EMBO Reports - Table of Contents alert Volume 14 Issue 6, pp 481-576

TABLE OF CONTENTS June 2013 | Volume 14, Issue 6 Upfront Science & Society Review Scientific Reports Also new AOP Sign up for e-alerts Recommend to your library Web feed Subscribe Advertisement The EMBO Meeting 2013 — 21-24 September in Amsterdam Keynotes: Kai Simons & Hans Clevers 20 concurrent sessions covering the life sciences Speakers include: Peer Bork, Vishva Dixit, Susan M Gasser, Stephen P Jackson, Timothy Mitchison Abstract submission & early registration: 12 June 2013, 14:00 CEST www.the-embo-meeting.org   Upfront Top Editorial Howyland A huge amount of time and money is wasted on a grants system few perceive as fair. Howy suggests a simplified approach that could produce a more satisfactory outcome. Howy Jacobs EMBO reports (2013), 14, 481; 10.1038/embor.2013.57 Full text | PDF Published online: 03 June 2013 Subject Categories: Science Policy & Funding Opinion Homo artefaciens Karl Popper's doctrine of empirical falsification has influenced many natural scientists, even though it denies the role of inductive reasoning. In reality, however, scientific progress can only come from objective measurements and the acknowledgement of the uncertainty of our models of the world. Ladislav Kováč EMBO reports (2013), 14, 482; 10.1038/embor.2013.66 Full text | PDF Published online: 17 May 2013 Subject Categories: Philosophy & History of Science Hot off the Press Macroautophagy—friend or foe of viral replication? Autophagy can either degrade pathogens or promote their replication. Both effects have been reported for Chikungunya virus and a recent study in EMBO reports solves this controversy, whilst indicating how to improve mouse models of the infection. Christian Münz EMBO reports (2013), 14, 483 - 484; 10.1038/embor.2013.55 Full text | PDF Published online: 10 May 2013 Subject Categories: Microbiology & Pathogens | Membranes & Transport | Immunology MicroRNA and autophagy—C. elegans joins the crew In this issue of EMBO reports, Zhang and Zhang reveal an inhibitory role of autophagy in miRNA function in C. elegans and show that autophagy selectively degrades the miRISC component AIN-1/GW182. Olivier Voinnet EMBO reports (2013), 14, 485 - 487; 10.1038/embor.2013.65 Full text | PDF Published online: 17 May 2013 Subject Categories: RNA | Membranes & Transport All astrocytes are not created equal—the role of astroglia in brain injury In two recent papers published in Nature Neuroscience and Cell Stem Cells, Magdalena Götz and colleagues shed new light on the in vivo response of glial cells to brain injury and characterize a highly heterogeneous behavior of astrocytes to chronic and acute brain injury. Darcie L Moore and Sebastian Jessberger EMBO reports (2013), 14, 487 - 488; 10.1038/embor.2013.54 Full text | PDF Published online: 26 April 2013 Subject Categories: Neuroscience Meeting Point Between new genetic discoveries and large randomized trials—neurological research in the era of systems medicine The 2012 Eibsee meeting on ‘Cellular Mechanisms of Neurodegeneration’ addressed the need to integrate research on classical neurodegenerative mechanisms with investigations that relate to the immunological, glial or vascular sequels that accompany and often propagate neuronal injury. Thomas Misgeld, Stefan F Lichtenthaler and Martin Dichgans EMBO reports (2013), 14, 489 - 492; 10.1038/embor.2013.70 Full text | PDF Published online: 14 May 2013 Subject Categories: Neuroscience | Molecular Biology of Disease | Genomic & Computational Biology Correspondence Response to ‘How good is research really?’ Alonso Rodríguez-Navarro EMBO reports (2013), 14, 493; 10.1038/embor.2013.60 Full text | PDF Published online: 14 May 2013 Subject Categories: Science Policy & Funding | Societal Issues & Politics Comments to the response of Rodríguez-Navarro Lutz Bornmann and Werner Marx EMBO reports (2013), 14, 494; 10.1038/embor.2013.63 Full text | PDF Published online: 14 May 2013 Subject Categories: Science Infrastructures & Publishing | Science Policy & Funding Response: 'Antibody crossreactivity between the tumour suppressor PHLPP1 and the proto-oncogene β-catenin' Eric W McIntush EMBO reports (2013), 14, 495 - 496; 10.1038/embor.2013.68 Full text | PDF Published online: 17 May 2013 Science & Society Top One world, one health From the point of view that all organisms and the environment share one health, expending effort to address the needs of animals and ecosystems might pay better dividends for human health in the longer term. Paul D van Helden, Lesley S van Helden and Eileen G Hoal EMBO reports (2013), 14, 497 - 501; 10.1038/embor.2013.61 Full text | PDF Published online: 17 May 2013 Subject Categories: Health & Disease | Evolution, Environment & Agriculture The balance of brains—corruption and migration Corruption plays a significant role in how (un)attractive a country is to skilled workers. Rather than focusing on education or immigration policies, governments ought first to tackle corruption in the labour market if they want to attract international talent. Andrea Ariu and Mara Pasquamaria Squicciarini EMBO reports (2013), 14, 502 - 504; 10.1038/embor.2013.59 Full text | PDF Published online: 17 May 2013 Subject Categories: Science Policy & Funding | Societal Issues & Politics Your decisions are what you eat Does being hungry affect your judgment? Is a good meal a precursor to a good mood? New research is discovering how metabolic state and the nutritional quality of food influence risk-taking and decision-making behaviours in animals and humans. Philip Hunter EMBO reports (2013), 14, 505 - 508; 10.1038/embor.2013.69 Full text | PDF Published online: 17 May 2013 Subject Categories: Evolution, Environment & Agriculture | Societal Issues & Politics Review Top Mechanosensitivity and compositional dynamics of cell–matrix adhesions This review provides an overview of the compositional dynamics of cell–matrix adhesions and discusses the most prevalent functional domains in adhesome proteins. It also reviews the current literature and concepts about mechanosensing mechanisms that operate at the adhesion site. Herbert B Schiller and Reinhard Fässler EMBO reports (2013), 14, 509 - 519; 10.1038/embor.2013.49 Abstract | Full text | PDF Published online: 17 May 2013 Subject Categories: Cell & Tissue Architecture | Signal Transduction | Proteins Scientific Reports Top Insights into congenital stationary night blindness based on the structure of G90D rhodopsin The G90D rhodopsin mutant causes congenital stationary night blindness. This study shows that the mutation interferes with the E113-K296 activation switch, introduces an alternative salt-bridge and thus promotes the constant basal activation of the visual signal cascade typical for this disease. Ankita Singhal, Martin K Ostermaier, Sergey A Vishnivetskiy, Valérie Panneels, Kristoff T Homan, John J G Tesmer, Dmitry Veprintsev, Xavier Deupi, Vsevolod V Gurevich, Gebhard F X Schertler and Joerg Standfuss EMBO reports (2013), 14, 520 - 526; 10.1038/embor.2013.44 Abstract | Full text | PDF | Supp. info. | Review Process File Published online: 12 April 2013 Subject Categories: Molecular Biology of Disease | Structural Biology Antisense regulation by transposon-derived RNAs in the hyperthermophilic archaeon Sulfolobus solfataricus   EMBO Open This study provides evidence that transposon-derived antisense RNAs in the hyperthermophilic archaeon Sulfolobus solfataricus can regulate gene expression in trans. Birgit Märtens, Salim Manoharadas, David Hasenöhrl, Andrea Manica and Udo Bläsi EMBO reports (2013), 14, 527 - 533; 10.1038/embor.2013.47 Abstract | Full text | PDF | Supp. info. | Review Process File Published online: 12 April 2013 Subject Categories: RNA | Microbiology & Pathogens Species-specific impact of the autophagy machinery on Chikungunya virus infection CHIKV interacts with the autophagy machinery, inducing a cytoprotective effect. In addition, binding to the human—but not mouse—autophagy receptor NDP52 promotes viral replication. This explains CHIKV species specificity and could help engineer a mouse model of infection. Delphine Judith, Serge Mostowy, Mehdi Bourai, Nicolas Gangneux, Mickaël Lelek, Marianne Lucas-Hourani, Nadège Cayet, Yves Jacob, Marie-Christine Prévost, Philippe