Nature Biotechnology Contents: Volume 33 pp 1 - 110

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Advertisement A*STAR Research - Highlighting the best of research at the Agency for Science, Technology and Research (A*STAR), Singapore's premier research organization   Recent Highlights                                           Bioinformatics: Genetic sleuth tracks undiagnosed diseases | Alzheimer's disease: Brain arteries in a dish | Cancer biology: Tumor-causing crosstalk Download the A*STAR Research app now!    TABLE OF CONTENTS January 2015 Volume 33, Issue 1 Editorial News Bioentrepreneur Opinion and Comment Features News and Views Computational Biology Research Careers and Recruitment Advertisement   Your definitive source for information on non-animal approaches to chemical safety assessment Science | Development | Validation | Acceptance | Policy Subscribe   Facebook   RSS   Recommend to library   Twitter   Advertisement Genomic know-how ® - it's how experiments succeed. You need answers to complex biological questions. We have deep expertise across a wide range of technologies to help you get it right the first time. At EA | Quintiles, our experienced scientists leverage innovative bioinformatics and methodologies to give you the genomic information you need to succeed. www.genomicknowhow.com   Advertisement BIOPHARMA DEALMAKERS Company Profiles and Partnering Opportunities   Editorial Top Bring out your dead   p1 doi:10.1038/nbt.3123 Despite recent progress, only a fraction of the drug industry's shelved compounds are shared with the research community. Could online collaborative research offer a solution? News Top IL-17-targeting biologics aim to become standard of care in psoriasis   pp3 - 4 Mark Ratner doi:10.1038/nbt0115-3 BioMarin moves into muscular dystrophy with acquisition   p4 doi:10.1038/nbt0115-4a PCORI takes up HCV treatment options   p4 doi:10.1038/nbt0115-4b Amgen's angiopoietin blocker fails in ovarian cancer   pp5 - 6 Cormac Sheridan doi:10.1038/nbt0115-5 Clinuvel's tanning agent nears approval for porphyria   p7 Asher Mullard doi:10.1038/nbt0115-7 Foundation receives $3.3-billion windfall for Kalydeco   pp8 - 9 Melanie Senior doi:10.1038/nbt0115-8 FDA OKs breakthrough B meningitis vaccine   p9 doi:10.1038/nbt0115-9a Universities, drug makers form GPCR Consortium   p9 doi:10.1038/nbt0115-9b BMS options Galecto buy   p9 doi:10.1038/nbt0115-9c IBM's Watson Group signs up genomics partners   pp10 - 11 Mark Ratner doi:10.1038/nbt0115-10 How frothy is this IPO window?   p11 Brian Orelli doi:10.1038/nbt0115-11 USDA approves next-generation GM potato   pp12 - 13 Emily Waltz doi:10.1038/nbt0115-12 Around the world in a month   p13 doi:10.1038/nbt0115-13 News Feature Social storm   pp14 - 17 Virginia Hughes doi:10.1038/nbt.3106 The drug industry is struggling to find ways of engaging with consumers on social media. Failure to adapt may bring substantial opportunity costs, argues Virginia Hughes. Bioentrepreneur Top Datapage Innovative startups in 2014   p18 Brady Huggett doi:10.1038/nbt.3113 Opinion and Comment Top Correspondence Biosimilars or semi-similars?   pp19 - 20 Huub Schellekens and Ellen Moors doi:10.1038/nbt.3083 Outcubation[mdash]where incubation meets outsourcing   pp20 - 21 Ulrich A K Betz and Christian A Tidona doi:10.1038/nbt.3112 PeptideShaker enables reanalysis of MS-derived proteomics data sets   pp22 - 24 Marc Vaudel, Julia M Burkhart, Rene P Zahedi, Eystein Oveland, Frode S Berven et al. doi:10.1038/nbt.3109 Intellectual property issues and synthetic biology standards   pp24 - 25 Jorge L Contreras, Arti K Rai and Andrew W Torrance doi:10.1038/nbt.3107 Reply to Intellectual property issues and synthetic biology standards   p25 doi:10.1038/nbt.3114 Status and market potential of transgenic biofortified crops   pp25 - 29 Hans De Steur, Dieter Blancquaert, Simon Strobbe, Willy Lambert, Xavier Gellynck et al. doi:10.1038/nbt.3110 Features Top Selling long life   pp31 - 40 Christopher Thomas Scott and Laura DeFrancesco doi:10.1038/nbt.3108 A new generation of commercial entities is beginning to explore opportunities for new types of interventions and services in a graying world. Patents The impact of European embryonic stem cell patent decisions on research strategies   pp41 - 43 Aurelie Mahalatchimy, Emmanuelle Rial-Sebbag, Anne-Marie Duguet, Florence Taboulet and Anne Cambon-Thomsen doi:10.1038/nbt.3105 Recent restrictions on the patentability of human embryonic stem cell inventions in Europe necessitate a shift in R&D strategies. News and Views Top Cancer immunotherapy meets biomaterials   pp44 - 45 Jeffrey S Weber and James J Mule doi:10.1038/nbt.3119 Engineered biomaterials boost the efficacy of cancer vaccines and adoptive T cell therapies. See also: Research by Kim et al. | Research by Stephan et al. Modeling the course of amyotrophic lateral sclerosis   pp45 - 47 Christina Fournier and Jonathan D Glass doi:10.1038/nbt.3118 Large-scale computational