Nature Biotechnology Contents: Volume 34 pp 1 - 114

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TABLE OF CONTENTS January 2016 Volume 34, Issue 1 Editorial News Bioentrepreneur Opinion and Comment Features News and Views Computational Biology Research Careers and Recruitment Subscribe   Facebook   RSS   Recommend to library   Twitter   Advertisement BIOPHARMA DEALMAKERS Company Profiles and Partnering Opportunities   Advertisement A new open access, online-only journal dedicated to publishing the highest quality research into ways to help the human body repair, replace, restore and regenerate damaged tissues and organs. Published by Nature Publishing Group in partnership with the Australian Regenerative Medicine Institute (ARMI) at Monash University.  Find out more    Editorial Top Xenotransplantation 2.0   p1 doi:10.1038/nbt.3466 Will targeted immunosuppressants and new tools in genome engineering be enough to finally give xenopigs wings? News Top Xenotransplantation makes a comeback   pp3 - 4 Jeffrey M Perkel doi:10.1038/nbt0116-3 CETP inhibitors boost 'good' cholesterol to no avail   pp5 - 6 Cormac Sheridan doi:10.1038/nbt0116-5 Roche's immuno squeeze   p6 doi:10.1038/nbt0116-6 Shire bites deeper into rare disease space   p7 doi:10.1038/nbt0116-7b GM salmon declared fit for dinner plates   pp7 - 9 Emily Waltz doi:10.1038/nbt0116-7a Gates champions CureVac   p8 doi:10.1038/nbt0116-8a Mexico dengue vaccine first   p8 doi:10.1038/nbt0116-8b Severe asthma gets first biologic in decades   pp10 - 11 Anna Azvolinsky doi:10.1038/nbt0116-10 First Rounders Podcast: James Wilson   p11 doi:10.1038/nbt.3457 Go-ahead for human genome editing with caveats   p11 doi:10.1038/nbt0116-11 Off-the-shelf CAR-T therapy induces remission in child with ALL   p12 Mark Ratner doi:10.1038/nbt0116-12 DuPont in CRISPR-Cas patent land grab   p13 Daniel Grushkin doi:10.1038/nbt0116-13 Around the world in a month   p14 doi:10.1038/nbt0116-14 News Feature Drugs go wireless   pp15 - 18 Emily Waltz doi:10.1038/nbt.3446 Electronic drugs and delivery systems are reaching the market, giving drug developers and healthcare providers a way to improve patient compliance and more. Emily Waltz reports. Advertisement All content now open access including archives! Nature Communications is an open access journal that publishes high-quality research from all areas of the natural sciences. Papers published by the journal represent important advances of significance to specialists within each subject area including the life sciences. Visit the website to explore ALL the content available within your field.    Bioentrepreneur Top Data page Innovative academic startups 2015   p19 Brady Huggett doi:10.1038/nbt.3447 Opinion and Comment Top Correspondence Gene-edited pigs are protected from porcine reproductive and respiratory syndrome virus   pp20 - 22 Kristin M Whitworth, Raymond R R Rowland, Catherine L Ewen, Benjamin R Trible, Maureen A Kerrigan et al. doi:10.1038/nbt.3434 Standing up for transparency   p23 Stacy Malkan doi:10.1038/nbt.3453 Standing up for scientific consensus   pp23 - 24 Jack M Payne doi:10.1038/nbt.3454 Reply to Standing up for transparency   p24 doi:10.1038/nbt0116-24 Commentary This time may be different   pp25 - 30 Bruce L Booth doi:10.1038/nbt.3452 The markets may be softening on biotech, but overall the sector remains in an incredibly strong environment. Features Top The global pipeline of GM crops out to 2020   pp31 - 36 Claudia Parisi, Pascal Tillie and Emilio Rodriguez-Cerezo doi:10.1038/nbt.3449 Although a few arable crops and agronomic traits will likely dominate commercial varieties for the foreseeable future, with many being stacked together, more quality traits and specialty crops are being introduced into the pipeline. Patents The patentability of human embryonic stem cell technology in China   pp37 - 39 Yaojin Peng doi:10.1038/nbt.3417 Although China has in the past decade been reluctant to grant patents on human embryonic stem cell technology, it has recently changed its patent policy to loosen some restrictions. Recent patents related to microbial genomics and metagenomics   p40 doi:10.1038/nbt.3465 News and Views Top Serotonin neurons in a dish   pp41 - 42 Patricia Gaspar and Stephane Nedelec doi:10.1038/nbt.3455 A method for generating serotonin raphe neurons in vitro will aid the study of genetic variants and drugs that modulate serotonin activity. See also: Research by Lu et al. Research Highlights   p42 doi:10.1038/nbt.3451 Optogenetics unleashed   pp43 - 44 Polina Anikeeva doi:10.1038/nbt.3458 Two recent studies report the development of miniaturized, fully-implantable devices that enable wireless optogenetic neuromodulation in peripheral nerves and spinal cord. A systems approach