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Visit our open access funding page or contact openaccess@nature.com to learn more about APC funding. | | | | | | Latest Articles | View all Articles | | | | | Social image concerns promote cooperation more than altruistic punishment OPEN | | | Gianluca Grimalda, Andreas Pondorfer and David P. Tracer | | | Cooperation requires individuals to sacrifice individual rewards for group benefits. Here, Grimalda, Pondorfer and Tracer show in a foraging society of Papua New Guinea that social image building is a more powerful motivator of social cooperation than altruistic punishment. | | | 09 August 2016 | doi: 10.1038/ncomms12288 | | |
| Aromatase inhibition remodels the clonal architecture of estrogen-receptor-positive breast cancers OPEN | | | Christopher A. Miller, Yevgeniy Gindin, Charles Lu, Obi L Griffith, Malachi Griffith, Dong Shen, Jeremy Hoog, Tiandao Li, David E. Larson, Mark Watson, Sherri R Davies, Kelly Hunt, Vera J. Suman, Jacqueline Snider, Thomas Walsh, Graham A. Colditz, Katherine DeSchryver, Richard K. Wilson, Elaine R. Mardis and Matthew J. Ellis et al. | | | Aromatase inhibitors are used to treat oestrogen-receptor-positive breast cancer. Here, the authors use genomic approaches to analyse tumours before and after neo-adjuvant treatment and find that treatment alters the clonal landscape of the tumours. | | | 09 August 2016 | doi: 10.1038/ncomms12498 | | |
| Force sensitivity of multilayer graphene optomechanical devices OPEN | | | P. Weber, J. Güttinger, A. Noury, J. Vergara-Cruz and A. Bachtold | | | Graphene is a promising material for the design of mechanical resonators. Here, the authors fabricate a multilayer graphene resonator coupled to a superconducting cavity, to achieve efficient readout of mechanical vibrations and quantitatively investigate its force sensing performance. | | | 09 August 2016 | doi: 10.1038/ncomms12496 | | |
| Local adaptation of a bacterium is as important as its presence in structuring a natural microbial community OPEN | | | Pedro Gómez, Steve Paterson, Luc De Meester, Xuan Liu, Luca Lenzi, M. D. Sharma, Kerensa McElroy and Angus Buckling | | | Though both the presence and traits of a species can influence the dynamics of its ecological community, the effects of these factors are difficult to disentangle. Here, Gómez et al. demonstrate in a microbial mesocosm that local adaptation of a focal species can influence the community as much as the presence of the focal species per se. | | | 09 August 2016 | doi: 10.1038/ncomms12453 | | |
| Association of variations in HLA class II and other loci with susceptibility to EGFR-mutated lung adenocarcinoma OPEN | | | Kouya Shiraishi, Yukinori Okada, Atsushi Takahashi, Yoichiro Kamatani, Yukihide Momozawa, Kyota Ashikawa, Hideo Kunitoh, Shingo Matsumoto, Atsushi Takano, Kimihiro Shimizu, Akiteru Goto, Koji Tsuta, Shun-ichi Watanabe, Yuichiro Ohe, Yukio Watanabe, Yasushi Goto, Hiroshi Nokihara, Koh Furuta, Akihiko Yoshida, Koichi Goto et al. | | | EGFR mutations in lung adenocarcinoma are more frequent in East Asians compared to other populations. Here, the authors carry out a genome-wide association study in EGFR mutant cancers and identify loci that are associated with risk of developing this molecular subtype of cancer. | | | 09 August 2016 | doi: 10.1038/ncomms12451 | | |
| A clock network for geodesy and fundamental science OPEN | | | C. Lisdat, G. Grosche, N. Quintin, C. Shi, S.M.F. Raupach, C. Grebing, D. Nicolodi, F. Stefani, A. Al-Masoudi, S. Dörscher, S. Häfner, J.-L. Robyr, N. Chiodo, S. Bilicki, E. Bookjans, A. Koczwara, S. Koke, A. Kuhl, F. Wiotte, F. Meynadier et al. | | | Comparing the frequency of two distant optical clocks will enable sensitive tests of fundamental physics. Here, the authors compare two strontium optical-lattice clocks 690 kilometres apart to a degree of accuracy that is limited only by the uncertainty of the individual clocks themselves. | | | 09 August 2016 | doi: 10.1038/ncomms12443 | | |
| Ferromagnetic particles as magnetic resonance imaging temperature sensors OPEN | | | J. H. Hankiewicz, Z. Celinski, K. F. Stupic, N. R. Anderson and R. E. Camley | | | Magnetic resonance imaging can distinguish between different tissue types by measuring the proton distribution in a living sample. Here, the authors demonstrate how this technique can be extended to provide temperature information by using ferromagnetic particles with temperature-dependent magnetization. | | | 09 August 2016 | doi: 10.1038/ncomms12415 | | |
