Nature Biotechnology Contents: Volume 32 pp 201 - 294

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TABLE OF CONTENTS March 2014 Volume 32, Issue 3 Editorial News Correction Bioentrepreneur Opinion and Comment Features News and Views Computational Biology Research Careers and Recruitment Subscribe   Facebook   RSS   Recommend to library   Twitter   Advertisement BIOPHARMA DEALMAKERS Company Profiles and Partnering Opportunities   Advertisement The Structural Genomics Consortium (SGC), Natureconferences, and the São Paulo Research Foundation are pleased to present: Chemical Probe-based Open Science: Uncovering New Human and Plant Biology April 28-29, 2014 Faculdade de Ciências Médicas, State University of Campinas (UNICAMP), Brazil Click here for more information or to register for this conference today!     Editorial Top Is this really the RNAissance?   p201 doi:10.1038/nbt.2853 Renewed investor interest in RNA interference (RNAi) is enabling pioneering companies to forge ahead in the clinic. Does this signify a renaissance in RNAi therapy? News Top Markets, venture investors and big pharma interest in RNAi soars   pp203 - 204 Aaron Bouchie doi:10.1038/nbt0314-203 First integrin inhibitor since Tysabri nears approval for IBD   pp205 - 207 Cormac Sheridan doi:10.1038/nbt0314-205 GSK picks six cancer research centers   p206 Suzanne Elvidge doi:10.1038/nbt0314-206 Intercept price quadruples in a day   p207 Brian Orelli doi:10.1038/nbt0314-207 Amgen and Regeneron push for a genetic renaissance in drug discovery   pp208 - 209 Michael Eisenstein doi:10.1038/nbt0314-208 BMS sells diabetes business   p209 Asher Mullard doi:10.1038/nbt0314-209 First recombinant Factor XIII approved   p210 Emma Dorey doi:10.1038/nbt0314-210a Around the world in a month   p210 doi:10.1038/nbt0314-210b Myriad diversifies, fights rearguard action on patents   p211 Malorye Allison doi:10.1038/nbt0314-211a Microbes unite Novozymes and Monsanto   p211 Jeffrey L Fox doi:10.1038/nbt0314-211b Roche bets on alpha-synuclein for Parkinson's   p212 Gunjan Sinha doi:10.1038/nbt0314-212a Correction Top Corrections   p212 doi:10.1038/nbt0314-212b Bioentrepreneur Top Building a business Acquiring orphans   pp213 - 216 Rogier Rooswinkel, Geert-Jan Mulder and Sander van Deventer doi:10.1038/nbt.2836 SciCafé Startups on the menu: Circuit Therapeutics   p216 doi:10.1038/nbt.2837 Opinion and Comment Top Correspondence Interactive visualization and analysis of large-scale sequencing datasets using ZENBU   pp217 - 219 Jessica Severin, Marina Lizio, Jayson Harshbarger, Hideya Kawaji, Carsten O Daub et al. doi:10.1038/nbt.2840 OpenSWATH enables automated, targeted analysis of data-independent acquisition MS data   pp219 - 223 Hannes L Rost, George Rosenberger, Pedro Navarro, Ludovic Gillet, Sasa M Miladinovic et al. doi:10.1038/nbt.2841 ProteomeXchange provides globally coordinated proteomics data submission and dissemination   pp223 - 226 Juan A Vizcaino, Eric W Deutsch, Rui Wang, Attila Csordas, Florian Reisinger et al. doi:10.1038/nbt.2839 Commentary From the analyst's couch: The outlook for biotech exits   pp227 - 228 Annette Grimaldi doi:10.1038/nbt.2852 The spectacular performance of biopharma companies in the public markets last year has carried over into optimism for early 2014. Will the boom continue? Features Top Nature Biotechnology's academic spinouts of 2013   pp229 - 238 Aaron Bouchie, Malorye Allison, Sarah Webb and Laura DeFrancesco doi:10.1038/nbt.2846 Ventures focusing on gene therapy, adoptive T-cell therapy, protein homeostasis and the microbiome are among those selected by the editors in 2013's crop of startups. Patents Recent patent applications in chimeric antigen receptors   p239 doi:10.1038/nbt.2854 News and Views Top Casting light on pain   pp240 - 241 Liam E Browne and Clifford J Woolf doi:10.1038/nbt.2844 Optogenetic methods to control nociceptors open up a wealth of potential applications in pain research and therapy. See also: Research by Iyer et al. E. coli network upgrade   pp241 - 243 Ulrich Stelzl doi:10.1038/nbt.2848 Combining yeast two-hybrid data with mass-spectrometry and structural data provides a detailed view of the E. coli interactome. See also: Research by Rajagopala et al. You are what you eat   pp243 - 245 Harald Brussow and Scott J Parkinson doi:10.1038/nbt.2845 Eating foods rich in plant fiber promotes health by changing the composition and metabolic products of gut bacteria. Research Highlights   p245 doi:10.1038/nbt.2849 Biotechnology JOBS of the week Doctoral Student in DISC1 and Underlying Gene Networks in Schizophrenia Institute for Molecular Medicine Finland (FIMM) Postdoc Position Adolphe Merkle Institute Post-doc in