Molecular Systems Biology - New articles published - 11 Jan 2016

December 2015 | Volume 11, Number 12 Submit Table of Contents Reports Articles Reviews Articles Commentary Editorial Reports Volume 11, Number 12 Reports Olfactory sensory neurons transiently express multiple olfactory receptors during development Single‐cell transcriptomic analyses of mouse olfactory sensory neurons reveal co‐expression of multiple olfactory receptors at an early developmental stage and provide insights into how the “one‐neuron‐one‐receptor” rule is established during neurogenesis. Longzhi Tan, Qian Li, and X Sunney Xie Published online 08.12.2015 Articles A genome‐scale screen reveals context‐dependent ovarian cancer sensitivity to miRNA overexpression A genomewide miRNA mimic toxicity screen indicates common and selective vulnerabilities of epithelial ovarian cancer cells. Follow‐up analyses offer mechanistic insights into the selective sensitivity of ovarian cancer cells to select miRNAs. Benjamin B Shields, Chad V Pecot, Hua Gao, Elizabeth McMillan, Malia Potts, Christa Nagel, Scott Purinton, Ying Wang, Cristina Ivan, Hyun Seok Kim, Robert J Borkowski, Shaheen Khan, Cristian Rodriguez‐Aguayo, Gabriel Lopez‐Berestein, Jayanthi Lea, Adi Gazdar, Keith A Baggerly, Anil K Sood, and Michael A White Published online 11.12.2015 Cell cycle networks link gene expression dysregulation, mutation, and brain maldevelopment in autistic toddlers Analyses of the relationship between blood gene expression and brain size in 142 Autism Spectrum Disorder (ASD) and control male toddlers reveal peripheral blood signatures of ASD and genetic mechanisms underlying abnormal early neural development. Tiziano Pramparo, Michael V Lombardo, Kathleen Campbell, Cynthia Carter Barnes, Steven Marinero, Stephanie Solso, Julia Young, Maisi Mayo, Anders Dale, Clelia Ahrens‐Barbeau, Sarah S Murray, Linda Lopez, Nathan Lewis, Karen Pierce, and Eric Courchesne Published online 14.12.2015 Reviews Fundamentals of protein interaction network mapping A practical guide to the fundamentals of protein interaction network mapping, providing information to help researchers make effective use of proteomics approaches. A range of new and well‐established experimental and computational methods and resources are covered. Jamie Snider, Max Kotlyar, Punit Saraon, Zhong Yao, Igor Jurisica, and Igor Stagljar Published online 17.12.2015 Articles The bimodally expressed microRNA miR‐142 gates exit from pluripotency The bimodally expressed microRNA miR‐142 defines two stochastically interconverting states of pluripotent embryonic stem cells: a state competent to differentiate and a state irresponsive to differentiation signals akin to a stem cell reservoir. Hanna L Sladitschek and Pierre A Neveu Published online 21.12.2015 Hierarchical folding and reorganization of chromosomes are linked to transcriptional changes in cellular differentiation Genome‐wide mapping of chromatin architecture reveals a hierarchical folding of chromatin that involves higher‐order domains interactions across the whole chromosomes, reflects epigenomic features and reorganizes upon differentiation‐induced gene expression changes. James Fraser, Carmelo Ferrai, Andrea M Chiariello, Markus Schueler, Tiago Rito, Giovanni Laudanno, Mariano Barbieri, Benjamin L Moore, Dorothee CA Kraemer, Stuart Aitken, Sheila Q Xie, Kelly J Morris, Masayoshi Itoh, Hideya Kawaji, Ines Jaeger, Yoshihide Hayashizaki, Piero Carninci, Alistair RR Forrest, The FANTOM Consortium, Colin A Semple, Josée Dostie, Ana Pombo, and Mario Nicodemi Published online 23.12.2015 A chemical–genetic interaction map of small molecules using high‐throughput imaging in cancer cells This study defines a quantitative map of phenotypic pharmacogenetic interactions in human cancer cells using high‐content imaging screens in a panel of isogenic cell lines. The resource is used to predict effective drug combinations, compound mode of action and off‐target effects. Marco Breinig, Felix A Klein, Wolfgang Huber, and Michael Boutros Published online 23.12.2015 Commentary The evolution of standards and data management practices in systems biology A recent community survey conducted by Infrastructure for Systems Biology Europe (ISBE) informs requirements for developing an efficient infrastructure for systems biology standards, data and model management. Natalie J Stanford, Katherine Wolstencroft, Martin Golebiewski, Renate Kania, Nick Juty, Christopher Tomlinson, Stuart Owen, Sarah Butcher, Henning Hermjakob, Nicolas Le Novère, Wolfgang Mueller, Jacky Snoep, and Carole Goble Published online 23.12.2015 The BioStudies database The BioStudies database is a new EMBL‐EBI resource that holds descriptions of biological studies, links to supporting data in other databases, and archives data files that do not fit in existing public structured archives. Jo McEntyre, Ugis Sarkans, and Alvis Brazma Published online 23.12.2015 Editorial Image data in need of a home Recognized public community databases for image data deposition have been lacking so far. New databases are emerging that provide a promising infrastructure for hosting and distributing high content imaging datasets. Thomas Lemberger Published online 23.12.2015 Reports Regulation of alternative splicing at the single‐cell level Single‐cell quantification of expression levels of alternatively spliced isoforms identifies what governs the precision of cassette exon inclusion levels among single cells in a cell population. Lior Faigenbloom, Nimrod D Rubinstein, Yoel Kloog, Itay Mayrose, Tal Pupko, and Reuven Stein Published online 28.12.2015   Unsubscribe from or edit your subscription for this service. Or by mail: Customer Service * 425 Broadway St * Redwood City, CA 94063 * U.S.A. Copyright © 2016 by the European Molecular Biology Organisation.