietic stem cell niche stromal components. | | 28 June 2018 | doi: 10.1038/s41467-018-04770-z | | Confocal microscopy Haematopoiesis Image processing Statistical methods Stem-cell niche | Footprints of parasitism in the genome of the parasitic flowering plant Cuscuta campestris OPEN | | Alexander Vogel, Rainer Schwacke, Alisandra K. Denton, Björn Usadel, Julien Hollmann, Karsten Fischer, Anthony Bolger, Maximilian H.-W. Schmidt, Marie E. Bolger, Heidrun Gundlach, Klaus F. X. Mayer, Hanna Weiss-Schneeweiss, Eva M. Temsch & Kirsten Krause | | | Parasitic lifestyles leave unique genomic footprints. Here, the authors describe the genome sequence of a parasitic plant, Cuscuta campestris, and find that gene losses and host gene acquisitions reflect the independence from photosynthesis and the ability to retain and express chunks of foreign genomic DNA. | | 28 June 2018 | doi: 10.1038/s41467-018-04344-z | | Genome evolution Plant molecular biology | FRET-enhanced photostability allows improved single-molecule tracking of proteins and protein complexes in live mammalian cells OPEN | | Srinjan Basu, Lisa-Maria Needham, David Lando, Edward J. R. Taylor, Kai J. Wohlfahrt, Devina Shah, Wayne Boucher, Yi Lei Tan, Lawrence E. Bates, Olga Tkachenko, Julie Cramard, B. Christoffer Lagerholm, Christian Eggeling, Brian Hendrich, Dave Klenerman, Steven F. Lee & Ernest D. Laue | | | Single molecule tracking of fluorescent proteins in live cells is temporally limited by fluorophore photobleaching. Here the authors show using fluorophore pairs that FRET competes with photobleaching to improve photostability and allow longer-term tracking of both single proteins and complexes. | | 28 June 2018 | doi: 10.1038/s41467-018-04486-0 | | Cellular imaging Fluorescence imaging Single-molecule biophysics Super-resolution microscopy | Promoter interactome of human embryonic stem cell-derived cardiomyocytes connects GWAS regions to cardiac gene networks OPEN | | Mun-Kit Choy, Biola M. Javierre, Simon G. Williams, Stephanie L. Baross, Yingjuan Liu, Steven W. Wingett, Artur Akbarov, Chris Wallace, Paula Freire-Pritchett, Peter J. Rugg-Gunn, Mikhail Spivakov, Peter Fraser & Bernard D. Keavney | | | Human embryonic stem cell-derived cardiomyocytes (hESC-CM) are a widely used model to study cardiac genomics. Here, Choy et al. perform promoter capture Hi-C to map long-range chromosomal interactions of hESC-CMs and to study overlap of such regions with genetic loci associated with cardiac phenotypes. | | 28 June 2018 | doi: 10.1038/s41467-018-04931-0 | | Cardiovascular genetics Chromatin structure Gene regulation Genetic variation | Molecular basis of Tousled-Like Kinase 2 activation OPEN | | Gulnahar B. Mortuza, Dario Hermida, Anna-Kathrine Pedersen, Sandra Segura-Bayona, Blanca López-Méndez, Pilar Redondo, Patrick Rüther, Irina Pozdnyakova, Ana M. Garrote, Inés G. Muñoz, Marina Villamor-Payà, Cristina Jauset, Jesper V. Olsen, Travis H. Stracker & Guillermo Montoya | | | The Tousled-like kinase (TLKs) family belongs to a distinct branch of Ser/Thr kinases that exhibit the highest levels of activity during DNA replication. Here the authors present the crystal structure of the kinase domain from human TLK2 and propose an activation model for TLK2 based on biochemical and phosphoproteomics experiments. | | 28 June 2018 | doi: 10.1038/s41467-018-04941-y | | Biophysics Chromatin Molecular biology X-ray crystallography | Excited-state vibrational dynamics toward the polaron in methylammonium lead iodide perovskite OPEN | | Myeongkee Park, Amanda J. Neukirch, Sebastian E. Reyes-Lillo, Minliang Lai, Scott R. Ellis, Daniel Dietze, Jeffrey B. Neaton, Peidong Yang, Sergei Tretiak & Richard A. Mathies | | | Elucidating electron-phonon coupling in hybrid organic-inorganic perovskites may help us to understand the high photovoltaic efficiency. Here, the authors observe low-frequency Raman modes and related nuclear displacements of the Pb–I framework, indicating how these vibrational motions lead to polaron