Nature Reviews Neuroscience contents June 2013 Volume 14 Number 6 pp 377-451

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TABLE OF CONTENTS
June 2013 Volume 14 Number 6
Impact Factor 30.455 *	In this issue Research Highlights Reviews Perspectives Also this month  Featured article: BDNF-based synaptic repair as a disease-modifying strategy for neurodegenerative diseases Bai Lu, Guhan Nagappan, Xiaoming Guan, Pradeep J. Nathan & Paul Wren
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RESEARCH HIGHLIGHTS Top Neuroendocrinology: Hypothalamic self-tuning to stress p377 | doi:10.1038/nrn3508 Stress induces a metaplastic signal at GABA synapses in the paraventricular nucleus of the hypothalamus that can account for both the early sensitization and the delayed inhibition of responses to subsequent stressors. PDF Pain: Feeling the heat (and cold) p378 | doi:10.1038/nrn3507 A new study shows that a subtype of dorsal root ganglion sensory neurons that express calcitonin gene-related peptide-α are involved in sensing heat but also indirectly modulate cold-sensing neurons. PDF Synaptic transmission: Summer blues p378 | doi:10.1038/nrn3517 Exposure to different day-night cycles leads to a change in the expression of neurotransmitters and behaviour in adult rats. PDF Sensory systems: Encoding aversion p378 | doi:10.1038/nrn3518 The gene encoding trace amine-associated receptor 4 (TAAR4) is essential for the detection of aversive odours in mice, demonstrating the importance of an individual receptor gene for odour perception. PDF Spatial processing: Place cells as route planners p380 | doi:10.1038/nrn3514 Rats may use sequences of activity in hippocampal place cells to plan a route to a remembered location. PDF Learning and memory: Learning with peaks and troughs p380 | doi:10.1038/nrn3515 Circadian corticosterone fluctuations support learning and memory by promoting learning-associated spine formation and elimination. PDF Auditory system: Sound choices p381 | doi:10.1038/nrn3523 Corticostriatal neuronal activity in the auditory cortex is necessary to drive behavioural choices in an auditory discrimination task. PDF IN BRIEF Metabolism: Flavours of value | Psychiatric disorders: Astrocytic ATP in depression | Neuroimaging: Evaluating ads with fMRI | Visual processing: Area V4 in motion | Circadian rhythms: Temperature training | Neuroimaging: Detecting consciousness in infants | Neural transplantation: Reprogramming fibroblasts to OPCs | Techniques: CLARITY in imaging PDF Neuroscience JOBS of the week Post-doctoral position in Computational Genomics Cold Spring Harbor Laboratory Scientist in Neurodevelopmental Diseases F. Hoffmann-La Roche AG Tenure Track Faculty Position Mie University Medical School Director, Alzheimer’s Disease and Dementia Initiative The New York Academy of Sciences (NYAS) Position for Stem Cell Researcher - PhD student Laval University More Science jobs from Neuroscience EVENT Methods in Computational Neuroscience 31.07.13 Woods Hole, US More science events from
REVIEWS		Top
NMDA receptor subunit diversity: impact on receptor properties, synaptic plasticity and disease Pierre Paoletti, Camilla Bellone & Qiang Zhou p383 | doi:10.1038/nrn3504 The subunit composition of NMDA receptors (NMDARs) determines their biophysical, pharmacological and signalling properties. Paoletti et al. examine the contribution of individual receptor subtypes to normal physiology and disease, and the potential benefits of targeting specific NMDAR subtypes to counteract the deleterious effects of deregulated glutamatergic transmission. Abstract | Full Text | PDF
BDNF-based synaptic repair as a disease-modifying strategy for neurodegenerative diseases Bai Lu, Guhan Nagappan, Xiaoming Guan, Pradeep J. Nathan & Paul Wren p401 | doi:10.1038/nrn3505 Synaptic dysfunction is a key pathophysiological hallmark in several neurodegenerative disorders. In this Review, Lu and colleagues consider a 'synaptic repair'-based therapy for neurodegenerative diseases that targets pathophysiology rather than pathogenesis and discuss BDNF as a potential synaptic repair molecule. Abstract | Full Text | PDF
The contextual brain: implications for fear conditioning, extinction and psychopathology Stephen Maren, K. Luan Phan & Israel Liberzon p417 | doi:10.1038/nrn3492 Contexts provide information that is central to understanding the meaning of events. Maren and colleagues describe the neural systems that underlie context processing and consider how deficits in these systems may be involved in several psychiatric conditions. Abstract | Full Text | PDF
Bridging the gap between theories of sensory cue integration and the physiology of multisensory neurons Christopher R. Fetsch, Gregory C. DeAngelis & Dora E. Angelaki p429 | doi:10.1038/nrn3503 Research in multisensory processing has exploded in recent years, but different experimental and theoretical approaches have yielded conflicting or seemingly unrelated results. In this Review, Fetsch et al. present a body of work that attempts to integrate and accommodate these findings. Abstract | Full Text | PDF
Erratum: Power failure: why small sample size undermines the reliability of neuroscience Katherine S. Button, John P. A. Ioannidis, Claire Mokrysz, Brian A. Nosek, Jonathan Flint, Emma S. J. Robinson & Marcus R. Munafó p442 | doi:10.1038/nrn3502 Full Text | PDF
Erratum: Emerging roles of astrocytes in neural circuit development Laura E. Clarke & Ben A. Barres p442 | doi:10.1038/nrn3506 Full Text | PDF
PERSPECTIVES		Top
OPINION Sleep and the single neuron: the role of global slow oscillations in individual cell rest Vladyslav V. Vyazovskiy & Kenneth D. Harris p443 | doi:10.1038/nrn3494 Sleep is characterized by globally synchronized neuronal activity. Vyazovskiy and Harris propose that the synchronous 'down states' of neuronal populations during sleep enable neurons to perform prophylactic maintenance in the absence of synaptic inputs and spiking activity, and hypothesize that this is a key function of sleep. Abstract | Full Text | PDF
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