Leukemia - Table of Contents alert Volume 30 Issue 1

If you are unable to see the message below, click here to view.

TABLE OF CONTENTS Volume 30, Issue 1 (January 2016) In this issue Original Articles Letters to the Editor Also new AOP Sign up for e-alerts Recommend to your library Web feed Follow on Twitter Subscribe Advertisement Blood Cancer Journal is an online-only, open access journal publishing high quality research on hematologic malignancies and related disorders.The journal has an Impact Factor of 3.467. Explore the benefits of submitting your next research article. Original Articles Top ACUTE MYELOID LEUKEMIA FoxO1-dependent induction of acute myeloid leukemia by osteoblasts in mice A Kode, I Mosialou, S J Manavalan, C V Rathinam, R A Friedman, J Teruya-Feldstein, G Bhagat, E Berman and S Kousteni Leukemia 2016 30: 1-13; advance online publication, June 25, 2015; 10.1038/leu.2015.161 Abstract | Full Text Genome-scale definition of the transcriptional programme associated with compromised PU.1 activity in acute myeloid leukaemia OPEN J I Sive, S Basilico, R Hannah, S J Kinston, F J Calero-Nieto and B Göttgens Leukemia 2016 30: 14-23; advance online publication, July 1, 2015; 10.1038/leu.2015.172 Abstract | Full Text Treatment, trial participation and survival in adult acute myeloid leukemia: a population-based study in the Netherlands, 1989–2012 A G Dinmohamed, O Visser, Y van Norden, N M A Blijlevens, J J Cornelissen, G A Huls, P C Huijgens, P Sonneveld, A A van de Loosdrecht, G J Ossenkoppele, B Löwenberg and M Jongen-Lavrencic Leukemia 2016 30: 24-31; advance online publication, July 17, 2015; 10.1038/leu.2015.188 Abstract | Full Text ACUTE LYMPHOBLASTIC LEUKEMIA Prognostic value of rare IKZF1 deletion in childhood B-cell precursor acute lymphoblastic leukemia: an international collaborative study J M Boer, A van der Veer, D Rizopoulos, M Fiocco, E Sonneveld, H A de Groot-Kruseman, R P Kuiper, P Hoogerbrugge, M Horstmann, M Zaliova, C Palmi, J Trka, E Fronkova, M Emerenciano, M do Socorro Pombo-de-Oliveira, W Mlynarski, T Szczepanski, K Nebral, A Attarbaschi, N Venn, R Sutton, C J Schwab, A Enshaei, A Vora, M Stanulla, M Schrappe, G Cazzaniga, V Conter, M Zimmermann, A V Moorman, R Pieters and M L den Boer Leukemia 2016 30: 32-38; advance online publication, July 23, 2015; 10.1038/leu.2015.199 Abstract | Full Text Impact of PTEN abnormalities on outcome in pediatric patients with T-cell acute lymphoblastic leukemia treated on the MRC UKALL2003 trial OPEN S Jenkinson, A A Kirkwood, N Goulden, A Vora, D C Linch and R E Gale Leukemia 2016 30: 39-47; advance online publication, July 29, 2015; 10.1038/leu.2015.206 Abstract | Full Text CHRONIC MYELOGENOUS LEUKEMIA Prognosis of long-term survival considering disease-specific death in patients with chronic myeloid leukemia M Pfirrmann, M Baccarani, S Saussele, J Guilhot, F Cervantes, G Ossenkoppele, V S Hoffmann, F Castagnetti, J Hasford, R Hehlmann and B Simonsson Leukemia 2016 30: 48-56; advance online publication, September 29, 2015; 10.1038/leu.2015.261 Abstract | Full Text Frontline nilotinib in patients with chronic myeloid leukemia in chronic phase: results from the European ENEST1st study OPEN A Hochhaus, G Rosti, N C P Cross, J L Steegmann, P le Coutre, G Ossenkoppele, L Petrov, T Masszi, A Hellmann, L Griskevicius, W Wiktor-Jedrzejczak, D Rea, D Coriu, T H Brümmendorf, K Porkka, G Saglio, G Gastl, M C Müller, P Schuld, P Di Matteo, A Pellegrino, L Dezzani, F-X Mahon, M Baccarani and F J Giles Leukemia 2016 30: 57-64; advance online publication, October 6, 2015; 10.1038/leu.2015.270 Abstract | Full Text CHRONIC LYMPHOCYTIC LEUKEMIA Metabolic plasticity in CLL: adaptation to the hypoxic niche OPEN K M Koczula, C Ludwig, R Hayden, L Cronin, G Pratt, H Parry, D Tennant, M Drayson, C M Bunce, F L Khanim and U L Günther Leukemia 2016 30: 65-73; advance online publication, July 23, 2015; 10.1038/leu.2015.187 