| Mode-locking via dissipative Faraday instability OPEN | | | Nikita Tarasov, Auro M. Perego, Dmitry V. Churkin, Kestutis Staliunas and Sergei K. Turitsyn | | | Dissipative Faraday instability by periodic zig-zag modulation of spectral losses can lead to pattern formation in variety of systems. Here, the authors employ this nonlinear instability as a technique to achieve high-order harmonic mode-locking in a fibre laser. | | | 09 August 2016 | doi: 10.1038/ncomms12441 | | |
| A genome-wide screening uncovers the role of CCAR2 as an antagonist of DNA end resection OPEN | | | Ana López-Saavedra, Daniel Gómez-Cabello, María Salud Domínguez-Sánchez, Fernando Mejías-Navarro, María Jesús Fernández-Ávila, Christoffel Dinant, María Isabel Martínez-Macías, Jiri Bartek and Pablo Huertas | | | A DNA double strand break can be repaired through either the non-homologous end-joining or the homologous recombination pathways. Here the authors conduct a genome-wide screen and identify a role for CCAR2 in pathway choice by regulating DNA end resection by CtIP. | | | 09 August 2016 | doi: 10.1038/ncomms12364 | | |
| Amorphous nickel boride membrane on a platinum–nickel alloy surface for enhanced oxygen reduction reaction OPEN | | | Daping He, Libo Zhang, Dongsheng He, Gang Zhou, Yue Lin, Zhaoxiang Deng, Xun Hong, Yuen Wu, Chen Chen and Yadong Li | | | Low activity of the oxygen reduction reaction (ORR) in polymer electrolyte membrane fuel cells is a barrier for commercial applications. Here the authors report a nickel boride membrane-coated Pt-Ni catalyst, achieving 27-fold enhancement in mass activity for ORR relative to commercial Pt/C. | | | 09 August 2016 | doi: 10.1038/ncomms12362 | | |
| A nickel iron diselenide-derived efficient oxygen-evolution catalyst OPEN | | | Xiang Xu, Fang Song and Xile Hu | | | Metal selenides have been reported as promising oxygen-evolution catalysts but their active forms are yet to be elucidated. Here, the authors show that metal selenides are unstable under oxygen-evolution conditions and that in situ generated metal oxides/hydroxides are responsible for their high activity. | | | 09 August 2016 | doi: 10.1038/ncomms12324 | | |
| A protein-truncating R179X variant in RNF186 confers protection against ulcerative colitis OPEN | | | Manuel A. Rivas, Daniel Graham, Patrick Sulem, Christine Stevens, A. Nicole Desch, Philippe Goyette, Daniel Gudbjartsson, Ingileif Jonsdottir, Unnur Thorsteinsdottir, Frauke Degenhardt, Sören Mucha, Mitja I. Kurki, Dalin Li, Mauro D’Amato, Vito Annese, Severine Vermeire, Rinse K. Weersma, Jonas Halfvarson, Paulina Paavola-Sakki, Maarit Lappalainen et al. | | | While hundreds of loci are linked with inflammatory bowel diseases (IBDs), the functional consequences of the associated variants remain unclear. Here, the authors screened in ulcerative colitis (UC) patients’ genomes for protein-truncating variants near IBD loci, and identify a protein truncating variant in RNF186 to be protective against UC. | | | 09 August 2016 | doi: 10.1038/ncomms12342 | | |
| Cell-permeable succinate prodrugs bypass mitochondrial complex I deficiency OPEN | | | Johannes K. Ehinger, Sarah Piel, Rhonan Ford, Michael Karlsson, Fredrik Sjövall, Eleonor Åsander Frostner, Saori Morota, Robert W. Taylor, Doug M. Turnbull, Clive Cornell, Steven J. Moss, Carsten Metzsch, Magnus J. Hansson, Hans Fliri and Eskil Elmér | | | Mitochondrial complex I deficiency is the most common respiratory chain defect in mitochondrial disease in children and currently there is no effective treatment. In this study, the authors show that succinate prodrugs can alleviate metabolic decompensation in Leigh syndrome patient fibroblasts. | | | 09 August 2016 | doi: 10.1038/ncomms12317 | | |
| Synthetic viability by BRCA2 and PARP1/ARTD1 deficiencies OPEN | | | Xia Ding, Arnab Ray Chaudhuri, Elsa Callen, Yan Pang, Kajal Biswas, Kimberly D. Klarmann, Betty K. Martin, Sandra Burkett, Linda Cleveland, Stacey Stauffer, Teresa Sullivan, Aashish Dewan, Hanna Marks, Anthony T. Tubbs, Nancy Wong, Eugen Buehler, Keiko Akagi, Scott E. Martin, Jonathan R. Keller, André Nussenzweig et al. | | | The PARP inhibitor olaparib is an approved treatment method for women with BRCA1 and BRCA2 mutation associated cancers. Here the authors show that olaparib can contribute to synthetic viability of cells if PARP1 is inhibited before BRCA2 loss. | | | 08 August 2016 | doi: 10.1038/ncomms12425 | | |