Process Design and Simulation of Biorefinery Concepts Ecole Polytechnique Fédérale de Lausanne (EPFL) Faculty Position Chemical Engineering Texas A&M University Postdoctoral Research Fellow Nanjing Agricultural University More Science jobs from Biotechnology EVENT 16 th International Biotechnology Symposium & Exhibition - IBS2014 September 14-19, 2014 Fortaleza, Brazil More science events from Computational Biology Top Analysis Integrating human sequence data sets provides a resource of benchmark SNP and indel genotype calls   pp246 - 251 Justin M Zook, Brad Chapman, Jason Wang, David Mittelman, Oliver Hofmann et al. doi:10.1038/nbt.2835 Zook et al. describe methods for integrating genome variants from five sequencing technologies to characterize the first benchmark sample that can be used to understand accuracy of human whole-genome and targeted sequencing. Research Top Perspective Mesenchymal stem cells: immune evasive, not immune privileged   pp252 - 260 James A Ankrum, Joon Faii Ong and Jeffrey M Karp doi:10.1038/nbt.2816 Articles Whole-genome haplotyping using long reads and statistical methods   pp261 - 266 Volodymyr Kuleshov, Dan Xie, Rui Chen, Dmitry Pushkarev, Zhihai Ma et al. doi:10.1038/nbt.2833 Haplotyping of human genomes is improved by augmenting experimental dilution-based haplotyping with statistical analyses, a strategy known until now only as 'Moleculo.' Genome-wide recessive genetic screening in mammalian cells with a lentiviral CRISPR-guide RNA library   pp267 - 273 Hiroko Koike-Yusa, Yilong Li, E-Pien Tan, Martin Del Castillo Velasco-Herrera and Kosuke Yusa doi:10.1038/nbt.2800 CRISPR-Cas9 genome editing technology is used for genome-wide genetic screens in mouse embryonic stem cells. Letters Virally mediated optogenetic excitation and inhibition of pain in freely moving nontransgenic mice   pp274 - 278 Shrivats Mohan Iyer, Kate L Montgomery, Chris Towne, Soo Yeun Lee, Charu Ramakrishnan et al. doi:10.1038/nbt.2834 Viral delivery of opsins to peripheral nociceptors allows optogenetic stimulation and inhibition of pain in non-transgenic freely moving mice. See also: News and Views by Browne & Woolf Improving CRISPR-Cas nuclease specificity using truncated guide RNAs   pp279 - 284 Yanfang Fu, Jeffry D Sander, Deepak Reyon, Vincent M Cascio and J Keith Joung doi:10.1038/nbt.2808 Guide RNAs with shorter regions of complementarity to target sites reduce off-target effects. Resources The binary protein-protein interaction landscape of Escherichia coli    pp285 - 290 Seesandra V Rajagopala, Patricia Sikorski, Ashwani Kumar, Roberto Mosca, James Vlasblom et al. doi:10.1038/nbt.2831 Yeast-two hybrid screening of E. coli proteins and integration with protein structure and genetic interaction data provides an extensive interactome resource. See also: News and Views by Stelzl Corrigenda Corrigendum: Reproducibility of high-throughput mRNA and small RNA sequencing across laboratories   p291 Peter A C 't Hoen, Marc R Friedlander, Jonas Almlof, Michael Sammeth, Irina Pulyakhina et al. doi:10.1038/nbt0314-291a Errata Erratum: A single-molecule long-read survey of the human transcriptome   p291 Donald Sharon, Hagen Tilgner, Fabian Grubert and Michael Snyder doi:10.1038/nbt0314-291b Erratum: Gap junction inhibition prevents drug-induced liver toxicity and fulminant hepatic failure   p291 Suraj J Patel, Jack M Milwid, Kevin R King, Stefan Bohr, Arvin Iracheta-Velle et al. doi:10.1038/nbt0314-291c Corrigendum Corrigendum: In search of dry powder   p291 Jonathan Behr and Phil Murray doi:10.1038/nbt0314-291d Careers and Recruitment Top Profiling the reform-era life sciences executive   pp292 - 293 John McLean doi:10.1038/nbt.2847 Healthcare's reform era is here, requiring executives in the life sciences industry to think differently about their skill sets and capabilities. People People   p294 doi:10.1038/nbt.2855 Advertisement nature.com webcasts Macmillan Science Communication presents a custom webcast: Realizing the promise of genomics through rapid innovation in biological analysis and interpretation. Thursday 13 March at 8am PDT/11am EDT/3pm GMT/4pm CET  Register for the free webcast followed by a live Q & A session  Sponsored by:     Natureevents is a fully searchable, multi-disciplinary database designed to maximise exposure for events organisers. The contents of the Natureevents Directory are now live. The digital version is available here. Find the latest scientific conferences, courses, meetings and symposia on natureevents.com. For event advertising opportunities across the Nature Publishing Group portfolio please contact natureevents@nature.com More Nature Events

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