Abstract | Full Text Cytoplasmic myosin-exposed apoptotic cells appear with caspase-3 activation and enhance CLL cell viability X Cui, L Zhang, A R Magli, R Catera, X-J Yan, D O Griffin, T L Rothstein, J Barrientos, J E Kolitz, S L Allen, K R Rai, N Chiorazzi and C C Chu Leukemia 2016 30: 74-85; advance online publication, July 29, 2015; 10.1038/leu.2015.204 Abstract | Full Text LYMPHOMA Dual inhibition of CDK4/Rb and PI3K/AKT/mTOR pathways by ON123300 induces synthetic lethality in mantle cell lymphomas S K A Divakar, M V Ramana Reddy, S C Cosenza, S J Baker, D Perumal, A C Antonelli, J Brody, B Akula, S Parekh and E Premkumar Reddy Leukemia 2016 30: 86-93; advance online publication, July 15, 2015; 10.1038/leu.2015.185 Abstract | Full Text Contribution of JAK2 mutations to T-cell lymphoblastic lymphoma development OPEN A M Roncero, P López-Nieva, M A Cobos-Fernández, M Villa-Morales, L González-Sánchez, J L López-Lorenzo, P Llamas, C Ayuso, S M Rodríguez-Pinilla, M C Arriba, M A Piris, P Fernández-Navarro, A F Fernández, M F Fraga, J Santos and J Fernández-Piqueras Leukemia 2016 30: 94-103; advance online publication, July 28, 2015; 10.1038/leu.2015.202 Abstract | Full Text MULTIPLE MYELOMA, GAMMOPATHIES Mitochondrial thioredoxin reductase regulates major cytotoxicity pathways of proteasome inhibitors in multiple myeloma cells E E Fink, S Mannava, A Bagati, A Bianchi-Smiraglia, J R Nair, K Moparthy, B C Lipchick, M Drokov, A Utley, J Ross, L P Mendeleeva, V G Savchenko, K P Lee and M A Nikiforov Leukemia 2016 30: 104-111; advance online publication, July 24, 2015; 10.1038/leu.2015.190 Abstract | Full Text MYELODYSPLASTIC SYNDROME Blockade of BCL-2 proteins efficiently induces apoptosis in progenitor cells of high-risk myelodysplastic syndromes patients S Jilg, V Reidel, C Müller-Thomas, J König, J Schauwecker, U Höckendorf, C Huberle, O Gorka, B Schmidt, R Burgkart, J Ruland, H-J Kolb, C Peschel, R A J Oostendorp, K S Götze and P J Jost Leukemia 2016 30: 112-123; advance online publication, July 8, 2015; 10.1038/leu.2015.179 Abstract | Full Text CHRONIC MYLEPROLIFERATIVE NEOPLASMS Increased IL6 plasma levels in indolent systemic mastocytosis patients are associated with high risk of disease progression A Mayado, C Teodosio, A C Garcia-Montero, A Matito, A Rodriguez-Caballero, J M Morgado, C Muñiz, M Jara-Acevedo, I Álvarez-Twose, L Sanchez-Muñoz, S Matarraz, C Caldas, J I Muñoz-González, L Escribano and A Orfao Leukemia 2016 30: 124-130; advance online publication, July 8, 2015; 10.1038/leu.2015.176 Abstract | Full Text A new monoclonal antibody (CAL2) detects CALRETICULIN mutations in formalin-fixed and paraffin-embedded bone marrow biopsies OPEN H Stein, R Bob, H Dürkop, C Erck, D Kämpfe, H-M Kvasnicka, H Martens, A Roth and A Streubel Leukemia 2016 30: 131-135; advance online publication, July 23, 2015; 10.1038/leu.2015.192 Abstract | Full Text Additional mutations in SRSF2, ASXL1 and/or RUNX1 identify a high-risk group of patients with KIT D816V+ advanced systemic mastocytosis M Jawhar, J Schwaab, S Schnittger, M Meggendorfer, M Pfirrmann, K Sotlar, H-P Horny, G Metzgeroth, S Kluger, N Naumann, C Haferlach, T Haferlach, P Valent, W-K Hofmann, A Fabarius, N C P Cross and A Reiter Leukemia 2016 30: 136-143; advance online publication, October 14, 2015; 10.1038/leu.2015.284 Abstract | Full Text STEM CELL BIOLOGY Activation of OCT4 enhances ex vivo expansion of human cord blood hematopoietic stem and progenitor cells by regulating HOXB4 expression X Huang, M-R Lee, S Cooper, G Hangoc, K-S Hong, H-M Chung and H E Broxmeyer Leukemia 2016 30: 144-153; advance online publication, July 23, 2015; 10.1038/leu.2015.189 Abstract | Full Text Altered mesenchymal niche cells impede generation of normal hematopoietic progenitor cells in leukemic bone marrow M Lim, Y Pang, S Ma, S Hao, H Shi, Y Zheng, C Hua, X Gu, F Yang, W Yuan and T Cheng Leukemia 2016 30: 154-162; advance online