| Crystal structure of the plant receptor-like kinase TDR in complex with the TDIF peptide OPEN | | | Junko Morita, Kazuki Kato, Takanori Nakane, Yuki Kondo, Hiroo Fukuda, Hiroshi Nishimasu, Ryuichiro Ishitani and Osamu Nureki | | | The TDF peptide interacts with the leucine-rich repeat receptor-like kinase TDR to regulate meristem differentiation in plants. Here, the authors solve the structure of the extracellular domain of TDR in complex with TDIF and propose a mechanism for TDIF recognition. | | | 08 August 2016 | doi: 10.1038/ncomms12383 | | |
| β-Catenin C-terminal signals suppress p53 and are essential for artery formation OPEN | | | Dario F. Riascos-Bernal, Prameladevi Chinnasamy, Longyue (Lily) Cao, Charlene M. Dunaway, Tomas Valenta, Konrad Basler and Nicholas E. S. Sibinga | | | How p53 is restrained in arterial maturation during embryonic development is unclear. Here, the authors show that β-catenin C-terminal interactions inhibit CREB binding protein-mediated acetylation and activation of p53 in smooth muscle cells, and that this function is essential for artery formation. | | | 08 August 2016 | doi: 10.1038/ncomms12389 | | |
| Widespread adaptive evolution during repeated evolutionary radiations in New World lupins OPEN | | | Bruno Nevado, Guy W. Atchison, Colin E. Hughes and Dmitry A. Filatov | | | Species radiations can be driven by both adaptive and non-adaptive processes, but the relative importance of these drivers is unknown. Here, Nevado et al. show that multiple radiations in the New World lupins were associated with genome-wide accelerations in both coding and regulatory evolution, suggesting a strong influence of adaptive processes. | | | 08 August 2016 | doi: 10.1038/ncomms12384 | | |
| Self-organized centripetal movement of corneal epithelium in the absence of external cues OPEN | | | Erwin P. Lobo, Naomi C. Delic, Alex Richardson, Vanisri Raviraj, Gary M. Halliday, Nick Di Girolamo, Mary R. Myerscough and J. Guy Lyons | | | The cornea is formed of cells that originate from the outer circle of stem cells and that move towards its centre. Here, the authors show that the movement pattern is self-organised, requiring no cues, and that stem cell leakage may account for the presence of stem cells at the centre of the cornea. | | | 08 August 2016 | doi: 10.1038/ncomms12388 | | |
| ATP-dependent substrate transport by the ABC transporter MsbA is proton-coupled OPEN | | | Himansha Singh, Saroj Velamakanni, Michael J. Deery, Julie Howard, Shen L. Wei and Hendrik W. van Veen | | | ABC exporters mediate the translocation of cytotoxic compounds to the cell exterior via ATP hydrolysis. Here, the authors show that the bacterial transporter MsbA requires additional energy from the transmembrane electrochemical proton gradient to facilitate drug transport. | | | 08 August 2016 | doi: 10.1038/ncomms12387 | | |
| Disorder engineering and conductivity dome in ReS2 with electrolyte gating OPEN | | | Dmitry Ovchinnikov, Fernando Gargiulo, Adrien Allain, Diego José Pasquier, Dumitru Dumcenco, Ching-Hwa Ho, Oleg V. Yazyev and Andras Kis | | | Rhenium disulphide, ReS2, is a member of the two-dimensional dichalcogenide family. Here, the authors find a suppression of conductivity at high charge density levels in devices with polymer electrolyte gates. The effects of doping and disorder are explored theoretically and experimentally. | | | 08 August 2016 | doi: 10.1038/ncomms12391 | | |
| Interdependent IL-7 and IFN-γ signalling in T-cell controls tumour eradication by combined α-CTLA-4+α-PD-1 therapy OPEN | | | Lewis Zhichang Shi, Tihui Fu, Baoxiang Guan, Jianfeng Chen, Jorge M. Blando, James P. Allison, Liangwen Xiong, Sumit K. Subudhi, Jianjun Gao and Padmanee Sharma | | | Combination therapy with α-CTLA-4 and α-PD-1 is showing improved therapeutic effects in clinical trials. Here, the authors report that mechanistically in bladder cancer such effect depends upon an upregulation of T cell activity mediated by the IL-7/IL-7R and IFN-γ/IFN-γR signalling pathways. | | | 08 August 2016 | doi: 10.1038/ncomms12335 | | |
