Nature Cell Biology contents: December 2016 Volume 18 Number 12, pp 1261 - 1367

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Advertisement SEE MORE THAN BEFORE Introducing the Eclipse Ti2 Inverted Microscope from Nikon. With its unprecedented 25mm field of view, you can capture twice as much data with a single image. The 4th generation Perfect Focus System combined with a completely redesigned Z-drive provide a super-stable imaging platform with high-precision focusing for demanding applications. For more info, go to www.nikon-ti2.com and stop by Nikon's booth at ASCB. TABLE OF CONTENTS December 2016 Volume 18, Issue 12 Obituary News and Views Articles Letter Erratum Advertisement   Deeper and Broader Analysis of the Metabolome No one type of analytical separation or detection technique is capable of characterizing the entire metabolome at once. A suite of technologies can offer broader and deeper analyses into the metabolome - from sample collection to interpretation.  Learn more about solutions designed to meet your metabolomics goals. Subscribe   Facebook   RSS   Recommend to library   Twitter   Advertisement Nature Outlook: Lysosomal Storage Disorders Lysosomal storage disorders are individually rare but collectively common. The study of these diseases is not only leading to better treatments, but also revealing many of the secrets of this underappreciated organelle.  Access the Outlook > Produced with support from:  Alexion Pharmaceuticals, Inc. Ultragenyx Pharmaceutical Inc. Produced with support of a grant from: Shire plc BioMarin Pharmaceutical Inc     Advertisement In January 2017 Cell Press will take over publishing the Molecular Therapy family of journals. To keep receiving e-alerts for these titles, please visit http://www.cell.com/molecular-therapy-family/home   Obituary Top Andrzej K. Tarkowski 1933-2016   p1261 Magdalena Zernicka-Goetz doi:10.1038/ncb3446 News and Views Top IQGAP1 makes PI(3)K signalling as easy as PIP, PIP2, PIP3   pp1263 - 1265 Lucia E. Rameh and Ashley M. Mackey doi:10.1038/ncb3440 Despite being one of the most studied signalling pathways, precisely how phospholipid synthesis is regulated in the phosphoinositide signalling cascade remains unclear. The scaffold protein IQGAP1 is now shown to orchestrate the assembly of a multi-enzyme complex that streamlines PtdIns(3,4,5)P3 synthesis to facilitate Akt activation in response to extracellular stimuli. See also: Article by Choi et al. Getting a grip on collective cell migration   pp1265 - 1267 Tamal Das and Joachim P. Spatz doi:10.1038/ncb3447 Many cell types in our body move in a collective manner, which requires individual cells to align their movements relative to that of their neighbours. A mechanism is now described in which cadherin-rich protrusions are extended from leading migrating cells and engulfed by follower cells to guide collective migration. See also: Article by Hayer et al. Remodelling germ cells by intercellular cannibalism   pp1267 - 1268 Jennifer K. Heppert and Bob Goldstein doi:10.1038/ncb3449 Work from the early 1980s reported strange lobes protruding from Caenorhabditis elegans germ cell precursors. However, the fate and potential significance of these lobes remained unexplored for decades. Now, neighbouring endodermal cells are shown to sever and digest these lobes, in an unexpected process of 'intercellular cannibalism', which could play an important part in regulating primordial germ cells. See also: Article by Abdu et al. Cell Biology JOBS of the week Director of the Stem Cell Biology Program University of Illinois at Chicago - Pharmacology Scientific Editor, Cell Press Elsevier Postdoctoral Scientist in Molecular genetics of human T cell development Ghent University Postdoc Positions in Cell Biology and Molecular Neuroscience Laboratory Lee Kong Chian School of Medicine, Joint medical school between, Imperial College London and Nanyang Technological University in Singapore Scientist (Ph.D)-Stem cell and ovarian tissue Engineering Fuent Biotechnology (shanghai) Co.,Ltd. More Science jobs from Cell Biology EVENT Genome rearrangements and mutation signatures in development and cancer 18.04.17 Boston, USA More science events from Advertisement Need access to Nature Plants at your workplace or institution? Site license access offers full online content plus added benefits!  Recommend site license access to your librarian.   