publication, August 4, 2015; 10.1038/leu.2015.210 Abstract | Full Text MOLECULAR TARGETS FOR THERAPY The BAFF receptor TACI controls IL-10 production by regulatory B cells and CLL B cells D Saulep-Easton, F B Vincent, P S Quah, A Wei, S B Ting, C M Croce, C Tam and F Mackay Leukemia 2016 30: 163-172; advance online publication, July 3, 2015; 10.1038/leu.2015.174 Abstract | Full Text Discovery of a BTK/MNK dual inhibitor for lymphoma and leukemia H Wu, C Hu, A Wang, E L Weisberg, Y Chen, C-H Yun, W Wang, Y Liu, X Liu, B Tian, J Wang, Z Zhao, Y Liang, B Li, L Wang, B Wang, C Chen, S J Buhrlage, Z Qi, F Zou, A Nonami, Y Li, S M Fernandes, S Adamia, R M Stone, I A Galinsky, X Wang, G Yang, J D Griffin, J R Brown, M J Eck, J Liu, N S Gray and Q Liu Leukemia 2016 30: 173-181; advance online publication, July 13, 2015; 10.1038/leu.2015.180 Abstract | Full Text NOTCH1 mutations associate with low CD20 level in chronic lymphocytic leukemia: evidence for a NOTCH1 mutation-driven epigenetic dysregulation F Pozzo, T Bittolo, F Arruga, P Bulian, P Macor, E Tissino, B Gizdic, F M Rossi, R Bomben, A Zucchetto, D Benedetti, M Degan, G D'Arena, A Chiarenza, F Zaja, G Pozzato, D Rossi, G Gaidano, G Del Poeta, S Deaglio, V Gattei and M Dal Bo Leukemia 2016 30: 182-189; advance online publication, July 13, 2015; 10.1038/leu.2015.182 Abstract | Full Text Activity of a selective inhibitor of nuclear export, selinexor (KPT-330), against AML-initiating cells engrafted into immunosuppressed NSG mice J Etchin, J Montero, A Berezovskaya, B T Le, A Kentsis, A L Christie, A S Conway, W C Chen, C Reed, M R Mansour, C E L Ng, S Adamia, S J Rodig, I A Galinsky, R M Stone, B Klebanov, Y Landesman, M Kauffman, S Shacham, A L Kung, J C Y Wang, A Letai and A T Look Leukemia 2016 30: 0; advance online publication, July 23, 2015; 10.1038/leu.2015.194 Abstract | Full Text Runx1 repression by histone deacetylation is critical for Setbp1-induced mouse myeloid leukemia development B A Vishwakarma, N Nguyen, H Makishima, N Hosono, K O Gudmundsson, V Negi, K Oakley, Y Han, B Przychodzen, J P Maciejewski and Y Du Leukemia 2016 30: 200-208; advance online publication, July 24, 2015; 10.1038/leu.2015.200 Abstract | Full Text Pharmacological inhibition of fatty-acid oxidation synergistically enhances the effect of l-asparaginase in childhood ALL cells I Hermanova, A Arruabarrena-Aristorena, K Valis, H Nuskova, M Alberich-Jorda, K Fiser, S Fernandez-Ruiz, D Kavan, A Pecinova, M Niso-Santano, M Zaliova, P Novak, J Houstek, T Mracek, G Kroemer, A Carracedo, J Trka and J Starkova Leukemia 2016 30: 209-218; advance online publication, August 4, 2015; 10.1038/leu.2015.213 Abstract | Full Text HSP90 inhibition leads to degradation of the TYK2 kinase and apoptotic cell death in T-cell acute lymphoblastic leukemia K Akahane, T Sanda, M R Mansour, T Radimerski, D J DeAngelo, D M Weinstock and A T Look Leukemia 2016 30: 219-228; advance online publication, August 12, 2015; 10.1038/leu.2015.222 Abstract | Full Text TRANSCRIPTIONAL CONTROL AND SIGNAL TRANSDUCTION, CELL CYCLE Aberrant expression of miR-9/9* in myeloid progenitors inhibits neutrophil differentiation by post-transcriptional regulation of ERG K Nowek, S M Sun, L Bullinger, E M J Bindels, C Exalto, M K Dijkstra, K van Lom, H Döhner, S J Erkeland, B Löwenberg and M Jongen-Lavrencic Leukemia 2016 30: 229-237; advance online publication, July 15, 2015; 10.1038/leu.2015.183 Abstract | Full Text Letters to the Editor Top PET/CT in primary mediastinal large B-cell lymphoma responding to rituximab-CHOP: An analysis of 106 patients regarding prognostic significance and implications for subsequent radiotherapy T P Vassilakopoulos, G A Pangalis, S Chatziioannou, S Papageorgiou, M K Angelopoulou, Z Galani, G Kourti, V Prassopoulos, T Leonidopoulou, E Terpos, M N Dimopoulou, S Sachanas, C Kalpadakis, P Konstantinidou, D Boutsis, E Stefanoudaki, L Kyriazopoulou, M P Siakantaris, M-C