| Structural basis of metallo-β-lactamase, serine-β-lactamase and penicillin-binding protein inhibition by cyclic boronates OPEN | | | Jürgen Brem, Ricky Cain, Samuel Cahill, Michael A. McDonough, Ian J. Clifton, Juan-Carlos Jiménez-Castellanos, Matthew B. Avison, James Spencer, Colin W. G. Fishwick and Christopher J. Schofield | | | Bacterial beta-lactamases are responsible for resistance to beta-lactams, the most important family of antibiotics. Here, the authors reveal cyclic boronate inhibitors that are active against both serine- and metallo-beta-lactamases and represent a promising strategy for combined antimicrobial treatments. | | | 08 August 2016 | doi: 10.1038/ncomms12406 | | |
| Iridium-based double perovskites for efficient water oxidation in acid media OPEN | | | Oscar Diaz-Morales, Stefan Raaijman, Ruud Kortlever, Patricia J. Kooyman, Tim Wezendonk, Jorge Gascon, W. T. Fu and Marc T. M. Koper | | | Iridium oxide is an active and stable catalyst for the oxygen evolution reaction, however Ir is very rare, making it unsuitable for large-scale application. Here the authors develop a class of Ir double perovskites containing less Ir than iridium oxide, but exhibiting 3-fold higher activity in acidic media. | | | 08 August 2016 | doi: 10.1038/ncomms12363 | | |
| Ultrafast acousto-optic mode conversion in optically birefringent ferroelectrics OPEN | | | Mariusz Lejman, Gwenaelle Vaudel, Ingrid C. Infante, Ievgeniia Chaban, Thomas Pezeril, Mathieu Edely, Guillaume F. Nataf, Mael Guennou, Jens Kreisel, Vitalyi E. Gusev, Brahim Dkhil and Pascal Ruello | | | Electrically driven acousto-optic light modulators are limited to frequencies of a few hundred megahertz and are typically no smaller than a few micrometres. Here, the authors demonstrate gigahertz acousto-optic conversion of light polarization in a region of a few nanometres using pulsed laser stimulation of a ferroelectric. | | | 05 August 2016 | doi: 10.1038/ncomms12345 | | |
| Oblique rift opening revealed by reoccurring magma injection in central Iceland OPEN | | | Joël Ruch, Teng Wang, Wenbin Xu, Martin Hensch and Sigurjón Jónsson | | | Deformation at divergent plate boundaries during rifting events is rarely observed and therefore poorly constrained. Ruch et al. show evidence of an oblique rift opening at the Bárðarbunga caldera, Iceland, which was one of the largest basaltic eruptions observed in the last 200 years | | | 05 August 2016 | doi: 10.1038/ncomms12352 | | |
| Electron–hole doping asymmetry of Fermi surface reconstructed in a simple Mott insulator OPEN | | | Yoshitaka Kawasugi, Kazuhiro Seki, Yusuke Edagawa, Yoshiaki Sato, Jiang Pu, Taishi Takenobu, Seiji Yunoki, Hiroshi M. Yamamoto and Reizo Kato | | | Electron or hole doping in a Mott insulator leads to superconductivity, with the mechanism obscured by multi-orbital Fermi surface reconstructions. Here, Kawasugi et al. report doping dependent Hall coefficients and resistivity anisotropy of an organic Mott insulator, revealing doping asymmetry of reconstructed Fermi surface of a single electronic orbital. | | | 05 August 2016 | doi: 10.1038/ncomms12356 | | |
| PTEN regulates EG5 to control spindle architecture and chromosome congression during mitosis OPEN | | | Jinxue He, Zhong Zhang, Meng Ouyang, Fan Yang, Hongbo Hao, Kristy L. Lamb, Jingyi Yang, Yuxin Yin and Wen H. Shen | | | One of the cellular functions of the tumour suppressor PTEN is to maintain genome stability. Here, the authors show that PTEN depletion leads to mitotic spindle shortening and chromosome misalignment due to aberrant EG5 activation. | | | 05 August 2016 | doi: 10.1038/ncomms12355 | | |
| Single-electron induced surface plasmons on a topological nanoparticle OPEN | | | G. Siroki, D.K.K. Lee, P. D. Haynes and V. Giannini | | | The surface states in topological insulators are delocalised and immune to imperfections. Here, the authors show that single electrons in topologically protected surface states on a nanoparticle can create a surface charge layer that screens the particle, mediating interaction between bulk phonons and light, giving an additional absorption peak. | | | 05 August 2016 | doi: 10.1038/ncomms12375 | | |
| Self-assembled oxide films with tailored nanoscale ionic and electronic channels for controlled resistive switching OPEN | | | Seungho Cho, Chao Yun, Stefan Tappertzhofen, Ahmed Kursumovic, Shinbuhm Lee, Ping Lu, Quanxi Jia, Meng Fan, Jie Jian, Haiyan Wang, Stephan Hofmann and Judith L. MacManus-Driscoll | | | Metal oxide resistive switches rely on the migration of oxygen vacancies and electrons under applied voltage. Here, Cho et al. use nanocomposites to control the electronic and ionic conductivities in spatially distinct channels, and fabricate memristors with high on/off ratios and reproducibility. | | | 05 August 2016 | doi: 10.1038/ncomms12373 | | |
