Nature Reviews Immunology Contents July 2013 Volume 13 Number 7 pp 469-542

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TABLE OF CONTENTS
July 2013 Volume 13 Number 7
Impact Factor 33.129 *	In this issue Research Highlights Reviews Perspectives Also this month  Featured article: Unravelling the mechanisms of durable control of HIV-1 Bruce D. Walker & Xu G. Yu
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RESEARCH HIGHLIGHTS Top Tumour immunology: Cracking the combination p469 | doi:10.1038/nri3481 Combined immunotherapies target macrophages and regulatory T cells to enhance antitumour responses. PDF Inflammation: IL-1α comes to the fore p470 | doi:10.1038/nri3482 IL-1α fosters autoinflammation in the absence of fully active SH2 domain-containing protein tyrosine phosphatase 1 (SHP1). PDF Haematopoiesis: Neutrophil clearance keeps the beat p470 | doi:10.1038/nri3483 Neutrophil clearance controls the circadian release of haematopoietic progenitor cells from the bone marrow in the steady state. PDF Mucosal immunology: Autophagy helps man the barriers p470 | doi:10.1038/nri3489 Autophagy is an epithelial cell-intrinsic innate immune mechanism that protects against the dissemination of invasive intestinal bacteria. PDF Immunometabolism: What is the point of Warburg? p472 | doi:10.1038/nri3485 The switch to aerobic glycolysis in activated CD4+ T cells is required for full effector function but not for proliferation or survival. PDF Regulatory T cells: MARCHing for tolerance p472 | doi:10.1038/nri3486 Ubiquitylation of MHC class II molecules by DC-expressed MARCH1 is required for thymic TReg cell development. PDF Mucosal immunology: ILCs broker peace deals in the gut p473 | doi:10.1038/nri3480 Group 3 ILCs promote tolerance to commensal bacteria by inhibiting adaptive T cell responses. PDF IN BRIEF B cell responses: Follicular DC traps protect antigens | T cell responses: Tuberculosis traps are highly conserved | Antibodies: Cow traps are structurally unique PDF Immunology JOBS of the week Faculty Positions in Human Immunology The Vaccine & Gene Therapy Institute of Florida (VGTI Florida) Faculty Position in Molecular Microbiology Wayne State University (WSU) Postdoctoral Fellow Mount Sinai School of Medicine Distinguished Professors, Biomedical research, Guilin, China Guangxi Normal University Senior Research Scientist position in Immunology - ERC Advanced Grant Project, Technische Universität München Klinikum rechts der Isar - Technische Universität München More Science jobs from
REVIEWS		Top
How B cells capture, process and present antigens: a crucial role for cell polarity Maria-Isabel Yuseff, Paolo Pierobon, Anne Reversat & Ana-Maria Lennon-Duménil p475 | doi:10.1038/nri3469 In this Review, the authors discuss the molecular mechanisms that enable B cells to internalize, process and present antigens on MHC class II molecules to CD4+ T cells. They focus on the importance of cytoskeletal rearrangements and the establishment of polarity in B cells for these processes. Abstract | Full Text | PDF
Unravelling the mechanisms of durable control of HIV-1 Bruce D. Walker & Xu G. Yu p487 | doi:10.1038/nri3478 This article describes recent progress in delineating the factors that contribute to spontaneous HIV-1 immune control, with the ultimate aim of translating these studies into clinical strategies to induce a 'functional cure' of HIV-1 infection. Abstract | Full Text | PDF
Specificity through cooperation: BATF–IRF interactions control immune-regulatory networks Theresa L. Murphy, Roxane Tussiwand & Kenneth M. Murphy p499 | doi:10.1038/nri3470 The transcription factors BATF (basic leucine zipper transcription factor ATF-like), BATF2 and BATF3 have unique positive transcriptional activities in the development and the function of dendritic cells, B cells and T cells, which are mediated through molecular interactions with interferon-regulatory factor 4 (IRF4) and IRF8. Abstract | Full Text | PDF
On guard: coronin proteins in innate and adaptive immunity Jean Pieters, Philipp Müller & Rajesh Jayachandran p510 | doi:10.1038/nri3465 Coronins were first characterized on the basis of their interactions with the actin cytoskeleton and were later linked to immune dysfunction. In this short, focused Review, the authors discuss the emerging roles of coronins in immune cell signalling. Abstract | Full Text | PDF
Primary antibody deficiencies Anne Durandy, Sven Kracker & Alain Fischer p519 | doi:10.1038/nri3466 Primary antibody deficiencies (PADs) are the most common form of hereditary immunodeficiencies. Here, the authors discuss how recent progress in the genetic and molecular understanding of PADs has illuminated previously unappreciated aspects of B cell function and has helped to explain the broad range of pathologies linked to PADs. Abstract | Full Text | PDF | Supplementary information
PERSPECTIVES		Top
TIMELINE 25 years of interferon-based treatment of chronic hepatitis C: an epoch coming to an end Markus H. Heim p535 | doi:10.1038/nri3463 The mechanisms underlying the antiviral activity of type I interferons (IFNs) are still unclear, but IFNα has long been used in the treatment of chronic hepatitis C (CHC). While reviewing the history of IFNα-based CHC treatment, Markus H. Heim highlights the remaining questions and discusses the future challenges of IFN-based therapies. Abstract | Full Text | PDF
Erratum: Molecular mechanisms of T cell co-stimulation and co-inhibition Lieping Chen & Dallas B. Flies p542 | doi:10.1038/nri3484 Full Text | PDF
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*2012 Journal Citation Report (Thomson Reuters, 2013)

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