Nature Biotechnology Contents: Volume 33 pp 1213 - 1300

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TABLE OF CONTENTS December 2015 Volume 33, Issue 12 Editorial News Bioentrepreneur Opinion and Comment Features News and Views Computational Biology Research Careers and Recruitment Subscribe   Facebook   RSS   Recommend to library   Twitter   Advertisement BIOPHARMA DEALMAKERS Company Profiles and Partnering Opportunities   Advertisement Nature Protocols is setting the benchmark for publishing high-quality peer-reviewed protocols for biological and biomedical research, containing all the technical info you need to reproduce experiments in your own lab. Visit the Nature Protocols website to access our step-by-step guides to using and adapting research techniques from the world's leading laboratories. www.nature.com/nprot      Editorial Top 20 years of bio-lox   p1213 doi:10.1038/nbt.3438 Here's hoping that a proposed shakeup of US regulations will mean that new biotech products avoid AquaAdvantage salmon's two-decade upstream struggle to regulatory approval. News Top Anti-CD20 antibody wows in multiple sclerosis   pp1215 - 1216 Cormac Sheridan doi:10.1038/nbt1215-1215 Predictive biomarkers for checkpoints, first tests approved   pp1217 - 1218 Ken Garber doi:10.1038/nbt1215-1217 IBM debuts hyped 'cognitive cloud' biotech HQ in Cambridge   pp1219 - 1220 Lucas Laursen doi:10.1038/nbt1215-1219 23andMe protects consumers' data   p1220 Laura DeFrancesco doi:10.1038/nbt1215-1220 A face-lift for biotech rules begins   pp1221 - 1222 Emily Waltz doi:10.1038/nbt1215-1221 Tumor macrophage target fuels $1.7-billion deal   p1222 Ken Garber doi:10.1038/nbt1215-1222 Trade pact blow for innovative drug developers   p1223 Chris Morrison doi:10.1038/nbt1215-1223 Advertisement Renova Life Inc. specializes in transgenic rabbits and guinea pigs production via conventional DNA or RNA microinjection, engaged in developing bioreactor systems and/or novel disease models with TELAN and CRISPR-Cas9 editing technologies. For more information, please see http://www.renovalife.com/transgenic_rabbits.php http://www.renovalife.com/gene%20editing.php Bioentrepreneur Top Building a business Share and share alike   pp1224 - 1228 Samuel K Sia and Matthew P Owens doi:10.1038/nbt.3422 Opinion and Comment Top Correspondence Trade-sale exits in different biotech sectors   pp1229 - 1231 Kenneth Fernald and Eric Claassen doi:10.1038/nbt.3304 Features Top Patents Patenting parthenotes in the US and Europe   pp1232 - 1234 Vincenzo Senatore, Christopher Thomas Scott and Vittorio Sebastiano doi:10.1038/nbt.3421 The real nature of a parthenote determines its ultimate value. Recent patents in antibody engineering   p1235 doi:10.1038/nbt.3430 News and Views Top Patching up hematopoietic stem cells   pp1236 - 1238 Giorgia Santilli and Adrian J Thrasher doi:10.1038/nbt.3425 An approach for efficient genome editing in human hematopoietic stem cells could be useful in the treatment of immunological disorders. See also: Research by Wang et al. Your gut microbiome, deconstructed   pp1238 - 1240 Dylan Dodd, Carolina Tropini and Justin L Sonnenburg doi:10.1038/nbt.3431 Use of sophisticated reductionist and whole-system approaches are providing much-needed technologies to unravel the complex melange of microbiome functions. Cas9 gets a classmate   pp1240 - 1241 Erik J Sontheimer and Scot A Wolfe doi:10.1038/nbt.3426 Cpf1 is one of a growing number of class II CRISPR-Cas effectors that expand both our understanding of bacterial immunity and our genome-editing toolset. Research Highlights   p1241 doi:10.1038/nbt.3424 Biotechnology JOBS of the week Faculty Positions