| Endothelial PDGF-CC regulates angiogenesis-dependent thermogenesis in beige fat OPEN | | | Takahiro Seki, Kayoko Hosaka, Sharon Lim, Carina Fischer, Jennifer Honek, Yunlong Yang, Patrik Andersson, Masaki Nakamura, Erik Näslund, Seppo Ylä-Herttuala, Meili Sun, Hideki Iwamoto, Xuri Li, Yizhi Liu, Nilesh J. Samani and Yihai Cao | | | Cold-induced activation of thermogenesis in white adipose tissue (WAT), or ‘beiging’, is associated with WAT angiogenesis. Here the authors show that PDGF-CC is secreted from endothelial cells in the context of WAT angiogenesis and its paracrine action on adipocytes contributes to cold-induced beiging. | | | 05 August 2016 | doi: 10.1038/ncomms12152 | | | Biological Sciences Medical research |
| Long-range movement of large mechanically interlocked DNA nanostructures OPEN | | | Jonathan List, Elisabeth Falgenhauer, Enzo Kopperger, Günther Pardatscher and Friedrich C. Simmel | | | Rotaxanes are interlocked molecules that can undergo sliding and rotational movements and can be used in artificial molecular machines and motors. Here, Simmel and co-workers show a rigid rotaxane structures consisting of DNA origami subunits that can slide over several hundreds of nanometres. | | | 05 August 2016 | doi: 10.1038/ncomms12414 | | |
| Sec16 alternative splicing dynamically controls COPII transport efficiency OPEN | | | Ilka Wilhelmi, Regina Kanski, Alexander Neumann, Olga Herdt, Florian Hoff, Ralf Jacob, Marco Preußner and Florian Heyd | | | The transport of secretory proteins from the endoplasmic reticulum to the Golgi depends on COPII-coated vesicles. Here, the authors show that activation-induced alternative splicing of Sec16 controls adaptation of COPII transport to increased secretory cargo upon T cell activation. | | | 05 August 2016 | doi: 10.1038/ncomms12347 | | |
| Zero-temperature quantum annealing bottlenecks in the spin-glass phase OPEN | | | Sergey Knysh | | | Quantum annealing can solve hard optimization problems, but it is limited by computational bottlenecks. Here, the author obtains the scaling of spin-glass bottlenecks with the problem size and explains a crossover to exponential complexity for large sizes. | | | 05 August 2016 | doi: 10.1038/ncomms12370 | | |
| Enhanced spin–orbit coupling in core/shell nanowires OPEN | | | Stephan Furthmeier, Florian Dirnberger, Martin Gmitra, Andreas Bayer, Moritz Forsch, Joachim Hubmann, Christian Schüller, Elisabeth Reiger, Jaroslav Fabian, Tobias Korn and Dominique Bougeard | | | Spin-orbit coupling underlies many important spintronic concepts, and is strongly influenced by crystal symmetry. Here, the authors demonstrate a strong enhancement of spin-orbit coupling in core/shell semiconductor nanowires induced by the large interfacial surface areas | | | 05 August 2016 | doi: 10.1038/ncomms12413 | | |
| LTβR controls thymic portal endothelial cells for haematopoietic progenitor cell homing and T-cell regeneration OPEN | | | Yaoyao Shi, Weiwei Wu, Qian Chai, Qingqing Li, Yu Hou, Huan Xia, Boyang Ren, Hairong Xu, Xiaohuan Guo, Caiwei Jin, Mengjie Lv, Zhongnan Wang, Yang-Xin Fu and Mingzhao Zhu | | | Lymphoid progenitors migrate from the bone marrow into the thymus to give rise to T and NK cell lineages. Here the authors characterize a lymphotoxin receptor beta-dependent population of thymic endothelial cells that guide lymphoid progenitor homing in the thymus. | | | 05 August 2016 | doi: 10.1038/ncomms12369 | | |
| Stromal Hedgehog signalling is downregulated in colon cancer and its restoration restrains tumour growth OPEN | | | Marco Gerling, Nikè V. J. A. Büller, Leonard M. Kirn, Simon Joost, Oliver Frings, Benjamin Englert, Åsa Bergström, Raoul V. Kuiper, Leander Blaas, Mattheus C. B. Wielenga, Sven Almer, Anja A. Kühl, Erik Fredlund, Gijs R. van den Brink and Rune Toftgård | | | The Hedgehog signalling pathway can drive tumorigenesis. Here, the authors show that in a colitis-associated colon cancer model downstream Hedgehog signalling is restricted to the stroma and its over-activation can inhibit tumorigenesis, associated with activation of BMP signaling. | | | 05 August 2016 | doi: 10.1038/ncomms12321 | | |
