Nature Reviews Immunology Contents August 2013 Volume 13 Number 8 pp 543-614

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TABLE OF CONTENTS
August 2013 Volume 13 Number 8
Impact Factor 33.129 *	In this issue Research Highlights Reviews Perspectives Also this month  Featured article: The role of dendritic cells in autoimmunity Dipyaman Ganguly, Stefan Haak, Vanja Sisirak & Boris Reizis
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RESEARCH HIGHLIGHTS Top Influenza virus: Lethal weapons p543 | doi:10.1038/nri3502 An unrestrained innate inflammatory response driven by pro-inflammatory neutrophils underlies lethal influenza virus infection. PDF Cytokines: True to their family name p544 | doi:10.1038/nri3496 IL-20R signalling inhibits pro-IL-1β expression and underlies susceptibility to infection with Staphylococcus aureus. PDF Immunogenetics: Serving up variation to fight adversity p544 | doi:10.1038/nri3505 Ethnic variation shapes inflammatory responses during cholera and tuberculosis infections. PDF Inflammasome: Fishing for anti-inflammatory mechanisms p545 | doi:10.1038/nri3498 Omega 3 fatty acids negatively regulate inflammasome activation through a G protein-coupled receptor pathway. PDF T cells: Maintaining T cell homeostasis p546 | doi:10.1038/nri3504 SHP1 negatively regulates IL-4R signalling to control the population expansion of memory-phenotype T cells. PDF Regulatory T cells: Distilling regulatory T cell inducers p546 | doi:10.1038/nri3506 Treatment with a mixture of 17 Clostridia strains or with short-chain fatty acids promotes colonic TReg cell function. PDF Viral immunity: Arms convoy p547 | doi:10.1038/nri3500 IFNα-induced exosomes transfer antiviral mediators to surrounding cells. PDF Immunodeficiency: Magnesium regulates antiviral immunity p548 | doi:10.1038/nri3501 NKG2D-mediated cytotoxicity of NK cells and CTLs is regulated by intracellular free Mg2+ concentration. PDF B cell tolerance: STALling B cell responses p548 | doi:10.1038/nri3503 Harmful B cell responses are eliminated using inhibitory liposomes. PDF IN BRIEF Inflammasome: Inflammasome is involved in parasite resistance | Osteoimmunology: The CD27-CD70 axis in osteoclast development | T cell memory: Right time, right place for protection | Monocytes: The monocyte family tree | NK cell responses: A dietary boost for NK cells | Macrophages: A role in early pregnancy PDF Immunology JOBS of the week Junior Research Group Leader (M / F) German Cancer Research Center (DKFZ) Postdoctoral fellow University of California, Riverside Postdoc - Gene Therapy Center University of Massachusetts Medical School (UMMS) Postdocoral Position Cellular and Molecular Immunology at the Free University of Brussels More Science jobs from Immunology EVENT Tumor Immunology and Immunotherapy 28.10.13 Suzhou, China More science events from
REVIEWS		Top
Newly described pattern recognition receptors team up against intracellular pathogens Petr Broz & Denise M. Monack p551 | doi:10.1038/nri3479 This Review provides a comprehensive overview of very recent progress in our understanding of the role of pattern recognition receptors, including Toll-like receptors, cytosolic nucleic acid receptors and NOD-like receptors that assemble inflammasomes, in the detection of and in the defence against intracellular pathogens. Abstract | Full Text | PDF
The role of dendritic cells in autoimmunity Dipyaman Ganguly, Stefan Haak, Vanja Sisirak & Boris Reizis p566 | doi:10.1038/nri3477 Dendritic cells (DCs) can promote both tolerogenic and pro-inflammatory immune responses and have been associated with various autoimmune diseases. However, it still remains unclear whether these cells have beneficial or detrimental functions in these settings. In this Review, the authors discuss the current understanding of the roles of distinct DC subsets in autoimmunity. Abstract | Full Text | PDF
New insights into pre-BCR and BCR signalling with relevance to B cell malignancies Robert C. Rickert p578 | doi:10.1038/nri3487 In this Review, the key signalling pathways that lie downstream of the pre-B cell receptor (BCR) and the BCR are discussed in terms of their contribution to B cell homeostasis and neoplasia, with a focus on the emerging distinctions between tonic and chronic active signalling. Abstract | Full Text | PDF
Applications of nanotechnology for immunology Douglas M. Smith, Jakub K. Simon & James R. Baker Jr p592 | doi:10.1038/nri3488 This Review describes the different types of nanotechnologies that can be used to target the immune system. The authors explain how the unique properties of different nanostructures can be used to either enhance or to suppress immune responses, and they discuss the promise of these strategies for developing more effective immunotherapies. Abstract | Full Text | PDF
PERSPECTIVES		Top
OPINION Type 2 immunity and wound healing: evolutionary refinement of adaptive immunity by helminths William C. Gause, Thomas A. Wynn & Judith E. Allen p607 | doi:10.1038/nri3476 In this Opinion, the authors provide their perspective on how the type 2 immune response may have evolved and how it functions to mediate both resistance and tolerance to tissue-destructive helminths. They propose that the damage induced during helminth migration and the subsequent need for tissue repair have been major factors in driving the evolution of the type 2 response. Abstract | Full Text | PDF
Erratum: Recognition of herpesviruses by the innate immune system Soren R. Paludan, Andrew G. Bowie, Kristy A. Horan & Katherine A. Fitzgerald p614 | doi:10.1038/nri3497 Full Text | PDF
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*2012 Journal Citation Report (Thomson Reuters, 2013)

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