Drug Discovery@nature.com 26 July 2013

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Read this Focus online: www.nature.com/neuro/focus/neurotechniques   News Top Researchers turn off Down's syndrome genes doi:10.1038/nature.2013.13406 Silencing extra chromosome in cell cultures could lead to new treatments for the disorder. Full Text Antibiotic resistance: The last resort doi:10.1038/499394a Health officials are watching in horror as bacteria become resistant to powerful carbapenem antibiotics – one of the last drugs on the shelf. Full Text Stricter standards sought to curb stem-cell confusion doi:10.1038/499389a Initiative aims to clarify description of mesenchymal cells. Full Text Made in Africa doi:10.1038/nm0713-803 The resource-poor countries of Africa have traditionally relied on Western nations for their drug supply, but a new drug development center with a promising antimalarial agent could pave the way for a homegrown pharmaceutical pipeline. Full Text Analysis Top S-nitrosylation boon to blood transfusions doi:10.1038/scibx.2013.673 The capacity of transfused red blood cells to transport oxygen is often reduced because of biochemical changes in the cells during storage. Now, Case Western and Duke researchers have improved oxygen delivery capacity by re-nitrosylating hemoglobin prior to transfusion and are planning to test the approach in clinical trials. Full Text New hope for dry AMD? doi:10.1038/nrd4038 There are no specific drugs on the market for dry age-related macular degeneration (AMD), but a pipeline of promising therapies are in development. Full Text Research Highlights Top Tumour immunology: Cracking the combination doi:10.1038/nri3481 Combined immunotherapies target macrophages and regulatory T cells to enhance antitumour responses. Full Text Metabolic disorders: Betatrophin boosts β-cells doi:10.1038/nrd4058 A novel liver-secreted hormone named betatrophin promotes β-cell proliferation and improves glucose tolerance in mice. Full Text Cancer: IL-22: linking inflammation and cancer doi:10.1038/nrd4065 IL-22 is a key player in the transition from intestinal inflammation to cancer. Full Text Research & Reviews Top Small-molecule modulation of neurotrophin receptors: a strategy for the treatment of neurological disease doi:10.1038/nrd4024 The therapeutic application of neurotrophins is limited by their poor pharmacological properties and undesirable pleiotropic actions. Targeting individual neurotrophin receptors using small-molecule ligands may overcome these limitations. Full Text New anti-inflammatory targets for chronic obstructive pulmonary disease doi:10.1038/nrd4025 This article highlights new therapeutic targets for COPD that have been discovered through a better understanding of the underlying inflammation, and discusses the development of anti-inflammatory drugs for this disorder. Full Text Cancer as a dysregulated epigenome allowing cellular growth advantage at the expense of the host doi:10.1038/nrc3486 The authors propose a model that suggests a new approach to cancer diagnosis and therapy that focuses on epigenetic dysregulation, and discuss its potential for risk detection and chemoprevention. Full Text In vivo cardiac reprogramming contributes to zebrafish heart regeneration doi:10.1038/nature12322 A cardiac injury study in zebrafish reveals the plasticity of heart cell lineages as shown by a Notch-dependent transdifferentiation of atrial to ventricular cardiomyocytes, regenerating a cell type that is damaged in human heart failure. Full Text Drug Discovery JOBS of the week PhD project on lncRNA role in cancer drug activity University of Rennes 1 Postdoctoral positions in GPCR Drug Discovery UNC Chapel Hill School of Medicine PhD in Biomedical Engineering: Ultrasound for Drug Delivery University of Glasgow Postdoctoral Research Associate - Drug Metabolism University of Washington Postdoctoral Position in Molecular Biology and Drug Discovery Moffitt Cancer Center & Research Institute More Science jobs from Drug Discovery EVENT 14th International Conference on Alzheimer's Drug Discovery 09.09.13 Jersey City, USA More science events from Careers Top Career snapshots archive Career snapshots feature people associated with drug discovery and drug development, with the aim of providing expert insights and advice on a wide range of positions and career paths in this field. Full Text Top   Natureevents is a fully searchable, multi-disciplinary database designed to maximise exposure for events organisers. The contents of the Natureevents Directory are now live. The digital version is available here. Find the latest scientific conferences, courses, meetings and symposia on natureevents.com. For event advertising opportunities across the Nature Publishing Group portfolio please contact natureevents@nature.com More Nature Events

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