| Integrated plasmonic circuitry on a vertical-cavity surface-emitting semiconductor laser platform OPEN | | | Cillian P. T. McPolin, Jean-Sebastien Bouillard, Sebastien Vilain, Alexey V. Krasavin, Wayne Dickson, Daniel O’Connor, Gregory A. Wurtz, John Justice, Brian Corbett and Anatoly V. Zayats | | | Integrated plasmonic sources are crucial in the development of plasmonic circuitry. Here, McPolin et al. show that vertical-cavity surface-emitting lasers can be employed as an on-chip, electrically pumped source or detector of plasmonic signals and also demonstrate waveguiding and frequency conversion on this platform. | | | 05 August 2016 | doi: 10.1038/ncomms12409 | | |
| Dectin-1-activated dendritic cells trigger potent antitumour immunity through the induction of Th9 cells OPEN | | | Yinghua Zhao, Xiao Chu, Jintong Chen, Ying Wang, Sujun Gao, Yuxue Jiang, Xiaoqing Zhu, Guangyun Tan, Wenjie Zhao, Huanfa Yi, Honglin Xu, Xingzhe Ma, Yong Lu, Qing Yi and Siqing Wang | | | Dendritic cells instruct different types of T cell responses depending on the types of microbial ligands sensed. Here the authors show that dendritic cells stimulated via Dectin-1 receptor upregulate TNFSF15 and OX40L and induce T helper 9 response and efficient antitumour immunity in mouse models. | | | 05 August 2016 | doi: 10.1038/ncomms12368 | | |
| DNA hydroxymethylation controls cardiomyocyte gene expression in development and hypertrophy OPEN | | | Carolina M. Greco, Paolo Kunderfranco, Marcello Rubino, Veronica Larcher, Pierluigi Carullo, Achille Anselmo, Kerstin Kurz, Thomas Carell, Andrea Angius, Michael V. G. Latronico, Roberto Papait and Gianluigi Condorelli | | | 5-hydroxymethylation of cysteine (5-hmC) plays a role in epigenetic regulation. Here the authors analyse the hydroxymethylome in embryonic, neonatal, adult and hypertrophic mouse cardiomyocytes and show that the dynamic modulation of hydroxymethylated DNA is important for cardiomyocyte gene expression programming in heart development and failure. | | | 04 August 2016 | doi: 10.1038/ncomms12418 | | |
| Normal stroma suppresses cancer cell proliferation via mechanosensitive regulation of JMJD1a-mediated transcription OPEN | | | Riina Kaukonen, Anja Mai, Maria Georgiadou, Markku Saari, Nicola De Franceschi, Timo Betz, Harri Sihto, Sami Ventelä, Laura Elo, Eija Jokitalo, Jukka Westermarck, Pirkko-Liisa Kellokumpu-Lehtinen, Heikki Joensuu, Reidar Grenman and Johanna Ivaska | | | The tumour stroma has altered stiffness and matrix architecture compared to normal tissue, which favours proliferation, and invasion. Here, the authors find that the extracellular matrix produced by normal fibroblasts inhibits cancer cell proliferation through mechanosensitive downregulation of JMJD1a. | | | 04 August 2016 | doi: 10.1038/ncomms12237 | | | Biological Sciences Cancer Cell biology Molecular biology |
| Mass production of shaped particles through vortex ring freezing OPEN | | | Duo An, Alex Warning, Kenneth G. Yancey, Chun-Ti Chang, Vanessa R. Kern, Ashim K. Datta, Paul H. Steen, Dan Luo and Minglin Ma | | | The evolution of vortex flow exhibits a rich spectrum of complicated geometries. Here, An et al. utilize these features to control and mass produce inorganic and organic particles via an electrospraying process, whereby the shape of vortex rings translates into particles during a freezing process. | | | 04 August 2016 | doi: 10.1038/ncomms12401 | | |
| An O2-sensing stressosome from a Gram-negative bacterium OPEN | | | Xin Jia, Jian-bo Wang, Shannon Rivera, Duc Duong and Emily E. Weinert | | | The stressosome is a multiprotein complex that regulates the expression of stress response genes in Gram-positive bacteria. Here the authors characterize a stressosome from a Gram-negative bacterium, showing that one of the protein components senses oxygen through a bound haem. | | | 04 August 2016 | doi: 10.1038/ncomms12381 | | |
| Load-induced enhancement of Dynein force production by LIS1–NudE in vivo and in vitro OPEN | | | Babu J. N. Reddy, Michelle Mattson, Caitlin L. Wynne, Omid Vadpey, Abdo Durra, Dail Chapman, Richard B. Vallee and Steven P. Gross | | | Transport of large cargo through the cytoplasm can encounter physical impediments which should be overcome. Here the authors show that lipid droplets constrained by an optical trap respond with an increase in dynein-mediated force that is dependent on dynein regulators LIS1 and NudE/L, but not on p150glued. | | | 04 August 2016 | doi: 10.1038/ncomms12259 | | | Biological Sciences Cell biology |
