The EDGE: Molecular Systems Biology - New articles published 25 June 2013

Integrative genomics of gene and metabolic regulation by estrogen receptors α and β, and their coregulators

To define how the estrogen receptors α and β control specific responses in breast cancer cells, genome-wide patterns of chromatin binding of the ERα and ERβ receptors and their coregulators, SRC3 and RIP140, were determined and integrated with gene expression data and functional analyses.

Zeynep Madak-Erdogan, Tze-Howe Charn, Yan Jiang, Edison T Liu, John A Katzenellenbogen & Benita S Katzenellenbogen

Molecular Systems Biology 9:676; doi:10.1038/msb.2013.28; published 18 June 2013

Full Text | PDF | Supp. Inf. | Review Process

Research Articles

Dissecting a complex chemical stress: chemogenomic profiling of plant hydrolysates

Complex chemical stress arises during the production of biofuels. Large-scale mutant fitness profiling was used to identify bacterial and yeast tolerance genes and to model fitness in a complex hydrolysate mixture. The resulting model can be used to engineer more tolerant strains.

Jeffrey M Skerker, Dacia Leon, Morgan N Price, Jordan S Mar, Daniel R Tarjan, Kelly M Wetmore, Adam M Deutschbauer, Jason K Baumohl, Stefan Bauer, Ana B Ibáñez, Valerie D Mitchell, Cindy H Wu, Ping Hu, Terry Hazen & Adam P Arkin

Molecular Systems Biology 9:674; doi:10.1038/msb.2013.30; published 18 June 2013

Full Text | PDF | Supp. Inf. | Review Process

Efficient translation initiation dictates codon usage at gene start

Rare codons are enriched at gene start in many genomes. Genome analysis and experimental testing show that this enrichment evolved to keep the ribosome binding site free from stable mRNA structures, in order to facilitate efficient translation initiation.

Kajetan Bentele, Paul Saffert, Robert Rauscher, Zoya Ignatova & Nils Blüthgen

Molecular Systems Biology 9:675; doi:10.1038/msb.2013.32; published 18 June 2013

Full Text | PDF | Supp. Inf. | Review Process

Report

In vitro integration of ribosomal RNA synthesis, ribosome assembly, and translation

This report describes an integrated method for in vitro construction of Escherichia coli ribosomes under near-physiological conditions. This method enables coupling of ribosome synthesis and assembly in a single, integrated system.

Michael C Jewett, Brian R Fritz, Laura E Timmerman & George M Church

Molecular Systems Biology 9:678; doi:10.1038/msb.2013.31; published 25 June 2013

Full Text | PDF | Supp. Inf. | Review Process



You have been sent this Table of Contents Alert because you have opted in to receive it. You can change or discontinue your e-mail alerts at any time, by modifying your preferences on your nature.com account at: www.nature.com/nams/svc/myaccount (You will need to log in to be recognised as a nature.com registrant). For further technical assistance, please contact our registration department. For print subscription enquiries, please contact our subscription department. For other enquiries, please contact our customer feedback department. Nature Publishing Group \| 75 Varick Street, 9th Floor \| New York \| NY 10013-1917 \| USA Nature Publishing Group's worldwide offices: London - Paris - Munich - New Delhi - Tokyo - Melbourne San Diego - San Francisco - Washington - New York - Boston Macmillan Publishers Limited is a company incorporated in England and Wales under company number 785998 and whose registered office is located at Brunel Road, Houndmills, Basingstoke, Hampshire RG21 6XS. © 2013 Nature Publishing Group, a division of Macmillan Publishers Limited. All Rights Reserved.