Kyrtsonis, E Variami, I Kotsianidis, A Symeonidis, E Michali, E Katodritou, G Kokkini, C Tsatalas, H Papadaki, M-A Dimopoulos, V Sotiropoulos, V Pappa, T Karmiris, J Meletis, J Apostolidis, I Datseris, P Panayiotidis, K Konstantopoulos, P Roussou and P Rondogianni Leukemia 2016 30: 238-242; advance online publication, May 14, 2015; 10.1038/leu.2015.120 Full Text Comprehensive analysis of factors impacting risks and outcomes of therapy-related myeloid neoplasms following breast cancer treatment K Sevcikova, Z Zhuang, G Garcia-Manero, R H Alvarez, H M Kantarjian, M Mego, C Albarracin, G Tang, S S Strom, L J Medeiros, G N Hortobagyi, J M Reuben and J D Khoury Leukemia 2016 30: 243-247; advance online publication, May 15, 2015; 10.1038/leu.2015.122 Full Text Targeted resequencing analysis of 31 genes commonly mutated in myeloid disorders in serial samples from myelodysplastic syndrome patients showing disease progression OPEN A Pellagatti, S Roy, C Di Genua, A Burns, K McGraw, S Valletta, M J Larrayoz, M Fernandez-Mercado, J Mason, S Killick, C Mecucci, M J Calasanz, A List, A Schuh and J Boultwood Leukemia 2016 30: 248-250; advance online publication, May 20, 2015; 10.1038/leu.2015.129 Full Text The leukemia-associated RUNX1/ETO oncoprotein confers a mutator phenotype OPEN V J Forster, M H Nahari, N Martinez-Soria, A K Bradburn, A Ptasinska, S A Assi, S E Fordham, H McNeil, C Bonifer, O Heidenreich and J M Allan Leukemia 2016 30: 251-254; advance online publication, June 8, 2015; 10.1038/leu.2015.133 Full Text IL1RAP expression as a measure of leukemic stem cell burden at diagnosis of chronic myeloid leukemia predicts therapy outcome N Landberg, N Hansen, M Askmyr, H Ågerstam, C Lassen, M Rissler, H Hjorth-Hansen, S Mustjoki, M Järås, J Richter and T Fioretos Leukemia 2016 30: 255-258; advance online publication, June 12, 2015; 10.1038/leu.2015.135 Full Text Array CGH identifies copy number changes in 11% of 520 MDS patients with normal karyotype and uncovers prognostically relevant deletions S Volkert, T Haferlach, J Holzwarth, M Zenger, W Kern, M Staller, Y Nagata, K Yoshida, S Ogawa, S Schnittger and C Haferlach Leukemia 2016 30: 259-261; advance online publication, September 22, 2015; 10.1038/leu.2015.257 Full Text Natureevents is a fully searchable, multi-disciplinary database designed to maximise exposure for events organisers. The contents of the Natureevents Directory are now live. The digital version is available here. Find the latest scientific conferences, courses, meetings and symposia on natureevents.com. For event advertising opportunities across the Nature Publishing Group portfolio please contact natureevents@nature.com More Nature Events Please note that you need to be a subscriber or site-licence holder to enjoy full-text access to Leukemia. In order to do so, please purchase a subscription. You have been sent this Table of Contents Alert because you have opted in to receive it. You can change or discontinue your e-mail alerts at any time, by modifying your preferences on your nature.com account at: www.nature.com/nams/svc/myaccount (You will need to log in to be recognised as a nature.com registrant). For further technical assistance, please contact our registration department. For print subscription enquiries, please contact our subscription department. For other enquiries, please contact our customer feedback department. Nature Publishing Group |One New York Plaza, Suite 4500 | New York | NY 10004-1562 | USA Nature Publishing Group's worldwide offices: London - Paris - Munich - New Delhi - Tokyo - Melbourne San Diego - San Francisco - Washington - New York - Boston Macmillan Publishers Limited is a company incorporated in England and Wales under company number 785998 and whose registered office is located at Brunel Road, Houndmills, Basingstoke, Hampshire RG21 6XS. © 2016 Nature Publishing Group, a division of Macmillan Publishers Limited. All Rights Reserved.