Nature Structural & Molecular Biology Contents: 2016 Volume #23 pp 1-91

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TABLE OF CONTENTS January 2016 Volume 23, Issue 1 Correspondence News and Views Review Articles Corrigendum Subscribe   Facebook   RSS   Recommend to library   Twitter   Correspondence Top Reappraising the effects of artemisinin on the ATPase activity of PfATP6 and SERCA1a E255L expressed in Xenopus laevis oocytes   pp1 - 2 Stéphanie David-Bosne, Michael Voldsgaard Clausen, Hanne Poulsen, Jesper Vuust Møller, Poul Nissen & Marc le Maire doi:10.1038/nsmb.3156 News and Views Top Motoring toward pre-60S-ribosome export   pp3 - 4 Vadim Shchepachev and David Tollervey doi:10.1038/nsmb.3154 Rea1 is an ATPase related to dynein motor proteins that has been implicated in the biogenesis of the 60S ribosomal subunit. A new cryo-EM study vividly demonstrates the power of structural methods, deciphering the role of Rea1 in monitoring key pre-60S maturation steps before the acquisition of export competence in budding yeast. See also: Article by Barrio-Garcia et al. The mystery of the fusion pore   pp5 - 6 Satyan Sharma and Manfred Lindau doi:10.1038/nsmb.3157 Release of neurotransmitters occurs by opening of a fusion pore in a manner thought to be mediated by SNARE proteins, but whether the fusion pore is a lipidic or a proteinaceous structure is controversial. A new study using very small nanodiscs shows that it is both. See also: Article by Bao et al. Structural & Molecular Biology JOBS of the week Research Fellow in Molecular Imaging University of Michigan Postdoctoral Position in Bioinformatics Max Planck Institute of Immunobiology and Epigenetics Head of Division of Structural Biology Institute of Cancer Research (ICR) Researcher - Laboratory Head Instituto de Tecnologia Química e Biológica (ITQB-NOVA) Head of Division of Structural Biology Institute of Cancer Research (ICR) More Science jobs from Review Top Ribosome-associated protein quality control   pp7 - 15 Onn Brandman and Ramanujan S Hegde doi:10.1038/nsmb.3147 A comprehensive review of the discovery and molecular dissection of the eukaryotic ribosome-associated quality-control pathway for degradation of nascent proteins arising from interrupted translation. Articles Top Recognition of distinct RNA motifs by the clustered CCCH zinc fingers of neuronal protein Unkempt   pp16 - 23 Jernej Murn, Marianna Teplova, Kathi Zarnack, Yang Shi and Dinshaw J Patel doi:10.1038/nsmb.3140 A new crystal structure of mouse Unkempt, a translational regulator of neuronal cell morphology, reveals how its two zinc-finger-triplet clusters recognize distinct cognate RNA sites. Identification of methylated deoxyadenosines in vertebrates reveals diversity in DNA modifications   pp24 - 30 Magdalena J Koziol, Charles R Bradshaw, George E Allen, Ana S H Costa, Christian Frezza & John B Gurdon doi:10.1038/nsmb.3145 The identification of N6-methyldeoxyadenosine in the DNA of Xenopus laevis, mice and humans extends the presence of this mark to vertebrates, thus fostering the potential importance of this mark as a carrier of epigenetic information. Structural dynamics of potassium-channel gating revealed by single-molecule FRET   pp31 - 36 Shizhen Wang, Reza Vafabakhsh, William F Borschel, Taekjip Ha and Colin G Nichols doi:10.1038/nsmb.3138 Single-molecule FRET provides insight into the structural dynamics of the KirBac1.1 potassium channel and reveals that channel gating is controlled by the tightness of the slide-helix 'belt'. Architecture of the Rix1-Rea1 checkpoint machinery during pre-60S-ribosome remodeling   pp37 - 44 Clara Barrio-Garcia, Matthias Thoms, Dirk Flemming, Lukas Kater, Otto Berninghausen, Jochen Baßler, Roland Beckmann & Ed Hurt doi:10.1038/nsmb.3132 The cryo-EM structure of a nucleoplasmic pre-60S particle with the Rix1-Rea1 checkpoint machinery reveals insights into pre-60S maturation before nuclear export. See also: News