formation in perovskites. | | 28 June 2018 | doi: 10.1038/s41467-018-04946-7 | | Chemistry Materials science | Astrometrically registered maps of H2O and SiO masers toward VX Sagittarii OPEN | | Dong-Hwan Yoon, Se-Hyung Cho, Youngjoo Yun, Yoon Kyung Choi, Richard Dodson, María Rioja, Jaeheon Kim, Hiroshi Imai, Dongjin Kim, Haneul Yang & Do-Young Byun | | | The red supergiant VX Sagittarii is a strong emitter of H2O and SiO masers, however its mass loss dynamics are still poorly understood. Here, the authors present astrometrically registered, simultaneous maps of SiO and H2O maser regions, and provide observational evidence for a break in spherical symmetry between the SiO and H2O maser zone. | | 28 June 2018 | doi: 10.1038/s41467-018-04767-8 | | Interstellar medium Stars | | | | | | | | Latest Correspondence | | | | On the origin of molecular oxygen in cometary comae OPEN | | K. L. Heritier, K. Altwegg, J.-J. Berthelier, A. Beth, C. M. Carr, J. De Keyser, A. I. Eriksson, S. A. Fuselier, M. Galand, T. I. Gombosi, P. Henri, F. L. Johansson, H. Nilsson, M. Rubin, C. Simon Wedlund, M. G. G. T. Taylor & E Vigren | | 03 July 2018 | doi: 10.1038/s41467-018-04972-5 | | Asteroids, comets and Kuiper belt Astronomy and planetary science | Reply to ‘Misestimation of heritability and prediction accuracy of male-pattern baldness’ OPEN | | Nicola Pirastu, Peter K. Joshi, Paul S. de Vries, Marilyn C. Cornelis, NaNa Keum, Nora Franceschini, Marco Colombo, Edward L. Giovannucci, Athina Spiliopoulou, Lude Franke, Kari E. North, Peter Kraft, Alanna C. Morrison, Tõnu Esko & James F. Wilson | | 29 June 2018 | doi: 10.1038/s41467-018-04808-2 | | Genetic predisposition to disease Genome-wide association studies | | | | | Latest Author Corrections | | | | Author Correction: GWAS for male-pattern baldness identifies 71 susceptibility loci explaining 38% of the risk OPEN | | Nicola Pirastu, Peter K. Joshi, Paul S. de Vries, Marilyn C. Cornelis, Paul M. McKeigue, NaNa Keum, Nora Franceschini, Marco Colombo, Edward L. Giovannucci, Athina Spiliopoulou, Lude Franke, Kari E. North, Peter Kraft, Alanna C. Morrison, Tõnu Esko & James F. Wilson | | 29 June 2018 | doi: 10.1038/s41467-018-04857-7 | | Genetic predisposition to disease Genome-wide association studies | Author Correction: TRPV1 SUMOylation regulates nociceptive signaling in models of inflammatory pain OPEN | | Yan Wang, Yingwei Gao, Quan Tian, Qi Deng, Yangbo Wang, Tian Zhou, Qiang Liu, Kaidi Mei, Yingping Wang, Huiqing Liu, Ruining Ma, Yuqiang Ding, Weifang Rong, Jinke Cheng, Jing Yao, Tian-Le Xu, Michael X. Zhu & Yong Li | | 28 June 2018 | doi: 10.1038/s41467-018-05022-w | | Chronic pain Post-translational modifications Transient receptor potential channels | | | | | Advertisement | | KACST Impact KACST Impact is a new online publication highlighting the latest cutting edge scientific research conducted at King Abdulaziz City for Science and Technology (KACST) that features various stories ranging from exciting new scientific finds to the commercialization of innovative discoveries. 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I think this site is useful in all that is suffering from HPV can show it to their friends and family and then there is a greater understanding I don't just know the reason why some people are finding it difficult to believe that, there is a cure for HPV, I have been suffering from HPV since 9month now but today I am happy that i am cure from it with the herbal medicine of Dr.Ben the great healer sent to me,I was browsing the internet searching for help when I came across a testimony shared by someone on how Dr.Ben cure his HPV I was so much in need of getting his treatment so I contacted Dr.Ben for the HPV cure.I am so much happy today that we have someone like this great herbal Dr Ben who has the cure to all types of virus contact Dr Ben on email address:
Benherbalcure@gmail.com
WhatsApp +2347064294395
Website http://benherbalcure.webs.com/
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