Articles Top Direct reprogramming of fibroblasts into renal tubular epithelial cells by defined transcription factors   pp1269 - 1280 Michael M. Kaminski, Jelena Tosic, Catena Kresbach, Hannes Engel, Jonas Klockenbusch et al. doi:10.1038/ncb3437 Kaminski et al. demonstrate that combined expression of the transcription factors Emx2, Hnf1b, Hnf4a and Pax8 converts mouse and human fibroblasts into induced renal tubular epithelial cells. Crumbs2 promotes cell ingression during the epithelial-to-mesenchymal transition at gastrulation   pp1281 - 1291 Nitya Ramkumar, Tatiana Omelchenko, Nancy F. Silva-Gagliardi, C. Jane McGlade, Jan Wijnholds et al. doi:10.1038/ncb3442 Ramkumar et al. demonstrate that Crumbs2 is required in the cells of the primitive streak to promote cell ingression during the epithelial-to-mesenchymal transition, and maintains the integrity of the epiblast. Asymmetric division coordinates collective cell migration in angiogenesis   pp1292 - 1301 Guilherme Costa, Kyle I. Harrington, Holly E. Lovegrove, Donna J. Page, Shilpa Chakravartula et al. doi:10.1038/ncb3443 Costa et al. show that asymmetric positioning of the mitotic spindle during endothelial tip cell divisions produces daughter cells of different sizes and the ensuing asymmetry of Vegfr distribution drives Notch-independent tip/stalk cell selection. Developmentally programmed germ cell remodelling by endodermal cell cannibalism   pp1302 - 1310 Yusuff Abdu, Chelsea Maniscalco, John M. Heddleston, Teng-Leong Chew and Jeremy Nance doi:10.1038/ncb3439 Caenorhabditis elegans primordial germ cells (PGCs) transiently extend large lobes, which are found to be actively removed and digested by endodermal cells to alter PGC content in a process dependent on actin and dynamin. See also: News and Views by Heppert & Goldstein Engulfed cadherin fingers are polarized junctional structures between collectively migrating endothelial cells   pp1311 - 1323 Arnold Hayer, Lin Shao, Mingyu Chung, Lydia-Marie Joubert, Hee Won Yang et al. doi:10.1038/ncb3438 Hayer et al. observe that collectively migrating endothelial cells extend rear VE-cadherin-rich membrane structures that are engulfed by follower cells, correlating spatially with the direction of movement. See also: News and Views by Das & Spatz Agonist-stimulated phosphatidylinositol-3,4,5-trisphosphate generation by scaffolded phosphoinositide kinases   pp1324 - 1335 Suyong Choi, Andrew C. Hedman, Samar Sayedyahossein, Narendra Thapa, David B. Sacks et al. doi:10.1038/ncb3441 Anderson et al. show that IQ-motif-containing GTPase-activating protein 1 (IQGAP1) acts as a scaffold for the phosphoinositide kinases that mediate the sequential phosphorylation of phosphoinositides to generate PtdIns(3,4,5)P3 and downstream signalling. See also: News and Views by Rameh & Mackey Tissue mechanics promote IDH1-dependent HIF1α-tenascin C feedback to regulate glioblastoma aggression   pp1336 - 1345 Yekaterina A. Miroshnikova, Janna K. Mouw, J. Matthew Barnes, Michael W. Pickup, Johnathan N. Lakins et al. doi:10.1038/ncb3429 Weaver and colleagues report that enrichment of the extracellular matrix with tenascin C promotes aggressiveness of IDH1-mutant glioblastoma by activating a HIF1α-controlled mechanosignalling feedback loop. Lgr6 labels a rare population of mammary gland progenitor cells that are able to originate luminal mammary tumours   pp1346 - 1356 Leander Blaas, Fabio Pucci, Hendrik A. Messal, Agneta B. Andersson, E. Josue Ruiz et al. doi:10.1038/ncb3434 Blaas et al. traced Lgr6+ cells during mammary gland formation, homeostasis, pregnancy and tumorigenesis, and found that they represent a population of unipotent progenitors that contribute to alveologenesis and can initiate luminal mammary tumours. Advertisement Nature Index 2016 Australia & New Zealand Nature Index 2016 Australia and New Zealand highlights the quality natural science research within these countries. This supplement examines the cities and institutions that largely contribute to the research as well as the factors that drive their success.  Access the free supplement for six months!     Letter Top SCAI promotes DNA double-strand break repair in distinct chromosomal contexts   pp1357 - 1366 Rebecca Kring Hansen, Andreas Mund, Sara Lund Poulsen, Maria Sandoval, Karolin Klement et al. doi:10.1038/ncb3436 Hansen et al. find that SCAI (suppressor of cancer cell invasion) is a 53BP1-binding protein that acts to repair in heterochromatin and to facilitate meiotic recombination in germ cells. Erratum Top Erratum: Activating ATR, the devil's in the dETAA1l   p1367 Wojciech Niedzwiedz doi:10.1038/ncb3448 Top Advertisement Springer Nature presents a custom webcast on: Nutrition and brain health Date: Thursday December 1, 2016 Time: 8AM PST, 11AM EST, 4PM GMT, 5PM CET Register for the webcast and live Q&A session Sponsored by: Nestlé   Natureevents is a fully searchable, multi-disciplinary database designed to maximise exposure for events organisers. The contents of the Natureevents Directory are now live. The digital version is available here. Find the latest scientific conferences, courses, meetings and symposia on natureevents.com. For event advertising opportunities across the Nature Publishing Group portfolio please contact natureevents@nature.com More Nature Events

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