in Translational Plant Sciences University of California, Riverside Postdoctoral Fellows Icahn School of Medicine at Mount Sinai Novo Nordisk Foundation Laureate Research Grants Novo Nordisk Foundation One PhD Position Leibniz-Institut für Polymerforschung Dresden e.V. (IPF) More Science jobs from Biotechnology EVENT ECB2016 - 17th European Congress on Biotechnology July 3, 2016 Kraków, Poland More science events from Computational Biology Top Analysis Affinity regression predicts the recognition code of nucleic acid-binding proteins   pp1242 - 1249 Raphael Pelossof, Irtisha Singh, Julie L Yang, Matthew T Weirauch, Timothy R Hughes et al. doi:10.1038/nbt.3343 The specificity of DNA- and RNA-binding proteins is predicted from primary protein sequences using a machine learning approach. Research Top Articles Safeguarding CRISPR-Cas9 gene drives in yeast   pp1250 - 1255 James E DiCarlo, Alejandro Chavez, Sven L Dietz, Kevin M Esvelt and George M Church doi:10.1038/nbt.3412 Molecular strategies are developed to safeguard the use of CRISPR-Cas9 gene drive technology. Homology-driven genome editing in hematopoietic stem and progenitor cells using ZFN mRNA and AAV6 donors   pp1256 - 1263 Jianbin Wang, Colin M Exline, Joshua J DeClercq, G Nicholas Llewellyn, Samuel B Hayward et al. doi:10.1038/nbt.3408 See also: News and Views by Santilli & Thrasher Long-term culture and expansion of primary human hepatocytes   pp1264 - 1271 Gahl Levy, David Bomze, Stefan Heinz, Sarada Devi Ramachandran, Astrid Noerenberg et al. doi:10.1038/nbt.3377 Primary human hepatocytes are expanded in culture while retaining metabolic function. Evolution of translation machinery in recoded bacteria enables multi-site incorporation of nonstandard amino acids   pp1272 - 1279 Miriam Amiram, Adrian D Haimovich, Chenguang Fan, Yane-Shih Wang, Hans-Rudolf Aerni et al. doi:10.1038/nbt.3372 Non-standard amino acids are incorporated into proteins at large numbers of sites using evolved translation components in recoded bacteria. Letters Soft, stretchable, fully implantable miniaturized optoelectronic systems for wireless optogenetics   pp1280 - 1286 Sung Il Park, Daniel S Brenner, Gunchul Shin, Clinton D Morgan, Bryan A Copits et al. doi:10.1038/nbt.3415 Optogenetic studies of the peripheral nervous system and spinal cord are enabled by soft, wirelessly powered biocompatible devices. GFP-specific CD8 T cells enable targeted cell depletion and visualization of T-cell interactions   pp1287 - 1292 Judith Agudo, Albert Ruzo, Eun Sook Park, Robert Sweeney, Veronika Kana et al. doi:10.1038/nbt.3386 T cells specific for GFP allow depletion of specific cell types in mice. Broadening the targeting range of Staphylococcus aureus CRISPR-Cas9 by modifying PAM recognition   pp1293 - 1298 Benjamin P Kleinstiver, Michelle S Prew, Shengdar Q Tsai, Nhu T Nguyen, Ved V Topkar et al. doi:10.1038/nbt.3404 Utility of the small Staphylococcus aureus Cas9 is improved by broadening its targeting range through molecular evolution of its PAM sequence. Careers and Recruitment Top People People   p1300 doi:10.1038/nbt.3429 Advertisement This special issue, the last of our 10th anniversary volume, presents a collection of articles focused on "Frontiers in chemical biology" and identifies some of the emerging scientific areas that will engage chemical biologists in the coming years.  Click here to see this issue!      Natureevents is a fully searchable, multi-disciplinary database designed to maximise exposure for events organisers. The contents of the Natureevents Directory are now live. The digital version is available here. 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