Pierre, Frédéric Tangy, Christophe Zimmer, Pierre-Olivier Vidalain, Thérèse Couderc and Marc Lecuit EMBO reports (2013), 14, 534 - 544; 10.1038/embor.2013.51 Abstract | Full text | PDF | Supp. info. | Review Process File Published online: 26 April 2013 Subject Categories: Microbiology & Pathogens | Membranes & Transport | Proteins Charcot-Marie-Tooth disease-associated mutants of GDAP1 dissociate its roles in peroxisomal and mitochondrial fission It is shown that, in addition to its role at mitochondria, the tail-anchored protein GDAP1 also regulates fission events at peroxisomes. Intriguingly, mutants of GDAP1 associated with inherited peripheral neuropathies differently affect peroxisomal and mitochondrial fission. Nina Huber, Sofia Guimaraes, Michael Schrader, Ueli Suter and Axel Niemann EMBO reports (2013), 14, 545 - 552; 10.1038/embor.2013.56 Abstract | Full text | PDF | Supp. info. | Review Process File Published online: 30 April 2013 Subject Categories: Membranes & Transport | Molecular Biology of Disease | Neuroscience Cuf2 boosts the transcription of APC/C activator Fzr1 to terminate the meiotic division cycle Only two nuclear divisions occur in meiosis. Here, fission yeast mutants in cuf2 or its target fzr1 are shown to enter into a third nuclear division, highlighting the role of Cuf2 in terminating M-phase and, thus, generating functional gametes. Yuki Aoi, Kunio Arai, Masaya Miyamoto, Yuji Katsuta, Akira Yamashita, Masamitsu Sato and Masayuki Yamamoto EMBO reports (2013), 14, 553 - 560; 10.1038/embor.2013.52 Abstract | Full text | PDF | Supp. info. | Review Process File Published online: 30 April 2013 Subject Categories: Cell Cycle The role of doublesex in the evolution of exaggerated horns in the Japanese rhinoceros beetle The doublesex (dsx) gene controls sex-specific morphologies in a wide variety of animals. This study shows that dsx has an antagonistic role in male and female rhinoceros beetle head horn formation and suggests that this sex-specific regulation of dsx was crucial for the evolution of exaggerated male horns. Yuta Ito, Ayane Harigai, Moe Nakata, Tadatsugu Hosoya, Kunio Araya, Yuichi Oba, Akinori Ito, Takahiro Ohde, Toshinobu Yaginuma and Teruyuki Niimi EMBO reports (2013), 14, 561 - 567; 10.1038/embor.2013.50 Abstract | Full text | PDF | Supp. info. | Review Process File Published online: 23 April 2013 Subject Categories: Development | Molecular Evolution Autophagy modulates miRNA-mediated gene silencing and selectively degrades AIN-1/GW182 in C. elegans This study shows that during Caenorhabditis elegans development autophagy modulates miRNA-mediated cell fate specification and that a key component of the miRISC, GW182, is selectively degraded by autophagy. Peipei Zhang and Hong Zhang EMBO reports (2013), 14, 568 - 576; 10.1038/embor.2013.53 Abstract | Full text | PDF | Supp. info. | Review Process File Published online: 26 April 2013 Subject Categories: RNA | Development | RNA Please note that you need to be a subscriber or site-licence holder to enjoy full-text access to EMBO reports. In order to do so, please purchase a subscription. You have been sent this Table of Contents Alert because you have opted in to receive it. You can change or discontinue your e-mail alerts at any time, by modifying your preferences on your nature.com account at: www.nature.com/nams/svc/myaccount (You will need to log in to be recognised as a nature.com registrant). For further technical assistance, please contact our registration department. For print subscription enquiries, please contact our subscription department. For other enquiries, please contact our customer feedback department. Nature Publishing Group | 75 Varick Street, 9th Floor | New York | NY 10013-1917 | USA Nature Publishing Group's worldwide offices: London - Paris - Munich - New Delhi - Tokyo - Melbourne San Diego - San Francisco - Washington - New York - Boston Macmillan Publishers Limited is a company incorporated in England and Wales under company number 785998 and whose registered office is located at Brunel Road, Houndmills, Basingstoke, Hampshire RG21 6XS. © 2011 European Molecular Biology Organization