| Chromatin remodelling and antisense-mediated up-regulation of the developmental switch gene eud-1 control predatory feeding plasticity OPEN | | | Vahan Serobyan, Hua Xiao, Suryesh Namdeo, Christian Rödelsperger, Bogdan Sieriebriennikov, Hanh Witte, Waltraud Röseler and Ralf J. Sommer | | | In the nematode Pristionchus pacificus, a developmental switch, the sulfatase eud-1, controls mouth-form plasticity. Here, the authors show that mutations in two conserved histone modifying enzymes mimic the eud-1 phenotype, in part mediated by an antisense eud-1 RNA, resulting in the absence of one mouth-form | | | 04 August 2016 | doi: 10.1038/ncomms12337 | | |
| Resilience of the Asian atmospheric circulation shown by Paleogene dust provenance OPEN | | | A. Licht, G. Dupont-Nivet, A. Pullen, P. Kapp, H. A. Abels, Z. Lai, Z. Guo, J. Abell and D. Giesler | | | The onset of modern central Asian atmospheric circulation is often linked to the interplay of late Cenozoic paleogeographic changes and global cooling. Here the authors present sedimentary provenance data from early Cenozoic dust deposits, which indicate long-term stability of the central Asian high pressure system. | | | 04 August 2016 | doi: 10.1038/ncomms12390 | | |
| Ionic imbalance induced self-propulsion of liquid metals OPEN | | | Ali Zavabeti, Torben Daeneke, Adam F. Chrimes, Anthony P. O’Mullane, Jian Zhen Ou, Arnan Mitchell, Khashayar Khoshmanesh and Kourosh Kalantar-zadeh | | | The control over the motion and deformation of liquid droplets is essential to many microfluidic and actuation systems. Zavabeti et al. demonstrate that applying a pH or ionic gradient across a droplet of liquid metal alloy of gallium results in its motion due to a breaking of the surface charge symmetry. | | | 04 August 2016 | doi: 10.1038/ncomms12402 | | |
| Intrinsic limits to gene regulation by global crosstalk OPEN | | | Tamar Friedlander, Roshan Prizak, Călin C. Guet, Nicholas H. Barton and Gašper Tkačik | | | Limited specificity of transcription factor-DNA interactions leads to crosstalk in gene regulation. Here the authors consider global crosstalk in regulatory networks of growing size and complexity, and show that it imposes constraints on gene regulation and on the evolution of regulatory networks. | | | 04 August 2016 | doi: 10.1038/ncomms12307 | | |
| Evolution of a G protein-coupled receptor response by mutations in regulatory network interactions OPEN | | | Raphaël B. Di Roberto, Belinda Chang, Ala Trusina and Sergio G. Peisajovich | | | Co-evolution of a new receptor-ligand pair will affect the downstream signal transduction network. Here, the authors use experimental evolution of yeast mating receptor Ste2 to show the effect of enhanced binding affinity and weakened interactions with the network's negative regulators on protein evolution. | | | 04 August 2016 | doi: 10.1038/ncomms12344 | | |
| Whole-animal genome-wide RNAi screen identifies networks regulating male germline stem cells in Drosophila OPEN | | | Ying Liu, Qinglan Ge, Brian Chan, Hanhan Liu, Shree Ram Singh, Jacob Manley, Jae Lee, Ann Marie Weideman, Gerald Hou and Steven X. Hou | | | Both intrinsic and external signals regulate stem cell fate. Here, the authors perform a genome-wide RNAi screen to identify regulators of testis germline stem cells (GSC) in Drosophila, finding more than half of the genes were external regulators and heterochromatin/cytokinesis proteins mediated GSC fate. | | | 03 August 2016 | doi: 10.1038/ncomms12149 | | | Biological Sciences Cell biology Developmental biology |
| Notch signalling mediates reproductive constraint in the adult worker honeybee OPEN | | | Elizabeth J. Duncan, Otto Hyink and Peter K. Dearden | | | In honeybees, pheromones produced by the queen inhibit reproduction by workers and enforce a eusocial division of labour. Here, Duncan, Hyink and Dearden show that this inhibition is mediated by the Notch signalling pathway in the workers' ovaries. | | | 03 August 2016 | doi: 10.1038/ncomms12427 | | |