and Views by Shchepachev & Tollervey Secondary ubiquitin-RING docking enhances Arkadia and Ark2C E3 ligase activity   pp45 - 52 Joshua D Wright, Peter D Mace and Catherine L Day doi:10.1038/nsmb.3142 Structural and biochemistry analyses reveal that the monomeric RING domains of E3 ligases Arkadia and Ark2C bind free ubiquitin with high affinity, and the RING-Ub complex stabilizes donor ubiquitin conjugated to E2, thus promoting transfer. Substrate protein folds while it is bound to the ATP-independent chaperone Spy   pp53 - 58 Frederick Stull, Philipp Koldewey, Julia R Humes, Sheena E Radford and James C A Bardwell doi:10.1038/nsmb.3133 Spy is an ATP-independent chaperone that resides in the Escherichia coli periplasm and promotes the folding of its client Im7. Kinetic analyses now reveal that Im7 folds into its native state while it is bound to Spy. Subunit connectivity, assembly determinants and architecture of the yeast exocyst complex   pp59 - 66 Margaret R Heider, Mingyu Gu, Caroline M Duffy, Anne M Mirza, Laura L Marcotte, Alexandra C Walls, Nicholas Farrall, Zhanna Hakhverdyan, Mark C Field, Michael P Rout, Adam Frost & Mary Munson doi:10.1038/nsmb.3146 Biochemical analyses, auxin-induced degradation experiments and EM imaging provide a map of the subunit connectivity of the yeast exocyst and show that the exocyst exists predominantly as a stable octameric complex. Exocytotic fusion pores are composed of both lipids and proteins   pp67 - 73 Huan Bao, Marcel Goldschen-Ohm, Pia Jeggle, Baron Chanda, J Michael Edwardson & Edwin R Chapman doi:10.1038/nsmb.3141 A nanodisc-based approach reveals that the fusion pores formed during neurotransmitter exocytosis are hybrid structures composed of both membrane lipids and SNARE proteins. See also: News and Views by Sharma & Lindau Atomic model of a nonenveloped virus reveals pH sensors for a coordinated process of cell entry   pp74 - 80 Xing Zhang, Avnish Patel, Cristina C Celma, Xuekui Yu, Polly Roy & Z Hong Zhou doi:10.1038/nsmb.3134 New cryo electron microscopy structures of bluetongue virus (BTV) under low- and high-pH conditions reveal pH sensors that mediate host-membrane fusion and penetration by a nonenveloped virus. Structures of HIV-1 Env V1V2 with broadly neutralizing antibodies reveal commonalities that enable vaccine design   pp81 - 90 Jason Gorman, Cinque Soto, Max M Yang, Thaddeus M Davenport, Miklos Guttman, Robert T Bailer, Michael Chambers, Gwo-Yu Chuang, Brandon J DeKosky, Nicole A Doria-Rose, Aliaksandr Druz, Michael J Ernandes, Ivelin S Georgiev, Marissa C Jarosinski, M Gordon Joyce, Thomas M Lemmin, Sherman Leung, Mark K Louder, Jonathan R McDaniel, Sandeep Narpala, Marie Pancera, Jonathan Stuckey, Xueling Wu, Yongping Yang, Baoshan Zhang, Tongqing Zhou, NISC Comparative Sequencing Program, James C Mullikin, Ulrich Baxa, George Georgiou, Adrian B McDermott, Mattia Bonsignori, Barton F Haynes, Penny L Moore, Lynn Morris, Kelly K Lee, Lawrence Shapiro, John R Mascola & Peter D Kwong doi:10.1038/nsmb.3144 Crystal structures of HIV-1 Env V1V2 in complex with human broadly neutralizing antibodies and ontogeny analyses allow the engineering of Env trimers that are recognized by ancestor and intermediate antibody forms. Corrigendum Top Corrigendum: Structural characterization of human heparanase reveals insights into substrate recognition   p91 Liang Wu, Cristina M Viola, Andrzej M Brzozowski and Gideon J Davies doi:10.1038/nsmb0116-91 Top Natureevents is a fully searchable, multi-disciplinary database designed to maximise exposure for events organisers. The contents of the Natureevents Directory are now live. The digital version is available here. Find the latest scientific conferences, courses, meetings and symposia on natureevents.com. For event advertising opportunities across the Nature Publishing Group portfolio please contact natureevents@nature.com More Nature Events

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