analysis of patient data leads to better models of disease progression. See also: Computational Biology by Kuffner et al. Systematic discovery of probiotics   pp47 - 49 Samuel C Forster and Trevor D Lawley doi:10.1038/nbt.3111 Systems-level modeling of the gut microbiota uncovers a candidate bacteriotherapy for Clostridium difficile. Research Highlights   p48 doi:10.1038/nbt.3120 DREAMing of benchmarks   pp49 - 50 Irene Jarchum and Susan Jones doi:10.1038/nbt.3115 Biotechnologuy JOBS of the week PhD Position in Structural Biology and Molecular Biophysics VIB Structural Biology Research Center Postdoctoral Scientist – Studying Peripheral Neuropathies in Drosophila VIB Department of Molecular Genetics, University of Antwerp Faculty Positions in Biomedical Sciences Alfaisal University Posdoctoral Reaserch in Biophotonics Ben-Gurion University of the Negev More Science jobs from Biotechnologuy EVENT Biotechnology for the Non-Biotechnologist April 22, 2015 Nice, France More science events from Computational Biology Top Analysis Crowdsourced analysis of clinical trial data to predict amyotrophic lateral sclerosis progression   pp51 - 57 Robert Kuffner, Neta Zach, Raquel Norel, Johann Hawe, David Schoenfeld et al. doi:10.1038/nbt.3051 An open competition to predict the progression of amyotrophic lateral sclerosis (ALS, also known as Lou Gehrigs disease) disease from the largest database of ALS clinical trial data yields potential new biomarkers and algorithms that outperform human clinicians. See also: News and Views by Fournier & Glass Research Top Analysis A comparison of non-integrating reprogramming methods   pp58 - 63 Thorsten M Schlaeger, Laurence Daheron, Thomas R Brickler, Samuel Entwisle, Karrie Chan et al. doi:10.1038/nbt.3070 A comparison of different ways of generating induced pluripotent stem cells helps researchers choose the most appropriate method for particular applications. Articles Injectable, spontaneously assembling, inorganic scaffolds modulate immune cells in vivo and increase vaccine efficacy   pp64 - 72 Jaeyun Kim, Weiwei Aileen Li, Youngjin Choi, Sarah A Lewin, Catia S Verbeke et al. doi:10.1038/nbt.3071 Vaccine efficiency is enhanced by mesoporous silica rods that spontaneously form a 3D microenvironment for immune cells. See also: News and Views by Weber & Mule Cationic lipid-mediated delivery of proteins enables efficient protein-based genome editing in vitro and in vivo    pp73 - 80 John A Zuris, David B Thompson, Yilai Shu, John P Guilinger, Jeffrey L Bessen et al. doi:10.1038/nbt.3081 Efficient protein delivery using cationic lipid transfection reagents enables high efficiency protein-based genome editing in vivo and in vitro. Engineered liposomes sequester bacterial exotoxins and protect from severe invasive infections in mice   pp81 - 88 Brian D Henry, Daniel R Neill, Katrin Anne Becker, Suzanna Gore, Laura Bricio-Moreno et al. doi:10.1038/nbt.3037 Decoy liposomes that bind and sequester bacterial exotoxins can be used to combat septicemia and infection. Combinatorial analysis of developmental cues efficiently converts human pluripotent stem cells into multiple neuronal subtypes   pp89 - 96 Yves Maury, Julien Come, Rebecca A Piskorowski, Nouzha Salah-Mohellibi, Vivien Chevaleyre et al. doi:10.1038/nbt.3049 Combinatorial screening of developmental factors improves directed differentiation of human pluripotent stem cells into neuronal subtypes. Letters Biopolymer implants enhance the efficacy of adoptive T-cell therapy   pp97 - 101 Sirkka B Stephan, Alexandria M Taber, Ilona Jileaeva, Ericka P Pegues, Charles L Sentman et al. doi:10.1038/nbt.3104 Delivery of T cells using an alginate polymer-based implant enhances the efficacy of cancer immunotherapy. See also: Research by Stephan et al. In vivo interrogation of gene function in the mammalian brain using CRISPR-Cas9   pp102 - 106 Lukasz Swiech, Matthias Heidenreich, Abhishek Banerjee, Naomi Habib, Yinqing Li et al. doi:10.1038/nbt.3055 CRISPR-Cas9 can be used to edit both single and multiple genes in postmitotic neurons in adult mice enabling rapid assessment of gene functions in the brain. Careers and Recruitment Top Life sciences workforce trends evolve with the industry   pp107 - 109 Kathy L Nugent and Lori Lindburg doi:10.1038/nbt.3116 As the biotech industry grows and shifts within an increasingly global economy, so does its need for talent that spans discovery through commercialization. People People   p110 doi:10.1038/nbt.3125 Top Natureevents is a fully searchable, multi-disciplinary database designed to maximise exposure for events organisers. The contents of the Natureevents Directory are now live. The digital version is available here. Find the latest scientific conferences, courses, meetings and symposia on natureevents.com. For event advertising opportunities across the Nature Publishing Group portfolio please contact natureevents@nature.com More Nature Events

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