| Cingulin and actin mediate midbody-dependent apical lumen formation during polarization of epithelial cells OPEN | | | Anthony J. Mangan, Daniel V. Sietsema, Dongying Li, Jeffrey K. Moore, Sandra Citi and Rytis Prekeris | | | Polarisation of epithelial cells causes lumen formation, which is mediated by apical membrane initiation site (AMIS) and FIP5, but how this is regulated is unclear. Here, the authors identify cingulin as a FIP-5 interacting protein, recruiting the Rac1-WAVE/Scar complex to the AMIS and branched actin formation. | | | 03 August 2016 | doi: 10.1038/ncomms12426 | | |
| Functional screening implicates miR-371-3p and peroxiredoxin 6 in reversible tolerance to cancer drugs OPEN | | | Nisebita Sahu, Jean-Philippe Stephan, Darlene Dela Cruz, Mark Merchant, Benjamin Haley, Richard Bourgon, Marie Classon and Jeff Settleman | | | Acquired resistance significantly limits the efficacy of cancer drug therapies. Here, the authors identify miR-371-3p as a suppressor of drug tolerance in cancer cell lines by its target gene PRDX6, which in turn regulates PLA2/PKCα signalling and ROS levels. | | | 03 August 2016 | doi: 10.1038/ncomms12351 | | |
| Evidence that birds sleep in mid-flight OPEN | | | Niels C Rattenborg, Bryson Voirin, Sebastian M. Cruz, Ryan Tisdale, Giacomo Dell’Omo, Hans-Peter Lipp, Martin Wikelski and Alexei L. Vyssotski | | | Whether and how birds sleep during long-distance flights has remained a mystery. Here, Rattenborg and colleagues show for the first time that frigatebirds can sleep during flight, but do so in remarkably small amounts. | | | 03 August 2016 | doi: 10.1038/ncomms12468 | | |
| PKM2 dephosphorylation by Cdc25A promotes the Warburg effect and tumorigenesis OPEN | | | Ji Liang, Ruixiu Cao, Yajuan Zhang, Yan Xia, Yanhua Zheng, Xinjian Li, Liwei Wang, Weiwei Yang and Zhimin Lu | | | Protein phosphatase Cdc25 controls cell cycle transitions by dephosphorylating CDK substrates. Here, the authors show that the Cdc25A isoform regulates glycolysis through dephosphorylation of pyruvate kinase PKM2, resulting in β-catenin activation and consequent upregulation of the transcription of glycolytic genes. | | | 03 August 2016 | doi: 10.1038/ncomms12431 | | |
| Quantum electromechanics on silicon nitride nanomembranes OPEN | | | J. M. Fink, M. Kalaee, A. Pitanti, R. Norte, L. Heinzle, M. Davanço, K. Srinivasan and O. Painter | | | Preparation and detection of mechanical objects at the quantum zero-point level has been achieved in both the optical and microwave regimes. Here, the authors develop silicon nitride nanomembranes that are suitable for integrating nanophotonic, nanomechanical and superconducting microwave circuits together. | | | 03 August 2016 | doi: 10.1038/ncomms12396 | | |
| MRF4 negatively regulates adult skeletal muscle growth by repressing MEF2 activity OPEN | | | Irene Moretti, Stefano Ciciliot, Kenneth A. Dyar, Reimar Abraham, Marta Murgia, Lisa Agatea, Takayuki Akimoto, Silvio Bicciato, Mattia Forcato, Philippe Pierre, N. Henriette Uhlenhaut, Peter W. J. Rigby, Jaime J. Carvajal, Bert Blaauw, Elisa Calabria and Stefano Schiaffino | | | Mrf4 is a transcription factor important for muscle development, but despite high expression its function in adults is unknown. Here the authors show that interfering with Mrf4 in adult mice leads to muscle hypertrophy by activating MEF2-dependent transcription and promoting protein synthesis. | | | 03 August 2016 | doi: 10.1038/ncomms12397 | | |
| Total synthesis of teixobactin OPEN | | | Kang Jin, Iek Hou Sam, Kathy Hiu Laam Po, Du’an Lin, Ebrahim H. Ghazvini Zadeh, Sheng Chen, Yu Yuan and Xuechen Li | | | Teixobactin is a recently identified antibiotic that shows activity against drug resistant strains of bacteria. Here, the authors report a highly convergent total synthesis of this natural product, with sufficient flexibility to also allow the synthesis of a number of analogues. | | | 03 August 2016 | doi: 10.1038/ncomms12394 | | | | | | | | | | | | | Latest Corrigenda | | | | | | Corrigendum: Observation of a topological crystalline insulator phase and topological phase transition in Pb1−xSnxTe | | | Su-Yang Xu, Chang Liu, N. Alidoust, M. Neupane, D. Qian, I. Belopolski, J. D. Denlinger, Y. J. Wang, H. Lin, L. A. Wray, G. Landolt, B. Slomski, J. H. Dil, A. Marcinkova, E. Morosan, Q. Gibson, R. Sankar, F. C. Chou, R. J. Cava, A. Bansil et al. | | | 04 August 2016 | doi: 10.1038/ncomms12505 | | | Physical Sciences Condensed matter Materials science |
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