to HIV-1 vaccines   pp44 - 46 Tianlei Ying, Ponraj Prabakaran and Dimiter S Dimitrov doi:10.1038/nbt.3456 Understanding the full breadth of immune responses that protect against HIV-1 may speed vaccine development. Getting rid of PERVs   p46 Irene Jarchum doi:10.1038/nbt.3448 Biotechnology JOBS of the week Research Position in Functional Genomics Texas Tech University Tenure Track Assistant / Associate / Full Professor Nanyang Technological University (NTU) The European P-SPHERE project offers 31 postdoctoral Marie Sklodowska-Curie positions Universitat Autònoma de Barcelona More Science jobs from Biotechnology EVENT ECB2016 - 17th European Congress on Biotechnology July 3, 2016 Kraków, Poland More science events from Computational Biology Top Analysis Mapping the effects of drugs on the immune system   pp47 - 54 Brian A Kidd, Aleksandra Wroblewska, Mary R Boland, Judith Agudo, Miriam Merad et al. doi:10.1038/nbt.3367 The effects of drugs on the immune system is predicted by a data integration method. Research Top Perspective A reassessment of the PROPATRIA study and its implications for probiotic therapy   pp55 - 63 Ger P A Bongaerts and Rene S V M Severijnen doi:10.1038/nbt.3436 The unprecedented number of fatalities in the PROPATRIA clinical trial using probiotics to treat patients with acute pancreatitis cast a shadow over the field. Bongaerts et al. provide rationales for the trial's high mortality rate and outline situations in which probiotic therapy may still be appropriate for this disease. Articles Synthetic long-read sequencing reveals intraspecies diversity in the human microbiome   pp64 - 69 Volodymyr Kuleshov, Chao Jiang, Wenyu Zhou, Fereshteh Jahanbani, Serafim Batzoglou et al. doi:10.1038/nbt.3416 Synthetic long-read sequencing technology (TruSeq) identifies substrain diversity in microbiome samples. Improving drug discovery with high-content phenotypic screens by systematic selection of reporter cell lines   pp70 - 77 Jungseog Kang, Chien-Hsiang Hsu, Qi Wu, Shanshan Liu, Adam D Coster et al. doi:10.1038/nbt.3419 A method to systematically identify optimal biomarkers improves high-content screening for drug candidates. Letters A CRISPR-Cas9 gene drive system targeting female reproduction in the malaria mosquito vector Anopheles gambiae    pp78 - 83 Andrew Hammond, Roberto Galizi, Kyros Kyrou, Alekos Simoni, Carla Siniscalchi et al. doi:10.1038/nbt.3439 Development of a CRISPR/Cas9-based gene drive system in Anopheles gambiae, the main vector for the malaria parasite, paves the way for control of this pest insect. Comprehensive analysis of protein glycosylation by solid-phase extraction of N-linked glycans and glycosite-containing peptides   pp84 - 88 Shisheng Sun, Punit Shah, Shadi Toghi Eshghi, Weiming Yang, Namita Trikannad et al. doi:10.1038/nbt.3403 A chemoenzymatic method enables the quantitative analysis of both overall glycosylation patterns and site-specific glycan occupancy. Generation of serotonin neurons from human pluripotent stem cells   pp89 - 94 Jianfeng Lu, Xuefei Zhong, Huisheng Liu, Ling Hao, Cindy Tzu-Ling Huang et al. doi:10.1038/nbt.3435 Human pluripotent stem cells are efficiently differentiated to serotonin neurons, a cell type associated with various psychiatric disorders. See also: News and Views by Gaspar & Nedelec Resources Comprehensive characterization of the Published Kinase Inhibitor Set   pp95 - 103 Jonathan M Elkins, Vita Fedele, Marta Szklarz, Kamal R Abdul Azeez, Eidarus Salah et al. doi:10.1038/nbt.3374 A well-characterized library of experimental kinase inhibitors provides leads for targeting the untargeted kinome. The quantitative and condition-dependent Escherichia coli proteome   pp104 - 110 Alexander Schmidt, Karl Kochanowski, Silke Vedelaar, Erik Ahrne, Benjamin Volkmer et al. doi:10.1038/nbt.3418 A large-scale quantification of Escherichia coli proteomes across 22 experimental conditions. Careers and Recruitment Top Preparing future professionals by enhancing workforce readiness   pp111 - 113 Heather L Norman-Burgdolf and Nathan L Vanderford doi:10.1038/nbt.3459 A new course aims to help combat the absence of sufficient workforce preparedness for graduate students and postdoctoral fellows. People People   p114 doi:10.1038/nbt.3464 Top Natureevents is a fully searchable, multi-disciplinary database designed to maximise exposure for events organisers. The contents of the Natureevents Directory are now live. The digital version is available here. Find the latest scientific conferences, courses, meetings and symposia on natureevents.com. For event advertising opportunities across the Nature Publishing Group portfolio please contact natureevents@nature.com More Nature Events

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